Nutrition reviews最新文献

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One Tax Does Not Fit All: Bridging Global Goals With Local Realities. 一种税不适合所有人:将全球目标与地方现实联系起来。
IF 4.9 2区 医学
Nutrition reviews Pub Date : 2025-10-13 DOI: 10.1093/nutrit/nuaf174
Herul Wahyudin, Maria Oktasari, Riza Amalia
{"title":"One Tax Does Not Fit All: Bridging Global Goals With Local Realities.","authors":"Herul Wahyudin, Maria Oktasari, Riza Amalia","doi":"10.1093/nutrit/nuaf174","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf174","url":null,"abstract":"","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tailoring Fiscal Food Policies to Diverse Contexts: A Shared Priority. 根据不同情况调整财政粮食政策:共同的优先事项。
IF 4.9 2区 医学
Nutrition reviews Pub Date : 2025-10-13 DOI: 10.1093/nutrit/nuaf175
Ágota Mészáros, Zoltán Vokó
{"title":"Tailoring Fiscal Food Policies to Diverse Contexts: A Shared Priority.","authors":"Ágota Mészáros, Zoltán Vokó","doi":"10.1093/nutrit/nuaf175","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf175","url":null,"abstract":"","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation Determinants of Nutrition Interventions in the Charitable Food System in the United States: A Scoping Review. 美国慈善食品系统中营养干预的实施决定因素:范围审查。
IF 4.9 2区 医学
Nutrition reviews Pub Date : 2025-10-13 DOI: 10.1093/nutrit/nuaf183
Ruyu Liu, Shariwa Oke, Qingyu Shao, Matthew R Kibbee
{"title":"Implementation Determinants of Nutrition Interventions in the Charitable Food System in the United States: A Scoping Review.","authors":"Ruyu Liu, Shariwa Oke, Qingyu Shao, Matthew R Kibbee","doi":"10.1093/nutrit/nuaf183","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf183","url":null,"abstract":"<p><p>This scoping review aims to describe the characteristics of nutrition interventions in the charitable food system (CFS), and to map knowledge gaps on the barriers and facilitators to implementing these interventions. Originally an emergency food source, the CFS has become the main food source for the food-insecure population in the United States. Nutrition interventions in this setting have proliferated; however, knowledge of their implementation remained fragmented. A search was conducted on November 22, 2023, in 7 databases (PubMed, Web of Science Core Collection, CAB Abstracts, BIOSIS Previews, PsycINFO, CINAHL, Scopus) and 4 gray literature sources (ProQuest Dissertations and Theses Global, PubAg, Healthy Eating Research Database, and Feeding America). Backward and forward citations of all included studies were screened for relevance. Studies were excluded if they were conducted outside the United States, did not involve the CFS, or did not address implementation. There were no restrictions on research design or publication year. Findings on implementation determinants were summarized based on the Consolidated Framework for Implementation Research. A total of 79 studies and 71 distinct interventions were included. Over half of the interventions took place in urban areas. Food banks and pantries were the most common settings. Most interventions were multicomponent, featuring nutrition and health education, behavioral economics, produce prescriptions, food provision, and nutrition policy and guideline modifications. Common implementation barriers were related to limited resources at CFS organizations and intervention participant characteristics. Common facilitators included partnerships and connections, meeting participants' needs, and alignment between the intervention's mission and that of the CFS organizations. Further research is needed to address knowledge gaps in underexplored implementation determinants, such as intervention deliverers' needs, intraorganizational communication, and external pressures. Additionally, there is a need to examine the implementation of nutrition interventions in rural areas and soup kitchens.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infant and Young Child Feeding in Crisis: Addressing Infant Nutrition Challenges During Humanitarian Emergencies-Editorial. 危机中的婴幼儿喂养:应对人道主义紧急情况下的婴儿营养挑战-社论。
IF 4.9 2区 医学
Nutrition reviews Pub Date : 2025-10-11 DOI: 10.1093/nutrit/nuaf173
Suriyaraj Shanmugasundaram Prema, Deepankumar Shanmugamprema
