Open Forum Infectious Diseases最新文献

{"title":"Absence of Macrolide-Resistant Mutations in <i>Bordetella pertussis</i> in Antananarivo (Madagascar) and Cambodia During the Last Pertussis Cycle Before the COVID-19 Pandemic.","authors":"Florence Campana, Mahdi Rajabizadeh, Mallorie Hide, Gauthier Delvallez, Samrach Han, Lala Rafetrarivony, Bunnet Dim, Aina Harimanana, Gaelle Noel, Mohand Ait-Ahmed, Jean-Marc Collard, Laurence Borand, Nicole Guiso, Fabien Taieb","doi":"10.1093/ofid/ofaf566","DOIUrl":"10.1093/ofid/ofaf566","url":null,"abstract":"<p><p>Macrolides are the first-line treatment against pertussis. The high prevalence of macrolide-resistant <i>Bordetella pertussis</i> (MRBP) strains reported in China is concerning. MBRP might be underestimated in other countries. Looking for the mutation causative for MRBP in retrospective studies conducted in Madagascar and Cambodia, we found no MRBP.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 10","pages":"ofaf566"},"PeriodicalIF":3.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes to Endemic Respiratory Virus Circulation and Testing Before, During, and After the COVID-19 Pandemic.","authors":"Kim El-Haddad, Wei Liu, Patrick Burke, Hannah Wang, Frank P Esper","doi":"10.1093/ofid/ofaf493","DOIUrl":"10.1093/ofid/ofaf493","url":null,"abstract":"<p><strong>Background: </strong>The SARS-CoV-2 pandemic and resulting countermeasures significantly disrupted the circulation of many endemic respiratory viruses. While most viruses experienced sharp declines immediately following the pandemic onset, recovery dynamics varied among species. We hypothesize that the degree of displacement in virus circulation and the time required to return to prepandemic patterns are influenced by the circulation overlap with SARS-CoV-2.</p><p><strong>Methods: </strong>Respiratory virus testing data from nasopharyngeal specimens (2015 through May 2024) were analyzed for 6 respiratory viruses grouped into 3 seasonality patterns: wintertime (influenza A, respiratory syncytial virus), springtime (human metapneumovirus, parainfluenza 3), and year-round (adenovirus, rhinovirus/enterovirus). Prepandemic and post-SARS-CoV-2 emergence trends in positivity and peak displacement were assessed and compared in interrupted time series, wavelet, and median regression analyses.</p><p><strong>Results: </strong>Marked disruptions in respiratory virus patterns occurred following the local spread of SARS-CoV-2. Winter viruses (influenza A and respiratory syncytial virus) showed significant declines in positivity during the postemergence period, with protracted resurgence thereafter. Spring viruses (parainfluenza 3 and human metapneumovirus) and year-round viruses (rhinovirus/enterovirus and adenovirus) were resilient, quickly returning to prepandemic positivity. Interrupted series and wavelet analyses revealed altered seasonality for winter viruses, with influenza A transitioning to a semiannual pattern before normalizing in 2024. Median peak displacement for spring viruses normalized within 2 seasons postemergence, while winter viruses had more pronounced shifts in seasonal timing.</p><p><strong>Conclusions: </strong>The COVID-19 pandemic and resulting countermeasures disproportionately affected winter-dominant viruses, delaying their recovery to prepandemic patterns in Cleveland, Ohio. Spring and year-round viruses experienced milder deviations and have largely normalized. These findings provide key insights for future pandemic preparedness.</p><p><strong>Article summary: </strong>The COVID-19 pandemic disproportionately affected endemic viruses whose circulation closely overlaps with peak SARS-CoV-2 circulation. Winter-dominant viruses had more severe and prolonged alterations while spring and year-round viruses experienced milder changes and recovered more quickly.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 9","pages":"ofaf493"},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium Intake and Bone Mineral Density in People With HIV and/or Chronic Hepatitis C.","authors":"Zoey B Temesgen, Zelalem Temesgen, Roger J Bedimo","doi":"10.1093/ofid/ofaf562","DOIUrl":"10.1093/ofid/ofaf562","url":null,"abstract":"<p><strong>Background: </strong>Increased prevalence of reduced bone mineral density (BMD) is well documented in persons infected with human immunodeficiency virus (HIV), hepatitis C virus (HCV), or both. This study's purpose was to determine if an association exists between dietary calcium intake and BMD in these patients.