Nutrition reviews最新文献

{"title":"Childcare and Meal Provision: A Systematic Literature Review.","authors":"Brett A Eiffes, Sarah A White, Sophia M Navarro, Maria H Boyle, Rebecca L Franckle","doi":"10.1093/nutrit/nuaf026","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf026","url":null,"abstract":"<p><strong>Background: </strong>The Child and Adult Care Food Program (CACFP) provides reimbursement for meals and snacks that meet nutrition standards served to children enrolled at participating childcare centers and family daycare homes. This program plays an important role in the health and well-being of children and families. Despite the benefits, many eligible childcare providers do not participate in CACFP. The barriers to participation have not been fully examined.</p><p><strong>Objectives: </strong>The objectives of this review are to describe meal service operations and practices of childcare providers who participate and those who do not participate in CACFP and to describe characteristics of childcare settings, including differences by CACFP participation status.</p><p><strong>Methods: </strong>The study team searched databases, including PubMed, Academic Search Ultimate, and Web of Science, for relevant literature published from 2013 to 2023. Studies were included if they described any type of meal service operation or practice in a childcare setting that served children from birth to age 5. A member of the review team extracted data on study characteristics, target populations, meal service and operations, childcare characteristics, staffing information, and barriers to and facilitators of CACFP participation. Results were synthesized thematically.</p><p><strong>Results: </strong>Thirty-seven articles were included in this review. Thirty of the studies used a cross-sectional design. Thirty of the studies were published between 2018 and 2022. The majority of studies identified in this review (n = 30) presented information on childcare characteristics. Nineteen studies discussed meal service operations and practices by CACFP participation status, and 18 studies identified barriers to and/or facilitators of CACFP participation.</p><p><strong>Conclusion: </strong>The information on barriers to CACFP participation and childcare meal service operations in this systematic literature review identified potential opportunities to increase CACFP participation. However, more geographically representative research is needed, in addition to research focused on providers who do not participate in CACFP.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Effects of Vitamin C Supplements on Clinical Outcomes and Hospitalization Duration for Patients with Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis.","authors":"","doi":"10.1093/nutrit/nuaf034","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf034","url":null,"abstract":"","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Properties of Questionnaires to Assess the Family Food Environment in the Pediatric Population: A Systematic Review.","authors":"Letícia Gabrielle Souza, Keisyanne De Araujo-Moura, Augusto César Ferreira De Moraes","doi":"10.1093/nutrit/nuaf018","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf018","url":null,"abstract":"<p><strong>Context: </strong>Given the diverse aspects of the family food environment, it is essential to clarify the availability of tools, the assessed dimensions, and the extent to which they offer a comprehensive and valid evaluation of the domestic food setting.</p><p><strong>Objective: </strong>This systematic review aims to assess the validity and reliability of instruments gauging the food environment within the pediatric population.</p><p><strong>Data sources: </strong>A systematic literature search was conducted in the EMBASE, Medline (PubMed), SCOPUS, Web of Science, and PsychINFO databases until December 2023, resulting in the identification of 2850 potentially eligible articles.</p><p><strong>Data extraction: </strong>After a thorough screening process, comprising language and title criteria, abstract scrutiny, and full-text reading, 179 full papers were separately reviewed, and 52 were chosen for analysis.</p><p><strong>Data analysis: </strong>Predominantly conducted in the United States utilizing adapted tools, the investigations focused on the sociocultural environment as the most addressed domain. It covered 80.7% of instruments for children and 54.9% for adolescents. The prevailing reliability assessment method was internal consistency, using Cronbach's alpha-coefficient. Acceptable values ranged from 0.70 to 0.96 for children and 0.77 to 0.94 for adolescents. Out of the 52 studies selected, only 22 presented validity measures, with a primary focus on convergent and construct validity assessed through Pearson or Spearman correlation. The findings indicate that, while questionnaires assessing the family food environment exhibited acceptable reliability, validity measures were deemed limited and somewhat ambiguous.