Nutrition reviews最新文献

{"title":"Impact of Nutrition on the Gut Microbiota: Implications for Parkinson's Disease.","authors":"Joana Sobral, Nuno Empadinhas, Ana Raquel Esteves, Sandra Morais Cardoso","doi":"10.1093/nutrit/nuae208","DOIUrl":"10.1093/nutrit/nuae208","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a multifactorial neurodegenerative disease that is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta and by the anomalous accumulation of α-synuclein aggregates into Lewy bodies and Lewy neurites. Research suggests 2 distinct subtypes of PD: the brain-first subtype if the pathology arises from the brain and then spreads to the peripheral nervous system (PNS) and the body-first subtype, where the pathological process begins in the PNS and then spreads to the central nervous system. This review primarily focuses on the body-first subtype. The influence of the gut microbiota on the development of PD has been the subject of growing interest among researchers. It has been suggested that gut inflammation may be closely associated with pathogenesis in PD, therefore leading to the hypothesis that gut microbiota modulation could play a significant role in this process. Nutrition can influence gut health and alter the risk and progression of PD by altering inflammatory markers. This review provides an overview of recent research that correlates variations in gut microbiota composition between patients with PD and healthy individuals with the impact of certain nutrients and dietary patterns, including the Mediterranean diet, the Western diet, and the ketogenic diet. It explores how these diets influence gut microbiota composition and, consequently, the risk of PD. Last, it examines fecal transplantation and the use of prebiotics, probiotics, or synbiotics as potential therapeutic strategies to balance the gut microbiome, aiming to reduce the risk or delay the progression of PD.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"713-727"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Sugar-Sweetened Beverages and Risk of Chronic Diseases: An Umbrella Review of Meta-analyses of Prospective Cohort Studies.","authors":"Sara Beigrezaei, Hamidreza Raeisi-Dehkordi, Juliana Alexandra Hernández Vargas, Mojgan Amiri, Vicente Artola Arita, Yvonne T van der Schouw, Amin Salehi-Abargouei, Taulant Muka, Angeline Chatelan, Oscar H Franco","doi":"10.1093/nutrit/nuae135","DOIUrl":"10.1093/nutrit/nuae135","url":null,"abstract":"<p><strong>Context: </strong>Several effects of non-sugar-sweetened beverage (NSSBs) intake on health outcomes have been reported; however, the evidence on the association between NSSBs intake and chronic diseases and mortality risk is still inconclusive.</p><p><strong>Objective: </strong>This umbrella review aimed to summarize the evidence on the association between NSSBs intake and the risk of chronic diseases and mortality.</p><p><strong>Data sources: </strong>Embase, ISI Web of Science, Cochrane Central, and PubMed were searched up to September 2023 for relevant meta-analyses of observational prospective cohort studies.</p><p><strong>Data extraction: </strong>Two groups of researchers independently extracted study data and assessed the risk of bias for meta-analyses and primary studies.</p><p><strong>Data analysis: </strong>Six meta-analyses, reporting 74 summary hazard ratios (HRs) for different outcomes obtained from 50 primary studies, were included. The summary HRs, 95% CIs, and certainty of evidence on the association of NSSBs intake with risk of chronic diseases and mortality were as follows: all-cause mortality (per 355 mL/d: 1.06 [1.01 to 1.10]; moderate certainty); stroke (per 250 mL/d: 1.09 [1.04 to 1.13]; high certainty); coronary heart disease (CHD) (per 250 mL/d: 1.06 [1.02 to 1.11]; high certainty); hypertension (HTN) (high vs low intake: 1.14 [1.09 to 1.18]; moderate certainty); type 2 diabetes (T2D) (high vs low intake: 1.16 [1.08 to 1.26]; low certainty); metabolic syndrome (MetS) (high vs low intake: 1.32 [1.22 to 1.43]; low certainty); colorectal cancer (high vs low intake: 0.78 [0.62 to 0.99]; moderate certainty); and leukemia (high vs low intake: 1.35 [1.03 to 1.77]; moderate certainty). For other outcomes, including the risk of cardiovascular and cancer mortality, chronic kidney diseases, breast cancer, prostate cancer, endometrial cancer, pancreatic cancer, multiple myeloma, and non-Hodgkin lymphoma, no association was found.</p><p><strong>Conclusion: </strong>This study provides further evidence that NSSBs are associated with increased risk of all-cause mortality, stroke, CHD, HTN, T2D, MetS, and leukemia. Moreover, a higher intake of NSSBs was associated with a lower risk of colorectal cancer. However, it should be noted that the magnitudes of the associations are not large. Further studies are needed to clarify the long-term effects of different NSSBs intakes on health.