Open Forum Infectious Diseases最新文献

{"title":"Correction to: Searching for Immunocompromising Conditions in Low-risk Adults After Invasive Pneumococcal Disease: An Opportunity to Uncover Multiple Myeloma Early.","authors":"","doi":"10.1093/ofid/ofae731","DOIUrl":"https://doi.org/10.1093/ofid/ofae731","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/ofid/ofae653.].</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"11 12","pages":"ofae731"},"PeriodicalIF":3.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Behavioral Analysis of Factors That Influence Antibiotic Prescribing in Hospitals: A Metasynthesis of Reviews.","authors":"Gracia Mabaya, Jenna M Evans, Christopher J Longo, Andrew M Morris","doi":"10.1093/ofid/ofae728","DOIUrl":"10.1093/ofid/ofae728","url":null,"abstract":"<p><p>Antibiotic resistance is a global public health threat driven, in part, by antibiotic overprescription. Behavior change theories are increasingly used to try to modify prescriber behavior. A metasynthesis of 8 reviews was conducted to identify factors influencing antibiotic prescribing for adults in hospital settings and to analyze these factors using 4 behavior change frameworks. Forty-three factors were identified across 7 thematic categories and then mapped to the theoretical domains framework and capability-opportunity-motivation model of behavior. The behavior change wheel and behavior change techniques taxonomy were then used to identify appropriate interventions and their components. The domain \"environmental context and resources\" was coded the most often, followed by \"social influences\" and \"beliefs about consequences,\" revealing that prominent sources of antibiotic prescribing behavior are \"physical opportunity\" and \"social opportunity.\" Based on these results, suggested interventions include environmental prompts/cues, education on consequences of antibiotic overuse, social comparison and support, and incentives.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 1","pages":"ofae728"},"PeriodicalIF":3.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of a Low-Intensity Intervention to Influence Antibiotic Prescribing Rates Use in Outpatient Settings: A Cluster Randomized Controlled Clinical Trial.","authors":"Taissa A Bej, Brigid M Wilson, Ukwen C Akpoji, Nicole Mongilardi, Tayoot Todd Chengsupanimit, Sunah Song, Corinne Kowal, Krysttel C Stryczek, Rene Hearns, Mark Honsberger, Tai-Lyn Wilkerson, Christine Firestone, Soumya Subramaniam, Lauren Stevenson, Sherry L Ball, Robin L P Jump, Federico Perez","doi":"10.1093/ofid/ofae725","DOIUrl":"https://doi.org/10.1093/ofid/ofae725","url":null,"abstract":"<p><strong>Background: </strong>Primary care providers (PCPs) may modify their antibiotic prescription practices if aware of their potentially damaging impact.</p><p><strong>Methods: </strong>We conducted a cluster randomized controlled trial at 12 Veterans Affairs community-based outpatient clinics. PCPs at clinics randomized to the intervention group received quarterly antibiotic use reports with feedback about antibiotics prescribed for acute respiratory infections and adverse event letters alerting about <i>Clostridioides difficile</i> infection or antibiotic-resistant gram-negative bacteria among their patients. The main outcome, antibiotic prescriptions in primary care visits, was compared in the preintervention (April-September 2020), intervention (October 2020 to September 2021), and postintervention periods (September 2021 to September 2022).</p><p><strong>Results: </strong>Among 52 PCPs at 6 clinics in the intervention group, 66% (33 of 52) and 54% (28 of 52) received ≥1 antibiotic use report and adverse event letter. In the intervention clinics, the proportion of primary care visits with antibiotic prescription during the preintervention, intervention, and postintervention periods was 1.4% (1088 of 77 697), 1.4% (2051 of 147 858), and 1.3% (1692 of 131 530). In the control clinics, this increased from 1.8% (1560 of 87 897) to 2.1% (3707 of 176 825) and 2.1% (3418 of 162 979), respectively, during the intervention and postintervention periods. The rate of visits with antibiotic prescription did not differ in the preintervention period (odds ratio [95% confidence interval], 1.10 [.87-1.39); <i>P</i> = .43) but did during the intervention (1.30 [1.04-1.62]; <i>P</i> = .022) and postintervention periods (1.38 [1.09-1.74]; <i>P</i> = .007). There were no differences in emergency department visits and hospitalizations.</p><p><strong>Conclusions: </strong>PCPs from clinics assigned to a low-intensity intervention combining comparative feedback with adverse event notifications had lower antibiotic prescription rates.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 1","pages":"ofae725"},"PeriodicalIF":3.