Do Aminopenicillins Have a Role in Treating Ampicillin-Resistant Enterococcus UTIs?

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2025-10-08 eCollection Date: 2025-10-01 DOI:10.1093/ofid/ofaf619

Armani M Hawes, Pranita D Tamma, Navaneeth Narayanan

引用次数: 0

Abstract

Urinary tract infections caused by Enterococcus species are a frequent clinical challenge. The rising prevalence of ampicillin resistance often seemingly precludes the use of aminopenicillins. However, evidence suggests that aminopenicillins may retain clinical efficacy, even when susceptibility testing indicates resistance. Integrating available pharmacokinetics/pharmacodynamics and clinical data and risk-benefit considerations, we seek to address the question: Can aminopenicillins still be a viable treatment option in the management of ampicillin-resistant Enterococcus infections?

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氨霉素在治疗氨苄西林耐药肠球菌uti中有作用吗？

肠球菌引起的尿路感染是一个常见的临床挑战。氨苄西林耐药的流行率不断上升，似乎往往排除了氨苄西林的使用。然而，有证据表明，即使在药敏试验显示耐药的情况下，氨霉素仍可保持临床疗效。综合现有的药代动力学/药效学、临床数据和风险-收益考虑，我们寻求解决这个问题：氨苄西林仍然是氨苄西林耐药肠球菌感染的可行治疗选择吗？

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.