</p><p><strong>Conclusion: </strong>Given the pivotal role of validity in evaluating methodological accuracy and relevance, particularly when measuring specific aspects, there is an imperative need to develop instruments that integrate robust validity measures for the comprehensive assessment of the family food environment.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42022333228.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Effects of Iron and Multiple Micronutrient Supplementation on Hematological and Growth Indicators among Older Children, Adolescents, and Young Adults in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Ai Zhao, Xiaona Na, Fengqi Liu, Zekun Chen, Huanhuan Yang, Dongqing Wang, Christopher R Sudfeld, Zhihui Li, Wafaie W Fawzi","doi":"10.1093/nutrit/nuaf019","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf019","url":null,"abstract":"<p><strong>Context: </strong>Middle childhood, adolescence, and young adulthood are characterized by high nutritional demands and vulnerability to anemia. Limited efforts have been made to synthesize the evidence comparing the effects of iron and multiple micronutrient (MMN) supplementation in these populations.</p><p><strong>Objective: </strong>In this study we sought to examine the effects of iron and MMN on anemia and anthropometric variables among people aged 5 to 24 years in low- and middle-income countries.</p><p><strong>Data sources: </strong>The PubMed, Embase, Cochrane Library, and CINAHL databases were searched from inception to July 2024 to identify 50 randomized controlled trials (RCTs) of iron or MMN supplementation with outcomes.</p><p><strong>Data extraction: </strong>Only RCTs that used iron or MMN were included in this analysis.</p><p><strong>Data analysis: </strong>Compared to placebo, supplementation with iron and MMN was associated with 5.81 g/L (95% CI: 4.19-7.44 g/L) and 4.82 g/L (95% CI: 2.32-7.32 g/L) incremental increases in hemoglobin levels, respectively. The therapeutic effects of MMN (hemoglobin: 9.3 g/L, 95% CI: 1.52-17.09 g/L) and iron (10.24 g/L, 95% CI: 5.10-15.39 g/L) were both observed in populations of older children, adolescents, and young adults with anemia. Stratified analysis showed that with either MMN or iron supplementation, higher iron content (> 30 mg/d) could lead to a higher increment of hemoglobin, while a shorter intervention duration (< 3 months) showed more benefits in improving hemoglobin. For ferritin, the significant benefit of supplementation was observed only with iron and not with MMN. Iron was also found to decrease serum transferrin receptor and zinc protoporphyrin, but there was no effect on C-reactive protein. For growth indicators, iron was found to increase weight (0.52 kg, 95% CI: 0.12-0.93 kg), while MMN was found to increase height (0.87 cm, 95% CI: 0.16-1.59 cm).</p><p><strong>Conclusions: </strong>Overall, supplementation with iron compared with MMN had similarly beneficial effects on improving the hemoglobin level in older children, adolescents, and young adults, but there was some indication that there may be differential effects on growth indicators.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Fluoride on Gut Microbiota: A Systematic Review.","authors":"Momina Yasin, Fatemeh Vida Zohoori, Elizabeth Adjoa Kumah, Murali Subramanian, Paul Dean, Caroline Hayley Orr","doi":"10.1093/nutrit/nuae202","DOIUrl":"https://doi.org/10.1093/nutrit/nuae202","url":null,"abstract":"<p><strong>Context: </strong>Fluoride can prevent dental caries by inhibiting demineralization and promoting remineralization of teeth while affecting the physiology of oral microbiota, thus inhibiting cellular enzymes. However, the effect of systemic fluoride on gut microbiota is unknown.</p><p><strong>Objective: </strong>To explore the impacts of systemic fluoride on gut microbiota composition and abundance and associated functions such as gene and metabolic regulation.</p><p><strong>Data sources: </strong>A systematic database search was conducted of MEDLINE, Web of Science, Scopus, PubMed, CINAHL, and Embase to find articles on studies reporting the effects of fluoride on gut microbiota.</p><p><strong>Data extraction: </strong>Forty-nine studies were included (n = 42 in animals, 4 of humans, 3 in vitro studies) after screening for title, abstract, and full text using Covidence to check against eligibility criteria. Data were extracted using Covidence and study quality was assessed using the Mixed Method Appraisal Tool by 2 reviewers independently.