One Health最新文献

{"title":"Design framework to develop sustainable innovations for addressing One Health challenges","authors":"Avis Anya Nowbuth ,&nbsp;Vikram Singh Parmar","doi":"10.1016/j.onehlt.2025.101031","DOIUrl":"10.1016/j.onehlt.2025.101031","url":null,"abstract":"<div><div>The complexity of global health challenges requires integrated approaches that crosses traditional boundaries. One Health (OH) offers a holistic approach to address health issues at the crossroads of human, animal, and environmental domains. Antimicrobial Resistance (AMR), a prime example of a cross-sectoral issue and OH challenge, highlights the need for coordinated interventions that consider multiple stakeholders. Current approaches to improve OH challenges and AMR have limited success, often due to a lack of a structured theoretical approach that informs the design and development of solutions for long-term sustainability. Existing frameworks focus primarily on human or veterinary sectors in isolation, leaving a gap in comprehensive, integrated approaches that align with OH principles. The proposed framework addresses this gap by offering a structured approach to both implementing and evaluating interventions that consider all three sectors.</div><div>This paper proposes the HEARTf of OHC (<em>Holistic Engagement and Adaptive Responses Theoretical framework of One Health challenges</em>), a user-centered design approach aimed at developing sustainable and innovative OHC interventions. The HEARTf of OHC integrates knowledge from social sciences, computer science, industrial design, pedagogy, and health sciences to create context specific solutions that address the specific needs of end-users in the human, animal, and environmental sectors. Additionally, this paper reviews existing frameworks addressing AMR, identifies limitations and outlines the need for a transdisciplinary approach when tackling OHC. By emphasizing the importance of the user-centered design, transdisciplinarity, and continuous evaluation, the HEARTf of OHC aims to bridge the gap between current strategies and improve the development and evaluation of innovative solutions or services. The HEARTf of OHC is a generalizable framework for the design, implementation, and evaluation of OH interventions, where we use AMR as a case study to demonstrate its application.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101031"},"PeriodicalIF":4.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Brucellosis in cattle, sheep, and goats in rural pastoral settings in Northern Tanzania","authors":"Sharadhuli I. Kimera ,&nbsp;Lesakit S.B. Mellau ,&nbsp;John B. Kaneene","doi":"10.1016/j.onehlt.2025.101033","DOIUrl":"10.1016/j.onehlt.2025.101033","url":null,"abstract":"<div><div>A study was designed and carried out between January and June 2016 as part of a larger initiative to assess the health status of animals in a pastoral village of Naitolia, Monduli District in northern Tanzania. A total of 511 blood samples from 239 cattle, 207 goats, and 65 sheep were collected and analyzed for the presence of haemoparasites causing tick-borne diseases and <em>Brucella spp</em> causing brucellosis in animals and humans. The serum obtained from the blood was tested using a Rose Bengal Plate test for Brucella where cattle had overall 4 positives (1.7 %) and in sheep and goats 12 were positive (4.41 %). Among the sheep and goats, the goats had 11 positives (5.31 %) and only one sheep (1.54 %) was positive for <em>Brucella</em> spp. There was no statistically significant difference with age, sub-village, lactation status and species, however, the Ormang'wai sub-village had a 25 % less chance of seroconversion, and lactating animals had 18 % more odds for seropositivity. On the other hand, goats had more than triple the chance of seroconversion. These findings indicate that herds in pastoral settings are exposed to infections and potentially pose a risk to communities, especially women and children who attend to the animals most of the time. We recommend incorporating food safety education as part of one health intervention to improve rural livelihoods and welfare.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101033"},"PeriodicalIF":4.