Organic & Medicinal Chemistry International Journal最新文献_第2页

Synthesis, In vitro Antibacterial and Antifungal Activities of Trifluoroalkyl-N, N’-Disubstituted Thioureas 三氟烷基-N, N ' -二取代硫脲的合成及体外抑菌活性研究

Organic & Medicinal Chemistry International Journal Pub Date : 2020-07-06 DOI: 10.19080/omcij.2019.09.555770

M. Sanhoury

引用次数: 2

Chemical Constituents of an Iranian Grown Capsicum annuum and their Cytotoxic Activities Evaluation 伊朗辣椒化学成分及其细胞毒活性评价

Organic & Medicinal Chemistry International Journal Pub Date : 2020-06-25 DOI: 10.19080/omcij.2019.09.555769

R. Zibaseresht

引用次数: 8

Synthesis Condition and Treatment Assisted Tuning of Structural, Magnetic Properties and Bandgap of Ni Nano Ferrite 镍纳米铁氧体的合成条件及处理辅助结构、磁性能和带隙调谐

Organic & Medicinal Chemistry International Journal Pub Date : 2020-06-24 DOI: 10.19080/omcij.2019.09.555768

Kane S N

{"title":"Synthesis Condition and Treatment Assisted Tuning of Structural, Magnetic Properties and Bandgap of Ni Nano Ferrite","authors":"Kane S N","doi":"10.19080/omcij.2019.09.555768","DOIUrl":"https://doi.org/10.19080/omcij.2019.09.555768","url":null,"abstract":"We report synthesis condition, and thermal treatment assisted tuning of structural, magnetic properties, and bandgap of Ni nano ferrite. Experimental techniques of x-ray diffraction ‘XRD,’ vibration sample magnetometry, Ultraviolet-visible (UV-Vis) diffuse reflectance measurements, Scanning Electron Microscopy ‘SEM,’ Energy Dispersive spectroscopy ‘EDS’ measurements, were used to study the synthesized samples. XRD verify the formation of nano spinel ferrite phase (grain diameter: 38.3-39.2nm), and incorporation of Ni, Fe in spinel lattice, with lattice parameter (0.8345-0.8352nm), which also shows the presence of α -Fe 2 O 3 phase. Results reveal that synthesis condition, and thermal treatment show: a) SEM images with non-homogeneous particle size dispersion, particle agglomeration, while EDS confirms the presence of all elements in studied NiFe 2 O 4 samples, b) non-equilibrium cation distribution, modification of inversion parameter, oxygen parameter, c) strengthening of A-O-B, A-O-A and weakening of B-O-B interaction super-exchange interactions, d) fine-tuning of bandgap (1.39 eV-1.68 eV), and depends on structural properties, e) observed magnetic properties are a collective effect of non-equilibrium cationic distribution; modification of A-O-B, A-O-A, B-O-B super-exchange interactions, and surface spin-canting. Prospective applications based on synthesized nano ferrites are also discussed. Thus, in this work we report, sol-gel auto-combustion synthesis of NiFe 2 O 4 : by varying synthesis conditions (via microwave-assisted sol-gel synthesis, conventional sol-gel synthesis in dry gel form), and post-preparation thermal annealing, to tune structural, magnetic properties and bandgap energy. Prepared samples are studied by x-ray diffraction ‘XRD,’ vibration sample magnetometry, Ultraviolet-visible (UV-Vis) diffuse reflectance measurements, Scanning Electron Microscopy SEM,’ Energy Dispersive spectroscopy ‘EDS’ measurements.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73063303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Characterization, Biological and Antitumor Activity of Co(II) , Ni (II) , Cu(II) and Zn (II) Complexes of N-(2-Chlorophenyl)-N’-Benzoyl Thiourea N-(2-氯苯基)-N′-苯甲酰硫脲Co(II)、Ni (II)、Cu(II)和Zn (II)配合物的合成、表征、生物学和抗肿瘤活性

Organic & Medicinal Chemistry International Journal Pub Date : 2020-06-04 DOI: 10.19080/omcij.2019.09.555767