{"title":"Infant and Young Child Feeding in Crisis: Addressing Infant Nutrition Challenges During Humanitarian Emergencies-Editorial.","authors":"Suriyaraj Shanmugasundaram Prema, Deepankumar Shanmugamprema","doi":"10.1093/nutrit/nuaf173","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf173","url":null,"abstract":"","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward Holistic Psychiatry: Saffron, SSRIs, and the Future of Natural Mental Health Interventions. 走向整体精神病学:藏红花、SSRIs和自然心理健康干预的未来。
IF 4.9 2区 医学
Nutrition reviews Pub Date : 2025-10-10 DOI: 10.1093/nutrit/nuaf180
Wikan Galuh Widyarto, Rudi Haryadi, Masnurrima Heriansyah, Rikas Saputra, Nila Zaimatus Septiana, Muchammad Saiful Machfud, Dony Apriatama, Nurul Aini
{"title":"Toward Holistic Psychiatry: Saffron, SSRIs, and the Future of Natural Mental Health Interventions.","authors":"Wikan Galuh Widyarto, Rudi Haryadi, Masnurrima Heriansyah, Rikas Saputra, Nila Zaimatus Septiana, Muchammad Saiful Machfud, Dony Apriatama, Nurul Aini","doi":"10.1093/nutrit/nuaf180","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf180","url":null,"abstract":"","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Nutritional Interventions for Stroke Recovery: A Systematic Review. 口服营养干预中风恢复:系统综述。
IF 4.9 2区 医学
Nutrition reviews Pub Date : 2025-10-09 DOI: 10.1093/nutrit/nuaf179
Alexander Lang, Mario Álvarez-Martínez, Mohammed Gulrez Zariwala, Aravind Ganesh, Sharon Geva, Sumantra Ray, Nicholas R Evans, Sanjoy K Deb
{"title":"Oral Nutritional Interventions for Stroke Recovery: A Systematic Review.","authors":"Alexander Lang, Mario Álvarez-Martínez, Mohammed Gulrez Zariwala, Aravind Ganesh, Sharon Geva, Sumantra Ray, Nicholas R Evans, Sanjoy K Deb","doi":"10.1093/nutrit/nuaf179","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf179","url":null,"abstract":"<p><strong>Context: </strong>Suboptimal nutritional status has been observed in stroke patients throughout the stroke recovery pathway, negatively impacting recovery and rehabilitation outcomes. Oral nutritional supplements (ONSs) can correct deficiencies and treat malnutrition and may support rehabilitation following a stroke.</p><p><strong>Objectives: </strong>In this systematic review we aimed to synthesize evidence on the effects of oral nutritional interventions on functional, cognitive, and psychological outcomes of stroke rehabilitation, such as independence or activities of daily living (ADLs), muscle function, cognition, and mood.</p><p><strong>Data sources: </strong>The search strategy and inclusion/exclusion criteria were established according to the participants, intervention, comparators, and outcome (PICO) framework. Two reviewers screened titles and abstracts using search terms related to stroke rehabilitation or recovery and nutritional supplementation using the databases Web of Sciences, PubMed, Google Scholar, and Scopus.</p><p><strong>Data extraction: </strong>This review included randomized controlled trials (RCTs) that assessed the effects of oral nutritional interventions on rehabilitation outcomes in stroke patients. Details of the interventions and main outcomes were extracted independently by 2 researchers.</p><p><strong>Data analysis: </strong>Twenty-four reports (comprising 23 studies) that met the inclusion/exclusion criteria were finally included in the review. The included studies were grouped according to the type of nutritional intervention, including protein-energy supplements, essential amino acids, vitamin D supplementation, and a heterogeneous group of interventions with different polyphenols and omega-3 supplements. Overall, this review reports mixed results for the effects of nutritional interventions on stroke survivors.</p><p><strong>Conclusions: </strong>The evidence suggests that stroke patients with greater nutritional needs may benefit most from targeted interventions. Furthermore, protein-based ONS interventions were suggested to augment functional outcomes when supplemented alongside exercise rehabilitation, including a resistance training component. Further evidence is needed before these findings can be adopted into clinical guidance. Although there were some promising results for other non-protein-related interventions, there were also contradictory findings, with heterogeneity between studies and variability in interventions limiting the transferability of findings to recommendations for clinical practice.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Undernutrition and Child Development in Low- and Middle-Income Countries: A Meta-analysis. 中低收入国家的急性营养不良与儿童发育:一项荟萃分析。
