{"title":"Effect of Fatty Acids on Glucose Metabolism and Type 2 Diabetes.","authors":"Dilek Sivri, Yasemin Akdevelioğlu","doi":"10.1093/nutrit/nuae165","DOIUrl":"10.1093/nutrit/nuae165","url":null,"abstract":"<p><p>Type 2 diabetes is an inflammatory, non-infectious disease characterized by dysfunctional pancreatic β-cells and insulin resistance. Although lifestyle, genetic, and environmental factors are associated with a high risk of type 2 diabetes, nutrition remains one of the most significant factors. Specific types and increased amounts of dietary fatty acids are associated with type 2 diabetes and its complications. Dietary recommendations for the prevention of type 2 diabetes advocate for a diet that is characterized by reduced saturated fatty acids and trans fatty acids alongside an increased consumption of monounsaturated fatty acids, polyunsaturated fatty acids, and omega-3 fatty acids. Although following the recommendations for dietary fatty acid intake is important for reducing type 2 diabetes and its related complications, the underlying mechanisms remain unclear. This review will provide an update on the mechanisms of action of fatty acids on glucose metabolism and type 2 diabetes, as well as dietary recommendations for the prevention of type 2 diabetes.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"897-907"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah H Kehoe, Sargoor R Veena, K N Kiran, T K Nagabharana, Shama V Joseph, Kalyanaraman Kumaran, Joanne E Arsenault, Nazia Binte Ali, Sabri Bromage, Megan Deitchler, Carolina Batis, Anali Castellanos Gutierrez, Caroline H D Fall, Ghattu V Krishnaveni
{"title":"How Are Global Diet Quality Scores at 9 Years Associated With Cardiometabolic Disease Risk in Early Adolescence in Mysore, India?","authors":"Sarah H Kehoe, Sargoor R Veena, K N Kiran, T K Nagabharana, Shama V Joseph, Kalyanaraman Kumaran, Joanne E Arsenault, Nazia Binte Ali, Sabri Bromage, Megan Deitchler, Carolina Batis, Anali Castellanos Gutierrez, Caroline H D Fall, Ghattu V Krishnaveni","doi":"10.1093/nutrit/nuaf002","DOIUrl":"10.1093/nutrit/nuaf002","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of the study was to assess Global Diet Quality Score (GDQS) at age 9.5 years and associated risk of cardiometabolic outcomes at 13.5 years in a birth cohort in Mysore, India.</p><p><strong>Background: </strong>Assessing relationships between diet quality and cardiometabolic outcomes among children is important to inform the targeting and development of interventions to prevent cardiometabolic diseases. At present, this evidence is lacking, particularly in low- and middle-income countries.</p><p><strong>Methods: </strong>Using data from the Mysore Parthenon Birth Cohort Study when children were 9.5 years of age, GDQS was computed from a 136-item food-frequency questionnaire. Children were categorized as being at low, moderate, or high risk of poor diet quality outcomes based on the GDQS value. At 13.5 years, cardiometabolic risk factor data were collected. Data were analyzed using linear and logistic regression models adjusted for covariates.</p><p><strong>Results: </strong>Data were available at both time points for 538 children. At 9.5 years, the majority of children (72%) were at moderate risk of poor diet quality outcomes, with 25% and 3% being at low and high risk, respectively. Higher total GDQSs at 9.5 years of age were associated with lower fasting plasma glucose, insulin concentrations, and insulin resistance at 13.5 years of age. There were no associations between GDQS and anthropometric measures, lipids, or blood pressure.</p><p><strong>Conclusion: </strong>The association between diet quality among children in this cohort and some elements of cardiometabolic risk in early adolescence adds to the case for early interventions to address risk of poor diet quality. Understanding context-specific barriers to a high-quality diet in different settings and developing solutions with communities to overcome these barriers should be a priority for researchers and policymakers.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":"83 Supplement_1","pages":"72-80"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alejandro García-Beltrán, Aida Lozano Melero, Rosario Martínez Martínez, Jesús María Porres Foulquie, María López Jurado Romero de la Cruz, Garyfallia Kapravelou
