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Organic & Medicinal Chemistry International Journal最新文献

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Phenolic Substances and Biological Activities of Verbana officinalis L.: A Mini-Review 马鞭草酚类物质及其生物活性综述
Organic & Medicinal Chemistry International Journal Pub Date : 2020-02-05 DOI: 10.19080/omcij.2019.09.555758
Ghayth Rigane
{"title":"Phenolic Substances and Biological Activities of Verbana officinalis L.: A Mini-Review","authors":"Ghayth Rigane","doi":"10.19080/omcij.2019.09.555758","DOIUrl":"https://doi.org/10.19080/omcij.2019.09.555758","url":null,"abstract":"The published data related to the identification of the major phenolic compounds as well as its biological activities present in Verbana officinalis L. This plant has received a great interest in the worldwide for its diuretic, expectorant and anti-rheumatic, anti-inflammatory, antifungal, antibacterial, analgesic and antioxidant activities.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"1998 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78108695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Noscapine as Anticancer Agent & Its Role in Ovarian Cancer 诺斯卡平的抗癌作用及其在卵巢癌中的作用
Organic & Medicinal Chemistry International Journal Pub Date : 2019-12-12 DOI: 10.19080/omcij.2019.09.555757
Ramesh Chandra
{"title":"Noscapine as Anticancer Agent & Its Role in Ovarian Cancer","authors":"Ramesh Chandra","doi":"10.19080/omcij.2019.09.555757","DOIUrl":"https://doi.org/10.19080/omcij.2019.09.555757","url":null,"abstract":"Cancer is a public health problem accounting for an estimated 9.6 million deaths worldwide, according to the latest WHO report, mainly affecting low-middle income countries. Noscapine (narcotize), a non-toxic benzylisoquinoline alkaloid derived from opium poppy, is commonly used as a cough suppressant in humans and exhibited various activities against a variety of cancers with unclear mechanism of action. Unlike other alkaloids obtained from opium poppy, noscapine is not sleep-inducing, hypnotic drug, rendering it as non-addictive drug and therefore used as antimitotic & antitussive drug around the world, can be orally consumed. Ovarian Cancer is one of the common causes of gynecologic cancer affecting women around the world. The main reason for treatment failure and mortality is the drug resistance against DDP (cisplatin), which has emerged the use of Noscapine against drug-resistant ovarian cancer cell line SKOV3/DDP by activation of apoptosis. Herein, we will describe noscapine chemically; its medicinal utility and pharmacological history behind the noscapine family of compounds then follow its journey for treating ovarian cancer (Figure 1).","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90010219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Synthesis of Acridone Base Phenolic Compounds for Antibacterial Activity 吖啶酮类酚类化合物抗菌活性的合成
Organic & Medicinal Chemistry International Journal Pub Date : 2019-11-14 DOI: 10.19080/omcij.2019.09.555756
Afreen Begum
{"title":"Synthesis of Acridone Base Phenolic Compounds for Antibacterial Activity","authors":"Afreen Begum","doi":"10.19080/omcij.2019.09.555756","DOIUrl":"https://doi.org/10.19080/omcij.2019.09.555756","url":null,"abstract":"","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84328842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preliminary Phytochemical Screening of Seeds of Phytolacca Latbenia (Moq.) walte. A Wild Medicinal Plant of Tropical and Sub-Tropical Region of Pakistan 植物种子的植物化学初步筛选。巴基斯坦热带和亚热带地区的一种野生药用植物
Organic & Medicinal Chemistry International Journal Pub Date : 2019-11-13 DOI: 10.19080/omcij.2019.09.555754
S. Ijaz
{"title":"Preliminary Phytochemical Screening of Seeds of Phytolacca Latbenia (Moq.) walte. A Wild Medicinal Plant of Tropical and Sub-Tropical Region of Pakistan","authors":"S. Ijaz","doi":"10.19080/omcij.2019.09.555754","DOIUrl":"https://doi.org/10.19080/omcij.2019.09.555754","url":null,"abstract":"Phytolacca latbenia (Moq.) walte locally known as Luber belonging to family Phytollacaceae is used in traditional medicine system and pharmaceutical industries as well. Whole plant is medicinally important. The aim of this study was to analyze the seeds of Phytolacca latbenia (Moq.) Walte physico-chemically and phytochemically. Various bioactive compounds (alkaloids, terpenoids, favonoids, saponins, carbohydrate, proteins etc) were detected in water extract, while other solvents were not ideal for extraction few compounds were screened out from them. High extraction was done by water solvent and low value was in acetone solvent. Seeds of Phytolacca latbenia showed variety of therapeutic potential due to the presence of several phytochemical compounds.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76223470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Review of 2,4-D Environmental Fate, Persistence and Toxicity Effects on Living Organisms 2,4- d对生物的环境命运、持久性和毒性作用研究进展
Organic & Medicinal Chemistry International Journal Pub Date : 2019-11-13 DOI: 10.19080/omcij.2019.09.555755
Chali Abate Jote
