Nigerian Journal of Clinical Practice最新文献

{"title":"Evaluation of Pudendal Thigh (Singapore) Flap Vaginoplasty for Acquired Gynatresia: A Retrospective Study from Enugu, Nigeria.","authors":"J U Achebe, O R Okwesili, C O Adiri, E E Asimadu, E C Nnadi, C B Eze, S O Okoro, Ocu Onyia, J E Nnagbo","doi":"10.4103/njcp.njcp_169_26","DOIUrl":"https://doi.org/10.4103/njcp.njcp_169_26","url":null,"abstract":"<p><strong>Background: </strong>Acquired gynatresia is an exhausting condition that affects sexual and reproductive health. Vaginoplasty using a bilateral pudendal thigh flap provides a good functional outcome.</p><p><strong>Aim: </strong>To evaluate the demographic data, clinical characteristics, and surgical outcomes of vaginoplasty using pudendal thigh flaps in patients with acquired gynatresia managed in Enugu, Nigeria.</p><p><strong>Methods: </strong>The study was a retrospective study of patients with acquired gynatresia who underwent vaginoplasty in Enugu from January 2 nd , 1999, to December 31 st , 2024. Data retrieved included patient demographics, etiology, degree of stenosis, perioperative details, and functional outcome. Descriptive statistics were used in data analysis, and the functional outcome was assessed. The vaginal assessment was based on the ease of penetration and coital pain/discomfort despite the use of lubricant.</p><p><strong>Results: </strong>A total of 19 patients were seen and treated. The mean age was 38.74 ± 4.62. Herbal pessary (17, 89.5%) was the predominant cause of gynatresia. Vaginal assessment scores increased from 0 during preoperative assessment to a mean score of 69.2 ± 7.9, with a range from 55 to 80 in the postoperative stage. Patients were followed up for at least 6 months.</p><p><strong>Conclusion: </strong>Vaginoplasty using pudendal thigh flaps is a reliable procedure for the effective management of acquired gynatresia, producing a functional outcome, that is, painless coitus and resumption of menstrual flow.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"29 8","pages":"864-870"},"PeriodicalIF":0.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-based Assessment of Cardiovascular Risk Factors among Young Hypertensives in a Tertiary Hospital in Southwestern Nigeria: A Cross-sectional Study.","authors":"B O Oguntola, S O Oguntola, O E Ojo, C M Muotoh, Puc Ogwumike, O D Bayo-Ilawole, T P Abe","doi":"10.4103/njcp.njcp_138_26","DOIUrl":"https://doi.org/10.4103/njcp.njcp_138_26","url":null,"abstract":"<p><strong>Background: </strong>Gender variation exists in the clustering of cardiovascular (CV) risk factors. Hypertension (HTN), diabetes mellitus (DM), lipid abnormalities, obesity, cigarette smoking, and significant alcohol use are risk factors that typically influence one another and predispose to cardiovascular disease (CVD).</p><p><strong>Aim: </strong>This study assessed gender-based variation in the prevalence of CV risk factors among young individuals with HTN.</p><p><strong>Methods: </strong>This was a cross-sectional study involving 157 participants aged between 18 and 45 years with systemic HTN. Participants were recruited consecutively and categorized by gender. Sociodemographic and clinical information were collected using a pro forma. Lipoprotein (a), lipid profile, fasting blood glucose, uric acid, and creatinine were obtained from a fasting venous blood sample. Data were analyzed using STATA 17.</p><p><strong>Results: </strong>The median age of the study participants was 30 years (24-37). Females accounted for 48% of the participants. A higher prevalence rate of significant alcohol use (34.2% vs 5.3%, P < 0.001), and cigarette smoking (14.6% vs 1.3%, P < 0.001) was found in males. A higher prevalence of LP (a) (2.2% vs 13.3%, P = 0.036) was found in the females. Moderate and severe obesity were more common among females ( P = 0.036). There was no significant difference in the prevalence of hyperuricemia, DM, dyslipidemia, reduced estimated glomerular filtration rate, and blood pressure control rate between the male and female participants.</p><p><strong>Conclusion: </strong>The study demonstrated some gender-based differences in the prevalence of some CV risk factors among young hypertensives. These findings are valuable for developing gender-specific strategies to reduce CV risk in this population.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"29 8","pages":"897-902"},"PeriodicalIF":0.