Open Forum Infectious Diseases最新文献

{"title":"Retrospective Analysis of Severe Fever With Thrombocytopenia Syndrome and Construction of a Nomogram Prediction Model for Mortality Risk Factors.","authors":"Gang Chen, Yuchen Du, Xiuchang Ma, Yaowen Liang, Apeng Chen, Jie Wei, Jinhuan Wu, Wenxian Qian, Shuqin Xie, Yi Yan, Zheng Hu, Yishan Zheng, Man Tian, Changhua Yi","doi":"10.1093/ofid/ofaf318","DOIUrl":"10.1093/ofid/ofaf318","url":null,"abstract":"<p><strong>Background: </strong>Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonotic infectious disease caused by the SFTS virus and is characterized by a high mortality rate. The primary objective of this study was to investigate high-mortality risk factors in SFTS and to create a nomogram model for personalized prediction.</p><p><strong>Methods: </strong>A total of 523 patients with SFTS who were admitted to the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, between January 2020 and December 2023 were retrospectively analyzed: 75 cases were classified in the death group and 448 cases in the survival group. Development of a predictive nomogram model was based on the independent risk factors that were stepwise screened through univariate analysis, LASSO analysis (least absolute shrinkage and selection operator), and multivariate logistic regression analysis.</p><p><strong>Results: </strong>Based on stepwise variable screening by univariate analysis, LASSO analysis, and multivariate logistic regression, the following were independent mortality risk factors in patients with SFTS: age (odds ratio [OR], 1.06; 95% CI, 1.03-1.10; <i>P</i> < .001), hemorrhagic symptoms (OR, 3.39; 95% CI, 1.31-8.78; <i>P</i> = .012), neurologic symptoms (OR, 4.89; 95% CI, 2.72-8.77; <i>P</i> < .001), platelet count (OR, 0.99; 95% CI, .98-.99; <i>P</i> = .045), prothrombin time (OR, 1.32; 95% CI, 1.11-1.56; <i>P</i> = .001), activated partial thromboplastin time (OR, 1.02; 95% CI, 1.01-1.03; <i>P</i> = .007), and viral load ≥10⁷copies/mL (OR, 2.66; 95% CI, 1.36-5.20; <i>P</i> = .004). The area under the curve (0.87; 95% CI, .832-.909) showed excellent predictive power. Calibration curves showed the accuracy of the assessed nomograms. Decision curve analysis results showed a greater net benefit when the threshold probability of patient death was between 0.02 and 0.75.</p><p><strong>Conclusions: </strong>A nomogram model consisting of 7 risk factors was successfully constructed, which can be used to predict SFTS mortality risk factors early.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 7","pages":"ofaf318"},"PeriodicalIF":3.8,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Changes in Nasopharyngeal Pneumococcal Colonization Density Associated With Respiratory Syncytial Virus and Influenza in a South African Household Cohort Study, 2016-2018.","authors":"Maimuna Carrim, Jackie Kleynhans, Stefano Tempia, Orienka Hellferscee, Florette K Treurnicht, Meredith L McMorrow, Jocelyn Moyes, Floidy Wafawanaka, Cheryl Cohen, Anne von Gottberg, Nicole Wolter","doi":"10.1093/ofid/ofaf267","DOIUrl":"10.1093/ofid/ofaf267","url":null,"abstract":"<p><strong>Background: </strong>Respiratory syncytial virus (RSV) and influenza infections are associated with increased pneumococcal colonization and disease risk. We assessed the impact of RSV and influenza on pneumococcal colonization density and factors influencing density changes during viral infection.</p><p><strong>Methods: </strong>Over 3 years, 1658 individuals from 325 households were enrolled, with nasopharyngeal swabs collected twice weekly for pneumococcus, RSV, and influenza A/B detection by real-time polymerase chain reaction. We analyzed samples from 2 weeks before, during, and 2 and 8 weeks after infection. Pneumococcal density was compared across infection periods by <i>t</i> tests, and multivariable regression identified factors influencing density changes.