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A Case of Syphilis With Ocular Involvement: Persistent Negative Serology in a Patient With Multiple Sclerosis. 一例眼部受累的梅毒患者:多发性硬化症患者血清持续阴性。
IF 3.8 4区 医学
Open Forum Infectious Diseases Pub Date : 2024-10-29 eCollection Date: 2024-10-01 DOI: 10.1093/ofid/ofae563
Luca Pipitò, Irene Ganci, Andrea Cicero, Alice Annalisa Medaglia, Simona D'Avenia, Edoardo Mandalà, Cinzia Calà, Paola Di Carlo, Antonio Cascio
{"title":"A Case of Syphilis With Ocular Involvement: Persistent Negative Serology in a Patient With Multiple Sclerosis.","authors":"Luca Pipitò, Irene Ganci, Andrea Cicero, Alice Annalisa Medaglia, Simona D'Avenia, Edoardo Mandalà, Cinzia Calà, Paola Di Carlo, Antonio Cascio","doi":"10.1093/ofid/ofae563","DOIUrl":"https://doi.org/10.1093/ofid/ofae563","url":null,"abstract":"<p><p>Diagnostic algorithms for syphilis are based on serology. However, with the advent of immunosuppressive therapies, these algorithms may fail. We report a case of an individual with multiple sclerosis on treatment with ofatumumab and secondary syphilis with visual and auditory systems involvement and persistent negative treponemal and nontreponemal tests.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"11 10","pages":"ofae563"},"PeriodicalIF":3.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lyme Disease Prophylaxis by Single-Dose Doxycycline in the United States, 2010-2020. 2010-2020 年美国使用单剂量强力霉素预防莱姆病的情况。
IF 3.8 4区 医学
Open Forum Infectious Diseases Pub Date : 2024-10-29 eCollection Date: 2024-10-01 DOI: 10.1093/ofid/ofae593
Grace E Marx, Alyssa Beck, Cate Corey, Candace C Fuller, Nicole Haug, Jenice S Ko, Dave Martin, Alison F Hinckley
{"title":"Lyme Disease Prophylaxis by Single-Dose Doxycycline in the United States, 2010-2020.","authors":"Grace E Marx, Alyssa Beck, Cate Corey, Candace C Fuller, Nicole Haug, Jenice S Ko, Dave Martin, Alison F Hinckley","doi":"10.1093/ofid/ofae593","DOIUrl":"https://doi.org/10.1093/ofid/ofae593","url":null,"abstract":"<p><p>Single-dose doxycycline after high-risk tick bites can prevent Lyme disease, which disproportionately affects children. We described single-dose doxycycline dispensings in an outpatient cohort in the United States. During 2010-2020, a total of 427 105 patients received ≥1 dispensing(s); most were aged ≥65 years. Lyme disease postexposure prophylaxis may be underprescribed for some groups, including children.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"11 10","pages":"ofae593"},"PeriodicalIF":3.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of Laboratory-Confirmed Creutzfeldt-Jakob Disease From 3 Ontario Tertiary Care Centers Between 2012 and 2022: A Retrospective Cohort Study. 2012年至2022年安大略省3家三级医疗中心实验室确诊的克雅氏病特征:一项回顾性队列研究。
IF 3.8 4区 医学
Open Forum Infectious Diseases Pub Date : 2024-10-28 eCollection Date: 2024-10-01 DOI: 10.1093/ofid/ofae551
Kayla Gaete, Soma Dalai, Ana Cabrera, Xena Li, Prameet M Sheth, Robert A Kozak, Mia J Biondi
{"title":"Characterization of Laboratory-Confirmed Creutzfeldt-Jakob Disease From 3 Ontario Tertiary Care Centers Between 2012 and 2022: A Retrospective Cohort Study.","authors":"Kayla Gaete, Soma Dalai, Ana Cabrera, Xena Li, Prameet M Sheth, Robert A Kozak, Mia J Biondi","doi":"10.1093/ofid/ofae551","DOIUrl":"10.1093/ofid/ofae551","url":null,"abstract":"<p><strong>Background: </strong>Globally, Creutzfeldt-Jakob disease (CJD) affects one in one million people annually, but there is a paucity of recent Canadian data. This study summarizes epidemiology trends and diagnostic timelines of laboratory-confirmed CJD cases in three tertiary Ontario hospitals.</p><p><strong>Method: </strong>Using laboratory information systems, we identified 30 patients with a laboratory-confirmed CJD diagnosis between 2012 and 2022 at three major tertiary hospitals in Ontario. Retrospective chart reviews were then completed.