IF 4.9 2区 医学
Nutrition reviews Pub Date : 2025-10-06 DOI: 10.1093/nutrit/nuaf178
Nazia Binte Ali, Mathilda Regan, Nandita Perumal, Carol Mita, Mark Lambiris, Günther Fink, Goodarz Danaei, Christopher R Sudfeld
{"title":"Acute Undernutrition and Child Development in Low- and Middle-Income Countries: A Meta-analysis.","authors":"Nazia Binte Ali, Mathilda Regan, Nandita Perumal, Carol Mita, Mark Lambiris, Günther Fink, Goodarz Danaei, Christopher R Sudfeld","doi":"10.1093/nutrit/nuaf178","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf178","url":null,"abstract":"<p><strong>Context: </strong>The association between linear growth faltering and child development outcomes is generally well recognized; however, the relationship between metrics of acute undernutrition and development has received less attention.</p><p><strong>Objectives: </strong>We aimed to quantify the association between metrics of acute undernutrition in childhood with development outcomes in low- and middle-income countries (LMICs).</p><p><strong>Methods: </strong>We conducted a systematic literature review of observational studies that assessed the association between metrics of acute undernutrition, including body mass index-for-age z score (BMIZ), midupper arm circumference (MUAC), weight-for-height/-length z score (WHZ/WLZ), wasting (WHZ/WLZ < -2), and severe acute malnutrition (SAM) among children under 5 years of age with cognitive, motor, language, and socioemotional development assessed to 19 years of age. We estimated the pooled correlation and standardized mean difference (SMD) for cross-sectional and longitudinal studies.</p><p><strong>Results: </strong>A total of 113 studies from 40 LMICs were identified. Metrics of acute undernutrition were associated with lower cognitive and motor development scores. In longitudinal studies that reported multivariable-adjusted estimates for the cognitive domain, SAM was associated with -1.06 SD lower scores (95% CI: -1.41, -0.72) compared with children without SAM. SAM was also associated with lower motor scores in longitudinal studies with unadjusted estimates (SMD: -0.42; 95% CI: -0.68, -0.15). In longitudinal studies with multivariable estimates, wasting was associated with lower motor scores (SMD: -0.30; 95% CI: -0.54, -0.06), but there was no association with language (SMD: -0.08; 95% CI: -0.24, 0.07) or prosocial development scores (SMD: -0.18; 95% CI: -0.38, 0.02).</p><p><strong>Conclusion: </strong>Metrics of acute undernutrition in childhood were consistently associated with lower development scores, and the magnitude appeared stronger for children with SAM or wasting.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42022310077.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Omega-3 Polyunsaturated Fatty Acid Supplements on Cognitive Performance in Patients with Mild Cognitive Impairment or Alzheimer's Disease: A Systematic Review and Meta-Analysis. 补充Omega-3多不饱和脂肪酸对轻度认知障碍或阿尔茨海默病患者认知能力的影响:一项系统综述和荟萃分析
IF 4.9 2区 医学
Nutrition reviews Pub Date : 2025-10-01 DOI: 10.1093/nutrit/nuaf167
Pipasha Khatun, Xinxin Li, Zhu Xiaoxi, Junya Zhai, Amin Ullah, Yacong Bo, Quanjun Lyu