{"title":"A Systematic Review of the Beneficial Effects of Berry Extracts on Non-Alcoholic Fatty Liver Disease in Animal Models.","authors":"Alejandro García-Beltrán, Aida Lozano Melero, Rosario Martínez Martínez, Jesús María Porres Foulquie, María López Jurado Romero de la Cruz, Garyfallia Kapravelou","doi":"10.1093/nutrit/nuae132","DOIUrl":"10.1093/nutrit/nuae132","url":null,"abstract":"<p><strong>Context: </strong>Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries and is strongly associated with several metabolic disorders. Plant-derived bioactive extracts, such as berry extracts, with high antioxidant capacity have been used for the treatment and prevention of this pathology. Moreover, they promote circular economy and sustainability.</p><p><strong>Objective: </strong>To study the beneficial effects of extracts from different parts of berry plants in animal models of NAFLD.</p><p><strong>Data sources: </strong>A systematic research of the MEDLINE (via PubMed), Cochrane, and Scopus databases was conducted to identify relevant studies published after January 2011. In vivo animal studies of NAFLD were included in which berry extracts of different parts of the plant were administered and significantly improved altered biomarkers related to the pathology, such as lipid metabolism and hepatic steatosis, glucose and glycogen metabolism, and antioxidant and anti-inflammatory biomarkers.</p><p><strong>Data extraction: </strong>Of a total of 203 articles identified, 31 studies were included after implementation of the inclusion and exclusion criteria.</p><p><strong>Data analysis: </strong>Most of the studies showed a decrease in steatosis and a stimulation of genes related to β-oxidation and downregulation of lipogenic genes, with administration of berry extracts. Berry extracts also attenuated inflammation and oxidative stress.</p><p><strong>Conclusions: </strong>Administration of berry extracts seems to have promising potential in the design of enriched foodstuffs or nutraceuticals for the treatment of NAFLD.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"819-841"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to: Toward Enhanced Methodological Rigor: Addressing Limitations in the Comparative Analysis of Probiotics and Antidepressants for Major Depressive Disorder Management.","authors":"Shilin Zhao, Jun Tao, Suisha Liang, Hein M Tun","doi":"10.1093/nutrit/nuae139","DOIUrl":"10.1093/nutrit/nuae139","url":null,"abstract":"","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"967-969"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Winnie Bell, Mia M Blakstad, Peiman Milani, Megan Deitchler
{"title":"The Global Diet Quality Score (GDQS)-Meal and GDQS-Menu Metrics: How to Measure Meal and Menu Quality in Institutional Feeding Programs.","authors":"Winnie Bell, Mia M Blakstad, Peiman Milani, Megan Deitchler","doi":"10.1093/nutrit/nuaf004","DOIUrl":"10.1093/nutrit/nuaf004","url":null,"abstract":"<p><p>To achieve equitable, environmentally sustainable, and nutritious food systems, transformational change is needed. One potential path to such change is through institutional feeding programs, such as schools feeding. Despite the wide reach of institutional feeding programs there has not until recently been a simple yet rigorous metric that can measure, track, and evaluate the nutritional quality of the meals and menus. This lack of standardized measurement is particularly noticeable in low- and middle-income countries, with the implication that the relative contribution of institutional feeding programs towards reducing malnutrition or how to invest to maximize impact remains largely unknown. The Global Diet Quality Score (GDQS)-Meal and GDQS-Menu metrics were designed to fill this gap and to enable consistent and accurate tracking of the nutritional quality of meals and menus around the world. Derived from the existing Global Diet Quality Score (GDQS) metric, the GDQS-Meal and GDQS-Menu metrics assign a point total for the overall nutritional quality of a meal or menu based on its performance of four sub-metrics: 1) Healthy GDQS-Meal (or Menu), 2) Unhealthy GDQS-Meal (or Menu), 3) Fortification and Biofortification, and 4) Food Group Diversity. The metrics were designed to be low-burden and easy-to-use while maintaining scientific rigor for individuals of all ages in schools and across other institutional feeding programs such as prisons and workplace cafeterias. Results from the GDQS-Meal and GDQS-Menu metrics can be used for identification of simple substitutions for healthier meal and menu options, enforcement of meal quality standards, benchmarking, educational purposes, and advocacy efforts to encourage institutional feeding programs to invest in healthier meal and menu options.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":"83 Supplement_1","pages":"81-92"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
İnci Türkoğlu, Koray Gorkem Sacinti, Andrea Panattoni, Ahmet Namazov, Nazlı Tunca Sanlier, Nevin Sanlier, Vito Cela