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How virus migration and meteorological elements shape the seasonality of influenza a/H3N2: A case study in China","authors":"Yilan Liao ,&nbsp;Tong Zhao ,&nbsp;Wei Du ,&nbsp;Dayan Wang ,&nbsp;Zhibin Peng ,&nbsp;Shan Xue ,&nbsp;Jianxing Yu ,&nbsp;An Zhang ,&nbsp;Hongyan Ren ,&nbsp;Zhoupeng Ren ,&nbsp;Geoge Fu Gao ,&nbsp;Jinfeng Wang ,&nbsp;Nils Christian Stenseth","doi":"10.1016/j.onehlt.2025.101037","DOIUrl":"10.1016/j.onehlt.2025.101037","url":null,"abstract":"<div><div>Recent global influenza resurgences, escalating to pandemics, emphasize the urgency for effective vaccinations. Despite their efficacy, vaccines offer limited protection against A/H3N2 variants. Thus, elucidating the spatial patterns and underlying drivers of A/H3N2 seasonality is critical for its management. However, the mechanisms governing this seasonality are not fully understood. The study conducted a collaborative and interdisciplinary analysis of influenza A/H3N2 epidemiology in China from 2012 to 2018, utilizing national influenza surveillance data, viral gene sequence data, and meteorological information. We initially examined the spatiotemporal distribution of influenza A/H3N2 across different temperate zones in China. Subsequently, we employed Bayesian “SkyGrid” reconstruction analysis to gain insights into the population dynamics of the influenza A/H3N2 virus within China's temperature zones. Additionally, we utilized generalized additive models (GAM) to assess the influence of meteorological factors on the seasonal prevalence of influenza A/H3N2. Our analysis of China's national influenza data revealed distinct seasonal patterns for A/H3N2: winter epidemics prevailed in temperate zones, while summer and autumn outbreaks occurred in subtropical and tropical areas. The seasonality of influenza A/H3N2 across China's diverse climatic zones is shaped by the interplay of virus migration and meteorological factors. Virus migration introduced new variant populations during seasonal epidemics of influenza A/H3N2 to different temperature zones in China, thereby seeding subsequent seasonal outbreaks. Our findings also indicate that meteorological elements trigger influenza A/H3N2 activity following virus migration. Moreover, the spatial variations in influenza A/H3N2 seasonality in China can be attributed to specific temperature thresholds, approximately 1 °C and 24 °C. These thresholds could serve as potential indicators for A/H3N2 prevalence. This insight is invaluable for tailoring region-specific prevention and control strategies in China and other regions with similar environmental conditions.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101037"},"PeriodicalIF":4.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First autochthonous transmission of West Nile virus (WNV) lineage 2 to humans in Spain","authors":"Maria Lara ,&nbsp;Carlos S. Casimiro-Soriguer ,&nbsp;Irene Pedrosa-Corral ,&nbsp;Cristina Gómez-Camarasa ,&nbsp;Nicola Lorusso ,&nbsp;Jose M. Navarro-Marí ,&nbsp;Joaquin Dopazo ,&nbsp;Javier Perez-Florido ,&nbsp;Sara Sanbonmatsu-Gámez","doi":"10.1016/j.onehlt.2025.101036","DOIUrl":"10.1016/j.onehlt.2025.101036","url":null,"abstract":"<div><div>West Nile Virus (WNV) lineage 2, primarily endemic to parts of Africa and Europe, has recently emerged as a public health concern in new geographic regions. In 2024, the first autochthonous human case of neuroinvasive disease caused by WNV lineage 2 was identified in Andalusia, Southern Spain. Molecular testing and whole-genome sequencing confirmed WNV lineage 2 as the causative agent. Phylogenetic analysis revealed a close relationship with strains circulating in Central Europe, distinct from previous WNV lineage 2 detections in Spain. Concurrently, WNV lineage 2 RNA was detected in an imperial eagle near the case location, suggesting local viral circulation. This case marks a significant shift in WNV epidemiology in Spain, where lineage 1 has historically been dominant. The findings underscore the expanding range of WNV lineage 2 and the necessity for enhanced vector surveillance, genomic monitoring, and strengthened One Health strategies to mitigate future outbreaks and protect public health.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101036"},"PeriodicalIF":4.