{"title":"Effect of Omega-3 Polyunsaturated Fatty Acid Supplements on Cognitive Performance in Patients with Mild Cognitive Impairment or Alzheimer's Disease: A Systematic Review and Meta-Analysis.","authors":"Pipasha Khatun, Xinxin Li, Zhu Xiaoxi, Junya Zhai, Amin Ullah, Yacong Bo, Quanjun Lyu","doi":"10.1093/nutrit/nuaf167","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf167","url":null,"abstract":"<p><strong>Context: </strong>A positive effect of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on brain activity has been observed within subjects who have Alzheimer's disease (AD) or mild cognitive impairment (MCI). However, inconsistent findings have been reported regarding the efficacy or ineffectiveness of an n-3 PUFA dietary intervention for cognitive improvement.</p><p><strong>Objective: </strong>To address this problem, our thorough investigation and statistical analysis sought to assess the impact of n-3 PUFA dietary intake on cognitive function among persons diagnosed with AD or MCI.</p><p><strong>Data sources: </strong>The databases consulted included PubMed, PubMed Central Library, and the Cochrane Library.</p><p><strong>Data extraction: </strong>Nine articles reporting on the findings of randomized controlled trials that looked at the link between n-3 PUFA intake and cognitive performance-related outcomes were included in the comprehensive evaluation, with the meta-analysis utilizing 7 of these. Key details such as author, publication year, study area, research type, pathology (MCI or AD), were incorporated into the data extraction procedure.</p><p><strong>Data analysis: </strong>Evaluation of the included studies used Cochrane risk-of-bias instruments, a random-effects model, standardized mean differences (SMDs) and 95% CIs.</p><p><strong>Results: </strong>Our findings have provided evidence of the effectiveness of an n-3 PUFA treatment in improving Full-Scale IQ (FSIQ) (SMD -0.82; 95% CI: -1.57, -0.08; P = .000), information processing (SMD -2.90; 95% CI: -5.25, -0.56; P = .000), and digit span/working memory/attention aspects of cognitive functioning (SMD -1.89; 95% CI: -3.27, -0.51; P = .000). No evidence was found for the effectiveness of an n-3 PUFA treatment in improving image completion (SMD -0.07; 95% CI: -0.50, 0.35; P = .000), picture layout (SMD -0.08; 95% CI: -0.32, 0.16; P = .075), block design SMD -0.15; 95% CI: -0.37, 0.03; P = .123), or arithmetic aspects of cognitive functioning (SMD -0.33; 95% CI: -0.61, 0.04; P = .007).</p><p><strong>Conclusion: </strong>In summary, n-3 PUFAs have been found to significantly affect some domains of cognitive function, such as FSIQ, information processing, and digit span/working memory/attention in subjects with MCI. However, no significant effect was observed for some domains, such as picture completion, picture arrangement, or block design.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Vitamin D Deficiency in Pregnant Women: Systematic Review and Meta-analysis. 孕妇维生素D缺乏症的患病率:系统回顾和荟萃分析。
IF 4.9 2区 医学
Nutrition reviews Pub Date : 2025-09-19 DOI: 10.1093/nutrit/nuaf168
Milena Martello Cristófalo, Júlio Oliva de Almeida Garcia, José Fernando Santos Aldrighi, Renan Martello Cristófalo, Maria Laura Marconi França, Liania Alves Luzia, Suleima Pedroza Vasconcelos, José Mendes Aldrighi
{"title":"Prevalence of Vitamin D Deficiency in Pregnant Women: Systematic Review and Meta-analysis.","authors":"Milena Martello Cristófalo, Júlio Oliva de Almeida Garcia, José Fernando Santos Aldrighi, Renan Martello Cristófalo, Maria Laura Marconi França, Liania Alves Luzia, Suleima Pedroza Vasconcelos, José Mendes Aldrighi","doi":"10.1093/nutrit/nuaf168","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf168","url":null,"abstract":"<p><strong>Context: </strong>Vitamin D is an essential steroid prehormone whose effects have garnered significant interest during pregnancy and lactation. Adequate vitamin D levels are crucial for embryonic implantation, immune modulation, and preventing adverse maternal outcomes such as preeclampsia, gestational diabetes, and preterm birth.</p><p><strong>Objectives: </strong>To estimate the prevalence of vitamin D deficiency in each trimester of pregnancy.</p><p><strong>Data sources: </strong>This is a systematic review and meta-analysis, conducted according to the PRISMA guidelines. Online databases were searched from inception to July 2023, including Medline/PubMed, Embase, and LILACS.</p><p><strong>Data extraction: </strong>All English, Spanish, and Portuguese articles that specified the prevalence of vitamin D deficiency in each of the 3 trimesters of pregnancy were included. All screening and data extraction were performed independently by 2 authors. Risk-of-bias assessment was performed using the Newcastle-Ottawa Scale.