Organic & Medicinal Chemistry International Journal最新文献

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New Utilities for Cancer Treatment to Inhibit Tubulin Assembly and Suppressing Microtubule Formation: Research Hypothesis 抑制微管蛋白组装和抑制微管形成在癌症治疗中的新应用:研究假设

Organic & Medicinal Chemistry International Journal Pub Date : 2018-09-27 DOI: 10.19080/omcij.2018.08.555727

V. Raj

引用次数: 0

Potentiometric Determination of Asenapine Maleate Using PVC Membrane and Carbon Paste Ion-selective Electrodes PVC膜-碳糊离子选择电极电位法测定马来酸阿西那平

Organic & Medicinal Chemistry International Journal Pub Date : 2018-09-20 DOI: 10.19080/omcij.2018.08.555726

Rowayda M Fouad

{"title":"Potentiometric Determination of Asenapine Maleate Using PVC Membrane and Carbon Paste Ion-selective Electrodes","authors":"Rowayda M Fouad","doi":"10.19080/omcij.2018.08.555726","DOIUrl":"https://doi.org/10.19080/omcij.2018.08.555726","url":null,"abstract":"Asenapine maleate is a white to off-white non hygroscopic powder, slightly soluble in water (5.80 mg/mL) [1], sparingly soluble in 0.1 M HCl, soluble in methanol. The pH of a saturated asenapine solution in water is 4.2 at 23.5 0C, its pKa is 8.6. AS is atypical antipsychotic drug developed for the treatment of schizophrenia and acute mania associated with bipolar disorder [2]. It shows high affinity for numerous receptors like serotonin, adrenergic, dopamine, histamine [3]. Many methods have been mentioned in the literature for the determination of AS in pure form, in pharmaceutical formulation, as well as in biological fluids as, Titrimetric method [4], Spectrophotometric methods [5-8]. Gas chromatography [9], Liquid chromatography [10,11] and Thin layer chromatography [12]. Different HPLC methods using different mobile phases and detectors [13-24]. There were 5 stability indicating HPLC methods [25-29]. No electrochemical method was introduced for determination of asenapine. Ionselective electrodes have been used recently for quantitative determination of drugs as it has many advantages comparing to other sophisticated methods [30,31]. ISEs have low detection limit, good accuracy, wide concentration range and good applicability to turbid and coloured solutions. ISEs give high selectivity towards the drugs in the presence of different excipients. The proposed work introduces three different electrodes for the determination of asenapine maleate according to ICH guidelines [32]. The electrochemical sensitivity of the electrode is based on the incorporation of ion pair (AS-AR and AS–PTA) using PVC membrane and carbon paste (Figure 1). Figure 1: Chemical Structure of Asenapine Maleate.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88597045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

HPLC Detectors, Their Types and Use: A Review 高效液相色谱检测器的类型及应用综述

Organic & Medicinal Chemistry International Journal Pub Date : 2018-05-29 DOI: 10.19080/OMCIJ.2018.06.555700

A. Sunil

引用次数: 5

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