衰老过程中肌酸与认知:对老年人证据的系统回顾。

IF 4.9 2区 医学 Q1 NUTRITION & DIETETICS
Samantha Marshall, Alexandra Kitzan, Jasmine Wright, Laura Bocicariu, Lindsay S Nagamatsu
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引用次数: 0

摘要

背景:肌酸是一种经过充分研究的膳食补充剂,已知对衰老的肌肉和骨骼有益,特别是与抗阻训练结合使用时。一些研究表明,肌酸也可能有利于认知功能,但这些独立的影响尚未在老年人中得到彻底的审查。目的:本研究的目的是系统地检查目前关于老年人肌酸和认知的文献。数据来源:在八个电子数据库中进行了全面的搜索。数据提取:纳入了调查老年人(55岁以上)补充肌酸和/或估计饮食肌酸摄入量的原始同行评议研究,并将认知评估作为结果。未单独检查肌酸和认知的研究,仅结合其他干预措施(如抗阻训练)被排除。使用Downs和Black(1998)检查表的修改版本对每项研究的方法学质量进行评估。数据分析:纳入6项研究,共1542名参与者(55.7%为女性)。大多数参与者样本包括健康的社区老年人,除了一项针对超重老年妇女的研究。两项研究是双盲干预,参与者补充一水肌酸。四项研究是横断面的,通过饮食回忆来估计肌酸消耗。六项研究中有五项(83.3%)报告了肌酸与老年人认知之间的正相关关系,特别是在记忆和注意力领域。一项研究的方法学质量评级为“好”,两项为“一般”,三项为“差”。结论:目前有限的证据表明,肌酸可能与一般健康老年人的认知益处有关。然而,需要高质量的临床试验来进一步验证这种关系。未来的研究应调查有明显认知缺陷的老年临床人群的肌酸补充情况,客观测量肌酸浓度,并考虑可能影响身体和大脑中肌酸水平的其他因素(如体重、肌肉质量、饮食摄入、身体活动水平)。系统评审注册:普洛斯彼罗号。CRD42025643617。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Creatine and Cognition in Aging: A Systematic Review of Evidence in Older Adults.

Context: Creatine is a well-studied dietary supplement that is known to benefit aging muscle and bone, especially when combined with resistance training. Some studies suggest that creatine may also be favorable for cognitive function, yet these independent effects have not been thoroughly reviewed in older adults.

Objective: The objective of this study was to systematically examine the current literature on creatine and cognition in older adults.

Data sources: A comprehensive search was conducted across eight electronic databases.

Data extraction: Original peer-reviewed studies investigating creatine supplementation and/or estimations of dietary creatine intake in older adults (aged 55+ years) with cognition assessed as an outcome were included. Studies not examining creatine and cognition exclusively, only in combination with another intervention (e.g., resistance training), were excluded. The methodological quality of each study was evaluated using a modified version of the Downs and Black (1998) checklist.

Data analysis: Six studies were included, with a total of 1542 participants (55.7% female). Most participant samples included healthy community-dwelling older adults, with the exception of one study examining overweight older women. Two studies were double-blind interventions in which participants were supplemented with creatine monohydrate. Four studies were cross-sectional and estimated creatine consumption through dietary recall. Five of the six (83.3%) studies reported a positive relationship between creatine and cognition in older adults, particularly in the domains of memory and attention. One study achieved a methodological quality rating of "good", two "fair", and three "poor".

Conclusion: The current limited evidence suggests that creatine may be associated with benefits for cognition in generally healthy older adults. However, high-quality clinical trials are warranted to further validate this relationship. Future research should investigate creatine supplementation in older clinical populations with notable cognitive deficits, objectively measure creatine concentrations, and consider additional factors that may influence creatine levels in the body and brain (e.g., body weight, muscle mass, dietary intake, physical activity levels).

Systematic review registration: PROSPERO No. CRD42025643617.

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来源期刊
Nutrition reviews
Nutrition reviews 医学-营养学
CiteScore
12.20
自引率
1.60%
发文量
121
审稿时长
6-12 weeks
期刊介绍: Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.
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