Wen-Chien Yang, Ramaa Chitale, Karen M O'Callaghan, Christopher R Sudfeld, Emily R Smith
{"title":"The Effects of Vitamin D Supplementation During Pregnancy on Maternal, Neonatal, and Infant Health: A Systematic Review and Meta-analysis.","authors":"Wen-Chien Yang, Ramaa Chitale, Karen M O'Callaghan, Christopher R Sudfeld, Emily R Smith","doi":"10.1093/nutrit/nuae065","DOIUrl":"10.1093/nutrit/nuae065","url":null,"abstract":"<p><strong>Context: </strong>Previous research linked vitamin D deficiency in pregnancy to adverse pregnancy outcomes.</p><p><strong>Objective: </strong>Update a 2017 systematic review and meta-analysis of randomized controlled trials (RCTs) on the effect of vitamin D supplementation during pregnancy, identify sources of heterogeneity between trials, and describe evidence gaps precluding a clinical recommendation.</p><p><strong>Data sources: </strong>The MEDLINE, PubMed, Europe PMC, Scopus, Cochrane Database of Systematic Reviews, Web of Science, and CINAHL databases were searched. Articles were included that reported on RCTs that included pregnant women given vitamin D supplements as compared with placebo, no intervention, or active control (≤600 IU d-1). Risk ratios (RRs) and mean differences were pooled for 38 maternal, birth, and infant outcomes, using random effects models. Subgroup analyses examined effect heterogeneity. The Cochrane risk of bias tool was used.</p><p><strong>Data extraction: </strong>Included articles reported on a total of 66 trials (n = 17 276 participants).</p><p><strong>Data analysis: </strong>The median vitamin D supplementation dose was 2000 IU d-1 (range: 400-60 000); 37 trials used placebo. Antenatal vitamin D supplementation had no effect on the risk of preeclampsia (RR, 0.81 [95% CI, 0.43-1.53]; n = 6 trials and 1483 participants), potentially protected against gestational diabetes mellitus (RR, 0.65 [95% CI, 0.49-0.86; n = 12 trials and 1992 participants), and increased infant birth weight by 53 g (95% CI, 16-90; n = 40 trials and 9954 participants). No effect of vitamin D on the risk of preterm birth, small-for-gestational age, or low birth weight infants was found. A total of 25 trials had at least 1 domain at high risk of bias.</p><p><strong>Conclusion: </strong>Additional studies among the general pregnant population are not needed, given the many existing trials. Instead, high-quality RCTs among populations with low vitamin D status or at greater risk of key outcomes are needed. Benefits of supplementation in pregnancy remain uncertain because current evidence has high heterogeneity, including variation in study context, baseline and achieved end-line 25-hydroxyvitamin D level, and studies with high risk of bias.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42022350057.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"e892-e903"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unraveling the Health Benefits and Mechanisms of Time-Restricted Feeding: Beyond Caloric Restriction.","authors":"Ruhan Wang, Yuxiao Liao, Yan Deng, Rong Shuang","doi":"10.1093/nutrit/nuae074","DOIUrl":"10.1093/nutrit/nuae074","url":null,"abstract":"<p><p>Time-restricted feeding (TRF) is a lifestyle intervention that aims to maintain a consistent daily cycle of feeding and fasting to support robust circadian rhythms. Recently, it has gained scientific, medical, and public attention due to its potential to enhance body composition, extend lifespan, and improve overall health, as well as induce autophagy and alleviate symptoms of diseases like cardiovascular diseases, type 2 diabetes, neurodegenerative diseases, cancer, and ischemic injury. However, there is still considerable debate on the primary factors that contribute to the health benefits of TRF. Despite not imposing strict limitations on calorie intake, TRF consistently led to reductions in calorie intake. Therefore, while some studies suggest that the health benefits of TRF are primarily due to caloric restriction (CR), others argue that the key advantages of TRF arise not only from CR but also from factors like the duration of fasting, the timing of the feeding period, and alignment with circadian rhythms. To elucidate the roles and mechanisms of TRF beyond CR, this review incorporates TRF studies that did not use CR, as well as TRF studies with equivalent energy intake to CR, which addresses the previous lack of comprehensive research on TRF without CR and provides a framework for future research directions.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"e1209-e1224"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kee June Ooi, Rachael M Taylor, Sasha Fenton, Melinda J Hutchesson, Clare E Collins