</p><p><strong>Systematic review registration: </strong>PROSPERO no. CRD42023429981.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"663-674"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrigenetic and Epigenetic Mechanisms of Maternal Nutrition-Induced Glucolipid Metabolism Changes in the Offspring.","authors":"Peng Jiao, Huizhen Lu, Lizhuang Hao, A Allan Degen, Jianbo Cheng, Zongjun Yin, Shengyong Mao, Yanfeng Xue","doi":"10.1093/nutrit/nuae048","DOIUrl":"10.1093/nutrit/nuae048","url":null,"abstract":"<p><p>Maternal nutrition during pregnancy regulates the offspring's metabolic homeostasis, including insulin sensitivity and the metabolism of glucose and lipids. The fetus undergoes a crucial period of plasticity in the uterus; metabolic changes in the fetus during pregnancy caused by maternal nutrition not only influence fetal growth and development but also have a long-term or even life-long impact for the offspring. Epigenetic modifications, such as DNA methylation, histone modification, and non-coding RNAs, play important roles in intergenerational and transgenerational effects. In this context, this narrative review comprehensively summarizes and analyzes the molecular mechanisms underlying how maternal nutrition, including a high-fat diet, polyunsaturated fatty acid diet, methyl donor nutrient supplementation, feed restriction, and protein restriction during pregnancy, impacts the genes involved in glucolipid metabolism in the liver, adipose tissue, hypothalamus, muscle, and oocytes of the offspring in terms of the epigenetic modifications. This will provide a foundation for the further exploration of nutrigenetic and epigenetic mechanisms for integrative mother-child nutrition and promotion of the offspring's health through the regulation of maternal nutrition during pregnancy. Note: This paper is part of the Nutrition Reviews Special Collection on Precision Nutrition.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"728-748"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Maternal Prepregnancy and Pregnancy Body Mass Index and Children's Telomere Length: A Systematic Review and Meta-analysis.","authors":"Amir Hossein Lame-Jouybari, Mohammad Salar Fahami, Mahla Sadat Hosseini, Maryam Moradpour, Ali Hojati, Mahdieh Abbasalizad-Farhangi","doi":"10.1093/nutrit/nuae187","DOIUrl":"10.1093/nutrit/nuae187","url":null,"abstract":"<p><strong>Context: </strong>Telomeres maintain chromosome stability and mark cellular aging, and their shortening with age compromises genomic stability.</p><p><strong>Objective: </strong>The purpose of this study was to conduct a meta-analysis of existing evidence to evaluate the relationship between the maternal pregnancy body mass index (BMI) and children's telomere length (TL).</p><p><strong>Data source: </strong>Web of Science, Scopus, and PubMed databases were systematically searched from their inception to August 27, 2023, for pertinent observational studies.</p><p><strong>Data extraction: </strong>The random-effects meta-analysis was conducted on eligible studies that investigated the linear relationship between exposure and the outcomes of interest, utilizing the reported β-coefficient. Cochran's Q test and I2 statistics were used to assess heterogeneity.</p><p><strong>Data analysis: </strong>A significant association was observed between maternal pregnancy BMI and children's TL (32 studies, pooled effect size [ES]: -0.04; 95% CI: -0.06 to -0.01; I2 = 47.51%, P < .001) and maternal prepregnancy BMI and children's TL at birth (16 studies; pooled ES: -0.05; 95% CI: -0.08 to -0.02; I2 = 53.49%, P < .001).</p><p><strong>Conclusion: </strong>The findings indicate an inverse association between maternal prepregnancy BMI and TL in infants, which is evident within the normal to obese BMI range. This underscores the significance of maternal weight status before pregnancy as a determinant of offspring TL.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42023466425.