Open Forum Infectious Diseases最新文献

{"title":"The Ethiopian Third National Tuberculosis Drug Resistance Survey Incorporating Whole Genome Sequencing.","authors":"Shewki Moga, Muluwork Getahun, Zemedu Mohammed, Ayinalem Alemu, Getu Diriba, Bazezew Yenew, Dinka Fikadu, Yeshiwork Abebaw, Misikir Amare, Ephrem Tesfaye, Abebaw Kebede, Zelalem Yaregal, Abyot Meaza, Hilina Mollalign, Biniyam Dagne, Mengistu Tadesse, Waganeh Sinshaw, Getachew Seid, Betselot Zerihun, Melak Getu, Gemechu Tadesse, Saro Abdella, Getachew Tollera, Abayneh Admas, Addisalem Yilma, Yohannes Molla, Fekadesselassie Mikru, Dawit Assefa, Tefera Girma, Beniam Feleke, Federico Di Marco, Daniela M Cirillo, Anna Dean, Andrea Maurizio Cabibbe, Eveline Klinkenberg","doi":"10.1093/ofid/ofaf367","DOIUrl":"https://doi.org/10.1093/ofid/ofaf367","url":null,"abstract":"<p><strong>Background: </strong>Drug-resistant tuberculosis (DR-TB) is a major challenge hindering global tuberculosis control. Ethiopia conducted a third national antituberculosis (TB) drug resistance survey, and this is the first survey to report on drug resistance using whole genome sequencing (WGS) in addition to genotypic and phenotypic test results. The aim of this study was to obtain up-to-date information regarding the magnitude and pattern of drug resistance in Ethiopia.</p><p><strong>Methods: </strong>A nationwide cross-sectional study was conducted in 217 health facilities across all Ethiopian regional states from August 2017 to January 2019. Sputum specimens were collected from patients with bacteriologically confirmed pulmonary TB to detect resistance to anti-TB drugs with Xpert MTB/RIF assay, culture-based phenotypic drug susceptibility testing (DST), and WGS with phylogenetic analysis.</p><p><strong>Results: </strong>The prevalence of rifampicin-resistant TB (RR-TB) was 1.07% (95% confidence interval [CI], .65%-1.74%) among new cases and 6.89% (95% CI, 4.02%-11.57%) among previously treated cases. The prevalence of isoniazid-resistant, rifampicin-susceptible TB was 4.15% (95% CI, 3.11%-5.53%) among new cases and 4.41% (95% CI, 1.97%-9.57%) among previously treated cases. While resistance to fluoroquinolones was detected in 1 RR-TB case, resistance to bedaquiline and linezolid was not detected in RR-TB cases. <i>Mycobacterium tuberculosis</i> lineage 4 was the most common, followed by lineage 3 and lineage 1, with sublineage 4.2.2 being the most frequent.</p><p><strong>Conclusions: </strong>The level of RR-TB remained low. Expanding baseline DST for isoniazid may help further lower the burden of DR-TB in Ethiopia.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 7","pages":"ofaf367"},"PeriodicalIF":3.8,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Human Metapneumovirus Among Older Adults in 10 High-Income Countries: A Systematic Literature Review, Meta-analysis, and Modeling Study.","authors":"Jiali Lei, Catherine W Gillespie, Serena Santoni, Jam Suba, Niranjan Kanesa-Thasan, Ajoke Sobanjo-Ter Meulen","doi":"10.1093/ofid/ofaf373","DOIUrl":"10.1093/ofid/ofaf373","url":null,"abstract":"<p><strong>Background: </strong>The epidemiologic landscape for human metapneumovirus (hMPV), a respiratory pathogen, is poorly characterized, particularly among older adults.</p><p><strong>Methods: </strong>Leveraging the latest estimates of lower respiratory infection (LRI) incidence from the Global Burden of Disease Study 2021 and meta-analyzed findings from a systematic literature review, we quantified the incidence of LRI with hMPV in 10 high-income locations among older adults in the most recent prepandemic year (2019): Canada, Chile, France, Germany, New Zealand, Netherlands, Italy, Spain, United Kingdom, and United States.</p><p><strong>Results: </strong>The systematic literature review identified 21 studies with data on the percentage of LRI episodes associated with hMPV in adults aged ≥60 years in the targeted locations. Combining the meta-analyzed percentage of LRI cases associated with hMPV from these studies (7.0%; 95% CI, 5.4%-9.1%) with age-, sex-, and location-specific estimates of LRI incidence from the Global Burden of Disease Study 2021, we estimated that hMPV incidence rates per 100 000 in 2019 among adults aged ≥60 ranged from 185.7 (95% uncertainty interval, 134.7-251.1) in Italy to 462.1 (333.1-628.2) in the United States.