Nutrition reviews最新文献

{"title":"Therapeutic Potential of Phytochemicals as Adjuvants in Head and Neck Cancer.","authors":"Mahesh Kaushik, Ashu Bhan Tiku","doi":"10.1093/nutrit/nuaf009","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf009","url":null,"abstract":"<p><p>Owing to the developments in various therapeutic modalities, cancer treatment has come a long way, including the discovery of various anticancer drugs, innovations in delivery technology, and increased personalization of treatments. Despite this, head and neck cancer (HNC) is a cancer that has eluded the current conventional treatments. To improve quality of life and preserve vital organ function in patients with HNC, there is a need for research into therapeutic regimes that would reduce the toxicity of the current therapeutic modalities. The use of a single approach has not been enough to completely eradicate this malignancy. Therefore, the use of adjuvants and combinatorial approaches, using molecules from natural compounds that have no or minimal side effects, is a growing area of research. One objective of this review was to clarify the potentiality of novel therapeutic strategies for HNC, such as the use of phytochemicals as adjuvants with chemotherapy or radiotherapy, and use of nano-formulation for therapeutic delivery. Another objective of this review was to delineate the associated challenges in the clinical application of these therapies in HNC. Possible strategies for overcoming critical issues associated with the clinical application of phytochemicals for HNC are also discussed.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fruit and Vegetable Consumption and Risk of All-Cause and Cause-Specific Mortality in Individuals With Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies.","authors":"Faezeh Geravand, Mohsen Montazer, Seyed Mohammad Mousavi, Leila Azadbakht","doi":"10.1093/nutrit/nuaf013","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf013","url":null,"abstract":"<p><strong>Context: </strong>Controversy exists regarding the association between fruit and vegetable consumption and all-cause and cause-specific mortality among individuals with type 2 diabetes (T2D).</p><p><strong>Objective: </strong>This study aims to inform dietary recommendations and add to the body of evidence by providing a thorough investigation of the association between the consumption of fruits and vegetables and the mortality risk in patients with T2D. The literature on this association was evaluated by a comprehensive systematic review and meta-analysis.</p><p><strong>Data sources: </strong>PubMed, Scopus, and Web of Science were searched up to 29 June 2024.</p><p><strong>Data extraction: </strong>Prospective cohort studies involving participants with diabetes aged over 18 years reporting risk estimates for the association between total fruit and vegetable intake and all-cause or cause-specific mortality (including cardiovascular disease [CVD], coronary heart disease, and stroke) were included.</p><p><strong>Data analysis: </strong>A random-effects approach was applied for combining risk estimates, and dose-response relationships were assessed using restricted cubic splines. Overall, 9 studies with 75 082 participants and 7590 deaths were included. Compared with the lowest intake, the highest fruit intake was associated with a decreased risk of all-cause (hazard ratio [HR]: 0.82; 95% CI: 0.75, 0.90; n = 6) and CVD (HR: 0.90; 95% CI: 0.84, 0.97; n = 4) mortality. The highest vegetable intake was also related to reduced all-cause (HR: 0.85; 95% CI: 0.73, 0.98; n = 6) and CVD (HR: 0.97; 95% CI: 0.94, 0.99; n = 2) mortality risk. An additional 200 g/day of fruit and vegetable consumption was associated with a 26% and 14% lower risk of all-cause mortality.</p><p><strong>Conclusion: </strong>This meta-analysis indicates an inverse association between fruit and vegetable intake and mortality from all causes and CVD in T2D patients.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42024571094.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resurgence of Iodine Deficiency in the United States During Pregnancy: Potential Implications for Cognitive Development in Children.","authors":"Kamsiyochukwu S Daniel, Kelsey M Mangano","doi":"10.1093/nutrit/nuaf025","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf025","url":null,"abstract":"<p><p>Iodine is an essential trace mineral for thyroid hormone synthesis, metabolism, and neurological development, particularly during pregnancy and early childhood. Although salt iodization in the 1920s significantly reduced iodine deficiency, recent studies suggest a resurgence in the United States, particularly among pregnant women. This review examines the resurgence of iodine deficiency among women in the United States while highlighting factors influencing intake, focusing on maternal iodine status during pregnancy, followed by its implications on cognitive health of children globally. Articles published from 2010 to 2024 were identified using PubMed, EMBASE, and Cochrane databases following PRISMA 2020 guidelines. Search terms included \"iodine deficiency in women\" and \"maternal iodine deficiency and neurodevelopment.