{"title":"Evaluating Validated Diet Quality Indices Used in Pregnant Women in High-Income Countries: A Systematic Review.","authors":"Kee June Ooi, Rachael M Taylor, Sasha Fenton, Melinda J Hutchesson, Clare E Collins","doi":"10.1093/nutrit/nuae073","DOIUrl":"10.1093/nutrit/nuae073","url":null,"abstract":"<p><strong>Context: </strong>Diet quality indices (DQIs) assess the level of adherence to dietary recommendations and a specified dietary pattern in populations; however, there is limited evidence regarding the construct criteria and validation methodology of DQIs used in pregnant women.</p><p><strong>Objectives: </strong>The objectives of this study were to (i) identify and describe characteristics of DQIs that have been validated for use in pregnant women in high-income countries, and (ii) evaluate criteria used to develop DQIs and validation methodologies employed.</p><p><strong>Data sources: </strong>CINAHL, Embase, Medline, SCOPUS, and Web of Science were systematically searched for eligible articles published between 1980 and November 2022 that focused on DQIs validated for use in pregnant women from high-income countries.</p><p><strong>Data extraction: </strong>Characteristics, development criteria, and validation methodologies used in the included articles were extracted by one reviewer and checked by a second reviewer.</p><p><strong>Data analysis: </strong>A narrative synthesis and descriptive statistics were used to summarize the review findings. Reporting was guided by the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement.</p><p><strong>Results: </strong>Six articles with 5 validated DQIs were identified. In total, 3777 participants were included - five articles had pregnant women aged 31-50 years and in their second trimester. Food frequency questionnaires were used as the dietary assessment method in all studies, and 3 DQIs were used to assess dietary intake at 1 time point, using 2 different dietary assessment methods. No indices fulfilled preferred features for the DQI development criteria developed by Burggraf et al (2018). Construct validity was assessed by all DQIs, followed by criterion validity (n = 4) and test-retest reliability (n = 2).</p><p><strong>Conclusion: </strong>Limited high-quality validated DQIs for use in pregnant women in high-income countries were identified. Scoring for DQI components were not specific to nutrient requirements for pregnant women. Findings from this review may inform the development of DQIs that evaluate specific dietary requirements and specific food safety considerations applicable to pregnancy.</p><p><strong>Systematic review registration: </strong>https://osf.io/u2hrq.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"e947-e964"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Qusay Khalid, Tabarek Najeeb Zaidan, Saatheeyavaane Bhuvanendran, Kasthuri B Magalingam, Shaza M Mohamedahmed, Premdass Ramdas, Ammu K Radhakrishnan
{"title":"Insights into the Anticancer Mechanisms Modulated by Gamma and Delta Tocotrienols in Colorectal Cancers.","authors":"Ali Qusay Khalid, Tabarek Najeeb Zaidan, Saatheeyavaane Bhuvanendran, Kasthuri B Magalingam, Shaza M Mohamedahmed, Premdass Ramdas, Ammu K Radhakrishnan","doi":"10.1093/nutrit/nuae108","DOIUrl":"10.1093/nutrit/nuae108","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is a growing concern all over the world. There has been a concerted effort to identify natural bioactive compounds that can be used to prevent or overcome this condition. Tocotrienols (T3s) are a naturally occurring form of vitamin E known for various therapeutic effects, such as anticancer, antioxidant, neuroprotective, and anti-inflammatory activities. The literature evidence suggests that two T3 analogues, ie, gamma (γ)- and delta (δ)-T3, can modulate cancers via several cancer-related signaling pathways. The aim of this review was to compile and analyze the existing literature on the diverse anticancer mechanisms of γT3 and δT3 exhibited in CRC cells, to showcase the anticancer potential of T3s. Medline was searched for research articles on anticancer effects of γT3 and δT3 in CRC published in the past 2 decades. A total of 38 articles (26 cell-based, 9 animal studies, 2 randomized clinical trials, and 1 scoping review) that report anticancer effects of γT3 and δT3 in CRC were identified. The findings reported in those articles indicate that γT3 and δT3 inhibit the proliferation of CRC cells, induce cell cycle arrest and apoptosis, suppress metastasis, and produce synergistic anticancer effects when combined with well-established anticancer agents. There is preliminary evidence that shows that T3s affect telomerase functions and support anticancer immune responses. γT3 and δT3 have the potential for development as anticancer agents.