</p><p><strong>Data analysis: </strong>Two human studies of dental fluorosis and 1 of patients with breast cancer (intestinal fluorine-18 fluorodeoxyglucose uptake) showed significant differences in gut microbial composition, with increased relative abundance of Acidobacteria and Proteobacteria, and decreased abundance of Firmicutes and Bacteroidetes. An ex vivo study of human feces indicated that ≤ 2 mg L-1 NaF might boost \"health-associated\" taxa, but concentrations (≥ 10 mg L-1 NaF) could increase the ratio of some unhealthy microbes after 24 hours. The animal studies examined the effects of high fluoride doses in water and diet (50-1200 mg L-1 NaF) for long-term (1-6 months) and short-term (6 hours to 7 days) exposure, with all showing a significant disturbance in the Firmicutes to Bacteroidota ratio.</p><p><strong>Conclusion: </strong>In humans, high doses potentially may be detrimental to the microbiome, whereas ≤ 2 mg L-1 NaF had positive effects. Similarly, in animals, ≥ 50 mg L-1 NaF was unsafe, whereas ≤ 25 mg L-1 NaF had harmless effects.</p><p><strong>Systematic review registration: </strong>PROSPERO registration No. CRD42022347357.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Increasing Red Meat Intake on Iron Status in Adults with Normal and Suboptimal Iron Status: A Systematic Literature Review and Meta-Analysis of Intervention Studies.","authors":"Laura McManus, Katherine Veras, Vinicius S Faria, Mika Manninen, Brendan Egan","doi":"10.1093/nutrit/nuaf016","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf016","url":null,"abstract":"<p><strong>Context: </strong>Iron deficiency is the most prevalent nutrient deficiency globally. There is increasing interest in the use of food-based approaches for improving and maintaining iron status.</p><p><strong>Objective: </strong>A systematic literature review was conducted to identify, critically-appraise, and meta-analyze data from intervention studies that investigated the effect of increasing red meat intake on iron status in adults.</p><p><strong>Data extraction: </strong>The search was conducted using the PubMed, Web of Science, Scopus, Embase, Cochrane, SPORTDiscus, and Google Scholar databases, as well as other supplementary search strategies up to October 2024. Inclusion criteria for reviewed articles were participants who were adults aged 18 to 70 years, interventions that involved ≥4 weeks of increased red meat intake, included a suitable control condition, and measured at least 1 biomarker of iron status. The initial search yielded 5212 articles, with 10 articles (n = 397 participants) meeting the inclusion criteria.</p><p><strong>Data analysis: </strong>The effect of intervention on markers of iron status were analyzed using a meta-analytic multivariate model, and the potential moderating effect of multiple variables were considered. The final meta-analysis included 42 effects (k) for serum ferritin (k = 25) and hemoglobin (Hb; k = 17) concentrations. Interventions involving increasing red meat intake had no significant effect on serum ferritin concentrations (raw mean change difference [RMCD] = 1.87 μg L-1; 95% CI, -0.73 to 4.48; t = 1.619; P = .139) but did have a positive effect on Hb concentrations (RMCD = 2.36 g L-1; 95% CI, 0.71 to 4.02; t = 3.297; P = .011). Moderator analysis revealed a positive effect of increasing red meat intake on serum ferritin concentrations when the intervention lasted at least 8 weeks (RMCD = 2.27 μg L-1; 95% CI, 0.87 to 3.67), and longer than 16 weeks (RMCD = 5.62 μg L-1; 95% CI, 0.67 to 10.6).</p><p><strong>Conclusions: </strong>Increasing red meat intake can improve iron status as indicated by increases in serum ferritin and Hb concentrations, but the extent to which such increases are clinically meaningful remains to be established.</p><p><strong>Systematic review registration: </strong>PROSPERO registration No. CRD42023479349.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Vitamin Administration on Orthodontic Tooth Movement: A Scoping Review.","authors":"Claudia Butrón-Téllez Girón, Moisés Sánchez-Almanza, Alan Martínez-Zumarán, Amaury Pozos-Guillén, Arturo Garrocho-Rangel","doi":"10.1093/nutrit/nuaf024","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf024","url":null,"abstract":"<p><strong>Context: </strong>Orthodontic tooth movement (OTM) is possible by bone remodeling that takes place during orthodontic therapy. The rate at which teeth move is determined by a variety of factors that can impact bone remodeling. Vitamins are well-known antioxidants that influence bone turnover.