</p><p><strong>Results: </strong>Patients had a mean of 2.2 hospital visits (SD, 1.2) prior to being admitted for testing. The most common symptom presentations included loss of coordination (63.3%), behavioral changes (60%), progressive mobility loss (53.4%), memory loss (50.0%), and involuntary movements (50.0%). Magnetic resonance imaging findings showed potential CJD in 76.7% of cases, and 56.7% exhibited periodic sharp wave complexes characteristic of CJD on electroencephalogram. The mean duration from symptom onset to microbiologic testing was 91 days (SD, 90.7). End-point quaking-induced conversion (EP-QuIC) testing of cerebrospinal fluid was positive in 90.0% of patients, while 83.3% tested positive for 14-3-3 on enzyme-linked immunosorbent assay. Elevated cerebrospinal fluid 14-3-3 levels significantly correlated with shorter duration from symptom onset to death (<i>R</i> <sup>2</sup> = 0.71, <i>F</i> = 19.55, <i>P</i> = .0022). Post-diagnosis, 46.7% of patients were discharged home, 16.6% were transferred to external palliative care or hospice facilities, and 36.7% died during admission. The mean time from symptom onset to death was 121 days (SD, 120.7), and from diagnosis to death 35 days (SD, 83.9).</p><p><strong>Conclusions: </strong>This study highlights the importance of early CJD consideration and laboratory testing when appropriate neurologic symptoms are present.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"11 10","pages":"ofae551"},"PeriodicalIF":3.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Neonatal and Maternal Nasal Microbiome Among Neonates in the Intensive Care Unit. 重症监护室新生儿与母亲鼻腔微生物组的关系
IF 3.8 4区 医学
Open Forum Infectious Diseases Pub Date : 2024-10-28 eCollection Date: 2024-11-01 DOI: 10.1093/ofid/ofae644
Shaoming Xiao, Wei Zhou, Ryan Caldwell, Slade Decker, Julia Oh, Aaron M Milstone
{"title":"Association of Neonatal and Maternal Nasal Microbiome Among Neonates in the Intensive Care Unit.","authors":"Shaoming Xiao, Wei Zhou, Ryan Caldwell, Slade Decker, Julia Oh, Aaron M Milstone","doi":"10.1093/ofid/ofae644","DOIUrl":"10.1093/ofid/ofae644","url":null,"abstract":"<p><p>The neonatal nasal microbiota may help protect neonates in the neonatal intensive care unit from pathogen colonization and infection. This preliminary study characterized the biodiversity of nasal microbiota comparing neonates in the neonatal intensive care unit and their mothers, highlighting the potential of strain sharing between mother-neonate pairs.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"11 11","pages":"ofae644"},"PeriodicalIF":3.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Mycobacterium tuberculosis Sensitization and Insulin Resistance Among US Adults Screened for Type 2 Diabetes Mellitus. 在接受 2 型糖尿病筛查的美国成年人中,结核分枝杆菌致敏与胰岛素抵抗之间的关系。
IF 3.8 4区 医学
Open Forum Infectious Diseases Pub Date : 2024-10-28 eCollection Date: 2024-10-01 DOI: 10.1093/ofid/ofae568
Itai M Magodoro, Aloice Aluoch, Brian Claggett, Moffat J Nyirenda, Mark J Siedner, Katalina A Wilkinson, Robert J Wilkinson, Ntobeko A B Ntusi
{"title":"Association Between <i>Mycobacterium tuberculosis</i> Sensitization and Insulin Resistance Among US Adults Screened for Type 2 Diabetes Mellitus.","authors":"Itai M Magodoro, Aloice Aluoch, Brian Claggett, Moffat J Nyirenda, Mark J Siedner, Katalina A Wilkinson, Robert J Wilkinson, Ntobeko A B Ntusi","doi":"10.1093/ofid/ofae568","DOIUrl":"10.1093/ofid/ofae568","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) may be a long-term sequela of infection with <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) by mechanisms that remain to be fully explained. We evaluated the association between <i>Mtb</i> sensitization and T2DM and, via mediation analysis, the extent to which it is mediated by insulin resistance and/or β-cell failure.