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strong Association Between HIV Incidence and Herpes Simplex Virus Type 2 in Zambia and South Africa: Prospective Data From the HPTN 071 (PopART) Trial.","authors":"J Bradley, S Floyd, E Piwowar-Manning, O Laeyendecker, O R Baker, N Bell-Mandla, J Bwalya, A Moore, S H Eshleman, D Donnell, P Bock, S Fidler, H Ayles, R J Hayes","doi":"10.1093/ofid/ofae721","DOIUrl":"https://doi.org/10.1093/ofid/ofae721","url":null,"abstract":"<p><strong>Background: </strong>Herpes simplex virus type 2 (HSV2) is an important cofactor for HIV acquisition and transmission. Associations between the infections are reexamined in longitudinal data from an HIV prevention trial.</p><p><strong>Methods: </strong>The HPTN 071 (PopART) trial evaluated a combination prevention intervention in 21 urban communities in Zambia and South Africa. HIV incidence was measured in a cohort of approximately 2000 adults (age, 18-44 years) selected randomly from each community and followed up for 36 months. Incidence of HSV2 infection was estimated, and the effects of risk factors were examined. The association between HIV incidence and HSV2 infection was examined at individual and community levels.</p><p><strong>Results: </strong>An overall 10 539 participants were HSV2 negative at baseline and retested after 36 months. Estimated HSV2 incidence was 5.4 per 100 person-years (95% CI, 5.0-5.7) for women and 2.9 per 100 person-years (95% CI, 2.6-3.2) for men. When compared with those remaining HSV2 negative, HIV incidence was higher in those who were HSV2 positive at baseline (women: adjusted rate ratio [aRR], 3.24 [95% CI, 2.50-4.20]; men: aRR, 2.57 [95% CI, 1.60-4.11]) and even higher in those who seroconverted to HSV2 during follow-up (women: aRR, 5.94 [95% CI, 4.42-7.98]; men: aRR, 8.37 [95% CI, 5.18-13.52]). At the community level, strong associations were seen between HIV incidence and HSV2 prevalence (<i>R</i> ² = 0.48, <i>P</i> < .001) and incidence (<i>R</i> ² = 0.36, <i>P</i> = .004).</p><p><strong>Conclusions: </strong>There were strong associations between HIV incidence and HSV2 prevalence and incidence at individual and community levels. HSV2 control could contribute to HIV prevention.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 1","pages":"ofae721"},"PeriodicalIF":3.8,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Diagnostic Dilemmas: A Review of Reported Cases of Human Herpesvirus 6 Encephalitis in Immunocompetent Adults.","authors":"","doi":"10.1093/ofid/ofae715","DOIUrl":"10.1093/ofid/ofae715","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/ofid/ofae501.].</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"11 12","pages":"ofae715"},"PeriodicalIF":3.8,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations on the Clinical Relevance of Climatic Differences in <i>Pseudomonas aeruginosa</i> Rates in Diabetic Foot Infection.","authors":"Hana Niino, Shunkichi Ikegaki, Kentaro Iwata","doi":"10.1093/ofid/ofae724","DOIUrl":"10.1093/ofid/ofae724","url":null,"abstract":"","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 1","pages":"ofae724"},"PeriodicalIF":3.8,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rapid Host Response Blood Test for Bacterial/Viral Infection Discrimination Using a Portable Molecular Diagnostic Platform.","authors":"Maria D Iglesias-Ussel, Nicholas O'Grady, Jack Anderson, Paul G Mitsis, Thomas W Burke, Ricardo Henao, Joseph Scavetta, Clare Camilleri, Sepideh Naderi, Amanda Carittini, Max Perelman, Rachel A Myers, Geoffrey S Ginsburg, Emily R Ko, Micah T McClain, Jesse van Westrienen, Ephraim L Tsalik, L Gayani Tillekeratne, Christopher W Woods","doi":"10.1093/ofid/ofae729","DOIUrl":"10.1093/ofid/ofae729","url":null,"abstract":"<p><strong>Background: </strong>Difficulty discriminating bacterial versus viral etiologies of infection drives unwarranted antibacterial prescriptions and, therefore, antibacterial resistance.</p><p><strong>Methods: </strong>Utilizing a rapid portable test that measures peripheral blood host gene expression to discriminate bacterial and viral etiologies of infection (the HR-B/V assay on Biomeme's polymerase chain reaction-based Franklin platform), we tested 3 cohorts of subjects with suspected infection: the HR-B/V training cohort, the HR-B/V technical correlation cohort, and a coronavirus disease 2019 cohort.