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"e1295-e1310"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ágota Mészáros, Norbert Dósa, Anna Péterfi, Krisztián Horváth, Zsófia Szarvas, Jeremiás M Balogh, Balázs Munkácsy, Zoltán Vokó
{"title":"Prospects of Food Taxes for Planetary Health: A Systematic Review of Modeling Studies.","authors":"Ágota Mészáros, Norbert Dósa, Anna Péterfi, Krisztián Horváth, Zsófia Szarvas, Jeremiás M Balogh, Balázs Munkácsy, Zoltán Vokó","doi":"10.1093/nutrit/nuae111","DOIUrl":"10.1093/nutrit/nuae111","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to analyze the modeling methodologies of fiscal policies on food with health or environmental outcomes.</p><p><strong>Background: </strong>Evidence suggests that fiscal policies on food can contribute to addressing the growing burden of noncommunicable diseases and climate change. These policies should be modeled in advance to see the implications for the environment and health.</p><p><strong>Methods: </strong>A systematic review was conducted of studies that modeled fiscal policies on the food groups targeted by the EAT-Lancet Commission and examined their health or environmental outcomes. The Scopus and PubMed databases were searched on November 30, 2021. The records were double-screened and data on modeling methods were extracted from the included studies.</p><p><strong>Results: </strong>A total of 55 studies were included in the review. The most frequently modeled interventions were fruit and vegetable subsidies (n = 19) and carbon taxes on food (n = 17). One study also included a consumer education campaign to enhance the effect of fiscal policy. The outcomes are highly sensitive to consumption change and price elasticities. None of the studies modeled the health effects of environmental outcomes.</p><p><strong>Conclusions: </strong>A model that covered all the relevant aspects of the issue was not found. Some parts were missing from all the included models. It is advisable to model the stability of the amount of diet consumed, either by keeping the amount of food in the diet stable or by taking a more conservative approach and keeping the consumed calories stable. It is preferable to keep the included diseases and environmental boundaries broad to have more valid outcome estimates on this complex issue. A more comprehensive understanding of fiscal policies would allow us to better anticipate the impact of our actions and inactions and thus could lead to more sophisticated measures taken by policymakers.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. 2022 CRD42022291945/.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"503-524"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to: Unraveling the Health Benefits and Mechanisms of Time-Restricted Feeding: Beyond Caloric Restriction.","authors":"","doi":"10.1093/nutrit/nuae198","DOIUrl":"10.1093/nutrit/nuae198","url":null,"abstract":"","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"596"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariana Rei, Alexandra Costa, Sofia Sosa, Sofia da Costa, Duarte Torres, Colin Sage, Sara Rodrigues
{"title":"Multicriteria Measures to Assess the Sustainability of Diets: A Systematic Review.","authors":"Mariana Rei, Alexandra Costa, Sofia Sosa, Sofia da Costa, Duarte Torres, Colin Sage, Sara Rodrigues","doi":"10.1093/nutrit/nuae081","DOIUrl":"10.1093/nutrit/nuae081","url":null,"abstract":"<p><strong>Context: </strong>Assessing the overall sustainability of a diet is a challenging undertaking requiring a holistic approach capable of addressing the multicriteria nature of this concept.</p><p><strong>Objective: </strong>The aim was to identify and summarize the multicriteria measures used to assess the sustainability characteristics of diets reported at the individual level by healthy adults.