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Ulcerative Keratitis Secondary to Hidradenitis Suppurativa: A Case Report.","authors":"M Showail, A E Rajab","doi":"10.4103/njcp.njcp_792_25","DOIUrl":"https://doi.org/10.4103/njcp.njcp_792_25","url":null,"abstract":"<p><p>Peripheral ulcerative keratitis (PUK) is an acute, destructive peripheral keratitis usually associated with an underlying systemic autoimmune disease. However, its association with hidradenitis suppurativa (HS) has been scarcely documented. We report a 35-year-old male with HS who presented with a 1-month history of a whitish spot in the left eye, associated with redness and pain. Visual acuity was 20/20 in the right eye and 20/30 in the left eye, with intraocular pressure of 14 mmHg and 13 mmHg, respectively. Slit-lamp examination revealed a crescent-shaped whitish peripheral corneal lesion at the 5 to 6 o'clock position near the limbus. Laboratory investigations were unremarkable except for elevated C-reactive protein, and the patient denied rheumatologic or autoimmune symptoms. He was treated with topical and systemic steroids, immunosuppressive therapy, biologic agents, and multiple conjunctival recession and resection procedures. PUK is a potentially serious but treatable condition; although the association with HS is rare, it should be considered in patients with HS presenting with ocular involvement.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"29 8","pages":"945-948"},"PeriodicalIF":0.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular and Visual Complications in Diabetic Patients at First Visit to an Ophthalmology Clinic in Hafar Al Batin, Saudi Arabia.","authors":"M A Alhamami, A Almutairi","doi":"10.4103/njcp.njcp_745_25","DOIUrl":"https://doi.org/10.4103/njcp.njcp_745_25","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the retinal and ocular findings and identify factors associated with the timing of the first ophthalmology visit among diabetic patients in Hafar Al Batin, Saudi Arabia, where there is concern that patients are not having prompt ophthalmic evaluation after diabetes mellitus (DM) diagnosis.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed data from 357 diabetic patients who had no prior ocular examination after their DM diagnosis at King Khaled General Hospital during the second semester of 2021-2022. Data on demographics, clinical characteristics, and the duration between DM diagnosis and the first ophthalmology visit were collected from medical records and analyzed using multiple regression.</p><p><strong>Results: </strong>A significant delay was found between initial DM diagnosis and the first ophthalmology visit. The prevalence of diabetic retinopathy (DR) and macular edema was approximately 42% and 30%, respectively. Longer delays were significantly associated with older age ( P < 0.001), elevated HbA1C levels ( P = 0.022), coexisting hypertension ( P = 0.012), Type I DM ( P < 0.001), and lower education level ( P < 0.001). Patients ultimately diagnosed with DR had a significantly longer delay compared to those within normal limits ( P < 0.001).</p><p><strong>Conclusion: </strong>A substantial delay exists between diabetes diagnosis and initial eye examination among patients in Hafar Al Batin, leading to a high prevalence of preventable, vision-threatening complications. These findings underscore the urgent need for proactive public health strategies focused on improving patient education and implementing timely screening protocols to mitigate the risk of vision loss from diabetes.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"29 8","pages":"916-922"},"PeriodicalIF":0.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic Nerve Sheath Diameter as a Marker of Elevated Intracranial Pressure in Preeclampsia Compared to Controls.","authors":"S Şimşek, I Başkır, T Sağlam, A Oğuz, B Çabuk","doi":"10.4103/njcp.njcp_572_25","DOIUrl":"https://doi.org/10.4103/njcp.njcp_572_25","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia may be complicated by cerebral edema and elevated intracranial pressure (ICP), yet magnetic resonance imaging is not always feasible for urgent or serial assessment. Ultrasonographic optic nerve sheath diameter (ONSD) measurement is a bedside surrogate that may reflect ICP-related changes.</p><p><strong>Aim: </strong>To compare ONSD values among nonpregnant healthy women, normotensive pregnant women, and women with preeclampsia (with and without severe features), and to evaluate the discriminative performance of ONSD for hypertensive disorders of pregnancy.