{"title":"Eating for Optimization: Unraveling the Dietary Patterns and Nutritional Strategies in Endometriosis Management.","authors":"İnci Türkoğlu, Koray Gorkem Sacinti, Andrea Panattoni, Ahmet Namazov, Nazlı Tunca Sanlier, Nevin Sanlier, Vito Cela","doi":"10.1093/nutrit/nuae120","DOIUrl":"10.1093/nutrit/nuae120","url":null,"abstract":"<p><p>Endometriosis is a chronic gynecological disorder affecting millions of women worldwide, causing chronic pelvic pain, dyspareunia, dysmenorrhea, and infertility, and severely impacting their quality of life. Treatment primarily involves hormonal therapies and surgical excision, but high recurrence rates and the economic burden are substantial. With these challenges, significant discussion surrounds the potential role of dietary patterns in managing endometriosis, making it necessary to bridge this critical gap. This review investigates the current scientific evidence on the dietary patterns (eg, Mediterranean, vegetarian, anti-inflammatory, low-fermentable oligosaccharides, disaccharides, monosaccharides, and polyols [low-FODMAP], and Western-style diets) associated with endometriosis and provides a concise, yet thorough, overview on the subject. In addition, antioxidants, microbiota, and artificial intelligence (AI) and their potential roles were also evaluated as future directions. An electronic-based search was performed in MEDLINE, Embase, Cochrane Library, CINAHL, ClinicalTrials.gov, Scopus, and Web of Science. The current data on the topic indicate that a diet based on the Mediterranean and anti-inflammatory diet pattern, rich in dietary fiber, omega-3 fatty acids, plant-based protein, and vitamins and minerals, has a positive influence on endometriosis, yielding a promising improvement in patient symptoms. Preclinical investigations and clinical trials indicate that dietary antioxidants and gut microbiota modulation present potential new approaches in managing endometriosis. Also, AI may offer a promising avenue to explore how dietary components interact with endometriosis. Ultimately, considering genetic and lifestyle factors, a healthy, balanced, personalized approach to diet may offer valuable insights on the role of diet as a means of symptom improvement, facilitating the utilization of nutrition for the management of endometriosis.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"869-879"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carolina Batis, Analí Castellanos-Gutiérrez, Nazia Binte Ali, Joanne E Arsenault, Agata M P Atayde, Sabri Bromage, Megan Deitchler, Loty Diop, Aulo Gelli, Sarah H Kehoe, Sofia Leonardo, Mourad Moursi, Brunhilda Tegomoh Nkengfack, Walter C Willett
{"title":"Validation of the Global Diet Quality Score (GDQS) Among Children 10 to 14 Years of Age.","authors":"Carolina Batis, Analí Castellanos-Gutiérrez, Nazia Binte Ali, Joanne E Arsenault, Agata M P Atayde, Sabri Bromage, Megan Deitchler, Loty Diop, Aulo Gelli, Sarah H Kehoe, Sofia Leonardo, Mourad Moursi, Brunhilda Tegomoh Nkengfack, Walter C Willett","doi":"10.1093/nutrit/nuaf006","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf006","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate the performance of the Global Diet Quality Score (GDQS) in predicting nutrient intake and health outcomes among children aged 10-14 years old in Mexico, the United States, the United Kingdom, and China. For comparison, we evaluated other dietary metrics (Minimum Dietary Diversity for Women [MDD-W], the Global Dietary Recommendations score [GDR], and the Healthy Eating Index-2020 [HEI-2020]).</p><p><strong>Background: </strong>Given the magnitude of the health burden associated with all forms of malnutrition, monitoring dietary quality is fundamental to improving global health. Early adolescence is a key stage of development, and thus validated tools to measure diet quality that are pertinent for the global context are needed.</p><p><strong>Methods: </strong>The GDQS and comparison metrics were estimated from 24-hour dietary recalls (Mexico: n = 2533; United States: n = 685; China: n = 1087, and United Kingdom: n = 1675). Regression models were conducted to evaluate the association between the change in 1 SD of each metric score and usual intake of nutrients, mean probability of nutrient adequacy, and biomarker and anthropometric outcomes adjusted by age, sex, socioeconomic status, educational level, urban/rural area, and usual energy intake (for dietary outcomes).