Khalid M Wahdan

引用次数: 2

An Assessment of the Anti-Inflammatory, Antimicrobial, and Antioxidant Activities of Ficus sur Stem-Bark 榕树茎皮抗炎、抗菌和抗氧化活性的研究

Organic & Medicinal Chemistry International Journal Pub Date : 2020-05-27 DOI: 10.19080/omcij.2019.09.555766

Clement Osei Akoto

{"title":"An Assessment of the Anti-Inflammatory, Antimicrobial, and Antioxidant Activities of Ficus sur Stem-Bark","authors":"Clement Osei Akoto","doi":"10.19080/omcij.2019.09.555766","DOIUrl":"https://doi.org/10.19080/omcij.2019.09.555766","url":null,"abstract":"Ficus sur (Moraceae), is a plant that has found use in traditional African medicine in the treatment of sickle cell disease, epilepsy, pain and inflammations. The present study was aimed at investigating hexane and methanol stem-bark extracts of Ficus sur for their phytoconstituents, anti-inflammatory, antimicrobial and antioxidant activities. Phytochemical screenings were performed using standard protocols. In-vitro anti-inflammatory activities were assessed using egg albumin denaturation method. In-vitro antimicrobial (agar and broth dilution method) and antioxidant [total antioxidant capacity (TAC), DPPH and H 2 O 2 scavenging] assays were carried out on the extracts. Thin layer chromatography was employed in the separation of the components of both extracts. The phytochemical investigation revealed the presence of secondary metabolites such as anthraquinones, terpenoids, flavonoids, steroids, saponins, phenols and tannins. The extracts showed anti-inflammatory activity comparable to that of diclofenac sodium. The extracts showed antimicrobial activity against test organisms with MICs ranging from 2.5- 40 mg/ mL. The IC 50 values for methanol and hexane extracts in the DPPH and H 2 O 2 assays were 89.95 ± 0.30 and 350.70 ± 0.72 μg/mL and 708.51 ± 0.28 and 682.76 ± 0.20 μg/mL, respectively. The TAC (gAAE/100 g) for methanol and hexane extracts were 23.560 ± 0.014 and 17.863 ± 0.037 g, respectively. The results suggest that the stem bark of Ficus sur could be exploited as potential therapeutic candidate for the treatment of bacterial infections, inflammations and diseases associated with oxidative-stress.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79387606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthesis of a Novel Sensor Electrode Based on Bromothymol Blue as an Indicator Electrode in Potentiometric Acid-Base Titration in Aqueous Solution 以溴百里香酚蓝为指示电极的新型传感器电极的合成及其在水溶液电位酸碱滴定中的应用

Organic & Medicinal Chemistry International Journal Pub Date : 2020-03-06 DOI: 10.19080/omcij.2019.09.555764

Nasser M Abu Ghalwa

引用次数: 0

LCA-AZT Conjugate Anti-Cancer invitro Activity LCA-AZT偶联抗肿瘤体外活性

Organic & Medicinal Chemistry International Journal Pub Date : 2020-02-21 DOI: 10.19080/omcij.2019.09.555760

Hengguang Li

{"title":"LCA-AZT Conjugate Anti-Cancer invitro Activity","authors":"Hengguang Li","doi":"10.19080/omcij.2019.09.555760","DOIUrl":"https://doi.org/10.19080/omcij.2019.09.555760","url":null,"abstract":"Pseudo nucleoside or short pseudo aptamer and telomerase have been selected as novel ligands and receptors in our effort to discover new anti-cancer reagents. We proposed that lithocholic acid (LCA) could be able to play the role of a vehicle to transport major therapeutic moiety into cell membrane through oral administration, like cholic acid delivering fatty acids, peptides in gastrointestinal track, but it’s more hydrophobic. Zidovudine or azidothymidine (AZT) was used as targeting head or/and therapeutic reagent aiming reverse transcriptase that plays central role of cancer cell telomere repairing. Telomerase is a reverse transcriptase, the major TERT, or hTERT in humans is a catalytic subunit of the entire enzyme. Even though both LCA and AZT have anticancer activities respectively, the conjugate of LCA-AZT was designed as our initial pseudo short aptamer inhibitor of cancer telomerase to verify our hypothetic concept that pseudo short aptamers targeting cancer telomerase are able to shut down the cancer cell growth, and cause the cells eventually senescence and mortality. As a consequence, two lung cancer cell lines and two colorectal cancer cell lines were treated by the conjugate, except lung cancer cell H1299, the efficacy of the conjugate was better than the parent compounds apparently. It conformed and proofed also the docking predictions via the molecular computational simulation. The all cancer cells used by a CCK-8 assay appeared apoptosis in the range of 56 μM – 90 μM IC50 after exposure to the LCA-AZT conjugate. The effectiveness of the conjugate was also time dependent, because the telomerase is a kind of reverse transcriptase, the mechanism would be like the inhibition of reverse transcriptase in HIV virus, the inhibition of telomere repairing toward cell death would be time consumable.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77112956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insight into Interactions of l-Arginine/l-Histidine with Drug Betaine Hydrochloride in Aqueous Medium at Different Temperatures by using Physicochemical Methods 物理化学方法研究l-精氨酸/l-组氨酸与盐酸甜菜碱在不同温度水溶液中的相互作用

