Synthesis, Characterization, Biological and Antitumor Activity of Co(II) , Ni (II) , Cu(II) and Zn (II) Complexes of N-(2-Chlorophenyl)-N’-Benzoyl Thiourea

Abstract

A derivative of thiourea ligand N-(2-chlorophenyl)-N’-Benzoyl thiourea (CBT) in equimolar ratio 1:1and its transition metal complexes Co II , Ni II , Cu II and Zn II were synthesized by microwave (green chemistry). The structure of ligand and its complexes have been characterized by using elemental analysis, mass Spectroscopy, FT-IR, UV-Vis,1HNMR and 13CNMR. The geometry of the proposed structures of the chelates based on their electronic spectra, electron spin resonance (ESR) and magnetic susceptibility. The stability of complexes was studied by TGA analysis (Thermal studies). The free derivative thiourea ligand (CBT) and its complexes were Studied for antibacterial and antifungal activity. Also the anticancer activity of ligand and its complexes were studied against breast cell cancer (MCF-7). It was noticed that the Ni II complex showed the highest cytotoxic activity (IC 50 =122) more than the free CBT ligand.