</p><p><strong>Results: </strong>The GDQS showed a higher diet quality in China (16.7 points) and Mexico (15.9 points), followed by the United States (13.6 points) and the United Kingdom (12.2 points). The GDQS was found to be associated with the intake of micronutrients as well as noncommunicable disease (NCD)-related nutrients (fiber, added sugar, and saturated fat) (P < .05). The performance of the GDQS was comparable to all other metrics; yet, in the case of NCD-related nutrients the MDD-W was slightly inferior. Few associations were found across countries and metrics with biomarker and anthropometric outcomes.</p><p><strong>Conclusion: </strong>The GDQS was associated with the intake of micronutrients and NCD-related nutrients; these results suggest that the GDQS is an appropriate tool to monitor dietary quality among 10-14-year-olds across several contexts globally.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":"83 Supplement_1","pages":"50-60"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Megan Deitchler, Carolina Batis, Sabri Bromage, Joanne E Arsenault
{"title":"Development and Validation of Metrics of Diet, Menu, and Meal Quality for Children 2 to 14 Years of Age: Overview.","authors":"Megan Deitchler, Carolina Batis, Sabri Bromage, Joanne E Arsenault","doi":"10.1093/nutrit/nuae125","DOIUrl":"https://doi.org/10.1093/nutrit/nuae125","url":null,"abstract":"<p><strong>Objective: </strong>To describe the motivation for undertaking research to validate the Global Diet Quality Score (GDQS) for use among children 2-14 years of age, and to summarize results from the GDQS child validation research initiative presented in this Supplemental Issue.</p><p><strong>Background: </strong>To advance an agenda to address diet quality among children globally requires the availability of diet quality metrics that meet the following 5 criteria: (1) cross-country relevance; (2) cross-country validity; (3) compatibility with the use of low-cost data collection methods; (4) straightforward tabulation methods; and (5) provides a whole-of-diet measure. No existing metric meets all 5 criteria. The research in this Supplement aims to fill this gap.</p><p><strong>Methods: </strong>The GDQS was adapted for 3 different age groups (24-59 months, 5-9 years, and 10-14 years) and validated for predicting nutrient adequacy and noncommunicable disease (NCD)-related outcomes by analyzing cross-sectional dietary data from a diverse set of countries. Longitudinal associations between the GDQS and NCD-related outcomes were also evaluated.</p><p><strong>Results: </strong>Validation results show the GDQS is positively associated with energy-adjusted intakes of micronutrients and fiber, and negatively associated with energy-adjusted intakes of added sugar in most data sets. In longitudinal analyses, the GDQS was negatively associated with several adiposity and cardiometabolic outcomes.</p><p><strong>Conclusion: </strong>To routinely measure the quality of diets of children globally requires a new set of tools. The research in this Supplement helps fill this gap by describing work to develop and validate the GDQS for use among children 2-14 years of age, using data sets from diverse contexts across low-, middle-, and high-income countries. The research also fills a gap in the availability of a standardized metric for assessing the quality of meals and menus in institutional feeding settings by applying the GDQS validated for children to the development of a GDQS-Meal and Menu metric.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":"83 Supplement_1","pages":"1-16"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joanne E Arsenault, Nazia Binte Ali, Agata M P Atayde, Carolina Batis, Elodie Becquey, Sabri Bromage, Megan Deitchler, Loty Diop, Aulo Gelli, Anali Castellanos Gutierrez, Sarah H Kehoe, Ghattu V Krishnaveni, Sofia Leonardo, Mourad Moursi, Brunhilda Tegomoh Nkengfack
{"title":"Development and Validation of the Global Diet Quality Score (GDQS) for Children 5 to 9 Years of Age.","authors":"Joanne E Arsenault, Nazia Binte Ali, Agata M P Atayde, Carolina Batis, Elodie Becquey, Sabri Bromage, Megan Deitchler, Loty Diop, Aulo Gelli, Anali Castellanos Gutierrez, Sarah H Kehoe, Ghattu V Krishnaveni, Sofia Leonardo, Mourad Moursi, Brunhilda Tegomoh Nkengfack","doi":"10.1093/nutrit/nuae146","DOIUrl":"https://doi.org/10.1093/nutrit/nuae146","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of the study was to develop and validate a Global Diet Quality Score (GDQS) for children aged 5-9 years adapted from the existing GDQS developed for adults.</p><p><strong>Background: </strong>Diet quality is important for nutrient adequacy and risk of nutrition-related chronic disease. A diet quality metric for global use with children is needed.