Are Sex-Specific Cutoffs Needed With a Next-Generation Urine Tenofovir Lateral Flow Assay for Antiretroviral Adherence Monitoring?

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2025-08-21 eCollection Date: 2025-09-01 DOI:10.1093/ofid/ofaf512

Xin Niu, Derin Sevenler, Sandy Dossantos, Mehmet Toner, Rebecca Sandlin, Oraphan Siriprakaisil, Pra-Ornsuda Sukrakanchana, Tim R Cressey, Paul K Drain

引用次数: 0

Abstract

Accurate point-of-care tools are needed to detect early nonadherence to daily HIV regimens and support timely transitions to long-acting options. Emerging evidence suggests that females may require higher adherence than males to achieve equivalent protection. Our next-generation urine tenofovir assay showed high accuracy across sexes but lower urine drug levels among female participants.

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新一代替诺福韦尿侧流试验是否需要性别特异性隔离来监测抗逆转录病毒依从性？

需要准确的即时护理工具来发现早期不遵守每日艾滋病毒治疗方案的情况，并支持及时过渡到长效方案。新出现的证据表明，女性可能需要比男性更高的依从性来获得同等的保护。我们的新一代尿替诺福韦测定在两性中显示出较高的准确性，但在女性参与者中尿药物水平较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.