</p><p><strong>Results: </strong>Pneumococcal density increased during RSV infection (log mean before vs during infection, 9.3 vs 10.2 genomic copies/mL; <i>P</i> < .01) but showed no significant overall increase with influenza (log mean before vs during infection, 9.6 vs 9.9 genomic copies/mL; <i>P</i> = .2). However, the following were correlated with increased pneumococcal density: higher influenza viral loads (cycle threshold [Ct] value <25: coefficient, 2.8; 95% CI 1.4-4.2) and RSV viral loads (viral Ct value <25: coefficient, 2.5 [95% CI, 1.1-3.9; <i>P</i> < .01]; viral Ct value of 25-29: coefficient, 1.1 [95% CI, .1-2.2; <i>P</i> = .04]; vs viral Ct value of 30-34). Participants who were underweight had lower pneumococcal density differences (coefficient, -1.8; 95% CI, -3.5 to -.1; <i>P</i> = .04) than those with a normal body mass index.</p><p><strong>Conclusions: </strong>RSV infection, especially with higher viral loads, increases pneumococcal colonization, while individuals who are underweight exhibit lower density changes.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 6","pages":"ofaf267"},"PeriodicalIF":3.8,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Highly Sensitive Multiplex Antibody Assay Reduces Window Period for Detection of <i>Babesia microti</i> Infection.","authors":"Scott Meredith, Ankit Puri, Victoria F Majam, Hong Zheng, Miranda S Oakley, Laura Tonnetti, Susan L Stramer, Sanjai Kumar","doi":"10.1093/ofid/ofaf253","DOIUrl":"10.1093/ofid/ofaf253","url":null,"abstract":"<p><strong>Background: </strong>The health burden of <i>Babesia microti</i>, the primary causative agent of human babesiosis in the United States, is significant and increasing. Diagnosis of clinical babesiosis still remains challenging, resulting in misdiagnosis and underreporting. The gold standard for detection of <i>B. microti</i>-specific antibody, immunofluorescence assay (IFA), is cumbersome and resource-intensive. A high-throughput assay to detect serological biomarkers of <i>B. microti</i> exposure would facilitate epidemiological studies and clinical diagnosis.</p><p><strong>Methods: </strong>We developed a multiantigen, high-throughput, and highly sensitive Luminex bead-based assay (LBA) for detection of <i>Babesia microti</i>--specific antibodies in babesiosis patients and endemic populations. Serum samples from 191 individuals who had confirmed <i>B. microti</i> exposure (IFA or polymerase chain reaction [PCR] positive) were screened for antibody reactivity to 4 immunodominant antigens-MCFRP1, BAHCS1, SERA1, and PiβS1-by LBA.</p><p><strong>Results: </strong>Among the 4 antigens evaluated, MCFRP1 and BAHCS1 were the most sensitive biomarkers for <i>B. microti</i> exposure, detecting 96.6% and 100% of IFA+/PCR+ and 75.3% and 87.6% of IFA+/PCR- samples, respectively. The \"window period\" before IFA-detectable seroconversion is of particular concern for clinical diagnosis using serological detection methods. Importantly, combining all 4 antigens allowed detection of 6/13 (46.2%) PCR-positive cases that were missed by IFA. No single antigen yielded reactivity to more than 3/13 (23.1%) IFA-/PCR+ cases in our LBA, indicating diversity in the polarization of early immune responses following <i>B. microti</i> exposure.</p><p><strong>Conclusions: </strong>Combination of these antigens in our LBA would reduce the window period before IFA-detectable seroconversion of detection in <i>Babesia microti</i>-exposed individuals.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 6","pages":"ofaf253"},"PeriodicalIF":3.8,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetics of Subcutaneous and Intravenous Ceftriaxone in an Older Population: The PhASAge Study.","authors":"Claire Roubaud-Baudron, Héloïse Fauchon, Françoise Stanke-Labesque, Marc Paccalin, Dominique Breilh, Nicolas Grégoire, Emmanuel Forestier, Tristan Ferry, Gaëtan Gavazzi, Sylvain Goutelle","doi":"10.1093/ofid/ofaf313","DOIUrl":"10.1093/ofid/ofaf313","url":null,"abstract":"<p><strong>Background: </strong>Ceftriaxone is frequently administered subcutaneously in France, especially in older patients, although this practice is currently off-label. This work aims to describe the pharmacokinetics (PK) and pharmacodynamics (PD) and tolerance of ceftriaxone administered by intravenous and subcutaneous routes in older patients.