</p><p><strong>Data analysis: </strong>A total of 2627 articles were retrieved, and after evaluating eligibility criteria, 116 full-text articles were included. These comprised observational studies, totaling 127 290 pregnant women who underwent serum 25(OH)D evaluation. Vitamin D deficiency is a common condition among pregnant women. The meta-analysis revealed that 68% (95% CI, 60%-76%) of pregnant women had 25(OH)D <30 ng/mL in the first trimester, 81% (95% CI, 74%-87%) in the second trimester, and 70% (95% CI, 64%-75%) in the third trimester, indicating a widespread deficiency of this vitamin.</p><p><strong>Conclusion: </strong>A thorough analysis of the studies included in this review shows that hypovitaminosis D during pregnancy is a highly prevalent condition that occurs in all 3 trimesters. Given this high prevalence, these findings may be valuable for planning public health policies aimed at pregnant women.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42022343256.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Vitamin D2 Supplementation on 25-Hydroxyvitamin D3 Status: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 补充维生素D2对25-羟基维生素D3状态的影响:随机对照试验的系统回顾和荟萃分析。
IF 4.9 2区 医学
Nutrition reviews Pub Date : 2025-09-18 DOI: 10.1093/nutrit/nuaf166
Emily I G Brown, Andrea L Darling, Tracey M Robertson, Kathryn H Hart, Jie Li, Cathie Martin, Martin J Warren, Colin P Smith, Susan A Lanham-New, Ruan M Elliott
{"title":"Effect of Vitamin D2 Supplementation on 25-Hydroxyvitamin D3 Status: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Emily I G Brown, Andrea L Darling, Tracey M Robertson, Kathryn H Hart, Jie Li, Cathie Martin, Martin J Warren, Colin P Smith, Susan A Lanham-New, Ruan M Elliott","doi":"10.1093/nutrit/nuaf166","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf166","url":null,"abstract":"<p><strong>Context: </strong>Researchers have identified differences in metabolic activity between vitamins D2 and D3. Moreover, it is suspected from randomized controlled trial data that vitamin D2 supplementation increases the metabolic clearance of 25-hydroxyvitamin D3 [25(OH)D3], but this effect has yet to be quantified.</p><p><strong>Objective: </strong>This study sought to undertake a systematic review and meta-analysis of the effect of vitamin D2 supplementation on serum 25(OH)D3 concentrations.</p><p><strong>Data sources: </strong>PUBMED was searched for articles published from January 1, 1975, to February 1, 2023. Of the 202 articles retrieved, 20 were included in this review, and of those, 11 were suitable for meta-analysis.</p><p><strong>Data extraction: </strong>Randomized controlled trials reporting either baseline and postintervention serum 25(OH)D3 concentrations (nmol/L) or absolute changes in concentrations were included. Random-effects meta-analyses were calculated using Review Manager (version 5.3; The Cochrane Collaboration). Mean differences were reported with 95% CIs.</p><p><strong>Data analysis: </strong>In meta-analyses there was a reduction in serum 25(OH)D3 after vitamin D2 supplementation compared with control for end-of-trial between-groups data (random weighted mean difference [WMD] = -17.99 nmol/L; 95% CI, -25.86 to -10.12; P < .00001) and absolute change over the trial (random WMD = -9.25 nmol/L; 95% CI, -14.40 to -4.10; P = .0004).</p><p><strong>Conclusions: </strong>Study participants who received vitamin D2 supplementation showed statistically significant reductions in serum 25(OH)D3 concentrations, compared to controls without supplementation. An inverse relationship between vitamin D2 and D3 concentrations has been proposed in the literature. A regulatory mechanism that increases the disposal rate of 25(OH)D after an increase in vitamin D concentrations could explain these results. However, further research is needed to establish whether vitamins D2 and D3 elicit different changes in overall vitamin D metabolism that might influence clinical advice to recommend vitamin D3 supplements over vitamin D2 supplements, where appropriate.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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