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One health behind bars: Seroincidence of Coxiella burnetii in women inmates, correctional officers, and feral cats","authors":"Danilo Alves de França ,&nbsp;Louise Bach Kmetiuk ,&nbsp;Gabriel Luís Brucinski Pinto ,&nbsp;Igor Silva Silito ,&nbsp;Jully Kosloski ,&nbsp;Ana Íris de Lima Duré ,&nbsp;Helio Langoni ,&nbsp;Juliano Ribeiro ,&nbsp;Marcelo Bahia Labruna ,&nbsp;Alexander Welker Biondo","doi":"10.1016/j.onehlt.2025.101032","DOIUrl":"10.1016/j.onehlt.2025.101032","url":null,"abstract":"<div><div>Although the Q fever causative agent <em>Coxiella burnetii</em> has presented a variety of infection sources, its epidemiology remains to be fully established in vulnerable populations. Accordingly, the aim of this study was to investigate the presence and dynamics of anti- <em>C. burnetii</em> antibodies and associated risk factors in incarcerated women, correctional officers and in-prison feral cats of a major Brazilian penitentiary complex in a one-year interval. Overall, 139/413 (33.7 %) inmates in 2020 and 68/166 (41.0 %) in 2021 were seropositive to <em>C. burnetii</em> by the indirect immunofluorescence assay (IFA). A statistical association was observed between seropositivity and inmate ethnicity (<em>p</em> = 0.0173), with Black individuals 2-fold more likely seropositive. No feral cat sample was seropositive. The one-year seroincidence was 14.5. The seroincidence and associated risk factors herein have been the first to <em>C. burnetii</em> during incarceration worldwide, serving as a One Health approach warning of Q Fever behind bars.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101032"},"PeriodicalIF":4.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of Campylobacter species infections in humans and food-producing animals in Nigeria, 2002-2023: The imperative of a One Health control approach","authors":"Emmanuel O. Njoga ,&nbsp;Victory C. Nnaemeka ,&nbsp;Ishmael F. Jaja ,&nbsp;James W. Oguttu ,&nbsp;John A. Nwanta ,&nbsp;Kennedy F. Chah","doi":"10.1016/j.onehlt.2025.101029","DOIUrl":"10.1016/j.onehlt.2025.101029","url":null,"abstract":"<div><div>Zoonotic <em>Campylobacter</em> species (ZCS), particularly <em>C. jejuni</em>, <em>C. coli,</em> and <em>C. lari</em>, pose significant health risks to humans and food-producing animals (FPAs). This study investigates the prevalence, geospatial and temporal distributions of Campylobacter species infections (CSI) in Nigeria from 2002 to 2023 through a systematic review and meta-analysis of 40 studies, adhering to PRISMA 2020 guidelines. The overall pooled prevalence of CSI was 33 % (95 % CI: 25 % - 41 %), with significant variations among hosts: poultry (42 %, 95 % CI: 27 % - 57 %), humans (30 %, 95 % CI: 23 % - 38 %), and cattle (21 %, 95 % CI: 15 % - 32 %). In humans, the prevalence were 20.3 % in healthy individuals, 23.8 % in diarrheic patients, and 34.2 % in HIV patients. <em>C. coli</em> was the predominant isolate in humans (87.5 %) and cattle (38.1 %), while <em>C. jejuni</em> was prevalent in poultry (76.2 %). The North-West geopolitical zone exhibited the highest geospatial prevalence at 40 % (95 % CI: 23 % - 57 %). Meta-regression analysis indicated that diagnostic method did not significantly impact prevalence (<em>p</em> = 0.2170), but sample type explained 25.70 % of the between-study variance (Wald χ² (2) = 33.10, <em>p</em> &lt; 0.0001). Poultry samples showed the highest predicted prevalence at 47.8 % (95 % CI: 39.01 % - 56.51 %), significantly greater than cattle at 18.3 % (95 % CI: 8.9 % - 27.8 %; coefficient = 0.2942, <em>p</em> &lt; 0.001). Sensitivity analyses showed minimal changes in pooled prevalence (33 % to 32 %), confirming the robustness of findings despite high heterogeneity (I² = 99.48 % vs. 99.52 %). Temporal analysis indicated that poultry infections peaked between 2016 and 2020. These findings highlight the critical importance of implementing effective biosecurity measures and enhancing food safety practices to mitigate <em>Campylobacter</em> transmission in Nigeria, particularly in poultry and the North-West zone, which exhibited the highest prevalence rates. The adoption of One Health control approach, including the “farm to fork” principle, is strongly recommended to limit human <em>Campylobacter</em> infections by ensuring comprehensive food safety practices throughout the livestock production and processing value chains.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101029"},"PeriodicalIF":4.