Liang En Wee, Jue Tao Lim, Janice Yu Jin Tan, Calvin Chiew, Chee-Fu Yung, Chia Yin Chong, David Chien Lye, Kelvin Bryan Tan
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引用次数: 0
Abstract
Background: Long-term postacute sequelae following SARS-CoV-2 infection in children have been extensively documented. However, while persistence of chronic symptoms following pediatric dengue infection has been documented in small prospective cohorts, population-based studies are limited. We evaluated the risk of multisystemic complications following dengue infection in contrast to that after SARS-CoV-2 infection in a multiethnic pediatric Asian population.
Methods: This retrospective population-based cohort study utilized national COVID-19/dengue registries to construct cohorts of Singaporean children aged 1 to 17 years with either laboratory-confirmed dengue infection from 1 January 2017 to 31 October 2022 or confirmed SARS-CoV-2 infection from 1 July 2021 to 31 October 2022. Cox regression was utilized to estimate risks of new-incident cardiovascular, neurologic, gastrointestinal, autoimmune, and respiratory complications, as identified by national health care claims data, at 31 to 300 days after dengue infection vs COVID-19. Risks were reported by 2 measures: adjusted hazard ratio (aHR) and excess burden.
Results: This study included 6452 children infected with dengue and 260 749 cases of COVID-19. Among children infected with dengue, there was increased risk of any postacute gastrointestinal sequelae (aHR, 2.98; 95% CI, 1.18-7.18), specifically appendicitis (aHR, 3.50; 95% CI, 1.36-8.99), when compared with children infected with SARS-CoV-2. In contrast to cases of unvaccinated COVID-19, children infected with dengue demonstrated lower risk (aHR, 0.42; 95% CI, .29-.61) and excess burden (-6.50; 95% CI, -9.80 to -3.20) of any sequelae, as well as lower risk of respiratory sequelae (aHR, 0.17; 95% CI, .09-.31).
Conclusions: Lower overall risk of postacute complications was observed in children following dengue infection vs COVID-19; however, higher risk of appendicitis was reported 31 to 300 days after dengue infection vs SARS-CoV-2. Public health strategies to mitigate the impact of dengue and COVID-19 in children should consider the possibility of chronic postinfectious sequelae.
期刊介绍：
Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.
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