</p><p><strong>Conclusions: </strong>Overall, our literature review, meta-analysis, and modeling study confirm a significant burden of hMPV-associated LRI in older adults. This work fills a critical evidence gap in the epidemiologic landscape of hMPV and yields actionable estimates to inform vaccine development strategies and other strategic initiatives. Future inclusion of hMPV in routine surveillance would enable more comprehensive estimates of hMPV incidence and outcomes.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 7","pages":"ofaf373"},"PeriodicalIF":3.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19-associated Pulmonary Aspergillosis in Mechanically Ventilated Patients at 7 US Hospitals: Epidemiology and Estimated Likelihood of Invasive Pulmonary Aspergillosis-Results of the Prospective MSG-017 Study.","authors":"M Hong Nguyen, Sixto M Leal, Luis Ostrosky-Zeichner, Andrej Spec, George R Thompson, Thomas F Patterson, John Baddley, Rachel McMullen, Drashti Shah, Cornelius J Clancy, Gerald McGwin, Peter G Pappas","doi":"10.1093/ofid/ofaf331","DOIUrl":"10.1093/ofid/ofaf331","url":null,"abstract":"<p><strong>Background: </strong>There is no prospective, US multicenter study of COVID-19-associated pulmonary aspergillosis (CAPA). CAPA definitions do not differentiate invasive aspergillosis (IPA) from colonization. Validity of single mycologic test results is unclear.</p><p><strong>Methods: </strong>We performed a prospective 7-center US study of mechanically ventilated adults with COVID-19 (April 2021-May 2022). Mycoses Study Group (MSGERC) CAPA criteria include host and clinical factors, imaging and test results (histopathology; bronchoalveolar lavage [BAL] culture and/or BAL or serum galactomannan-immunoassay). Proven, putative, and unlikely IPA were defined by clinical criteria. CAPA-unlikely IPA criteria included survival or negative autopsy following no/limited antifungal treatment. IPA likelihood was estimated using sensitivity/specificity of tests from autopsy data.</p><p><strong>Results: </strong>CAPA incidence was 7% (14/212). Independent CAPA risk factors were EORTC/MSGERC host factor and cavitary lesions. Seven percent, 79%, and 14% of CAPA patients had proven, putative, and unlikely IPA, respectively. Respective estimated IPA likelihoods were 84%, 7%-99%, and 1%-8%. Overall, median estimated IPA likelihood was 30%. Patients with CAPA-unlikely IPA had a single positive BAL galactomannan-immunoassay with other negative tests. CAPA mortality (71%) was not impacted by antifungal treatment or significantly different than without CAPA. CAPA incidence was 10% and 16% by European Confederation of Medical Mycology and Public Health Wales definitions, respectively. IPA was unlikely in 75% (6/8) and 57% (13/23) diagnosed by these definitions but not MSGERC.</p><p><strong>Conclusions: </strong>CAPA is associated with high mortality, but IPA's contribution is unclear. Single positive tests are insufficient for diagnosing CAPA-IPA. IPA likelihood is best estimated by combining test results (both positive and negative).</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 7","pages":"ofaf331"},"PeriodicalIF":3.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance (Sensitivity and Specificity) of a New Point-of-Care Immunochromatography to Screen for Imported Chronic Schistosomiasis Among Long-Term Sub-Saharan Migrants.","authors":"Alaa H A Hegazy, Olga Pérez-Quílez, Israel López-Muñoz, Anna Chamorro, Elena Abad, Alba San José, Júlia Valera, Lluís Valerio, Laura Soldevila, Ester Gorriz, Dolores Herena, Elia Fernández-Pedregal, Josep M Llibre, Gema Fernández-Rivas, Pere Joan Cardona, Xavier Vallès, Sílvia Roure","doi":"10.1093/ofid/ofaf328","DOIUrl":"10.1093/ofid/ofaf328","url":null,"abstract":"<p><strong>Background: </strong>Imported schistosomiasis is underdiagnosed among long-term migrants in non-endemic countries. Reference standard tests are lacking for the diagnosis of chronic schistosomiasis.