\" Studies on urinary iodine concentration (UIC) in nonpregnant, pregnant, and lactating women in the United States, and maternal iodine deficiency impact on offspring neurodevelopment globally, were included. Nine articles were reviewed addressing current iodine status among women in the United States, 4 of which used the National Health and Nutrition Examination Survey (NHANES). NHANES data (2011-2020) indicated declining median UIC (mUIC) among women of reproductive age and mUICs in pregnant women were below the World Health Organization recommendation (<150 µg/L). Prevalence of inadequate iodine status ranged from 23% to 59% in pregnant women. The primary contributing factor to declining iodine status is dietary changes, specifically reduced milk consumption. Eleven additional articles examined maternal UIC and cognition in global populations, highlighting the association between low UIC during pregnancy, particularly in the first and second trimesters, and poor neurodevelopmental outcomes such as reduced IQ scores in offspring outside of the United States. Offspring born to mothers with iodine deficiency are at greater risk of poor cognitive health. Comprehensive nutrition policies are needed to raise awareness of adequate iodine intake during critical developmental periods and to support food-system changes, ensuring sufficient intake.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Properties of Questionnaires to Assess the Family Food Environment in the Pediatric Population: A Systematic Review.","authors":"Letícia Gabrielle Souza, Keisyanne De Araujo-Moura, Augusto César Ferreira De Moraes","doi":"10.1093/nutrit/nuaf018","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf018","url":null,"abstract":"<p><strong>Context: </strong>Given the diverse aspects of the family food environment, it is essential to clarify the availability of tools, the assessed dimensions, and the extent to which they offer a comprehensive and valid evaluation of the domestic food setting.</p><p><strong>Objective: </strong>This systematic review aims to assess the validity and reliability of instruments gauging the food environment within the pediatric population.</p><p><strong>Data sources: </strong>A systematic literature search was conducted in the EMBASE, Medline (PubMed), SCOPUS, Web of Science, and PsychINFO databases until December 2023, resulting in the identification of 2850 potentially eligible articles.</p><p><strong>Data extraction: </strong>After a thorough screening process, comprising language and title criteria, abstract scrutiny, and full-text reading, 179 full papers were separately reviewed, and 52 were chosen for analysis.</p><p><strong>Data analysis: </strong>Predominantly conducted in the United States utilizing adapted tools, the investigations focused on the sociocultural environment as the most addressed domain. It covered 80.7% of instruments for children and 54.9% for adolescents. The prevailing reliability assessment method was internal consistency, using Cronbach's alpha-coefficient. Acceptable values ranged from 0.70 to 0.96 for children and 0.77 to 0.94 for adolescents. Out of the 52 studies selected, only 22 presented validity measures, with a primary focus on convergent and construct validity assessed through Pearson or Spearman correlation. The findings indicate that, while questionnaires assessing the family food environment exhibited acceptable reliability, validity measures were deemed limited and somewhat ambiguous.</p><p><strong>Conclusion: </strong>Given the pivotal role of validity in evaluating methodological accuracy and relevance, particularly when measuring specific aspects, there is an imperative need to develop instruments that integrate robust validity measures for the comprehensive assessment of the family food environment.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42022333228.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Impact of Current Diets and Alternative Dietary Scenarios Worldwide: A Systematic Review.","authors":"Aliki Kalmpourtzidou, Beatrice Biasini, Alice Rosi, Francesca Scazzina","doi":"10.1093/nutrit/nuae215","DOIUrl":"https://doi.org/10.1093/nutrit/nuae215","url":null,"abstract":"<p><strong>Context: </strong>Unhealthy and unsustainable diets are common worldwide. Health and sustainability need to be balanced because environmentally sustainable diets may lack macro- and/or micronutrients, resulting in nutrient deficiencies.</p><p><strong>Objective: </strong>A systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines to analyze the environmental impact of current diets and alternative dietary scenarios worldwide based on food-group consumption.