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One health approach to Rickettsia spp.: Brazilian indigenous individuals, their dogs and ticks, and healthcare professionals","authors":"Louise Bach Kmetiuk ,&nbsp;Vamilton Alvares Santarém ,&nbsp;Daniele Rodrigues ,&nbsp;Suelen Teixeira de Faria Resende ,&nbsp;Isabella Braghin Ferreira ,&nbsp;Rogério Giuffrida ,&nbsp;Bianca Bárbara Fonseca da Silva ,&nbsp;Lucianne Cardoso Neves ,&nbsp;Raphaela Bueno Mendes Bittencourt ,&nbsp;Leandro Meneguelli Biondo ,&nbsp;Fabiano Borges Figueiredo ,&nbsp;Felipe da Silva Krawczak ,&nbsp;Alexander Welker Biondo","doi":"10.1016/j.onehlt.2025.101025","DOIUrl":"10.1016/j.onehlt.2025.101025","url":null,"abstract":"<div><div>Although Indigenous populations have historically overlapped the occurrence of vector-borne pathogens, no One Health approach study has investigated <em>Rickettsia</em> spp. in indigenous communities worldwide. Accordingly, the aim of this study was to investigate anti-<em>Rickettsia</em> spp. antibodies in indigenous individuals, their dogs and healthcare professionals, and <em>Rickettsia</em> spp. infection in ticks from ten indigenous communities of southern and southeastern Brazil. In overall, 66/771 (8.6 %) indigenous individuals, 9/99 (9.1 %) healthcare professionals and 116/386 (30.1 %) dogs were seropositive for at least one out four <em>Rickettsia</em> species tested by immunofluorescence assay (IFA). Out of 603 ticks collected from dogs in indigenous communities, 9/190 (4.7 %) tested positive to fragment of <em>Rickettsia gltA</em> gene by real-time PCR. The homologous antigenic reactions in dogs were significantly more frequent for <em>R. bellii</em> when compared to <em>R. parkeri</em> and <em>R. amblyommatis</em> and may be associated with the high diversity of hard and soft ticks in Americas, and <em>R. bellii</em> capacity of inhibiting another pathogenic rickettsia. Tick bite history increased the seropositivity (odds ratio = 9.29; <em>p</em> = 0.019) in healthcare professionals. This difference may be consequence of higher capacity to recognize tick bites by healthcare professionals, which highlighted the necessity of health care education for indigenous individuals for prevention and early recognition of tick-borne diseases in indigenous communities. In addition, the One Health approach herein has provided a holistic understanding of <em>Rickettsia</em> spp. infection in such communities and correspondent healthcare personal.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101025"},"PeriodicalIF":4.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the impact of biosecurity compliance on farmworker and livestock health within a one health modeling framework","authors":"Arash Arjmand ,&nbsp;Majid Bani-Yaghoub ,&nbsp;Kiel Corkran ,&nbsp;Pranav S. Pandit ,&nbsp;Sharif S. Aly","doi":"10.1016/j.onehlt.2025.101023","DOIUrl":"10.1016/j.onehlt.2025.101023","url":null,"abstract":"<div><div>Biosecurity compliance refers to adherence to protocols aimed at preventing infectious disease outbreaks and controlling antimicrobial resistance (AMR) across human, animal, and environmental interfaces. While many models focus solely on animal health, this study develops a One Health modeling framework to assess the impact of different compliance levels on both animal and farmworker health. The model integrates Ordinary Differential Equations (ODE) for pathogen transmission in animals and the environment with Stochastic Differential Equations (SDE) for disease spread among farmworkers. The next-generation matrix approach estimates the basic reproduction number <span><math><mfenced><msubsup><mi>R</mi><mn>0</mn><mfenced><mi>i</mi></mfenced></msubsup></mfenced></math></span> specific to each pathogen strain <span><math><mi>i</mi></math></span>, identifying thresholds for outbreaks or elimination of infection. Using literature-derived data on <em>Salmonella</em> transmission dynamics, the model is validated, and key parameters values are estimated. Using the calibrated model, we examine infection transmission in dairy cattle and zoonotic spillover to farmworkers with a focus on five key biosecurity measures: (1) animal movement control and quarantine, (2) disease monitoring and reporting, (3) hygiene and disinfection, (4) feeding and watering practices, and (5) antimicrobial stewardship. Simulations reveal that compliance with biosecurity measures that reduce host-to-host transmission in the animal population has the highest impact on the reduction of infection both in animal and farmworker populations. Further ODE-SDE model analysis indicates that full compliance with the other biosecurity measures is insufficient to prevent outbreaks in a dairy farm. These results are consistent with the local and global sensitivity analyses of the model. The One Health modeling framework developed in this study can also be applied to other zoonotic diseases as a guiding tool for decision making and optimal resource allocation to reduce the likelihood of spillover.