</p><p><strong>Methods: </strong>This study evaluated the sensitivity and specificity of a new immunochromatography (ICT) test using serum (s) or point-of-care finger-prick (FP) whole blood against standard serological tests in long-term migrants from sub-Saharan Africa.</p><p><strong>Results: </strong>A total of 202 individuals were screened, with a mean age of 42.7 years. Of these, 75.7% were male, and 42.6% were from Senegal. Test positivity rates were 15.8% for ELISA, 24.3% for ICT-p, 46.5% for ICT-b (s), and 28.7% for ICT-b (FP). All tests showed good agreement with a clinical score but with heterogeneous agreement between them. Our results indicates a higher sensitivity for ICT-b (s). Positive responses after treatment suggest good specificity for all tests.</p><p><strong>Conclusions: </strong>ICT-b (s) shows a higher sensitivity than the other standard tests. An ICT-b (FP) strategy could be used as a first-step point-of-care screening tool for probable chronic schistosomiasis.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 7","pages":"ofaf328"},"PeriodicalIF":3.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Doravirine-based Regimens by Sex and Race: Long-term Results From Three Phase 3 Clinical Trials.","authors":"Sharon L Walmsley, Princy N Kumar, Chloe Orkin, Melanie Thompson, Kathleen Squires, Zhi Jin Xu, Wayne Greaves, Rebeca M Plank, Yohance Whiteside, Rima Lahoulou","doi":"10.1093/ofid/ofaf356","DOIUrl":"10.1093/ofid/ofaf356","url":null,"abstract":"<p><strong>Background: </strong>Females and persons of Black race are often underrepresented in clinical trials. This post hoc analysis of data from three phase 3 studies evaluated the efficacy and safety of doravirine (DOR) by sex and race in adults living with HIV-1.</p><p><strong>Methods: </strong>DRIVE-FORWARD and DRIVE-AHEAD open-label extensions were pooled; participants randomized to first-line DOR-based regimen continued from week (W) 96 to W192 (DOR-continued group) and participants randomized to comparators switched to DOR from W96 to W192 (DOR-switch group). In DRIVE-SHIFT, virologically suppressed adults were randomized to switch to a DOR-based regimen on day 1 (immediate-switch group) or W24 (delayed-switch group) and continued through W144. Results are reported by sex assigned at birth (male vs female) and race (Black vs non-Black).</p><p><strong>Results: </strong>Across trials, female and Black participants each represented <20% of study populations. After continuing or switching to DOR, percentages of participants with HIV-1 RNA <50 copies/mL were comparable between sex and race subgroups. Mean changes in CD4+ T-cell counts and proportions of participants with drug-related adverse events or serious adverse events were generally similar between subgroups. In DRIVE-SHIFT, higher rates of nontreatment-related discontinuations were observed within Black versus non-Black subgroups. Differences in median weight change were generally larger between race subgroups than sex subgroups, although interquartile ranges were wide for all.</p><p><strong>Conclusions: </strong>Participants who continued or switched to DOR generally had comparable efficacy and safety outcomes across sex and race subgroups. However, the sample size was limited. Future studies should ensure greater diversity when investigating factors leading to outcome disparities. <b>ClinicalTrials.gov:</b> NCT02275780, NCT02403674, NCT02397096.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 7","pages":"ofaf356"},"PeriodicalIF":3.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic and Phenotypic Characterization of Mupirocin-resistant <i>Staphylococcus aureus</i> Clinical Isolates.","authors":"Ariana M Virgillio, Emily A Felton, Jessica K Jackson, Sarah J Kennedy, Deanna N Becker, Amorce Lima, Kimberly Atrubin, Eleonora Cella, Taj Azarian, Suzane Silbert, Lindsey N Shaw, Kami Kim","doi":"10.1093/ofid/ofaf374","DOIUrl":"https://doi.org/10.1093/ofid/ofaf374","url":null,"abstract":"<p><strong>Background: </strong>Colonization with <i>Staphylococcus aureus</i> is a risk factor for subsequent infection. Decolonization with the topical antibiotic mupirocin is effective and reduces the risk of subsequent <i>S. aureus</i> infection for both methicillin-sensitive and methicillin-resistant (MRSA) strains but may select for mupirocin-resistant isolates.