</p><p><strong>Objective: </strong>This scoping review was designed to appraise the effects of the local and systemic administration of vitamins C, D, and E principally on fixed orthodontic treatment, retention, and relapse.</p><p><strong>Method: </strong>A scoping review protocol was applied following the recommendations of the Preferred Reporting Item for Systematic Reviews and Meta-analysis Guidelines for Scoping Reviews. A detailed search strategy, including main keywords and synonyms, was applied in the following electronic databases: PubMed (via MEDLINE), Embase (via Ovid), Cochrane Library, and Web of Sciences, for articles published in English in the past 10 years.</p><p><strong>Results: </strong>The database online search identified 70 potential articles. After removing duplicates, 39 full-text articles were independently evaluated. Eighteen studies were discarded. The remaining 21 studies were finally included. Of these selected studies, 8 were conducted on animals, 9 were conducted with human participants, 1 was an in vitro study, and 3 were systematic reviews. One systematic review and meta-analysis was also included.</p><p><strong>Conclusion: </strong>Based on a variety of animal and human investigations, the findings of this scoping review imply that vitamins C, D, and E accelerate OTM by facilitating the bone remodeling process. However, more powerful randomized clinical trials are still required to reinforce the knowledge of vitamins' influence on orthodontic therapy.</p><p><strong>Scoping review registration: </strong>OSF identifier 10.17605/OSF.IO/HNW9Z.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Chrono-Exercise and Chrono-Nutrition on Muscle Health: Understanding the Molecular Mechanisms Activated by Timed Exercise and Consumption of Proteins and Carbohydrates.","authors":"Mariarosaria Negri, Claudia Pivonello, Feliciana Amatrudo, Fabiano Cimmino, Giovanna Trinchese, Claudia Vetrani, Guido Iaccarino, Rosario Pivonello, Maria Pina Mollica, Annamaria Colao","doi":"10.1093/nutrit/nuaf007","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf007","url":null,"abstract":"<p><p>The circadian clock is an endogenous timekeeping system that regulates various physiological and behavioral processes. Recently, it has been shown that the timing of physical activity and food intake can significantly influence metabolic muscle health. Some recent clinical evidence has shown that physical activity practiced in the late afternoon can be more effective in terms of performance and muscle strength. Preclinical studies have highlighted that the explanation for this effect lies in the different daily expression in the muscle of clock genes and clock-controlled genes involved in muscle development and hypertrophy. In conjunction with scientific advances in understanding the molecular mechanisms that regulate circadian rhythms and muscle trophy, chrono-nutrition has gained scientific resonance and has become a promising field, aimed at understanding the regulation of body metabolism. Clinical and preclinical studies have shown that protein consumption at specific circadian time points during the day, or precisely after exercise, can activate signaling pathways involved in muscle protein synthesis and, thus, favor skeletal muscle mass development as well as mitochondrial biogenesis, thereby improving skeletal muscle cell energy production and function. On the other hand, some studies have shown that the consumption of carbohydrates immediately after exercise increases insulin secretion, which facilitates glucose uptake by muscle cells to replenish glycogen. This review summarizes the current scientific literature concerning chrono-exercise and chrono-nutrition and muscle health, focusing on molecular mechanisms involving the circadian regulation of muscle mass, strength, and health. Understanding the intricate molecular relationship between circadian rhythms, exercise, nutrition, and muscle metabolism is essential for optimizing nutritional strategies to prevent or treat muscle wasting. In addition, tailoring protein and carbohydrate intake to timing and individual needs can improve muscle maintenance, growth, and performance.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Circulating Levels of Magnesium and Metabolic Syndrome: A Systematic Review and Meta-Analysis of Observational Studies with GRADE Assessment.","authors":"Zahra Moradmand, Parisa Rouhani, Parvane Saneei","doi":"10.1093/nutrit/nuaf020","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf020","url":null,"abstract":"<p><strong>Context: </strong>Evidence on the associations between circulating magnesium (Mg) levels and metabolic syndrome (MetS) is inconclusive.