</p><p><strong>Methods: </strong>This single-center retrospective cohort study (January 2021-January 2025) included 79 participants: nonpregnant healthy women ( n = 19), normotensive pregnant women ( n = 20), preeclampsia ( n = 20), and severe preeclampsia ( n = 20). Preeclampsia diagnosis/severity followed the American College of Obstetricians and Gynecologists criteria. ONSD was measured by ocular ultrasonography (Voluson S8) 3 mm posterior to the globe in both eyes; the mean of both eyes was analyzed. Measurements were performed contemporaneously by four radiologists and recorded by consensus.</p><p><strong>Results: </strong>Groups were comparable regarding age, gravidity, parity, and gestational week at measurement (mean gestational age 34.20 ± 0.70 weeks; P > 0.05). Mean ONSD increased stepwise across groups: 4.11 ± 0.21 mm (nonpregnant controls), 4.62 ± 0.19 mm (pregnant controls), 5.71 ± 0.18 mm (preeclampsia), and 5.99 ± 0.20 mm (severe preeclampsia) ( P < 0.001). An ONSD cutoff of 5.15 mm distinguished preeclampsia/severe preeclampsia from the control groups with excellent diagnostic performance (AUC = 1.000; P < 0.001).</p><p><strong>Conclusion: </strong>ONSD is higher in preeclampsia, especially in severe cases. Ocular ultrasound may help with quick screening and follow-up, but confirmation in larger studies using imaging or invasive ICP standards is needed.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"29 8","pages":"890-896"},"PeriodicalIF":0.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Membrane Stripping Versus Castor Oil for Induction of Labor in Prevention of Post-Term Pregnancy in Enugu: A Randomized Controlled Trial.","authors":"G U Odoh, P C Udealor, C I Onwuka, E O Ugwu, E I Iloghalu, E O Izuka, S N Obi, E C Ezugwu","doi":"10.4103/njcp.njcp_725_25","DOIUrl":"10.4103/njcp.njcp_725_25","url":null,"abstract":"<p><strong>Background: </strong>Post-term pregnancy increases maternal and perinatal morbidity. Methods that promote spontaneous labor before 42 weeks may reduce the need for formal induction. Membrane sweeping (MS) is recommended by World Health Organization, whereas castor oil is commonly used in some settings but is not routinely guideline-endorsed. This study compared MS, castor oil, and expectant management for prevention of post-term pregnancy in Enugu.</p><p><strong>Aim: </strong>This study compared MS, castor oil, and expectant management for prevention of post term pregnancy in Enugu.</p><p><strong>Methods: </strong>This randomized controlled trial enrolled women at 40 + 0 to 41 + 0 weeks' gestation in two hospitals in Enugu, who were allocated in a 1:1:1 ratio to MS, castor oil, or control using a computer-generated random sequence with sealed opaque envelopes. The primary outcome was labor within 48 hours. Secondary outcomes included subsequent formal induction, mode of delivery, and maternal/neonatal outcomes.</p><p><strong>Results: </strong>Labor within 48 hours occurred more frequently after MS (44/70, 62.9%) and castor oil (37/70, 52.9%) than control (17/70, 24.3%). Compared with control, MS increased the odds of labor within 48 hours (OR 5.28, 95% CI 2.54-10.95; P < 0.001), as did castor oil (OR 3.50, 95% CI 1.70-7.18; P = 0.001). There was no significant difference between membrane sweeping and castor oil (OR 1.51, 95% CI 0.77-2.96; P = 0.232). Subsequent formal induction was more common in the control group.</p><p><strong>Conclusion: </strong>Compared with expectant management, both membrane sweeping and castor oil were associated with higher rates of labor within 48 hours and lower need for formal induction. Neither intervention was superior for the primary outcome. Larger studies are needed to confirm maternal and neonatal safety outcomes.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"29 8","pages":"835-841"},"PeriodicalIF":0.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Bowel Cleansing Agents on Colonoscopy Outcomes: A Retrospective Study of Preparation Quality and Procedure Metrics.","authors":"C I Bulut, O Sakallı, A İ Küçük, M Aziret","doi":"10.4103/njcp.njcp_657_25","DOIUrl":"https://doi.org/10.4103/njcp.njcp_657_25","url":null,"abstract":"<p><strong>Background: </strong>Adequate bowel preparation is essential for colonoscopy, directly influencing diagnostic accuracy, therapeutic safety, and procedural efficiency. Different cleansing agents, including polyethylene glycol (PEG), sodium phosphate, and sennosides, are commonly used in clinical practice, but their comparative effectiveness remains debated.