</p><p><strong>Methods: </strong>Patients aged ≥65 years receiving intravenous or subcutaneous ceftriaxone 1 g every 24 hours were included. Steady-state plasma concentrations of ceftriaxone were measured. Based on intravenous and subcutaneous ceftriaxone concentrations and 24-hour area under the concentration-time curve (AUC), a population PK model was developed for probability of target attainment (PTA) analysis. Local and systemic adverse events (AEs) were collected.</p><p><strong>Results: </strong>Data from 47 patients (24 in subcutaneous and 23 in intravenous groups) were analyzed. No between-group difference was observed in demographic and biological characteristics, ceftriaxone trough concentrations, or AUC. Bioavailability of subcutaneous ceftriaxone was estimated at 99% by population modeling. The PTA associated with subcutaneous administration were similar to or slightly better than that of the intravenous route. A dosing regimen of 1 or 2 g every 24 hours was associated with acceptable PTA and a low risk of overexposure in patients with normal or moderately altered renal function. Tolerance was assessed on 149 infusions (67 intravenous and 82 subcutaneous). One local AE (1.5%) was reported in the intravenous group versus 11 local AEs (mainly edema) in the subcutaneous group (13%), all transient and nonsevere.</p><p><strong>Conclusions: </strong>Subcutaneous administration of ceftriaxone was associated with PK/PD and dosage requirements comparable to those of intravenous administration, supporting the use of subcutaneous ceftriaxone in older patients.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 6","pages":"ofaf313"},"PeriodicalIF":3.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Spectrum and Dynamics of Sequelae Following Tick-Borne Encephalitis Virus Infection: A Systematic Literature Review.","authors":"Kate Halsby, Liesl Gildea, Pingping Zhang, Frederick J Angulo, Andreas Pilz, Jennifer Moisi, Ann Colosia, Johann Sellner","doi":"10.1093/ofid/ofaf317","DOIUrl":"10.1093/ofid/ofaf317","url":null,"abstract":"<p><strong>Background: </strong>Infection with the tick-borne encephalitis virus (TBEV) can affect the nervous system and lead to significant morbidity. To summarize current knowledge of long-term outcomes following TBEV infection, we systematically reviewed the prevalence of TBEV infection sequelae after hospital discharge across different age groups and follow-up time points.</p><p><strong>Methods: </strong>Studies of adults, children, and \"all-age\" populations with laboratory-confirmed TBEV infection were identified via electronic database searches. Study categorization was based on follow-up time after hospital discharge: ≤6, 7 to ≤12, or >12 months. Sequelae signs/symptoms were divided into 3 categories: neurological, neuropsychiatric, and other. Data were normalized using weighted means. Heterogeneity was estimated using a meta-analytic random-effects model.</p><p><strong>Results: </strong>Fifteen studies were eligible for analysis (13 included only hospitalized patients). Seventy-nine unique sequelae symptoms were identified. Adults had a higher frequency of persistent symptoms than children (20.6%-100% vs 1.7%-69%). There were high levels of data heterogeneity (<i>I</i> ² > 90%) among all studies. Although the proportion of patients with each sequela fluctuated across time, headache was reported by ≥20% of patients at all time points. Some sequelae also varied by age group; for example, irritability was more frequent in children, while insomnia/sleep disorders were more frequent in adults. Predominant neurological symptoms included balance disorders and headache. Predominant neuropsychiatric symptoms included concentration and memory disorders.