</p><p><strong>Data sources: </strong>The Scopus, Web of Sciences, and PubMed literature databases were searched. Only studies quantifying the food composition of diets per food group and their environmental impact were eligible.</p><p><strong>Data extraction: </strong>Data were extracted for food groups as averages, means, or medians, depending on how they were reported in the original publication, for both environmental impact indicators and grams consumed.</p><p><strong>Data analysis: </strong>A total of 120 original articles from 41 countries were included and 703 diets were analyzed. Current diets were the most prevalent (42%). Among the environmental indicators, carbon footprint (CF) was the most reported (86% of diets), followed by land (36%), total freshwater (22%), blue water (15%), and cumulative energy use (14%). Data about food consumption and environmental impact were available mainly for European countries (n = 471 diets; 67%), and Africa was the most underrepresented continent, with data from only 2 countries.</p><p><strong>Conclusion: </strong>The environmental impact of food consumption varied widely among diet types and continents, due to methodology heterogeneity of dietary assessment and different definitions of diets and food groups. Diets enhancing healthiness, such as the Mediterranean diet and food-based dietary guidelines, were associated with a higher CF than diets reducing meat consumption. Furthermore, diets including meat substitutes were associated with a higher CF than other plant-based diets that did not include them. Affordable diets involved more freshwater use, whereas acceptable diets that include high amounts of meat intake had a high CF. Finally, extensive research on dietary intake and environmental impact in low- and middle-income countries is required due to lack of available studies and data in these areas.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Increasing Red Meat Intake on Iron Status in Adults with Normal and Suboptimal Iron Status: A Systematic Literature Review and Meta-Analysis of Intervention Studies.","authors":"Laura McManus, Katherine Veras, Vinicius S Faria, Mika Manninen, Brendan Egan","doi":"10.1093/nutrit/nuaf016","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf016","url":null,"abstract":"<p><strong>Context: </strong>Iron deficiency is the most prevalent nutrient deficiency globally. There is increasing interest in the use of food-based approaches for improving and maintaining iron status.</p><p><strong>Objective: </strong>A systematic literature review was conducted to identify, critically-appraise, and meta-analyze data from intervention studies that investigated the effect of increasing red meat intake on iron status in adults.</p><p><strong>Data extraction: </strong>The search was conducted using the PubMed, Web of Science, Scopus, Embase, Cochrane, SPORTDiscus, and Google Scholar databases, as well as other supplementary search strategies up to October 2024. Inclusion criteria for reviewed articles were participants who were adults aged 18 to 70 years, interventions that involved ≥4 weeks of increased red meat intake, included a suitable control condition, and measured at least 1 biomarker of iron status. The initial search yielded 5212 articles, with 10 articles (n = 397 participants) meeting the inclusion criteria.</p><p><strong>Data analysis: </strong>The effect of intervention on markers of iron status were analyzed using a meta-analytic multivariate model, and the potential moderating effect of multiple variables were considered. The final meta-analysis included 42 effects (k) for serum ferritin (k = 25) and hemoglobin (Hb; k = 17) concentrations. Interventions involving increasing red meat intake had no significant effect on serum ferritin concentrations (raw mean change difference [RMCD] = 1.87 μg L-1; 95% CI, -0.73 to 4.48; t = 1.619; P = .139) but did have a positive effect on Hb concentrations (RMCD = 2.36 g L-1; 95% CI, 0.71 to 4.02; t = 3.297; P = .011). Moderator analysis revealed a positive effect of increasing red meat intake on serum ferritin concentrations when the intervention lasted at least 8 weeks (RMCD = 2.27 μg L-1; 95% CI, 0.87 to 3.67), and longer than 16 weeks (RMCD = 5.62 μg L-1; 95% CI, 0.67 to 10.6).</p><p><strong>Conclusions: </strong>Increasing red meat intake can improve iron status as indicated by increases in serum ferritin and Hb concentrations, but the extent to which such increases are clinically meaningful remains to be established.</p><p><strong>Systematic review registration: </strong>PROSPERO registration No. CRD42023479349.