</p><p><strong>Methods: </strong>Adults were assessed for T2DM by fasting plasma glucose, 2-hour oral glucose tolerance testing, and hemoglobin A<sub>1c</sub>; β-cell dysfunction and insulin resistance by homoeostasis model assessment 2; and <i>Mtb</i> sensitization by tuberculin skin testing. Associations between <i>Mtb</i> sensitization and T2DM were modeled with probit regression and decomposed into indirect effects of β-cell dysfunction and insulin resistance. Analyses were adjusted for sociodemographic, behavioral, and clinical characteristics.</p><p><strong>Results: </strong>We included 1843 adults. Individuals with <i>Mtb</i> sensitization were older than those without <i>Mtb</i> (median [IQR], 54 [39-64] vs 47 [33-62] years). As compared with being uninfected, <i>Mtb</i> sensitization was associated with T2DM (adjusted absolute risk difference, 9.34% [95% CI, 2.38%-15.0%]; <i>P</i> < .001) and increased insulin resistance (adjusted median difference, 0.16 [95% CI, .03-.29]; <i>P</i> = .014) but not β-cell dysfunction (adjusted median difference, -3.1 [95% CI, -10.4 to 4.3]; <i>P</i> = .42). In mediation analyses, insulin resistance mediated 18.3% (95% CI, 3.29%-36.0%; <i>P</i> = .020) of the total effect of the association between <i>Mtb</i> sensitization and T2DM.</p><p><strong>Conclusions: </strong>Definitive prospective studies examining incident T2DM following tuberculosis are warranted. Notwithstanding, our findings suggest that exposure to <i>Mtb</i> may be a novel risk factor for T2DM, likely driven by an increase in insulin resistance.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"11 10","pages":"ofae568"},"PeriodicalIF":3.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Let's Have a Chat: How Well Does an Artificial Intelligence Chatbot Answer Clinical Infectious Diseases Pharmacotherapy Questions? 我们来聊聊人工智能聊天机器人如何回答临床传染病药物治疗问题?
IF 3.8 4区 医学
Open Forum Infectious Diseases Pub Date : 2024-10-25 eCollection Date: 2024-11-01 DOI: 10.1093/ofid/ofae641
Wesley D Kufel, Kathleen D Hanrahan, Robert W Seabury, Katie A Parsels, Jason C Gallagher, Conan MacDougall, Elizabeth W Covington, Elias B Chahine, Rachel S Britt, Jeffrey M Steele
{"title":"Let's Have a Chat: How Well Does an Artificial Intelligence Chatbot Answer Clinical Infectious Diseases Pharmacotherapy Questions?","authors":"Wesley D Kufel, Kathleen D Hanrahan, Robert W Seabury, Katie A Parsels, Jason C Gallagher, Conan MacDougall, Elizabeth W Covington, Elias B Chahine, Rachel S Britt, Jeffrey M Steele","doi":"10.1093/ofid/ofae641","DOIUrl":"https://doi.org/10.1093/ofid/ofae641","url":null,"abstract":"<p><strong>Background: </strong>It is unknown whether ChatGPT provides quality responses to infectious diseases (ID) pharmacotherapy questions. This study surveyed ID pharmacist subject matter experts (SMEs) to assess the quality of ChatGPT version 3.5 (GPT-3.5) responses.</p><p><strong>Methods: </strong>The primary outcome was the percentage of GPT-3.5 responses considered useful by SME rating. Secondary outcomes were SMEs' ratings of correctness, completeness, and safety. Rating definitions were based on literature review. One hundred ID pharmacotherapy questions were entered into GPT-3.5 without custom instructions or additional prompts, and responses were recorded. A 0-10 rating scale for correctness, completeness, and safety was developed and validated for interrater reliability. Continuous and categorical variables were assessed for interrater reliability via average measures intraclass correlation coefficient and Fleiss multirater kappa, respectively. SMEs' responses were compared by the Kruskal-Wallis test and chi-square test for continuous and categorical variables.</p><p><strong>Results: </strong>SMEs considered 41.8% of responses useful. Median (IQR) ratings for correctness, completeness, and safety were 7 (4-9), 5 (3-8), and 8 (4-10), respectively. The Fleiss multirater kappa for usefulness was 0.379 (95% CI, .317-.441) indicating fair agreement, and intraclass correlation coefficients were 0.820 (95% CI, .758-.870), 0.745 (95% CI, .656-.816), and 0.833 (95% CI, .775-.880) for correctness, completeness, and safety, indicating at least substantial agreement. No significant difference was observed among SME responses for percentage of responses considered useful.