</p><p><strong>Aim: </strong>The primary aim of this study was to compare the bowel cleansing efficacy of senna, sodium phosphate, and PEG using the Aronchick Bowel Preparation Scale. Additionally, we sought to evaluate secondary objectives, including the impact of these agents on cecal intubation time, lesion detection rates, and patient tolerability.</p><p><strong>Methods: </strong>Patients were categorized into three groups based on bowel preparation regimen: PEG, sodium phosphate, and sennosides. Data collected included demographic characteristics, preparation quality assessed by the Aronchick Bowel Preparation Scale, procedure time, cecal intubation success, and detection of polyps or diverticula.</p><p><strong>Results: </strong>A total of 200 patients were included. The overall mean Aronchick score was 2.09±1.07, with no statistically significant difference among groups ( P =0.325). Polyp detection ( P =0.084), diverticula presence ( P =0.059), and maneuver requirement ( P =0.060) were also comparable. However, cecal intubation time differed significantly ( P <0.001).</p><p><strong>Conclusion: </strong>In conclusion, all three bowel preparation agents were comparable in terms of cleansing quality and tolerability. However, sodium phosphate was associated with a shorter cecal intubation time. These findings suggest that bowel preparation should be individualized based on patient characteristics and institutional practices. Further prospective studies with larger sample sizes are recommended to validate these results.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"29 8","pages":"829-834"},"PeriodicalIF":0.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns and Factors Associated with Intrauterine Pathologies at Hysteroscopy among Women Evaluated for Infertility in a Private Endoscopy Center in Southeast Nigeria: A Retrospective Cross-Sectional Study.","authors":"O M Ogelle, G Olorunfemi, L U Okafor, C I Enechukwu, Ioj Okonkwo, A A Mathias, W N Ogelle, C M Okeke, E C Ogelle, T B Ejikeme, C Okoro, C G Ikpeze, M C Andeh, V C Ani, G U Eleje, I I Mbachu, J O Ugboaja, A O Igwegbe, N C Ngene","doi":"10.4103/njcp.njcp_836_25","DOIUrl":"https://doi.org/10.4103/njcp.njcp_836_25","url":null,"abstract":"<p><strong>Background: </strong>Intrauterine pathologies are common among women with infertility and may negatively impact fertility treatment outcomes if undetected.</p><p><strong>Aim: </strong>To determine the patterns and associated clinical factors of intrauterine pathologies at hysteroscopy in women evaluated for infertility.</p><p><strong>Methods: </strong>A retrospective cross-sectional study of 282 women with infertility was carried out at Blessed Specialist Hospital, Npor, Anambra state a private endoscopy center in Southeast Nigeria over 10 years. Clinical data and hysteroscopic findings were extracted. Statistical associations were analyzed using Chi-square tests with a significance level of P < 0.05.</p><p><strong>Results: </strong>The mean age of the participants was 34.8 ± 5.2 years. Uterine pathologies were confirmed hysteroscopically in 50.35% (n = 142/282) of the patients. The most frequent intrauterine pathologies identified were intrauterine adhesions (24.47%, n = 69), endometrial polyps (14.18%, n = 40), submucous myomas (12.06%, n = 34), and uterine septa (5.32%, n = 15). Regarding procedures, 22.80% (n = 57/250) of patients with complete surgical logs underwent therapeutic hysteroscopy, while 77.20% (n = 193/282) had diagnostic interventions. Bivariate analysis revealed significant statistical associations between the presence of intrauterine pathologies and both maternal age ≥35 years ( P = 0.012) and uterine enlargement ( P < 0.001).</p><p><strong>Conclusion: </strong>Intrauterine pathologies affect half of the women evaluated for infertility in this cohort, with intrauterine adhesions being the most prevalent entity. Advanced maternal age and uterine enlargement are strongly associated with these anomalies. Hysteroscopy remains crucial for accurate diagnosis during fertility work-ups.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"29 8","pages":"842-851"},"PeriodicalIF":0.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Immediate versus Early Skin-to-Skin Contact after Cesarean Section on Maternal and Neonatal Outcomes within the First 24 Hours: A Quasi-Experimental Study.","authors":"E A Gürcüoğlu, A Ş Erenel","doi":"10.4103/njcp.njcp_711_25","DOIUrl":"https://doi.org/10.4103/njcp.njcp_711_25","url":null,"abstract":"<p><strong>Background: </strong>In Türkiye and moderate-income developing countries, skin-to-skin contact (SSC) is not a routine practice and is often neglected, especially after a cesarean.