</p><p><strong>Conclusions: </strong>Patients experience a variety of neurological, neuropsychiatric, or other sequelae symptoms following TBEV infection that vary over time and across age groups. This study highlights the need for standardized symptom categorization and follow-up time for TBE sequelae studies.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 6","pages":"ofaf317"},"PeriodicalIF":3.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A One Health Insight into Noncholeric <i>Vibrio</i> spp. Infections in a French Atlantic Coastal Region.","authors":"Natacha Eyraud, Fatima Mzali, Victor Hemar, David Robert, Camille Paviot, Antoine Touzalin, Alexandre Isidore, Guillaume Vignon, Jérémie Violette, Delphine Chrisment, Stéphane Poirot-Mazères, Amaury Barret, Philippe Morel, Ana Mendes-Moreira, Sabine Pereyre, Charles Cazanave, Marc-Olivier Vareil, Mathilde Puges","doi":"10.1093/ofid/ofaf309","DOIUrl":"10.1093/ofid/ofaf309","url":null,"abstract":"<p><strong>Background: </strong>Data on \"non-choleric <i>Vibrios</i> spp.\" (NCV) infections remain scarce, despite their classification as emerging pathogens. Indeed, their incidence is increasing with global warming, as observed in North Atlantic countries. Furthermore, their prognosis is complicated by high morbidity and mortality rates.</p><p><strong>Methods: </strong>We investigated the epidemiology of NCV infections in hospital, community, and environmental settings along the French West coastline. A retrospective multicenter study was carried out in 10 hospitals and 3 community laboratories between 2017 and 2020 in the Nouvelle-Aquitaine region to collect clinical data on all documented <i>Vibrio</i> infections, which were later compared to data collected on environmental <i>Vibrio</i> strains recovered concomitantly from the same coastal region.</p><p><strong>Results: </strong>A total of 223 cases were documented, suggesting that NCV infections are widely underestimated in France, as the number of patients included in this study in a single region exceeded the total cases reported by the French National Reference Center for <i>Vibrio</i> species during the same period (202). Additionally, gastroenteritis caused by NCVs increased from .13% in 2017 to 0.39% in 2019. The most at-risk patients were immunocompromised or those with cancer. The clinical symptoms were mainly gastroenteritis or skin infections. The treatments prescribed did not align always with current recommendations and susceptibility to tetracycline, the recommended treatment, was never assessed. Antibiotic resistance seemed more common in environmental strains than in clinical strains, notably to aminoglycosides.</p><p><strong>Conclusions: </strong>NCV infection incidence has been increasing in this Atlantic coastal region of France, and the high rates of antibiotic resistance among environmental strains are worrying.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 6","pages":"ofaf309"},"PeriodicalIF":3.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population Prevalence and Correlates of Syphilis in Rural, Southwestern Uganda.","authors":"Pooja Chitneni, Nicholas Musinguzi, Charles Baguma, Justin M Rasmussen, Emily N Satinsky, Justus Kananura, Patience Ayebare, Patrick Gumisiriza, Godfrey Masette, Mark J Siedner, Jessica E Haberer, Lynn T Matthews, Bernard Kakuhikire, Alexander C Tsai","doi":"10.1093/ofid/ofaf290","DOIUrl":"10.1093/ofid/ofaf290","url":null,"abstract":"<p><strong>Background: </strong>The global incidence of syphilis has increased in recent years. Understanding syphilis epidemiology will inform screening and treatment programs. However, such data are lacking in many communities. We outline a population-based syphilis screening program in a rural community in southwestern Uganda to describe the population prevalence of syphilis.