{"title":"A Review of 2,4-D Environmental Fate, Persistence and Toxicity Effects on Living Organisms","authors":"Chali Abate Jote","doi":"10.19080/omcij.2019.09.555755","DOIUrl":"https://doi.org/10.19080/omcij.2019.09.555755","url":null,"abstract":"2,4-D is one of the most used herbicides in the world. It has been used since 1940s and its popularity seems to be increasing. Due to its broad range of application and excessive usage, it has becoming a serious problem as it can cause pollution to the environment. Extensive researches have been done for 2,4-D but comparatively few for its derivatives. Therefore, in this review article, I focused on 2,4-D environmental fates, persistence and effects on living organisms. Hence, its toxicity levels, toxicity classification and ecotoxicity studies were reviewed based on available references. In this review article, also discussed the toxicity effects of 2,4-D on animals and humans.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75614211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Are the Authors of Scientific Articles Protected Against Plagiarism? 27 Years of Experience Shows that Rather Plagiarists are Protected in the Peer Review System 科学论文的作者是否受到抄袭的保护?27年的经验表明，剽窃者在同行评审制度中受到保护
Organic & Medicinal Chemistry International Journal Pub Date : 2019-10-23 DOI: 10.19080/omcij.2019.09.555753
Á. Furka
{"title":"Are the Authors of Scientific Articles Protected Against Plagiarism? 27 Years of Experience Shows that Rather Plagiarists are Protected in the Peer Review System","authors":"Á. Furka","doi":"10.19080/omcij.2019.09.555753","DOIUrl":"https://doi.org/10.19080/omcij.2019.09.555753","url":null,"abstract":"The Author of this article in 1990 submitted for publishing a manuscript describing the split-mix combinatorial synthesis and the invention was expropriated and published by the Editor in Chief of International Journal of Peptide and Protein Research and all the three reviewers are suspected to do so. The Author tried to seek justice but it was refused by the Editor in chief of Nature (where the expropriated invention was published), by the Office of Research Integrity at NIH and by the by the Munksgaard International Publishers, Copenhagen, publisher of the International Journal of Peptide and Protein Research. Since the plagiarists continued to publish misleading papers the Author sent 10 correction letters to the journals but only three were published. The Committee on Ethics of the American Chemical Society also refrained from acting. In order to avoid happening again of the mentioned type of plagiarism, introduction of new rules is suggested by the Author.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76230897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Characterization of New Biologically Active Pyrrolo[2,3-b]Pyridine Scaffolds 新型生物活性吡咯[2,3-b]吡啶支架的合成与表征
Organic & Medicinal Chemistry International Journal Pub Date : 2019-09-16 DOI: 10.19080/omcij.2019.09.555752
Farid M Sroor
{"title":"Synthesis and Characterization of New Biologically Active Pyrrolo[2,3-b]Pyridine Scaffolds","authors":"Farid M Sroor","doi":"10.19080/omcij.2019.09.555752","DOIUrl":"https://doi.org/10.19080/omcij.2019.09.555752","url":null,"abstract":"The 4-amino-1-(2,4-dichlorophenyl)-3-(3,4-dimethoxyphenyl)-6-phenyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile, 8 and 4-amino- 6-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile, 9 were prepared and fully characterized by reaction of the new 2-amino-1-(2,4-dichlorophenyl)-4-(3,4-dimethoxyphenyl)-1H-pyrrole-3-carbonitrile 4 with 2-arylidenemalononitriles 6 and 7 in ethanol and the presence of piperidine (1 mL) to afford 8 and 9 in excellent yield 87% and 91%, respectively.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80905699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Donor and Acceptor Substituents in 1,3-Oxazole Derivatives and Their Anti-Cancer Activity 1,3-恶唑衍生物中供体和受体取代基的影响及其抗癌活性
Organic & Medicinal Chemistry International Journal Pub Date : 2019-09-13 DOI: 10.19080/omcij.2019.09.555751
Nataliya V Obernikhina
{"title":"Influence of Donor and Acceptor Substituents in 1,3-Oxazole Derivatives and Their Anti-Cancer Activity","authors":"Nataliya V Obernikhina","doi":"10.19080/omcij.2019.09.555751","DOIUrl":"https://doi.org/10.19080/omcij.2019.09.555751","url":null,"abstract":"","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85949058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Cytotoxicity Evaluation of Some New 4-(4oxo-4H-Quinazoline-3yl)- Thiobenzoic Acid-S-(1-H-Benzimidazole-2-Yl) Ester Derivates 新型4-(4oxo- 4h -喹唑啉-3基)-硫代苯甲酸- s -(1- h -苯并咪唑-2基)酯衍生物的合成及细胞毒性评价
Organic & Medicinal Chemistry International Journal Pub Date : 2019-09-11 DOI: 10.19080/omcij.2019.08.555750
F. Hassanzadeh
{"title":"Synthesis and Cytotoxicity Evaluation of Some New 4-(4oxo-4H-Quinazoline-3yl)- Thiobenzoic Acid-S-(1-H-Benzimidazole-2-Yl) Ester Derivates","authors":"F. Hassanzadeh","doi":"10.19080/omcij.2019.08.555750","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555750","url":null,"abstract":"","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80392397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrochemical Determination of Ascorbic Acid in Pharmaceutical Tablets using Carbon Paste Electrode 碳糊电极电化学测定片剂中的抗坏血酸
Organic & Medicinal Chemistry International Journal Pub Date : 2019-08-30 DOI: 10.19080/omcij.2019.08.555749
Meareg Amare
{"title":"Electrochemical Determination of Ascorbic Acid in Pharmaceutical Tablets using Carbon Paste Electrode","authors":"Meareg Amare","doi":"10.19080/omcij.2019.08.555749","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555749","url":null,"abstract":"","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91536884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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