Investigating the Molecular Epidemiology of Extended-Spectrum β-Lactamase-Producing Enterobacterales (ESBL-E) Among Patients Admitted to the Intensive Care Unit.

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2025-10-21 eCollection Date: 2025-10-01 DOI:10.1093/ofid/ofaf590

Sima L Sharara, Patricia J Simner, Yehudit Bergman, Emily Jacobs, Suiyini Fiawoo, Eili Y Klein, Sara E Cosgrove, Pranita D Tamma

引用次数: 0

Abstract

At a United States hospital, sequencing of ICU rectal surveillance cultures indicated 5% ESBL-E colonization. Of confirmed ESBL isolates, 91% were Escherichia coli or Klebsiella pneumoniae; 6% carried non-bla _CTX-M genes. Only 53% of third-generation cephalosporin-resistant Enterobacterales harbored ESBL genes, underscoring the limitations of phenotypic approaches as ESBL surrogates, particularly for non-E. coli/K. pneumoniae species.

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重症监护病房住院患者产β-内酰胺酶的广谱肠杆菌（ESBL-E）分子流行病学研究

在美国一家医院，ICU直肠监测培养测序显示5% ESBL-E定植。在确诊的ESBL分离株中，91%为大肠埃希菌或肺炎克雷伯菌；6%携带非bla CTX-M基因。只有53%的第三代头孢菌素耐药肠杆菌携带ESBL基因，这强调了表型方法作为ESBL替代品的局限性，特别是对于非e。杆菌/ K。肺炎的物种。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.