</p><p><strong>Data sources: </strong>Articles were identified via PubMed, Scopus, and Web of Science. The search strategy consisted of key words and MeSH terms, and was concluded in September 2022, covering references in English, Spanish, and Portuguese.</p><p><strong>Data extraction: </strong>This systematic review followed the PRISMA guidelines. The search identified 5663 references, from which 1794 were duplicates. Two reviewers independently screened the titles and abstracts of each of the 3869 records and the full-text of the 144 references selected. Of these, 7 studies met the inclusion criteria.</p><p><strong>Data analysis: </strong>A total of 6 multicriteria measures were identified: 3 different Sustainable Diet Indices, the Quality Environmental Costs of Diet, the Quality Financial Costs of Diet, and the Environmental Impact of Diet. All of these incorporated a health/nutrition dimension, while the environmental and economic dimensions were the second and the third most integrated, respectively. A sociocultural sustainability dimension was included in only 1 of the measures.</p><p><strong>Conclusion: </strong>Despite some methodological concerns in the development and validation process of the identified measures, their inclusion is considered indispensable in assessing the transition towards sustainable diets in future studies.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42022358824.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"e980-e990"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tianxu Liu, Ismail Muhammad Asif, Chengmei Bai, Yutian Huang, Bin Li, Ling Wang
{"title":"The effectiveness and safety of natural food and food-derived extract supplements for treating functional gastrointestinal disorders-current perspectives.","authors":"Tianxu Liu, Ismail Muhammad Asif, Chengmei Bai, Yutian Huang, Bin Li, Ling Wang","doi":"10.1093/nutrit/nuae047","DOIUrl":"10.1093/nutrit/nuae047","url":null,"abstract":"<p><p>Functional gastrointestinal disorders (FGIDs) were highly prevalent and involve gastrointestinal discomfort characterized by non-organic abnormalities in the morphology and physiology of the gastrointestinal tract. According to the Rome IV criteria, irritable bowel syndrome and functional dyspepsia are the most common FGIDs. Complementary and alternative medicines are employed by increasing numbers of individuals around the world, and they include herbal and dietary supplements, acupuncture, and hypnosis. Of these, herbal and dietary supplements seem to have the greatest potential for relieving FGIDs, through multiple modes of action. However, despite the extensive application of natural extracts in alternative treatments for FGIDs, the safety and effectiveness of food and orally ingested food-derived extracts remain uncertain. Many randomized controlled trials have provided compelling evidence supporting their potential, as detailed in this review. The consumption of certain foods (eg, kiwifruit, mentha, ginger, etc) and food ingredients may contribute to the alleviation of symptoms associated with FGID,. However, it is crucial to emphasize that the short-term consumption of these components may not yield satisfactory efficacy. Physicians are advised to share both the benefits and potential risks of these alternative therapies with patients. Furthermore, larger randomized clinical trials with appropriate comparators are imperative.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"e1158-e1171"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Contreras Navarro, Kerrie Gallagher, Sally Griffin, Clarissa L Leydon, Ivan J Perry, Janas M Harrington
{"title":"Systematic Review on the Impact of Salt-Reduction Initiatives by Socioeconomic Position to Address Health Inequalities in Adult Populations.","authors":"Ana Contreras Navarro, Kerrie Gallagher, Sally Griffin, Clarissa L Leydon, Ivan J Perry, Janas M Harrington","doi":"10.1093/nutrit/nuae088","DOIUrl":"10.1093/nutrit/nuae088","url":null,"abstract":"<p><strong>Context: </strong>International evidence shows that individuals from low socioeconomic positions (SEPs) consume a greater amount of salt than those from higher SEPs. This health inequality reflects a disproportionate effect of salt-reduction initiatives, and explains a higher prevalence of cardiovascular disease among the most vulnerable populations. Assessing this impact can help tailor implementation strategies in the future for the benefit of the whole population.