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Vitamin Administration on Orthodontic Tooth Movement: A Scoping Review.","authors":"Claudia Butrón-Téllez Girón, Moisés Sánchez-Almanza, Alan Martínez-Zumarán, Amaury Pozos-Guillén, Arturo Garrocho-Rangel","doi":"10.1093/nutrit/nuaf024","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf024","url":null,"abstract":"<p><strong>Context: </strong>Orthodontic tooth movement (OTM) is possible by bone remodeling that takes place during orthodontic therapy. The rate at which teeth move is determined by a variety of factors that can impact bone remodeling. Vitamins are well-known antioxidants that influence bone turnover.</p><p><strong>Objective: </strong>This scoping review was designed to appraise the effects of the local and systemic administration of vitamins C, D, and E principally on fixed orthodontic treatment, retention, and relapse.</p><p><strong>Method: </strong>A scoping review protocol was applied following the recommendations of the Preferred Reporting Item for Systematic Reviews and Meta-analysis Guidelines for Scoping Reviews. A detailed search strategy, including main keywords and synonyms, was applied in the following electronic databases: PubMed (via MEDLINE), Embase (via Ovid), Cochrane Library, and Web of Sciences, for articles published in English in the past 10 years.</p><p><strong>Results: </strong>The database online search identified 70 potential articles. After removing duplicates, 39 full-text articles were independently evaluated. Eighteen studies were discarded. The remaining 21 studies were finally included. Of these selected studies, 8 were conducted on animals, 9 were conducted with human participants, 1 was an in vitro study, and 3 were systematic reviews. One systematic review and meta-analysis was also included.</p><p><strong>Conclusion: </strong>Based on a variety of animal and human investigations, the findings of this scoping review imply that vitamins C, D, and E accelerate OTM by facilitating the bone remodeling process. However, more powerful randomized clinical trials are still required to reinforce the knowledge of vitamins' influence on orthodontic therapy.</p><p><strong>Scoping review registration: </strong>OSF identifier 10.17605/OSF.IO/HNW9Z.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Chrono-Exercise and Chrono-Nutrition on Muscle Health: Understanding the Molecular Mechanisms Activated by Timed Exercise and Consumption of Proteins and Carbohydrates.","authors":"Mariarosaria Negri, Claudia Pivonello, Feliciana Amatrudo, Fabiano Cimmino, Giovanna Trinchese, Claudia Vetrani, Guido Iaccarino, Rosario Pivonello, Maria Pina Mollica, Annamaria Colao","doi":"10.1093/nutrit/nuaf007","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf007","url":null,"abstract":"<p><p>The circadian clock is an endogenous timekeeping system that regulates various physiological and behavioral processes. Recently, it has been shown that the timing of physical activity and food intake can significantly influence metabolic muscle health. Some recent clinical evidence has shown that physical activity practiced in the late afternoon can be more effective in terms of performance and muscle strength. Preclinical studies have highlighted that the explanation for this effect lies in the different daily expression in the muscle of clock genes and clock-controlled genes involved in muscle development and hypertrophy. In conjunction with scientific advances in understanding the molecular mechanisms that regulate circadian rhythms and muscle trophy, chrono-nutrition has gained scientific resonance and has become a promising field, aimed at understanding the regulation of body metabolism. Clinical and preclinical studies have shown that protein consumption at specific circadian time points during the day, or precisely after exercise, can activate signaling pathways involved in muscle protein synthesis and, thus, favor skeletal muscle mass development as well as mitochondrial biogenesis, thereby improving skeletal muscle cell energy production and function. On the other hand, some studies have shown that the consumption of carbohydrates immediately after exercise increases insulin secretion, which facilitates glucose uptake by muscle cells to replenish glycogen. This review summarizes the current scientific literature concerning chrono-exercise and chrono-nutrition and muscle health, focusing on molecular mechanisms involving the circadian regulation of muscle mass, strength, and health. Understanding the intricate molecular relationship between circadian rhythms, exercise, nutrition, and muscle metabolism is essential for optimizing nutritional strategies to prevent or treat muscle wasting. In addition, tailoring protein and carbohydrate intake to timing and individual needs can improve muscle maintenance, growth, and performance.