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101023"},"PeriodicalIF":4.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of bacterial contamination on wild meat processing and cooking surfaces in rural Cameroon","authors":"Sara M. Soto ,&nbsp;Laura Castellsagués ,&nbsp;Victoria Ballén ,&nbsp;Yaiza Gabasa ,&nbsp;Pedro Mayor ,&nbsp;Guillermo Ros Brull ,&nbsp;Stephan M. Funk ,&nbsp;Julia E. Fa","doi":"10.1016/j.onehlt.2025.101028","DOIUrl":"10.1016/j.onehlt.2025.101028","url":null,"abstract":"<div><div>The transmission of food-borne pathogens from wildlife to humans presents a significant public health challenge. The recent COVID-19 pandemic has highlighted the critical need to enhance our understanding of wild animals' role in transmitting infectious diseases. The handling and consumption of wild meat carry inherent risks of contracting foodborne illnesses. We analysed the prevalence of bacterial pathogens encountered in wild meat processing in four villages in southern Cameroon, highlighting the critical role of hygienic practices in preventing disease. We collected 100 samples from various utensils and surfaces involved in wild meat preparation and assessed them for bacterial contamination. We isolated 577 bacterial strains, of which 154 (27 %) were pathogenic, with a high prevalence (75 %) of pathogenic bacteria on commonly used utensils, with cooking pots identified as significant reservoirs of bacteria. Antimicrobial resistance among the order Enterobacteriales included high levels of resistance to ampicillin, amoxicillin-clavulanic acid, ciprofloxacin, cotrimoxazole, and gentamicin. The study also explores the impact of cleaning practices, the materials of cooking utensils, and the potential economic consequences of foodborne illnesses. The results underscore the urgent need for improved sanitation measures and provide insights into the health risks posed by wild meat consumption. They also serve as a foundation for comparative studies and the development of region-specific interventions. Following safe handling and cooking guidelines is critical to safeguarding public health and mitigating the risks associated with food-borne diseases, particularly in regions where wild meat is a significant part of the diet. Our results reinforce the need to implement the Standard Operating Procedures (SOP) recently approved by the Ministry of Livestock, Fisheries and Animal Industries of Cameroon, providing comprehensive guidelines for safe handling, preparing and consuming wild meat.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101028"},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating One Health research in Sarawak, Malaysia: Addressing emerging and re-emerging infectious disease through international collaboration","authors":"Teck-Hock Toh ,&nbsp;Jeffrey Soon-Yit Lee ,&nbsp;Kamilah Dahian ,&nbsp;Aw-Zien Toh ,&nbsp;Jo-Hun Teh ,&nbsp;Mohd Raili Suhaili ,&nbsp;Gregory Charles Gray","doi":"10.1016/j.onehlt.2025.101027","DOIUrl":"10.1016/j.onehlt.2025.101027","url":null,"abstract":"<div><div>Comprising much of the northern side of the Island of Borneo, the Malaysian region of Sarawak is unique for its dense rainforests, diverse wildlife, and a human population that interacts closely with nature. One Health research in Sarawak, particularly that conducted by the Duke-SEGi-CRC Laboratory in the town of Sibu, has led to discoveries that are improving the health of Sarawakians. One Health research has resulted in the discovery of a novel canine-feline recombinant alphacoronavirus (genotype II), highlighting the potential for zoonotic transmission of respiratory viruses. Other One Health research has helped to determine the etiologies of human encephalitis and diarrheal illnesses, and specially improved the understanding of Japanese encephalitis (JE), <em>Plasmodium knowlesi</em> malaria, and melioidosis in Sarawak. This paper highlights the recent impact of international One Health collaborations in emerging and re-emerging infectious disease surveillance in this region. The collaborations have markedly improved local diagnostic capacity, identified previously unrecognized pathogens, and provided public health officials with a better understanding regarding the epidemiology of a number of infectious diseases.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101027"},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}