One Health最新文献

{"title":"Government policy targeting antimicrobial use in production animals: A call to action commentary.","authors":"Fiona Emdin, Kayla Strong, Daniela Corno, Jaskeerat Singh, Susan Rogers Van Katwyk, Heather Ganshorn, Arne Ruckert, Jeremy M Grimshaw, Mathieu Jp Poirier","doi":"10.1016/j.onehlt.2025.101221","DOIUrl":"10.1016/j.onehlt.2025.101221","url":null,"abstract":"<p><p>This commentary is submitted in support of a systematic review titled \"Government policy interventions to reduce veterinary antimicrobial consumption in production animals: a systematic review and evidence map,\" which is currently under review for publication. While the systematic review synthesizes and critically appraises the global evidence on government policy interventions to reduce antimicrobial use (AMU) and antimicrobial resistance (AMR) in production animals, this commentary highlights the key policy implications of that evidence.</p>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"22 ","pages":"101221"},"PeriodicalIF":5.3,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13308216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A virtual One Health Community of practice in West Nile sub-region, Uganda: Implementation experience and participation trends.","authors":"Dickson Akankwatsa, Maureen Kesande, Ivan Segawa, Gilbert Aniku, Dathan Byonanebye","doi":"10.1016/j.onehlt.2026.101471","DOIUrl":"10.1016/j.onehlt.2026.101471","url":null,"abstract":"<p><p>Uganda faces recurrent and emerging health threats due to its proximity to the biodiverse Congo Basin. A multi-hazard risk assessment using the WHO Strategic Toolkit for Assessing Risks identified and prioritized nine public health hazards in the West-Nile sub-region, Uganda. Recognizing that most hazards had significant One Health implications, a One Health Community of Practice (OHCoP) was established to enhance cross-sectoral collaboration and coordination. Based on a Strengths, Weaknesses, Opportunities, and Threats analysis, virtual engagement was selected as the most feasible, cost-effective, and scalable dissemination strategy. Between April 2023 and September 2024, 11 of 18 planned virtual sessions were conducted, with a median attendance of 33 (range: 20-145), predominantly human health professionals (94%). Although the virtual OHCoP proved a practical and low-cost model for cross-sectoral knowledge exchange, stronger inclusion of non-human health sectors will require improved digital literacy, professional incentives, blended formats, and institutional commitment to joint planning and decision-making.</p>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"22 ","pages":"101471"},"PeriodicalIF":5.3,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13273853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One Health ethics in context: Justice, interdependence, and normative pluralism.","authors":"Andrea Ford, Lisa Boden, Paulo Ferrinho, Saana Jukola, Lucy Robertson, Jakob Zinsstag","doi":"10.1016/j.onehlt.2026.101467","DOIUrl":"10.1016/j.onehlt.2026.101467","url":null,"abstract":"","PeriodicalId":19577,"journal":{"name":"One Health","volume":"22 ","pages":"101467"},"PeriodicalIF":5.3,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13262169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the ability of a thermal biology-informed reproduction number to explain patterns of West Nile incidence in Europe.","authors":"Julian Heidecke, Hedi Katre Kriit, Peter Fransson, Jonas Wallin, Joacim Rocklöv","doi":"10.1016/j.onehlt.2026.101469","DOIUrl":"10.1016/j.onehlt.2026.101469","url":null,"abstract":"<p><p>West Nile virus (WNV) is a growing risk to public and veterinary health in Europe, with intensifying outbreaks over recent decades coinciding with a rapidly warming climate. Thermal biology models parameterized through laboratory experiments on the mosquito vectors and the pathogen play a central role in our causal understanding of the effects of temperature on WNV transmission. We evaluated the ability of a thermal biology model of WNV's relative basic reproduction number (R₀) to explain patterns of real-world transmission risk using monthly records of human West Nile virus neuroinvasive disease (WNND) in Europe between 2010 and 2023. We assessed spatial and temporal alignments of R₀ estimates and WNND observations and calculated R₀ estimates from temperature data of varying resolution, assessing the value of these estimates for WNND risk ranking compared to temperature alone. Moreover, we used generalized additive models to investigate if the effect of temperature on the WNND incidence across Europe mirrors the R₀ temperature response, including the optimal temperature for transmission. We found that R₀ accurately captured the seasonality of WNND, the temperatures associated with peak risk, and marginally improved WNND risk ranking compared to temperature alone. However, R₀ poorly explained the irregular interannual incidence pattern and more