</p><p><strong>Conclusions: </strong>Fewer than 50% of GPT-3.5 responses were considered useful by SMEs. Responses were mostly considered correct and safe but were often incomplete, suggesting that GPT-3.5 responses may not replace an ID pharmacist's responses.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"11 11","pages":"ofae641"},"PeriodicalIF":3.8,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Randomized Controlled Trial of the Immunogenicity and Safety of a Serum-Free Purified Vero Rabies Vaccine (PVRV-NG2) Using a Simulated Postexposure Zagreb Regimen With Human Rabies Immunoglobulin in Adults in Thailand. 无血清纯化狂犬病疫苗(PVRV-NG2)的免疫原性和安全性随机对照试验--在泰国成人中使用人狂犬病免疫球蛋白的模拟暴露后萨格勒布疗法》(Randomized Controlled Trial of Immunogenicity and Safety of a Serum-Free Purified Vero Rabies Vaccine (PVRV-NG2) Using a Simulated Postexposure Zagreb Regimen with Human Rabies Immunoglobulin in Adults in Thailand)。
IF 3.8 4区 医学
Open Forum Infectious Diseases Pub Date : 2024-10-25 eCollection Date: 2024-11-01 DOI: 10.1093/ofid/ofae633
Danaya Chansinghakul, Terapong Tantawichien, Kriengsak Limkittikul, Winai Ratanasuwan, Yuancheng Wang, Celine Petit, Francoise Guinet-Morlot, Carina Frago, Andrea-Clemencia Pineda-Peña
{"title":"Randomized Controlled Trial of the Immunogenicity and Safety of a Serum-Free Purified Vero Rabies Vaccine (PVRV-NG2) Using a Simulated Postexposure Zagreb Regimen With Human Rabies Immunoglobulin in Adults in Thailand.","authors":"Danaya Chansinghakul, Terapong Tantawichien, Kriengsak Limkittikul, Winai Ratanasuwan, Yuancheng Wang, Celine Petit, Francoise Guinet-Morlot, Carina Frago, Andrea-Clemencia Pineda-Peña","doi":"10.1093/ofid/ofae633","DOIUrl":"10.1093/ofid/ofae633","url":null,"abstract":"<p><strong>Background: </strong>A serum-free, highly purified Vero rabies vaccine-next generation (PVRV-NG2) is under development. We conducted a phase III trial to describe the safety and immunogenicity profile of PVRV-NG2 compared with those of licensed purified Vero rabies vaccine (PVRV) in a simulated rabies postexposure prophylaxis (PEP) Zagreb regimen in Thailand.</p><p><strong>Methods: </strong>Healthy adults aged ≥18 years (n = 201) were randomized in a 2:1 ratio to receive PVRV-NG2 or PVRV in a rabies PEP Zagreb (days 0, 7, 21 [2-1-1]) regimen, with concomitant human rabies immunoglobulin (HRIG) at day 0. Immunogenicity end points included the proportion of participants with rabies virus-neutralizing antibody (RVNA) titers ≥0.5 IU/mL at days 0, 14, and 35. Safety outcomes were also assessed.</p><p><strong>Results: </strong>A total of 199 participants completed the study (PVRV-NG2 n = 133, PVRV n = 66). In the PVRV-NG2 group and PVRV group, respectively, 91.0% (95% CI, 84.1%-95.6%) and 94.6% (95% CI, 85.1%-98.9%) had RVNA titers ≥0.5 IU/mL at day 14, increasing to 100% (95% CI, 96.8%-100%) and 100% (95% CI, 93.5%-100%) by day 35. The vaccines had similar safety profiles, and there were no safety concerns.</p><p><strong>Conclusions: </strong>PVRV-NG2 showed acceptable safety and immunogenicity profiles when co-administered with HRIG in a simulated PEP Zagreb regimen in healthy adults in Thailand.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"11 11","pages":"ofae633"},"PeriodicalIF":3.8,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Associated With Death at 30 Days and Evaluation of Clinical Risk Scores Among Patients With Cancer Admitted With Postchemotherapy Infection in Uganda: A Prospective Cohort Study. 乌干达因化疗后感染入院的癌症患者 30 天内死亡的相关因素及临床风险评分评估:前瞻性队列研究
IF 3.8 4区 医学
Open Forum Infectious Diseases Pub Date : 2024-10-25 eCollection Date: 2024-11-01 DOI: 10.1093/ofid/ofae634