</p><p><strong>Results: </strong>The Biomeme HR-B/V test showed very good performance at discriminating bacterial and viral infections, with a bacterial model accuracy of 84.5% (95% confidence interval [CI], 80.8%-87.5%), positive percent agreement (PPA) of 88.5% (95% CI, 81.3%-93.2%), negative percent agreement (NPA) of 83.1% (95% CI, 78.7%-86.7%), positive predictive value of 64.1% (95% CI, 56.3%-71.2%), and negative predictive value of 95.5% (95% CI, 92.4%-97.3%). The test showed excellent agreement with a previously developed BioFire HR-B/V test, with 100% (95% CI, 85.7%-100.0%) PPA and 94.9% (95% CI, 86.1%-98.3%) NPA for bacterial infection, and 100% (95% CI, 93.9%-100.0%) PPA and 100% (95% CI, 85.7%-100.0%) NPA for viral infection. Among subjects with acute severe acute respiratory syndrome coronavirus 2 infection of ≤7 days, accuracy was 93.3% (95% CI, 78.7%-98.2%) for 30 outpatients and 75.9% (95% CI, 57.9%-87.8%) for 29 inpatients.</p><p><strong>Conclusions: </strong>The Biomeme HR-B/V test is a rapid, portable test with high performance at identifying patients unlikely to have bacterial infection, offering a promising antibiotic stewardship strategy that could be deployed as a portable, laboratory-based test.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 1","pages":"ofae729"},"PeriodicalIF":3.8,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dengue Virus Structural Proteins Are Expressed on the Surface of DENV-Infected Cells and Are a Target for Antibody-Dependent Cellular Phagocytosis.","authors":"Mitchell J Waldran, Elizabeth A Kurtz, Chad J Gebo, Timothy J Rooney, Frank A Middleton, Nathan H Roy, Jeffrey R Currier, Adam T Waickman","doi":"10.1093/ofid/ofae720","DOIUrl":"10.1093/ofid/ofae720","url":null,"abstract":"<p><strong>Background: </strong>Dengue virus (DENV) is an arboviral pathogen found in >100 countries and a source of significant morbidity and mortality. While the mechanisms underpinning the pathophysiology of severe Dengue are incompletely understood, it has been hypothesized that antibodies directed against the DENV envelope (E) protein can facilitate antibody-dependent enhancement (ADE) of the infection, increasing the number of infected cells and the severity of disease in an exposed individual. Accordingly, there is interest in defining mechanisms for directly targeting DENV-infected cells for immunologic clearance, an approach that bypasses the risk of ADE.</p><p><strong>Methods: </strong>We have previously demonstrated that antibodies specific to DENV nonstructural protein 1 (NS1) can opsonize and facilitate the phagocytic clearance of DENV-infected cells. However, it is currently unclear if other DENV antigens are expressed on the surface of infected cells and if these antigens can be targeted by antibody-dependent clearance mechanisms.</p><p><strong>Results: </strong>In this study, we demonstrate that DENV structural proteins are expressed on the surface of DENV-infected cells and that these antigens can be opsonized by both DENV-immune sera and monoclonal antibodies. In addition, DENV E-specific antibodies can facilitate phagocytic uptake of material from DENV-infected cells, resulting in the target-cell membrane localizing to endosomes of the engulfing phagocyte. Notably, there was no selective enrichment of DENV genomic material in monocytes that had phagocytosed DENV-infected cell material compared with nonphagocytic monocytes.</p><p><strong>Discussion: </strong>In their totality, these data reinforce the concept that DENV E-reactive antibodies have a multifaceted role in DENV immunity and pathogenesis beyond neutralization and/or infection enhancement.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 1","pages":"ofae720"},"PeriodicalIF":3.8,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Epidemiology of <i>Campylobacter</i> Species Infection in Kidney Transplant Recipients: A Retrospective Multicentric Case-Control Study in France.","authors":"","doi":"10.1093/ofid/ofae713","DOIUrl":"10.1093/ofid/ofae713","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/ofid/ofae498.].</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"11 12","pages":"ofae713"},"PeriodicalIF":3.8,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months.","authors":"Maarten M Immink, Nicoline A T van der Maas, Mireille N Bekker, Hester E de Melker, Gerco den Hartog, Nynke Y Rots, Pieter G M van Gageldonk, Floris Groenendaal, Elisabeth A M Sanders","doi":"10.1093/ofid/ofae717","DOIUrl":"10.1093/ofid/ofae717","url":null,"abstract":"<p><p>A post hoc analysis of maternally derived antibodies at birth and age 2 months following second trimester maternal Tdap vaccination between 20 and 24 weeks' gestational age (GA) showed a faster decay rate of Tdap-related immunoglobulin G in early preterms born before 32 weeks' GA compared with moderate-to-late preterms and full-terms. This is different from previous studies and merits further research.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 1","pages":"ofae717"},"PeriodicalIF":3.8,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}