</p><p><strong>Methods: </strong>Participants were individuals with virologically suppressed HIV or untreated HCV monoinfections, those with HIV/HCV coinfection, and noninfected controls. The Hertzler-Frary dietary calcium questionnaire documented calcium intake with calcium amounts based on the US Department of Agriculture nutrient database. BMD was measured at baseline by dual-energy x-ray absorptiometry, and χ² tests were used to assess the relationship between BMD and infection status. One-way analysis of covariance was used to compare calcium intake data with the prevalence of normal BMD and osteoporosis by infection group. Adjustments were made for race, age, body mass index, and smoking status. Spearman correlation was used to identify relationships between calcium intake from foods/beverages and BMD.</p><p><strong>Results: </strong>A total of 452 men were recruited into the study. Osteoporosis and osteopenia were prevalent, but there was no association between infection group and BMD result ( <math><msup><mi>χ</mi> <mn>2</mn></msup> <mrow></mrow> <mo>(</mo> <mn>6</mn> <mo>)</mo> <mspace></mspace></math> = 6.813; <i>P</i> = .34). Only HCV-infected patients with osteoporosis had lower calcium intake than patients with normal BMD (mean difference, 409 mg/d [95% confidence interval, 35-784 mg/d]; <i>P</i> = .03).</p><p><strong>Conclusions: </strong>In this study population, dietary calcium intake was correlated with reduced BMD only in patients with HCV monoinfection.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 9","pages":"ofaf562"},"PeriodicalIF":3.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Efficacy of Crushed Bictegravir/Emtricitabine/Tenofovir Alafenamide Administered via Tube.","authors":"Joshua Mercure, Kayla Bey, Eric Gillett, Jeffrey C Pearson, Suzanne M McCluskey, Alex E Rock","doi":"10.1093/ofid/ofaf588","DOIUrl":"10.1093/ofid/ofaf588","url":null,"abstract":"<p><p>Human immunodeficiency virus (HIV) viral suppression was evaluated after receipt of crushed or dissolved bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) administered via enteral tube during hospitalization. Eighty-nine percent of patients (17/19) were virally suppressed (<200 copies/mL) within 1 year of receiving B/F/TAF via tube, suggesting that administration via tube is a reasonable alternative to changing antiretroviral regimens.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 10","pages":"ofaf588"},"PeriodicalIF":3.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Transcriptomic Markers Associated With Neutrophil Extracellular Traps to Predict Mortality Risk in Neonatal Sepsis.","authors":"Deepshikha Shaw, Sridhar Santhanam, Tapas Kumar Som, Samsiddhi Bhattacharjee, Saroj Kant Mohapatra","doi":"10.1093/ofid/ofaf570","DOIUrl":"10.1093/ofid/ofaf570","url":null,"abstract":"<p><strong>Background: </strong>Neonates are highly susceptible to sepsis, which is often accompanied by fatal coagulopathy. Anticoagulant therapies have not reduced sepsis-related mortality in clinical trials, possibly due to patient heterogeneity. Neutrophil extracellular traps (NETs) enhance coagulation by activating platelets, suggesting that NET-specific biomarkers may identify patients who may benefit from targeted anticoagulant treatment. This study evaluated the association between NET gene expression and adverse outcomes in neonatal sepsis.</p><p><strong>Methods: </strong>We analyzed whole blood transcriptomes from 123 neonates with sepsis and developed a predictive model, the NET score, based on NET-related gene expression. Model performance was assessed in two independent validation sets. Mediation and correlation analyses explored the relationship between the NET score and a coagulation score. Temporal transcriptomic data from septic shock cases further tested this interaction.</p><p><strong>Results: </strong>The NET score achieved AUCs of 88.7% and 85.4% in validation Sets 1 and 2, respectively, indicating strong predictive performance. Mediation and temporal analyses supported a sequential relationship between NETosis and coagulation in sepsis. Age-specificity of the model was confirmed using pediatric (<i>n</i> = 163) and adult (<i>n</i> = 86) sepsis transcriptomic datasets. Neonates with disseminated intravascular coagulation exhibited a trend toward elevated NET scores.</p><p><strong>Conclusions: </strong>Our findings support a novel risk stratification approach using the NET score to identify neonates at increased risk for sepsis-associated coagulopathy and poor outcomes, potentially guiding targeted therapeutic strategies.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 9","pages":"ofaf570"},"PeriodicalIF":3.