limited geographical range of reported WNND cases. Additionally, nonlinear averaging of R₀ calculations from high temporal resolution temperature data slightly improved risk ranking at elevated temperatures, whereas estimates based on average temperatures were better when lower temperatures were also included. Sensitivity analyses suggested that the validation of the optimal transmission temperature was largely informed by observations from Greece, as other countries contributed little information at such high temperatures. These findings demonstrate that thermal biology models capture important aspects of WNND risk in Europe. However, incorporation of additional ecological and epidemiological drivers is needed to develop more accurate risk predictions.</p>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"22 ","pages":"101469"},"PeriodicalIF":5.3,"publicationDate":"2026-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13262279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of bovine coronavirus in myocardial tissue of a naturally infected calf.","authors":"Violetta Iris Vasinioti, Adriana Lo Giudice, Marco Cordisco, Maria Stella Lucente, Valeria Buonfrate, Canio Buonavoglia, Paolo Capozza, Nicola Decaro, Annamaria Pratelli","doi":"10.1016/j.onehlt.2026.101464","DOIUrl":"10.1016/j.onehlt.2026.101464","url":null,"abstract":"<p><p>Coronaviruses are RNA viruses with high genomic plasticity and with the ability to infect a wide range of animal hosts, including humans. Among them, the highly pathogenic SARS-CoV-2, a <i>betacoronavirus,</i> is the causative agent of severe respiratory infection, and has also been associated with extrapulmonary manifestations, including cardiac involvement. BCoV, another <i>betacoronavirus,</i> is a major pathogen of cattle, primarily affecting the respiratory and enteric systems. Herein, a case of death in a calf with clinical signs consistent with BCoV infection is described. Potential cardiac involvement was further investigated, motivated by evidence of SARS-CoV-2 associated cardiac pathology in humans. Pulmonary and cardiac tissues were subjected to molecular and histological analyses. BCoV RNA was detected in both heart and lungs while immunohistochemical and immunofluorescence analyses confirmed BCoV antigen presence in both tissues. Cardiac detection was mainly observed in the conduction system and the endothelial cells. This study provides the first evidence of cardiac detection of BCoV and lays the foundation for future research on the closely related human coronavirus OC43, contributing to the One Health approach.</p>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"22 ","pages":"101464"},"PeriodicalIF":5.3,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13264246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transmission and genomic insights into <i>Elizabethkingia miricola</i>: A zoonotic pathogen with intrinsic resistance and nosocomial outbreak potential.","authors":"Shaohua Hu, Xiaohua Meng, Guo Tian, Shujun Ni, Shaojun Hu","doi":"10.1016/j.onehlt.2026.101465","DOIUrl":"10.1016/j.onehlt.2026.101465","url":null,"abstract":"<p><p><i>Elizabethkingia miricola</i> is an emerging opportunistic pathogen with increasing human clinical isolation. Infections pose major therapeutic challenges. This study sequenced the genomes of five clinical <i>E. miricola</i> isolates and employed comparative genomics with globally sourced strains to investigate resistance mechanisms, pathogenicity, phylogenetic relationships, and transmission patterns. Phylogenetic analysis revealed that <i>E. miricola</i> evolution exhibits no strict correlation with sample source, geographical origin, or region. Isolates from amphibians clustered within clinical lineages, implicating environmental reservoirs-potentially sink water-as infection sources. Geographically, pathogenic <i>E. miricola</i> demonstrates worldwide dissemination, with high prevalence in China and Europe. Putative transmission networks indicate intra-hospital spread and transnational circulation, suggesting nosocomial outbreak risks. Shared resistance genes (including <i>BlaB</i> and <i>GOB</i> β-lactamases) and virulence profiles between human and anuran strains highlight intrinsic resistance and pathogenic potential. Minocycline and doxycycline exhibited potent antimicrobial activity, indicating promising therapeutic alternatives. These findings highlight the zoonotic threat of <i>E. miricola</i> via nosocomial and potentially international horizontal transmission. Preventing outbreaks necessitates enhanced genomic surveillance of this pathogen.