</p><p><strong>Methods: </strong>The 25 food groups of the GDQS were used to assign points for categories of consumption according to gram-weight cutoffs adapted for children based on energy requirements. As a preliminary step, alternative versions of gram-weight cutoffs were tested by comparing correlation analyses using 4 existing dietary datasets from low-, middle-, and high-income countries. A final GDQS metric version, selected based on strength of correlations and operational feasibility, was further examined in regression analyses with individual nutrient intake an overall nutrient intake adequacy score and biomarker and anthropometry outcomes in 7 dietary datasets from different countries. Regressions were also undertaken with other diet quality metrics to compare their relative performance with that of the GDQS.</p><p><strong>Results: </strong>The GDQS had strong associations with most nutrient intakes, including an overall mean nutrient adequacy score and some nutrients associated with noncommunicable disease risk, such as fiber and added sugar. Biomarker data were limited in the available datasets and few associations with GDQS were found. The GDQS performed better or as well as other dietary quality metrics in predicting nutrient intakes.</p><p><strong>Conclusion: </strong>The GDQS was associated with nutrient intakes and fills a gap in a global diet quality metric for children. The GDQS will be a useful tool to measure diet quality and monitoring changes in diet quality over time.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":"83 Supplement_1","pages":"37-49"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victor de la O, Edwin Fernández-Cruz, Alberto Valdés, Alejandro Cifuentes, Janette Walton, J Alfredo Martínez
{"title":"Exhaustive Search of Dietary Intake Biomarkers as Objective Tools for Personalized Nutrimetabolomics and Precision Nutrition Implementation.","authors":"Victor de la O, Edwin Fernández-Cruz, Alberto Valdés, Alejandro Cifuentes, Janette Walton, J Alfredo Martínez","doi":"10.1093/nutrit/nuae133","DOIUrl":"10.1093/nutrit/nuae133","url":null,"abstract":"<p><strong>Objective: </strong>To conduct an exhaustive scoping search of existing literature, incorporating diverse bibliographic sources to elucidate the relationships between metabolite biomarkers in human fluids and dietary intake.</p><p><strong>Background: </strong>The search for biomarkers linked to specific dietary food intake holds immense significance for precision health and nutrition research. Using objective methods to track food consumption through metabolites offers a more accurate way to provide dietary advice and prescriptions on healthy dietary patterns by healthcare professionals. An extensive investigation was conducted on biomarkers associated with the consumption of several food groups and consumption patterns. Evidence is integrated from observational studies, systematic reviews, and meta-analyses to achieve precision nutrition and metabolism personalization.</p><p><strong>Methods: </strong>Tailored search strategies were applied across databases and gray literature, yielding 158 primary research articles that met strict inclusion criteria. The collected data underwent rigorous analysis using STATA and Python tools. Biomarker-food associations were categorized into 5 groups: cereals and grains, dairy products, protein-rich foods, plant-based foods, and a miscellaneous group. Specific cutoff points (≥3 or ≥4 bibliographic appearances) were established to identify reliable biomarkers indicative of dietary consumption.</p><p><strong>Results: </strong>Key metabolites in plasma, serum, and urine revealed intake from different food groups. For cereals and grains, 3-(3,5-dihydroxyphenyl) propanoic acid glucuronide and 3,5-dihydroxybenzoic acid were significant. Omega-3 fatty acids and specific amino acids showcased dairy and protein foods consumption. Nuts and seafood were linked to hypaphorine and trimethylamine N-oxide. The miscellaneous group featured compounds like theobromine, 7-methylxanthine, caffeine, quinic acid, paraxanthine, and theophylline associated with coffee intake.</p><p><strong>Conclusions: </strong>Data collected from this research demonstrate potential for incorporating precision nutrition into clinical settings and nutritional advice based on accurate estimation of food intake. By customizing dietary recommendations based on individualized metabolic profiles, this approach could significantly improve personalized food consumption health prescriptions and support integrating multiple nutritional data.This article is part of a Nutrition Reviews special collection on Precision Nutrition.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"925-942"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}