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12459259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of State Legislation Restricting Reproductive and LGBT Rights With Infectious Diseases Fellowship Match Rates.","authors":"Michael Z Chen, Aniruddha Hazra, Alan L Hutchison, Anna E Czapar","doi":"10.1093/ofid/ofaf534","DOIUrl":"10.1093/ofid/ofaf534","url":null,"abstract":"<p><strong>Background: </strong>Infectious diseases (ID) fellowship match rates have declined over the last decade. Previous studies have identified factors that influence interest in ID and fellowship match rates, but the association of state legislation restricting reproductive and/or lesbian, gay, bisexual, and transgender (LGBT) rights with ID fellowship match rates is unknown.</p><p><strong>Methods: </strong>All adult ID fellowship programs in the United States from 2017 to 2025 were categorized as located in states, districts, or territories with or without restrictions on reproductive and/or lesbian, gay, bisexual, and transgender rights. Programs were also categorized by academic status as academic, university-affiliated community, or pure community programs. Match rates were compared between programs when stratifying by state restrictions, academic status, and both status using χ² tests.</p><p><strong>Results: </strong>In 6 of the 9 years studied, match rates of adult ID fellowship programs were higher to a significant degree for academic programs in permissive states than for those in restrictive states (2017-2018, 2021-2023, 2025; <i>P</i> = .002 to <i>P</i> = .02). In the same period, there were no differences in match rates between university-affiliated community programs or pure community programs in states with and without restrictions.</p><p><strong>Conclusions: </strong>The presence of legislation restricting reproductive and/or LGBT rights was associated with significantly reduced match rates in academic programs but not in university-affiliated community programs or pure community programs. Academic fellowship programs represent the majority of ID fellowship programs and must make note of this when recruiting fellows.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 9","pages":"ofaf534"},"PeriodicalIF":3.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Majority of <i>Bacillus subtilis</i> Strains Isolated From Blood Cultures Were Derived From Traditional Japanese Fermented Soybeans Natto: A Single-center Retrospective Study.","authors":"Ryuichi Minoda Sada, Go Yamamoto, Shigeto Hamaguchi, Eisuke Kuroda, Akiko Okura, Manke Cai, Kotone Nakanishi, Noriyuki Abe, Shungo Yamamoto, Satoshi Kutsuna","doi":"10.1093/ofid/ofaf574","DOIUrl":"10.1093/ofid/ofaf574","url":null,"abstract":"<p><strong>Background: </strong>Natto consumption has been associated with improved cardiovascular and survival outcomes. <i>Bacillus subtilis</i> variant <i>natto</i> (<i>B. subtilis</i> var. <i>natto</i>) is essential for soybean fermentation in natto production. Recently, several cases of <i>B. subtilis</i> var. <i>natto</i> bacteremia have been reported, although the contribution of <i>B. subtilis</i> var. <i>natto</i> remains unclear. This study assessed the prevalence and clinical impact of <i>B. subtilis</i> var. <i>natto</i> in <i>B. subtilis</i> bacteremia.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed medical records of patients with positive <i>B. subtilis</i> blood cultures at Tenri Hospital from 1 April 2016 to 31 March 2023. True bacteremia required portal-of-entry or, for intra-abdominal/abscess, 2-physician adjudication; if no portal, 2 or more same-day blood culture-positive sets. Genetic testing confirmed <i>B. subtilis</i> var. <i>natto</i> through specific mutations in the <i>bioF</i> and <i>bioW</i> genes.</p><p><strong>Results: </strong>Of 4634 positive blood cultures, 70 (1.5%) were identified as <i>B. subtilis</i>, with 69 (99%) classified as <i>B. subtilis</i> var. <i>natto</i>. Of these, 25 cases (36%) were confirmed as true bacteremia. The primary diagnoses included intra-abdominal infections, pneumonia, and urinary tract infection. The median patient age was 79 years, with 9 being women. The median Pitt bacteremia score was 0 (interquartile range: 0-1). Seven patients (28%) required urgent surgery or endoscopic procedures, while 4 (16%) died within 30 days.</p><p><strong>Conclusions: </strong>Most <i>B. subtilis</i> blood strains isolates were <i>B. subtilis</i> var. <i>natto</i>. This bacteremia carried significant severity, with a 16% 30-day mortality rate and 28% requiring urgent interventions. Clinicians should not dismiss <i>B. subtilis</i> var. <i>natto</i>, a probiotic strain, as harmless.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 9","pages":"ofaf574"},"PeriodicalIF":3.