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"622-635"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Metabolic Characteristics and Bioavailability of Resveratrol Based on Metabolic Enzymes.","authors":"Yang Yang, Yan Sun, Tianyi Gu, Yang Yan, Jiaxiu Guo, Xue Zhang, Hanqing Pang, Jing Chen","doi":"10.1093/nutrit/nuae161","DOIUrl":"10.1093/nutrit/nuae161","url":null,"abstract":"<p><p>The natural polyphenol resveratrol (RV) has garnered fame for its extensive pharmacological properties. Although clinical studies have shown some positive results, many contradictory outcomes remain. An important obstacle to the development of therapeutic applications for RV is its low bioavailability in vivo. This may be partially attributed to biotransformation mediated by phase I and II enzymes, such as cytochrome P450s, UDP-glucuronosyltransferases, and sulfotransferases. To date, more than 20 different types of metabolites have been detected after catalysis by these enzymes. Notably, RV and some of its metabolites serve as substrates for these enzymes. Conversely, RV can directly regulate the expression or activity of these enzymes. Given the increasing number of studies investigating the bioactivity of RV, this review summarizes its physicochemical and pharmacokinetic characteristics and describes the metabolism of RV and the bioactivities of its metabolites, with emphasis on the interaction between RV and its related metabolic enzymes. In addition to hepatic metabolism, the crucial roles of RV metabolism in multiple other tissues and organs cannot be overlooked, and they reveal the relationship between RV metabolism and its biological potential.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"749-770"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Individuals' Biological and Meals' Nutritional Characteristics on the Thermic Effect of Food in Humans: Meta-Regression of Clinical Trials.","authors":"Karine Maria Moreira Almeida, Maria Bárbara Galdino-Silva, Déborah Tenório da Costa Paula, Guilherme César Oliveira de Carvalho, Maykon Douglas Ramos Barros, Thays Cristhyna Guimarães Reis, Mateus de Lima Macena, Nassib Bezerra Bueno","doi":"10.1093/nutrit/nuae163","DOIUrl":"10.1093/nutrit/nuae163","url":null,"abstract":"<p><strong>Context: </strong>The thermic effect of food (TEF) may be a therapeutic target for the prevention and treatment of obesity.</p><p><strong>Objective: </strong>The impact of different biological and nutritional characteristics on TEF in humans was analyzed.</p><p><strong>Data sources: </strong>The MEDLINE/PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Latin American and Caribbean Health Sciences Literature databases were searched until November 2023 without language restrictions.</p><p><strong>Data extraction: </strong>Clinical trials were included that offered an oral test meal to adult and elderly individuals in a fasting state and measured TEF using calorimetry. The average TEF of each group was the outcome, and the impact of the individuals' and meal characteristics on the TEF was assessed using subgroups, meta-regression, and compositional analysis.</p><p><strong>Data analysis: </strong>The review included 133 studies, with 321 different groups. The mean TEF at 60 minutes after the test meal was 262 (95% CI, 236-288) kcal/d and decreased over time until 240 minutes after the test meal (P < .01). Male participants, individuals with normal body mass index, meals with energy content offered according to individual requirements, and meals with a mixed degree of food processing yielded a higher TEF. The total energy content of meals was the variable most strongly associated with TEF. Compositional analysis showed that the amount of lipids in meals was the only macronutrient consistently and negatively associated with TEF.</p><p><strong>Conclusions: </strong>The TEF is influenced by specific individuals' and meal characteristics. Total energy content and the amount of lipids were the characteristics of the meals most consistently associated with TEF. However, due to important methodological differences between studies, it is difficult to determine how to use TEF as a potential therapeutic target against obesity.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42023432504.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"597-608"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fifteen Years of NOVA Food-Processing Classification: \"Friend or Foe\" Among Sustainable Diet Indicators? A Scoping Review.","authors":"Orsolya Tompa, Anna Kiss, Sándor Soós, Zoltán Lakner, Ana Raner, Gyula Kasza, Dávid Szakos","doi":"10.1093/nutrit/nuae207","DOIUrl":"10.1093/nutrit/nuae207","url":null,"abstract":"<p><p>It has been 15 years since the introduction of the NOVA food-processing classification. While it was designed to identify ultra-processed foods linked to noncommunicable diseases, the NOVA system has a holistic concept that fits with sustainable nutrition. However, NOVA's connection to other sustainable diet indicators has not been thoroughly explored. The aim was to summarize the research and methodological context of using the NOVA system with other sustainable diet indicators and to investigate NOVA's synergies and discordance with them. A scoping review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-Extension for Scoping Reviews (PRISMA-ScR). Studies published between 2009 and 2023 were collected from the Web of Science, Scopus, and PubMed databases. 