</p><p><strong>Methods: </strong>We characterized oxacillin and mupirocin susceptibility amongst 384 <i>S. aureus</i> strains isolated from clinical samples isolated in 2017-2023 in Tampa, Florida, spanning strains collected before and after the onset of the coronavirus disease 2019 (COVID-19) pandemic. Whole genome sequencing of bacterial isolates was conducted in parallel and correlated with drug susceptibility profiles.</p><p><strong>Results: </strong>Mupirocin resistance (MupR) was nearly exclusively present in MRSA strains (103/106, 97.1% of MupR; 103/299, 34.4% of MRSA). Although our hospital protocol for decolonization shifted to povidone iodine in the post-COVID period, the overall prevalence of MupR did not change in pre-COVID and post-COVID samples (28.9% vs 26%). Genotype correlated with antibiotic susceptibility with low-level MupR, linked to mutations in <i>ileS</i> and high-level MupR, linked to the presence of <i>mupA</i>. Genome analysis revealed that most MupR strains fell into 3 sequence types (ST) falling into 2 major clonal complexes (CC): CC8 ST8 (including community-associated MRSA strains USA300 and USA500), CC5 ST5 (associated with healthcare-associated MRSA such as USA100), and CC5 ST3390. ST3390 isolates had the highest prevalence of MupR (30/36 83%; high-level MupR 20/36 55.6%; low-level MupR 10/36 27.8%).</p><p><strong>Conclusions: </strong>Mupirocin resistance was prevalent in our hospital MRSA strains. We also found evidence for emergence and persistence of ST3390 MRSA-MupR strains in Florida.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 7","pages":"ofaf374"},"PeriodicalIF":3.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Cases of Mycotic Aneurysms Caused by <i>Brucella suis</i> Infection of Aortic Graft Material.","authors":"Brandi M Mize, Emily Laskey, Gregory L Damhorst, Colleen S Kraft, Guillermo A Escobar","doi":"10.1093/ofid/ofaf404","DOIUrl":"https://doi.org/10.1093/ofid/ofaf404","url":null,"abstract":"<p><p><i>Brucella suis</i>, a zoonotic pathogen, can affect multiple human organ systems causing various clinical manifestations. While aortoiliac involvement is rare worldwide, we report 2 cases of aortic brucellosis following abdominal aortic aneurysm repairs within a 9-year period at a single US institution in Georgia. One case was an infected aortic endograft, which may be the first reported. <i>B suis</i> aortoiliac infections are rare even in endemic areas, thus highlighting how uncommon these cases are in Georgia. Acknowledging the dismal prognosis with symptomatic aortic graft infections, we wish to share our experience in successfully treating them, including an infected aortic endograft. We recommend obtaining a robust history when evaluating individuals with suspected mycotic aneurysms who frequently handle animals. Education on protective equipment and proper handling of animals is imperative to reduce the risk of aortic graft brucellosis infections. Our institutional experience suggests that graft explantation and doxycycline-rifampin are acceptable treatment options.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 7","pages":"ofaf404"},"PeriodicalIF":3.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing Birth-Dose Hepatitis B Vaccination in Nigeria: Qualitative Analysis of Data From a Crowdsourcing Open Call.","authors":"Sonam J Shah, Rayna Haque, Abdulhammed Opeyemi Babatunde, Folahanmi T Akinsolu, Maria Afadapa, Nkiruka Obodoechina, Joseph Ogbeh, Olufunto A Olusanya, Temitope Ojo, Dawit Alemu, Peyton Thompson, Oluwaseun Falade-Nwulia, Suzanne Day, Dan Wu, Olufunmilayo Lesi, Ucheoma Nwaozuru, Titilola Abike Gbaja-Biamila, Abideen Salako, Adesola Zaidat Musa, Ifeoma Idigbe, Kristie Foley, Juliet Iwelunmor, Oliver C Ezechi, Joseph D Tucker","doi":"10.1093/ofid/ofaf400","DOIUrl":"https://doi.org/10.1093/ofid/ofaf400","url":null,"abstract":"<p><strong>Background: </strong>Despite World Health Organization and Nigerian recommendations for hepatitis B birth-dose (HepB-BD) vaccination, only one-third of Nigerian newborns receive timely HepB-BD vaccination, This study identified facilitators to increasing HepB-BD vaccination based on data from a crowdsourcing open call in Nigeria.