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Function 1 Year After COVID Infection.","authors":"Joviane Daher, Ziad Koberssy, Jared C Durieux, Ornina Atieh, Jhony Baissary, Marc Abboud, Grace A McComsey","doi":"10.1093/ofid/ofaf583","DOIUrl":"10.1093/ofid/ofaf583","url":null,"abstract":"<p><strong>Background: </strong>While emerging evidence suggests a potential link between COVID-19 and cognitive impairment, there is a lack of prospective longitudinal research that objectively assesses cognitive outcomes after SARS-CoV-2 infection. This study aims to evaluate changes in cognitive function following COVID-19 in a group of individuals with baseline pre-infectious cognitive assessments.</p><p><strong>Methods: </strong>In this cohort study, cognitive function was objectively measured using the computerized Cognivue Clarity® device. All participants who had available Cognivue® testing were followed with a second Cognivue® assessment ∼1 year later. Based on whether they contracted COVID-19 during this period, participants were categorized into 2 groups according to COVID status.</p><p><strong>Results: </strong>We enrolled 110 participants with a median age of 45 years, 35% females and 46% white; 55 (50%) participants experienced a documented COVID-19 infection during the follow-up period (COVID + group), and the rest remained free of COVID infection (COVID- group). COVID- and COVID + groups were balanced for demographics and duration of follow-up. In the COVID + group, only memory scores changed during follow-up (+3.9; <i>P</i> = .03). The COVID- group showed improvements in the overall Cognivue® score (+2; <i>P</i> = .03), as well as in visuospatial (+1.9; <i>P</i> = .04), executive function (+2.2; <i>P</i> = .02), and naming language (+2.2; <i>P</i> = .01) scores. No statistically significant differences were observed in the overall cognitive score or its subdomains between the 2 groups.</p><p><strong>Conclusions: </strong>In a 45-year-old average population, no decrease in cognitive function was observed 1 year after COVID-19 infection.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 10","pages":"ofaf583"},"PeriodicalIF":3.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious Complications Following CD30 Chimeric Antigen Receptor T-cell Therapy in Adults.","authors":"Felicia Cao, Yueling Xiu, Michael Mohnasky, Jonathan S Serody, Paul Armistead, Gianpietro Dotti, Melody Smith, Jonathan Huggins, Julia Messina, Bhanu Ramachandran, Jennifer Saullo, Joseph Stromberg, Manish K Saha, Megan Walsh, Barbara Savoldo, Natalie Grover, Heather I Henderson, Tessa M Andermann","doi":"10.1093/ofid/ofaf541","DOIUrl":"10.1093/ofid/ofaf541","url":null,"abstract":"<p><p>Infections are increasingly recognized as a complication of chimeric antigen receptor T-cell (CAR-T) therapy however the incidence of infections after non-CD19 targeted CAR-T is not yet known. We report, for the first time, infectious complications after CD30 CAR T-cell treatment for patients with Hodgkin lymphoma and peripheral T-cell lymphoma. We retrospectively evaluated all 64 adult patients with relapsed/refractory CD30+ lymphomas who received anti-CD30 CAR T-cells at a single institution between 2016-2021. We assessed microbiologically confirmed infections within 1 year after cell infusion, censoring for relapse. We calculated infection density (total infections per 100 patient-days-at-risk), and cumulative incidence of infection divided into time periods postinfusion (days 0-28, 29-90, and 91-365). We compared infectious outcomes to a concurrent cohort of CD19 CAR-T recipients (n = 50) at the same institution. Infection density in the first year after CD30 CAR T-cell infusion was 0.131 per 100 patient-days-at-risk, with 17 patients developing 19 total infections including 15 mild, 3 moderate, and 1 severe infection (1-year cumulative incidence of 32%; 95% confidence interval [CI], 19-47]). Infections were primarily viral (30%; 95% CI, 17-44) and most common early after infusion. Far fewer infections were bacterial in CD30 CAR-T recipients (4.9%; 95% CI, 1.3-13), in contrast to the CD19 cohort in which bacterial infections predominated and were more severe. Microbiologically confirmed infections, primarily with respiratory viruses, were most common in the first 28 days after CD30 CAR-T infusion and most were mild. Our findings may have implications for antimicrobial prophylaxis guidelines after CD30 CAR-T therapy.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 9","pages":"ofaf541"},"PeriodicalIF":3.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Long-term Risk of Infection Among Patients Colonized With Antimicrobial-Resistant Pathogens: A Population-wide Cohort Study.","authors":"","doi":"10.1093/ofid/ofaf569","DOIUrl":"https://doi.org/10.1093/ofid/ofaf569","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/ofid/ofae712.].</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 9","pages":"ofaf569"},"PeriodicalIF":3.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}