</p>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"22 ","pages":"101465"},"PeriodicalIF":5.3,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13264240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmid-borne <i>mcr-4.3</i> in <i>Acinetobacter nosocomialis</i> recovered from imported beef cattle: Genomic characterization and one health implications.","authors":"Hao Xu, Yaling Li, Shaohua Hu, Ruishan Liu, Kun Wang, Beiwen Zheng, Yonghong Xiao","doi":"10.1016/j.onehlt.2026.101466","DOIUrl":"10.1016/j.onehlt.2026.101466","url":null,"abstract":"<p><strong>Background: </strong>The emergence of mobile colistin resistance determinants in clinically relevant Acinetobacter species poses a growing challenge to antimicrobial stewardship and One Health surveillance. Although <i>mcr-4.3</i> has been reported in <i>Acinetobacter</i>, its occurrence in imported food animals and its broader phylogenomic context remain poorly defined.</p><p><strong>Methods: </strong>We investigated fecal samples collected from 150 beef cattle imported from Australia to China. <i>Acinetobacter</i> isolates recovered by selective culture were subjected to whole-genome sequencing, and the <i>mcr-4.3</i>-positive isolate was further resolved by hybrid assembly using short- and long-read sequencing. Comparative plasmid analysis and global phylogenomic analysis were performed using publicly available <i>A. nosocomialis</i> genomes.</p><p><strong>Results: </strong>Among 54 <i>Acinetobacter</i> isolates recovered from imported cattle, one <i>A. nosocomialis</i> isolate, NB148, carried <i>mcr-4.3</i>. Complete genome sequencing showed that <i>mcr-4.3</i> was located on a 28,233-bp plasmid, designated pNB148_mcr-4.3, which harbored plasmid maintenance-associated toxin-antitoxin systems and shared substantial backbone similarity with previously reported <i>mcr-4.3</i>-bearing plasmids from <i>Acinetobacter</i> species. The <i>mcr-4.3</i> region was positioned downstream of a putative recombinase and a Tn<i>3</i>-family transposase, suggesting a conserved genetic framework for this resistance determinant. Global phylogenomic analysis incorporating 574 publicly available <i>A. nosocomialis</i> genomes placed NB148 within a diverse international population characterized by mixing across animal, environmental, and human sources. Among the global collection, 11 genomes carried <i>mcr-4.3</i>, of which 10 belonged to ST279, indicating that this lineage may represent an important genomic background for the persistence and international distribution of <i>mcr-4.3</i>-positive <i>A. nosocomialis</i>.</p><p><strong>Conclusions: </strong>This study documents plasmid-borne <i>mcr-4.3</i> in <i>A. nosocomialis</i> recovered from imported beef cattle and places this finding within a broader international One Health context. Our data expand the known ecological range of <i>mcr-4.3</i>-positive <i>A. nosocomialis</i> and support strengthened genomic surveillance at animal-human-environment interfaces, particularly in importation and border inspection settings.</p>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"22 ","pages":"101466"},"PeriodicalIF":5.3,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13265652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zoonotic tuberculosis: When diagnostic and surveillance systems are not designed to detect it.","authors":"Ana Marcia Sá Guimarães, Kevim Bordignon Guterres, Maria Clara da Silva Galrão Cunha, Erica Chimara, Maria de Lourdes Viude de Oliveira, Flábio Araújo","doi":"10.1016/j.onehlt.2026.101463","DOIUrl":"10.1016/j.onehlt.2026.101463","url":null,"abstract":"<p><p>Zoonotic tuberculosis (zTB) remains a blind spot in TB control, sustained less by biological rarity than by diagnostic and surveillance design. Brazil illustrates this gap: despite endemic bovine TB and sustained zoonotic transmission risks, zTB is rarely identified because it is not actively targeted. We show that only two human zTB cases were notified between 2013 and 2024 following introduction of reporting, and six cases are described in the literature. Further detection of mono-pyrazinamide resistance may represent undiagnosed zTB, but diagnostic gaps prevent estimation. By outlining current diagnostic paths, we argue that the human-centric diagnostics obscures occupational, foodborne, and animal-linked infection. Emerging subnational One Health initiatives demonstrate that integrated animal-human surveillance is feasible. Therefore, we propose a risk-based, One Health diagnostic protocol for zTB within the Brazilian public health system, and argue that without structural and policy adaptation, human-TB elimination strategies will continue to exclude zTB by design, not only in Brazil.</p>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"22 ","pages":"101463"},"PeriodicalIF":5.3,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13265693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated meta-analysis and sentinel surveillance: Global prevalence and risk factors for Mycoplasma bovis in cattle (2007–2023)","authors":"Sen Zhang ,&nbsp;Guoxing Liu ,&nbsp;Fansong Yu ,&nbsp;Jiyu Zhang ,&nbsp;Xuzheng Zhou ,&nbsp;Aizhen Guo ,&nbsp;Yingyu Chen","doi":"10.1016/j.onehlt.2026.101318","DOIUrl":"10.1016/j.onehlt.2026.101318","url":null,"abstract":"<div><h3>Background</h3><div><em>Mycoplasma bovis</em> (<em>M. bovis</em>) is a major pathogen of cattle and contributes to substantial economic losses worldwide. A comprehensive understanding of its global prevalence is lacking, hindering the development of effective control strategies.