Ambaru Jacinta Ojia, Sophie E Lyon, Jane Francis Birungi, Catherine Owomugisha, Rose Muhindo, Semei Buwambaza Sekitene, Christopher C Moore, Edwin Nuwagira
{"title":"Factors Associated With Death at 30 Days and Evaluation of Clinical Risk Scores Among Patients With Cancer Admitted With Postchemotherapy Infection in Uganda: A Prospective Cohort Study.","authors":"Ambaru Jacinta Ojia, Sophie E Lyon, Jane Francis Birungi, Catherine Owomugisha, Rose Muhindo, Semei Buwambaza Sekitene, Christopher C Moore, Edwin Nuwagira","doi":"10.1093/ofid/ofae634","DOIUrl":"10.1093/ofid/ofae634","url":null,"abstract":"<p><strong>Background: </strong>Little is known about outcomes from cancer chemotherapy--associated infections in sub-Saharan Africa. Accordingly, among patients with cancer admitted with postchemotherapy infection in Mbarara, Uganda, we aimed to determine (1) the 30-day case fatality rate, (2) factors associated with mortality rate, and (3) clinical risk score performance.</p><p><strong>Methods: </strong>We enrolled participants aged ≥18 years if they (1) received cancer chemotherapy within the past 30 days, (2) were admitted to the oncology ward, and (3) were prescribed intravenous antibiotics. We used Cox proportional hazards regression to determine predictors of death at 30 days and calculated the area under the receiver operating characteristic curve (AUC) for each clinical risk score.</p><p><strong>Results: </strong>Among 150 participants, 67 (45%) were female, and the median (interquartile range) age was 56 (43-66) years. Esophageal cancer (18%) and pneumonia (42%) were the most common cancer and infection, respectively. Death occurred within 30 days in 63 participants (42%). Quick Sequential Organ Failure Assessment (qSOFA) score ≥2 (adjusted hazard ratio, 2.51 [95% confidence interval, 1.42-4.44]; <i>P</i> = .001), and Universal Vital Assessment (UVA) score >4 (2.13 [.08-4.18, <i>P</i> = .03) were independently associated with death at 30 days. An Eastern Cooperative Oncology Group (ECOG) score ≥3 was similarly independently associated with death at 30 days in the qSOFA and UVA models. The AUCs for qSOFA and UVA scores were 0.70 (95% confidence interval, .63-.79) and 0.72 (.64-.80), respectively.</p><p><strong>Conclusions: </strong>In participants with postchemotherapy infection in Mbarara, Uganda, the case fatality rate was high. ECOG, qSOFA, and UVA scores were associated with death at 30 days.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"11 11","pages":"ofae634"},"PeriodicalIF":3.8,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatitis B Triple Panel Testing Implementation in the Obstetric Care Setting: Unique Predictors of Hepatitis B Virus Vaccine Immunity, Exposure, and Positivity. 在产科护理环境中实施乙肝三项检测:乙型肝炎病毒疫苗免疫、暴露和阳性的独特预测因素。
IF 3.8 4区 医学
Open Forum Infectious Diseases Pub Date : 2024-10-23 eCollection Date: 2024-11-01 DOI: 10.1093/ofid/ofae632
Natalia Schmidt, Jeanette Rios, Lauren Alpert, Anna Mageras, Whitney Lieb, Tatyana Kushner
{"title":"Hepatitis B Triple Panel Testing Implementation in the Obstetric Care Setting: Unique Predictors of Hepatitis B Virus Vaccine Immunity, Exposure, and Positivity.","authors":"Natalia Schmidt, Jeanette Rios, Lauren Alpert, Anna Mageras, Whitney Lieb, Tatyana Kushner","doi":"10.1093/ofid/ofae632","DOIUrl":"10.1093/ofid/ofae632","url":null,"abstract":"","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"11 11","pages":"ofae632"},"PeriodicalIF":3.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond Words: Enhancing Clinical Guideline Comprehension With Icons. 超越文字:用图标加强临床指南的理解。
IF 3.8 4区 医学
Open Forum Infectious Diseases Pub Date : 2024-10-23 eCollection Date: 2024-11-01 DOI: 10.1093/ofid/ofae637
Isin Y Comba, John C O'Horo, Joel E Gordon, Yngve Falck-Ytter, Matthew M Moore, Rebecca L Morgan, Reem A Mustafa, Adarsh Bhimraj
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