Organic & Medicinal Chemistry International Journal Pub Date : 2020-02-20 DOI: 10.19080/omcij.2019.09.555763

Anil Kumar Nain

{"title":"Insight into Interactions of l-Arginine/l-Histidine with Drug Betaine Hydrochloride in Aqueous Medium at Different Temperatures by using Physicochemical Methods","authors":"Anil Kumar Nain","doi":"10.19080/omcij.2019.09.555763","DOIUrl":"https://doi.org/10.19080/omcij.2019.09.555763","url":null,"abstract":"Studies on physicochemical properties of l -arginine/ l -histidine in aqueous solutions of betaine hydrochloride are beneficial in understanding solute-solvent interactions. The densities, ρ , ultrasonic speeds, u and viscosities, η of l -arginine and l -histidine in water and in aqueous-betaine hydrochloride (1 % and 2 % betaine hydrochloride in water, w/w) solvents have been experimentally measured at six temperatures (293.15, 298.15, 303.15, 308.15, 313.15 and 318.15) K and at atmospheric pressure in nine different concentrations. Related molecular and thermodynamic properties like the apparent molar volume, V φ , limiting apparent molar volume, and transfer volume, , were also evaluated in this study using density data. Likewise from the ultrasonic data, different thermo-acoustical parameters, such as apparent molar compressibility, , s K φ , limiting apparent molar compressibility, , s K οφ and transfer compressibility, , , s tr K οφ have been evaluated. The trends in transfer properties have been interpreted in terms of cosphere overlap model. In addition, the rheological data have been used to determine Falkenhagen Coefficient, A , Jones-Dole coefficient, B , free energy of activation of viscous flow per mole of solvent, and solute, #2 , entropies, # S ο ∆ and enthalpies, # H ο ∆ of activation of viscous flow. Hydration number, H n has also been calculated. Different parameters such as nature of solute, solute-solvent interactions, etc., were categorized by using different analytical and physical loom. The results show that the studied drug is a structure maker compound in all systems of this work. The free energy parameters indicate the formation of transition state in the presence of amino acids. The solute co-solute interactions are strongest in the system containing l -arginine.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84907011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

New MCl3 (M = Y, Dy, Pr) Salicylato, Maleato, Phtalato, Phenylsufonato and Phosphato Complexes and Adducts: Synthesis and Infrared Study 新型MCl3 (M = Y, Dy, Pr)水杨酸、马来酸、酞酸、苯基磺酰基和磷酸配合物及加合物的合成与红外研究

Organic & Medicinal Chemistry International Journal Pub Date : 2020-02-20 DOI: 10.19080/omcij.2019.09.555761

Dame Seye

引用次数: 0

Essential Oil Activity Against Methicillin-Resistant Staphylococcus aureus and Multidrug-Resistant Mycobacterium tuberculosis: A Mini-Review 精油抗耐甲氧西林金黄色葡萄球菌和耐多药结核分枝杆菌活性:综述

Organic & Medicinal Chemistry International Journal Pub Date : 2020-02-18 DOI: 10.19080/omcij.2019.09.555759

A. Intisar

引用次数: 0