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Circulating Levels of Magnesium and Metabolic Syndrome: A Systematic Review and Meta-Analysis of Observational Studies with GRADE Assessment.","authors":"Zahra Moradmand, Parisa Rouhani, Parvane Saneei","doi":"10.1093/nutrit/nuaf020","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf020","url":null,"abstract":"<p><strong>Context: </strong>Evidence on the associations between circulating magnesium (Mg) levels and metabolic syndrome (MetS) is inconclusive.</p><p><strong>Objective: </strong>In this meta-analysis we examined the relationship between Mg concentrations and MetS.</p><p><strong>Data sources: </strong>Observational studies were searched through the PubMed, EmBase, ISI Web of Science, and Scopus databases and Google Scholar, without time or language limitations, up to January 2024.</p><p><strong>Data extraction: </strong>Eligible studies were epidemiological investigations that reported relative risks or odds ratios [ORs] of MetS in relation to serum, plasma, or blood Mg levels. The certainty of each meta-analysis was assessed by use of the grading of recommendations, assessment, development, and evaluation (GRADE) approach.</p><p><strong>Data analysis: </strong>A total of 11 studies (9 cross-sectional and 2 case-control) were eligible to be included. Pooling estimates of these studies (with 14 188 individuals and 4724 cases with MetS) revealed that compared to individuals with the lowest level of Mg concentration, those with the highest Mg concentration had 46% significantly lower odds of MetS (OR = 0.54; 95% CI: 0.34-0.86). Each 0.5-mg/dL increase in the level of circulating Mg was related to an 11% reduction in the odds of contracting MetS (OR = 0.89; 95% CI: 0.83-0.96). Nonlinear analysis showed a U-shaped curve; the lowest likelihood of MetS was seen at a circulating Mg concentration of 2.5 mg/dL. Certainty of the evidence was high.</p><p><strong>Conclusions: </strong>In this meta-analysis of epidemiologic studies we documented that circulating Mg levels were inversely associated with MetS. Additional prospective studies are needed to provide more solid evidence for the optimal range of circulating Mg concentrations with respect to prevention of MetS.</p><p><strong>Systematic review registration: </strong>PROSPERO registration No. CRD42024535236.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Controlled Trials Investigating the Effect of Curcumin Supplementation on Lipid Profiles.","authors":"Chanita Unhapipatpong, Narachai Julanon, Prapimporn Chattranukulchai Shantavasinkul, Nint Polruang, Pawin Numthavaj, Ammarin Thakkinstian","doi":"10.1093/nutrit/nuaf012","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf012","url":null,"abstract":"<p><strong>Context: </strong>Dyslipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD), and curcumin may help improve lipid metabolism.</p><p><strong>Objective: </strong>This umbrella review and updated meta-analysis assessed the effects of curcumin supplementation on lipid profiles.</p><p><strong>Data sources: </strong>Electronic databases (Medline, Scopus, Cochrane, and Google Scholar) were searched through March 31, 2023, without language restrictions.</p><p><strong>Data extraction: </strong>Two independent authors selected eligible randomized controlled trials (RCTs) involving curcumin supplementation compared with placebo, measuring total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-c), high-density-lipoprotein cholesterol (HDL-c), and triglyceride (TG) levels.</p><p><strong>Data analysis: </strong>This study identified 26 systematic reviews and meta-analyses (MAs) that met the inclusion criteria for the umbrella review. Of these, 53 RCTs, with a corrected coverage area of 9.76% indicating a moderate degree of overlap, were included for re-pooling. Additionally, this study found 19 more RCTs, bringing the total number of studies for the updated MAs to 72.</p><p><strong>Results: </strong>Curcumin significantly reduced TC, LDL-c, and TG, with mean differences (MDs) of -7.76 mg/dL (95% CI: -11.29, -4.22; I2 = 97%), -5.84 mg/dL (95% CI: -11.63, -0.05; I2 = 98%), and -13.15 mg/dL (95% CI: -17.31, -8.98; I2 = 94%), respectively, and increased HDL-c by 2.4 mg/dL (95% CI: 1.22, 3.57; I2 = 94%). The reductions in LDL-c and TG reached the minimally clinically important differences (MCIDs). However, the reduction in TC and increase in HDL-c did not meet their respective MCIDs. Subgroup analysis showed greater lipid improvements in patients with metabolic-related diseases, particularly type 2 diabetes. Enhanced bioavailability forms of curcumin, supplementation for at least 8 weeks, and exercise yielded additional benefits.</p><p><strong>Conclusion: </strong>The study confirmed that curcumin has an anti-lipidemic effect on patients with noncommunicable diseases. A form of curcumin with enhanced bioavailability is preferred, and supplementation for at least 8 weeks, along with exercise, may be used as an accessible approach to reduce the risk of ASCVD.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42023415577.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}