</p><p><strong>Methods: </strong>In June 2019 we conducted a cross-sectional, population-based study of adults >18 years of age. Two-stage syphilis testing was completed with <i>Treponema pallidum</i> hemagglutination (TPHA) rapid immunochromatographic testing, confirmed by rapid plasma reagin (RPR) in those with positive TPHA (syphilis seroprevalence). We calculate inverse probability of treatment (IPT) weights using logistic regression to estimate the population prevalence of positive TPHA. We included covariates with a univariable α = .10 in multivariable logistic regression models, stratified by sex, to estimate correlates of syphilis seroprevalence.</p><p><strong>Results: </strong>Among 749 participants who participated in this population-based study, 724 (97%) completed syphilis screening. The median age was 42.9 years (standard deviation, 15.6 years) and 456 of 724 (63%) were women. Based on the IPT-weighted adjusted model, the syphilis population seroprevalence was 10.6% (95% confidence interval, 8.4%-13.4%). Among the 62 of 79 (78%) participants who completed RPR testing, all had titers ≤1:4. Syphilis seroprevalence was associated with less education, human immunodeficiency virus (HIV) infection, and ≥2 sexual partners in the prior month among women and with HIV among men.</p><p><strong>Conclusions: </strong>We describe a high prevalence of current or former syphilis (10.6%) in a population-based study in rural Uganda. Syphilis screening and surveillance programs in this region require expansion to capture populations not routinely in care.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 5","pages":"ofaf290"},"PeriodicalIF":3.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Dose Probiotic Mix of <i>Lactobacillus</i> Spp, <i>Bifidobacterium</i> Spp, <i>Bacillus coagulans</i>, and <i>Saccharomyces boulardii</i> to Prevent Antibiotic-Associated Diarrhea in Adults: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial (SPAADA).","authors":"Cynthia Isabel Ortiz-Lopez, Adrian Camacho-Ortiz","doi":"10.1093/ofid/ofaf316","DOIUrl":"10.1093/ofid/ofaf316","url":null,"abstract":"","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 6","pages":"ofaf316"},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Incidence of <i>Clostridioides difficile</i> Infection in Patients Receiving Outpatient Parenteral Antibiotic Therapy at an Urban Academic Medical Center.","authors":"Christopher Vo, Jared Coe, Tabeer Ahmed, Kelsie Cowman, Yi Guo, Priya Nori","doi":"10.1093/ofid/ofaf314","DOIUrl":"10.1093/ofid/ofaf314","url":null,"abstract":"<p><p>Data on <i>Clostridioides difficile</i> infection (CDI) among patients receiving outpatient parenteral antibiotic therapy (OPAT) are limited. Herein, we describe characteristics of OPAT patients with CDI at a large academic medical center. Despite prolonged antibiotic exposure, the incidence rate of CDI was low.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 6","pages":"ofaf314"},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Adoptive Immunotherapy With Hepatitis E Virus (HEV)-Specific T Cells Address the Unmet Need in Refractory Chronic HEV Infection?","authors":"Temi Lampejo","doi":"10.1093/ofid/ofaf231","DOIUrl":"10.1093/ofid/ofaf231","url":null,"abstract":"<p><p>Chronic hepatitis E virus (HEV) infection, which primarily affects the immunocompromised, can rapidly progress to liver fibrosis and cirrhosis if untreated. However, current therapeutic options are extremely limited and have significant adverse effects. Over the past decade, virus-specific T-cell therapy has shown promise as an alternative safe and effective treatment strategy for other refractory viral infections such as cytomegalovirus, adenovirus, and polyomavirus infections in hematopoietic stem cell and solid organ transplant recipients. Given the key role of T lymphocytes in the control of HEV replication and the fact that HEV-specific T-cell responses are typically diminished in immunosuppressed patients with persistent HEV infection, adoptive immunotherapy with HEV-specific T cells could serve as a novel addition to the HEV treatment repertoire, which is in dire need of expansion.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 5","pages":"ofaf231"},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}