</p><p><strong>Objective: </strong>In this meta-analysis we examined the relationship between Mg concentrations and MetS.</p><p><strong>Data sources: </strong>Observational studies were searched through the PubMed, EmBase, ISI Web of Science, and Scopus databases and Google Scholar, without time or language limitations, up to January 2024.</p><p><strong>Data extraction: </strong>Eligible studies were epidemiological investigations that reported relative risks or odds ratios [ORs] of MetS in relation to serum, plasma, or blood Mg levels. The certainty of each meta-analysis was assessed by use of the grading of recommendations, assessment, development, and evaluation (GRADE) approach.</p><p><strong>Data analysis: </strong>A total of 11 studies (9 cross-sectional and 2 case-control) were eligible to be included. Pooling estimates of these studies (with 14 188 individuals and 4724 cases with MetS) revealed that compared to individuals with the lowest level of Mg concentration, those with the highest Mg concentration had 46% significantly lower odds of MetS (OR = 0.54; 95% CI: 0.34-0.86). Each 0.5-mg/dL increase in the level of circulating Mg was related to an 11% reduction in the odds of contracting MetS (OR = 0.89; 95% CI: 0.83-0.96). Nonlinear analysis showed a U-shaped curve; the lowest likelihood of MetS was seen at a circulating Mg concentration of 2.5 mg/dL. Certainty of the evidence was high.</p><p><strong>Conclusions: </strong>In this meta-analysis of epidemiologic studies we documented that circulating Mg levels were inversely associated with MetS. Additional prospective studies are needed to provide more solid evidence for the optimal range of circulating Mg concentrations with respect to prevention of MetS.</p><p><strong>Systematic review registration: </strong>PROSPERO registration No. CRD42024535236.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Controlled Trials Investigating the Effect of Curcumin Supplementation on Lipid Profiles.","authors":"Chanita Unhapipatpong, Narachai Julanon, Prapimporn Chattranukulchai Shantavasinkul, Nint Polruang, Pawin Numthavaj, Ammarin Thakkinstian","doi":"10.1093/nutrit/nuaf012","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf012","url":null,"abstract":"<p><strong>Context: </strong>Dyslipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD), and curcumin may help improve lipid metabolism.</p><p><strong>Objective: </strong>This umbrella review and updated meta-analysis assessed the effects of curcumin supplementation on lipid profiles.</p><p><strong>Data sources: </strong>Electronic databases (Medline, Scopus, Cochrane, and Google Scholar) were searched through March 31, 2023, without language restrictions.</p><p><strong>Data extraction: </strong>Two independent authors selected eligible randomized controlled trials (RCTs) involving curcumin supplementation compared with placebo, measuring total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-c), high-density-lipoprotein cholesterol (HDL-c), and triglyceride (TG) levels.</p><p><strong>Data analysis: </strong>This study identified 26 systematic reviews and meta-analyses (MAs) that met the inclusion criteria for the umbrella review. Of these, 53 RCTs, with a corrected coverage area of 9.76% indicating a moderate degree of overlap, were included for re-pooling. Additionally, this study found 19 more RCTs, bringing the total number of studies for the updated MAs to 72.</p><p><strong>Results: </strong>Curcumin significantly reduced TC, LDL-c, and TG, with mean differences (MDs) of -7.76 mg/dL (95% CI: -11.29, -4.22; I2 = 97%), -5.84 mg/dL (95% CI: -11.63, -0.05; I2 = 98%), and -13.15 mg/dL (95% CI: -17.31, -8.98; I2 = 94%), respectively, and increased HDL-c by 2.4 mg/dL (95% CI: 1.22, 3.57; I2 = 94%). The reductions in LDL-c and TG reached the minimally clinically important differences (MCIDs). However, the reduction in TC and increase in HDL-c did not meet their respective MCIDs. Subgroup analysis showed greater lipid improvements in patients with metabolic-related diseases, particularly type 2 diabetes. Enhanced bioavailability forms of curcumin, supplementation for at least 8 weeks, and exercise yielded additional benefits.</p><p><strong>Conclusion: </strong>The study confirmed that curcumin has an anti-lipidemic effect on patients with noncommunicable diseases. A form of curcumin with enhanced bioavailability is preferred, and supplementation for at least 8 weeks, along with exercise, may be used as an accessible approach to reduce the risk of ASCVD.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42023415577.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}