Hepatitis B Core-Related Antigen Point-of-Care Tests as a Risk Stratification Tool for Treatment Eligibility: Experience From Kenya.

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2025-03-06 eCollection Date: 2025-03-01 DOI:10.1093/ofid/ofaf125

Louise O Downs, Dorcas Okanda, Oscar Chirro, Mwanakombo Zaharani, Benson Safari, Nadia Aliyan, Monique I Andersson, Yasuhito Tanaka, Anthony O Etyang, Yusuke Shimakawa, George Githinji, Philippa C Matthews

引用次数: 0

Abstract

We undertook a point-of-care test for hepatitis B core-related antigen in adults with hepatitis B virus in Kilifi, Kenya. A positive test identified all individuals with a hepatitis B viral load >200 000 IU/mL and who were hepatitis B e antigen positive. It also correlated with a higher alanine aminotransferase (ALT) level (P = .03), raised aspartate transaminase-to-platelet ratio index (APRI) (P < .001), and higher elastography scores (P = .03).

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我们对肯尼亚基利菲的成年乙肝病毒携带者进行了乙肝核心相关抗原的护理点检测。检测结果呈阳性可确定所有乙肝病毒载量大于 200 000 IU/mL 且乙肝 e 抗原呈阳性的患者。它还与较高的丙氨酸氨基转移酶（ALT）水平（P = .03）、较高的天冬氨酸转氨酶与血小板比值指数（APRI）（P < .001）和较高的弹性成像评分（P = .03）相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.