</p><p><strong>Aim: </strong>The aim of this research was to evaluate the effect of immediate and early SSC after cesarean on maternal and neonatal parameters in the first 24 hours.</p><p><strong>Methods: </strong>This quasi-experimental clinical study involved 92 mother-neonate pairs. Uninterrupted 40-minute SSC was implemented within the first 5 minutes in the immediate SSC (ISSC) group and within the first hour after cesarean in the early SSC (ESSC) group. Routine care was given to the control group. Data collected with the Infant Breastfeeding Assessment Tool, State Anxiety Inventory and maternal-neonatal monitoring timeline.</p><p><strong>Results: </strong>The maternal anxiety scores and hemorrhage amounts were similar between the groups ( P > 0.05). Breastfeeding initiation in the ISSC group was significantly earlier than in other groups ( P = 0.006). The 24 th -hour breastfeeding scores and body temperature of neonates in the ISSC group were found to be significantly higher than those of the control group ( P = 0.032; P = 0.038, respectively). There were no differences between the neonates in terms of pulse, respiratory rate and peripheral oxygen saturation values, crying, postnatal 2 nd hour blood glucose, weight loss, urine and stool outputs ( P > 0.05). However, those in the ESSC group were determined to sleep significantly longer compared to the control group ( P = 0.014).</p><p><strong>Conclusion: </strong>Immediate and uninterrupted 40-minute SSC significantly promoted earlier breastfeeding initiation, improved 24-hour breastfeeding success and neonatal thermoregulation. ESSC has been associated with prolonged sleep duration in newborns. Consequently, SSC is a feasible, low-cost intervention that can be incorporated into routine postnatal care.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"29 8","pages":"852-863"},"PeriodicalIF":0.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Damage Caused by the COVID-19 Pandemic to the Jacie Accredited Apheresis Unit and its Implications.","authors":"G Akyol, M Baydar, M Keklik, A Ünal, M Çetin, B Eser, L Kaynar","doi":"10.4103/njcp.njcp_709_25","DOIUrl":"10.4103/njcp.njcp_709_25","url":null,"abstract":"<p><strong>Background: </strong>The investigation aimed to determine whether there has been an increase in the amount of stem cells discarded due to patient mortality resulting from COVID-19 infection in our apheresis unit. Records were reviewed to investigate whether there were any differences in stem cell discards before and after the COVID-19 pandemic period following 2015.</p><p><strong>Results: </strong>In both periods, products retrieved from patients with myeloma and non-Hodgkin lymphoma constituted the majority of discarded stem cells. The process of discarding 230 hematopoietic stem cell products that were discarded after 2015 involved a period of five years prior to the COVID-19 pandemic, during which half of the products were discarded, and the other half were discarded in the last 2.5 years of the pandemic. Over 90% of the discarded products were autologous stem cell products. Additionally, 43 patients had their products discarded due to mortality associated with COVID-19 infection. This number does not include those who passed away at home for unknown reasons or in cases where COVID-19 infection could not be confirmed. The disposal of a single hematopoietic stem cell product, including the cost of the collection bag and DMSO freezing, was approximately 5,000 Turkish Lira during that period. In our country, which has around 50 hematopoietic stem cell transplantation centers, if we assume an average of about 40 stem cell disposals per center, this would result in a total loss of approximately 10 million Turkish Lira (calculated as 5,000 TL x 40 x 50 centers = 10,000,000 TL). This figure does not account for personnel labor costs.</p><p><strong>Conclusion: </strong>Furthermore, this review suggests that, similar to previous observations, preserving stem cells for second transplants in patients with non-Hodgkin lymphoma and certain elderly myeloma patients may be unnecessary.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"29 8","pages":"912-915"},"PeriodicalIF":0.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}