</p><p><strong>Objective: </strong>The aim was to systematically review the literature and assess the impact of salt-reduction initiatives on health and behavioral outcomes of adults by SEP.</p><p><strong>Data sources: </strong>The search strategy was conducted in 6 databases (CINAHL, Scopus, Embase, MEDLINE, PubMed, and Web of Science) using the terms sodium or salt, social class, policy, intervention or campaign. Peer-reviewed articles assessing salt-reduction interventions in adults reporting dietary or behavioral changes on salt consumption measurements by SEP were considered for inclusion. Articles in which salt intake data were not reported by SEP were excluded.</p><p><strong>Data extraction: </strong>Two reviewers collected data independently using a predesigned electronic form. The AXIS and RoB 2 tools were used for critical appraisal.</p><p><strong>Data analysis: </strong>Eight studies containing data from 111 548 adults were interpreted according to study design following a narrative synthesis approach.</p><p><strong>Results: </strong>Salt-reduction initiatives are effective at reducing the intake of salt and sodium in adults. When reporting the impact of these initiatives, research outcomes are generally not evaluated by SEP, representing a question yet to be explored.</p><p><strong>Conclusion: </strong>A small number of articles that focused on the impact of salt-reduction interventions reported salt consumption measurements by SEP, indicating a critical gap in research. The limited evidence suggests potentially greater health benefits to be gained from the implementation of population-wide initiatives in adults of low SEP.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42021238055.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"e1090-e1100"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Supatchayaporn Nitsuwat, James Webster, Anwesha Sarkar, Janet Cade
{"title":"The Association of Oral Processing Factors and Nutrient Intake in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.","authors":"Supatchayaporn Nitsuwat, James Webster, Anwesha Sarkar, Janet Cade","doi":"10.1093/nutrit/nuae080","DOIUrl":"10.1093/nutrit/nuae080","url":null,"abstract":"<p><strong>Context: </strong>Oral health and food oral-processing issues emerge with functional decline in the older adult population, potentially increasing the risk of malnutrition. Impairment of oral health is associated with poorer nutrition status; however, the relationship between oral factors and the intake of each nutrient remains poorly understood.</p><p><strong>Objective: </strong>The associations between different oral factors and nutrient intakes among community-dwelling older adults were investigated.</p><p><strong>Data sources: </strong>A literature search from 5 databases (Web of Science, Scopus, Cochrane Library, Ovid [MEDLINE and Embase], and CINAHL) was completed on February 1, 2022. The search was limited to peer-reviewed articles published between the years 2012 and 2022.</p><p><strong>Data extraction: </strong>Six cross-sectional studies were included in the meta-analysis. Two authors independently completed the data extraction and summarized the study characteristics, factors adjusted for in the statistical analysis, the outcome, and summary statistics of the results.</p><p><strong>Data analysis: </strong>Meta-analyses showed evidence of a significant association between compromised oral factors (namely, denture status, chewing ability, and the number of teeth) with lower energy (weighted mean difference [WMD], -107 kcal d-1 (95% CI, -132 to -81), protein (WMD, -5.2 g d-1; 95% CI, -6.6 to -3.8), fat (WMD, -4.6 g d-1; 95% CI, -6.7 to -2.6), carbohydrate (WMD, -8.8 g d-1; 95% CI, -13.9 to -3.7), and vitamin C intakes (WMD, -12.9 mg d-1; 95% CI, -16.6 to -9.2) in older adults.</p><p><strong>Conclusion: </strong>Oral health can be an indicator of compromised daily energy, protein, fat, carbohydrate, and vitamin C intakes in older adults. However, the small sample size of the studies included in this review and the heterogeneity among macronutrient studies should be considered. Because of the lack of studies covering all aspects of food oral processing (eg, salivary flow rate, tongue pressure), the associations between oral processing and nutrient intake were not thoroughly explored.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42022308823.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"e762-e777"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}