1612 studies were initially screened; in the selected studies (n = 77), the NOVA system was applied in addition to other sustainable diet indicator(s). The studies were analyzed within a qualitative data analysis framework. 77 studies were analyzed in which healthiness (n = 66), environmental pressure (n = 9), affordability (n = 11), other processing classifications (n = 6), and other sustainable diet indicators (n = 10) were applied with NOVA. Among them, the identified relationships between the NOVA system and other healthfulness indicators were synergistic in the majority of studies (n = 70/93). For environmental pressure indicators, a mixed picture was observed; the NOVA classification was predominantly synergistic with greenhouse gas emissions (n = 8/13), while it was mostly discordant with fresh water use (n = 8/12). Economic affordability was also found to be discordant with the NOVA classification in the majority of studies (n = 10/16). To complete the NOVA classification with nutrient profiling would be beneficial to identify healthy diets. In the case of the integration of NOVA into sustainable nutrition research, environmental pressure and economic affordability indicators should be controlled to reach optimal trade-offs for more sustainable diets. The application of NOVA is gaining relevance; thus, its methodological adaptation to sustainable nutrition research is necessary.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"771-791"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whey Protein Intervention and Inflammatory Factors and Oxidative Stress: Systematic Review and Meta-analysis of Randomized Controlled Trials.","authors":"Fatemeh Farahmandpour, Fatemeh Haidari, Zeinab Heidari, Samaneh Hajjarzadeh, Akram Ahangarpour","doi":"10.1093/nutrit/nuae100","DOIUrl":"10.1093/nutrit/nuae100","url":null,"abstract":"<p><strong>Context: </strong>Whey protein (WP), a high-biological-value protein contained in milk, may have anti-inflammatory properties and can reduce proinflammatory cytokines; however, the current evidence is inconclusive.</p><p><strong>Objective: </strong>The aim of this study was to further investigate the effects of whey protein supplementation on inflammatory factors and oxidative stress in adults.</p><p><strong>Data sources: </strong>We conducted a comprehensive search up to March 2022 using relevant key words in databases such as PubMed, Scopus, Embase, and the Cochrane Central Register of Controlled Trials, focusing on randomized controlled trials (RCTs).</p><p><strong>Data extraction: </strong>RCTs that examined the impact of WP on C-reactive protein, tumor necrosis factor alpha, interleukin-6, glutathione, malondialdehyde, and total antioxidant capacity were selected independently by 2 authors. Results were pooled using a random-effects model as weighted mean differences and 95% CIs.</p><p><strong>Data analysis: </strong>The results of the present study demonstrated that WP supplementation had no significant effect on the modulation of inflammation and oxidative stress compared with the control. None of the predefined subgroup analyses explained the differences in the effects of WP supplementation on inflammatory factors and oxidative stress.</p><p><strong>Conclusion: </strong>This research suggests that WP supplementation had no significant effect on inflammatory factors and oxidative stress.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42022325855.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":"609-621"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142086131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Do Australians Eat? A Systematic Review of Dietary Patterns and Adverse Health Outcomes.","authors":"Zegeye Abebe, Kacie Dickinson, Tefera Chane Mekonnen, Amy Reynolds, Sarah Appleton, Leila Mohammadi, Danny J Eckert, Robert Adams, Katherine M Livingstone, Yohannes Adama Melaku","doi":"10.1093/nutrit/nuaf028","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf028","url":null,"abstract":"<p><strong>Context: </strong>A suboptimal diet is a leading factor in the current burden of chronic diseases. In Australia, dietary factors contribute to one-fifth of the chronic disease burden. Understanding the dietary patterns of Australian adults and summarizing their effects on chronic conditions are imperative for improving interventions targeting dietary behaviors.</p><p><strong>Objective: </strong>This systematic review aims to summarize the dietary patterns of Australian adults derived using a posteriori and hybrid analysis methods and their associations with adverse health outcomes.