</div></div><div><h3>Objectives</h3><div>This study aimed to determine the global pooled prevalence of <em>M. bovis</em>, identify key factors influencing its epidemiology, and validate the findings with recent regional surveillance data.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. A literature search was performed across four databases in June 2025, encompassing studies published between 2007 and 2023. Additionally, 979 nasal swab samples from Chinese herds from 2021 to 2024 were analyzed using conventional PCR.</div></div><div><h3>Results</h3><div>Twenty-three studies from 13 countries were included. The global pooled prevalence was 24.5 % (95 % CI: 12.7 %–38.7 %), with extremely high heterogeneity (<em>I</em>^<em>2</em> = 99.9 %). Our independent laboratory data also revealed a nearly identical positivity level of 21.9 % in Chinese herds from 2021 to 2024. Subgroup analyses identified age as the most significant risk factor, with a dramatically greater prevalence in young stock (&lt; 12 months) (56.2 %) than in adults (6.7 %) (<em>p</em> = 0.01). A relatively high prevalence was also associated with beef production systems, male cattle, serum samples, and culture method. Sensitivity analysis and publication bias assessment confirmed the robustness of the findings.</div></div><div><h3>Conclusion</h3><div>This study provides the first robust estimate of the global prevalence of <em>M. bovis</em>, validated by contemporary surveillance data. These findings underscore the severe burden of infection in young stock and provide crucial evidence to inform targeted surveillance and control programs in the global cattle industry.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"22 ","pages":"Article 101318"},"PeriodicalIF":4.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of water quality and associated health risks in community-managed water systems in highland areas: A case study Chiang Rai province, Thailand","authors":"Suntorn Sudsandee ,&nbsp;Wissanupong Kliengchuay ,&nbsp;Vivat Keawduanglek ,&nbsp;Anuttara Hongtong ,&nbsp;Weerayuth Siriratruengsuk ,&nbsp;Sarima Niampradit ,&nbsp;Rachaneekorn Mingkhwan ,&nbsp;Nuttapohn Kiangkoo ,&nbsp;Nopadol Precha ,&nbsp;Kraichat Tantrakarnapa","doi":"10.1016/j.onehlt.2025.101290","DOIUrl":"10.1016/j.onehlt.2025.101290","url":null,"abstract":"<div><h3>Background</h3><div>The present study addresses the persistent challenges associated with access to safe drinking water in highland communities of Thailand. Informal water supply systems, often managed by local villagers, rely heavily on untreated groundwater and surface water sources. This study assessed the quality of community-managed water supply systems and the associated health risks in Bandu and Nang Lae sub-districts, Chiang Rai Province, Thailand.</div></div><div><h3>Methods</h3><div>To evaluate the quality of these community-managed water systems, a total of 66 water samples from 22 villages were collected and analyzed for physical, chemical, and biological parameters. Heavy metal concentrations were measured, and health risk assessments were conducted through dermal and oral exposure routes based on U.S. EPA guidelines. The One health concept was integrated to explain the association among human, animal, and ecological systems.</div></div><div><h3>Results</h3><div>Monitoring data showed that many parameters exceeded the Provincial Waterworks Authority (PWA)’s standard, including pH (41 %), iron (32 %), lead (5 %), turbidity (2 %), mercury (2 %), and lack of free residual chlorine (100 %). The water samples showed signs of biological contamination. Total coliform bacteria were found in 39 % of the samples, fecal coliform bacteria in 27 %, and <em>Escherichia coli</em> in 9 %. Health risk assessments indicated that hazard quotients (HQs) and hazard indices (HIs) for heavy metals were less than 1, suggesting a negligible health risk. Total coliform bacteria levels in household water samples were positively correlated with diarrhea incidence (<em>r</em> = 0.54, <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>However, a positive correlation was observed between total coliform presence and reported diarrhea cases. The findings underscore the urgent need for improved water treatment practices, animal excreta management, ecological systems, and government interventions to ensure access to a safe water supply for highland communities in Thailand, which are under the one health concept. However, it highlights the need to focus on water quality, as in SDG 6 ensuring the availability and sustainable management of water and sanitation for all.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"22 ","pages":"Article 101290"},"PeriodicalIF":4.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}