Assessment of Cross-Reactive Neutralizing Antibodies Induction Against H5N1 Clade 2.3.4.4b by Prior Seasonal Influenza Immunization in Retail Workers.

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2025-08-20 eCollection Date: 2025-08-01 DOI:10.1093/ofid/ofaf463

Andrea Arroyave, Henintsoa Rabezanahary, Aude Wantchecon, Vonintsoa Lalaina Rahajamanana, Ahmed Sahli, Mathieu Thériault, Denis Boudreau, Caroline Gilbert, Sylvie Trottier, Mariana Baz

引用次数: 0

Abstract

This study evaluated whether immunity from seasonal influenza induces cross-reactive antibodies against recent avian and bovine H5N1 strains in serum from retail workers. Despite strong neutralizing activity against seasonal strains, no cross-reactivity against H5N1 was detected, emphasizing the need to assess broader immune responses and targeted vaccines for H5N1 viruses.

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零售工人季节性流感免疫诱导H5N1分支2.3.4.4b交叉反应中和抗体的评估

本研究评估季节性流感免疫是否会在零售工人血清中诱导针对最近禽流感和牛H5N1毒株的交叉反应性抗体。尽管对季节性毒株有很强的中和作用，但未发现对H5N1的交叉反应，这强调需要评估更广泛的免疫反应和针对H5N1病毒的靶向疫苗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.