</p><p><strong>Methods: </strong>Our team conducted an open call across Nigeria for teams to submit ideas on how to increase HepB-BD vaccination. Independent judges evaluated the submissions based on predefined criteria. We analyzed textual data from the top 29 entries using iterative coding and thematic analysis within a socioecological model to identify priority facilitators.</p><p><strong>Results: </strong>The open call received 362 total submissions, and 58.5% (215/362) of submissions were from women. Analysis of the top 29 submissions revealed 6 priority facilitators for increasing HepB-BD vaccination: (1) engage religious and healthcare leaders to educate pregnant women; (2) strengthen national policies for vaccination support and tracking; (3) counter misconceptions to promote attitude and behavior changes; (4) utilize rural infrastructure like town halls and radio programs to disseminate information; (5) translate educational materials into local languages like pidgin; and (6) organize financial or social incentives.</p><p><strong>Conclusions: </strong>Our crowdsourcing open call identified key facilitators and strategies for increasing HepB-BD vaccination among Nigerian newborns. The findings from this study can inform HepB-BD initiatives in Nigeria and other low- and middle-income countries.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 7","pages":"ofaf400"},"PeriodicalIF":3.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Pneumocystis Pneumonia-Is it Still a Threat Among People With Human Immunodeficiency Virus (HIV)? A Danish HIV Cohort Study.","authors":"","doi":"10.1093/ofid/ofaf354","DOIUrl":"https://doi.org/10.1093/ofid/ofaf354","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/ofid/ofaf289.].</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 7","pages":"ofaf354"},"PeriodicalIF":3.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Willingness to Take Long-Acting Injectable Preexposure Prophylaxis (PrEP) and Preference for PrEP Modalities Among People Who Inject Drugs in Washington, DC.","authors":"Xinyi Li, Sydney Bornstein, Madhu Balachandran, Manya Magnus, Kate Drezner, Brittani Saafir-Callaway, Irene Kuo","doi":"10.1093/ofid/ofaf389","DOIUrl":"10.1093/ofid/ofaf389","url":null,"abstract":"<p><strong>Background: </strong>People who inject drugs (PWID) face multilevel barriers to adhering to daily oral preexposure prophylaxis (PrEP). Long-acting injectable (LAI) PrEP may help overcome some of these barriers. Understanding willingness among PWID to take LAI PrEP and preferences for PrEP modality is important to promote LAI PrEP when it becomes available to them.</p><p><strong>Methods: </strong>We analyzed data from the 2018 National HIV Behavioral Surveillance PWID data collection cycle in Washington, DC. Respondent-driven sampling weighted proportions and correlates of willingness to take LAI PrEP and preference for LAI PrEP versus daily oral PrEP were reported, overall and stratified by gender.</p><p><strong>Results: </strong>Of 402 PWID, 69.1% reported being extremely likely/likely to take LAI PrEP; 52.4% preferred LAI PrEP over daily oral PrEP. Being female and uninsured were associated with higher odds of willingness to take LAI PrEP. Having no/low income and past-year sexual violence were associated with preferring LAI PrEP over daily oral PrEP. Men who inject drugs who were aware of PrEP had higher odds to prefer LAI PrEP over daily oral PrEP. Women who inject drugs (WWID) reporting no/low income, sexual violence, and receptive needle sharing were more likely to prefer LAI PrEP over daily oral PrEP.</p><p><strong>Conclusions: </strong>PWID in Washington, DC reported high willingness to take LAI PrEP; half reported preferring LAI PrEP. Improving education about PrEP is important for healthcare providers and PWID. Subgroups of WWID experiencing sexual violence may benefit from LAI PrEP. Human immunodeficiency virus prevention programs for PWID should consider gender differences when implementing LAI PrEP.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 7","pages":"ofaf389"},"PeriodicalIF":3.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}