</p><p><strong>Data sources: </strong>Six databases were first searched in December 2020 and updated in August 2023.</p><p><strong>Data extraction: </strong>Cardiometabolic health, cardiovascular mortality, cancer, pregnancy-related metabolic conditions (gestational diabetes mellitus [GDM] or hypertensive disorders during pregnancy [HDP]), mental health, and cognitive function were the main health outcomes.</p><p><strong>Data analysis: </strong>Dietary patterns from each study were classified as either healthy or unhealthy. A narrative synthesis was used to describe the association of dietary patterns with adverse health outcomes in longitudinal studies. Fifty-nine observational studies (31 cross-sectional, 3 case-control, 22 longitudinal, and 3 combining both cross-sectional and longitudinal designs) were included, involving a total of 362 263 participants aged 18 years and older.</p><p><strong>Conclusion: </strong>Higher adherence to a healthy dietary pattern (characterized by higher consumption of dark-yellow, green leafy, cruciferous vegetables and fruits, nuts, whole grains, tomatoes, fish, and low-fat dairy) is associated with improved cardiometabolic risk factors, reduced risk of GDM and HDP, better mental health, and improved pregnancy outcomes. On the other hand, an unhealthy dietary pattern (characterized by a higher intake of processed and red meat, takeaway foods, white bread, high-fat dairy, potatoes, discretionary fat, sweet snacks, soft drinks, fat spreads, jam, and Vegemite) is linked to increased cardiometabolic risks. Overall, while healthy dietary patterns are associated with a reduced risk of several physical and mental health outcomes, unhealthy dietary patterns are linked to an increased risk in Australian adults.</p><p><strong>Systematic review registration: </strong>PROSPERO registration no. CRD42023452960.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Processed Meat Intake and Changes in Weight, Waist, Body Mass Index, and Fat Mass: Systematic Literature Review, Meta-Analysis, and GRADE Assessment of Cohort Studies of Adults.","authors":"Mina N Händel, Jeanett F Rohde, Sofus C Larsen, Thorkild I A Sørensen, Berit L Heitmann","doi":"10.1093/nutrit/nuaf030","DOIUrl":"https://doi.org/10.1093/nutrit/nuaf030","url":null,"abstract":"<p><strong>Context: </strong>Previous reviews have indicated that abstaining from processed meat may play a part in weight management; however, the certainty of these results has not been assessed systematically.</p><p><strong>Objective: </strong>We sought to estimate the association between processed meat intake (including studies specifically mentioning \"processed meat\" and/or listing processed meat items and subsequent change in weight, waist circumference, body mass index (BMI), and fat mass among adults by summarizing evidence of cohort studies.</p><p><strong>Data sources: </strong>A systematic literature search was performed in Embase and Medline via Ovid (including the Cochrane Database of Systematic Reviews) from inception to June 2024.</p><p><strong>Data extraction: </strong>The data were extracted by 2 reviewers independently. The certainty in the estimates was assessed with the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) tool, and the risk of bias was assessed using the Cochrane's Risk of Bias in Nonrandomized Studies of Interventions (ROBINS-I) assessment tool.</p><p><strong>Data analyses: </strong>The search resulted in a total of 2974 potential articles, of which 11 cohort studies (6 unique studies) were eligible for inclusion. Three studies (n = 381 291) were included in the random-effects model of measured body weight, resulting in a summary increase of 0.26 kg/y per 1 daily serving of processed meat (95% confidence interval [CI], 0.03-0.48; τ2: 0.03; I2: 92.95%). Four studies (n = 51 310) were included in the random-effects model of measured waist circumference, resulting in a summary increase of 0.14 cm/y per 1 daily serving of processed meat (95% CI, 0.02-0.26; τ2: 0.01; I2: 81.12%). The certainties of these estimates were low, due to serious risk of bias.</p><p><strong>Conclusion: </strong>The analyses suggested a very weak association between increased processed meat intake and subsequent increase in measured weight, larger measured waist circumference, increase in self-reported BMI, and an increase in fat mass. However, due to methodological limitations the certainty of these results was low, and cautious interpretation of the results is warranted.</p><p><strong>Systematic review registration: </strong>PROSPERO registration No. CRD42022335022.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}