Nigerian Journal of Clinical Practice最新文献

{"title":"A Cross-Sectional Study on the Relationship between the HEART Score and the Severity of CAD using the SYNTAX Score in Patients with NSTEMI Admitted to the Emergency Department: A Study from Turkey.","authors":"M S Pepele, I Aktas, O Demiroz, S Derya, E Yildirim, M N Bilen, B Demir","doi":"10.4103/njcp.njcp_417_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_417_24","url":null,"abstract":"<p><strong>Background: </strong>The HEART score is a risk stratification tool for acute chest pain, evaluating history, ECG, age, risk factors, and troponin. The SYNTAX (synergy between percutaneous coronary intervention with TAXUS and cardiac surgery) score assesses the extent and complexity of coronary artery disease (CAD) and is widely used in patients undergoing coronary interventions.</p><p><strong>Aim: </strong>To determine the relationship between the HEART and SYNTAX scores in patients with non-ST elevation myocardial infarction (NSTEMI).</p><p><strong>Method: </strong>A total of 222 NSTEMI patients who underwent coronary angiography were included. The HEART score was calculated at admission, and all patients underwent angiography within 12 hours. SYNTAX was used to evaluate CAD severity. Patients were divided into two groups based on SYNTAX scores. Comparisons were made according to demographic data, laboratory findings, and risk factors. Variables associated with high SYNTAX scores were identified. A P value of < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The mean age was 63.67 ± 11.89 years, and 74.77% of the patients were male. Patients with high SYNTAX scores had significantly higher HEART scores and more frequent diabetes and hypertension. High HEART score (OR: 3.09; 95% confidence intervals [CI]: 2.06-4.63; P < 0.001) and diabetes mellitus (OR: 4.57; 95% CI: 1.44-14.47; P = 0.010) were independently associated with high SYNTAX scores. A HEART score >7.5 predicted high SYNTAX scores with 82.1% sensitivity and 84.3% specificity (area under curve [AUC]: 0.892; P < 0.001). A strong positive correlation was found between HEART and SYNTAX scores (P < 0.001, R² =0.672).</p><p><strong>Conclusion: </strong>The HEART score was significantly associated with the severity and complexity of CAD in patients with NSTEMI.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 6","pages":"758-763"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the Factors Affecting the Nutritional Behavior and Nutritional Knowledge Levels of Breastfeeding Women in the Postpartum Period.","authors":"E Sarı, A Eker, A Saltekin","doi":"10.4103/njcp.njcp_834_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_834_24","url":null,"abstract":"<p><strong>Background: </strong>Postpartum women's nutrition is shaped by social, psychological, and cultural factors, affecting maternal and infant health.</p><p><strong>Aim: </strong>The aim of this study was to determine the level of nutritional knowledge of postpartum women living in Türkiye and the factors affecting their nutritional behaviors.</p><p><strong>Methods: </strong>Women who were in the first 6 months postpartum and breastfeeding in Türkiye were reached through social media. A total of 264 volunteer women were included in the study. Participant introduction form, breastfeeding mother nutrition knowledge level measurement form, identification of factors affecting nutrition form, and informed consent form were applied to the women.</p><p><strong>Results: </strong>The majority of mothers (60.2%) reported not receiving nutritional information during the puerperium. A significant proportion (45.1%) indicated experiencing pressure from their social environment regarding dietary practices, which negatively affected their mental well-being (69.7%) and led to changes in their dietary habits (30.3%). Sleep disturbances were reported to impact dietary behavior by 67.6% of mothers, primarily causing them to skip main meals (35.4%). Additionally, 44.7% of participants noted that home visits influenced their nutritional practices, often leading to the consumption of puerperal sherbet and calorie-dense foods such as pastries and desserts. Mothers who received education about puerperium nutrition demonstrated significantly higher levels of accurate nutritional knowledge (P = 0.011), highlighting the importance of targeted educational interventions.</p><p><strong>Conclusion: </strong>While nutrition education programs for mothers are organized by health professionals in the postpartum period, importance should be given to increasing the awareness and consciousness levels of the mother's close circle.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 6","pages":"687-694"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Hearing Threshold and Pattern of Tympanograms of Sickle Cell Disease Patients in Calabar, Nigeria.","authors":"A G Adekanye, J B Okoi-Obuli, K O Akaba, A Umana, P M Francis","doi":"10.4103/njcp.njcp_572_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_572_24","url":null,"abstract":"<p><strong>Background: </strong>Sickle cell disease patients often have high level of hearing threshold due to their susceptibility to pneumococcal infections, otitis media, and vaso-occlusive injury to the cochlea.</p><p><strong>Aims: </strong>This study aimed to determine the associations between the hemoglobin variants and hearing thresholds, hearing loss (HL), and tympanometry distributions in patients with sickle cell disease (SCD).</p><p><strong>Methods: </strong>This hospital-based study was conducted between September 2019 and September 2021. We recruited 110 confirmed SS and SC patients from adult and pediatric sickle cell clinics, Calabar sickle cell clubs, and 110 healthy controls (AA and AS). Structured questionnaires were used to interview the study population, and all of them underwent ear, nose, and throat examinations, tympanometry, and pure tone audiometry for those aged >5 years after obtaining informed consent and medical ethics committee approval. Data were analyzed using international business machine (IBM) corporation statistical product and service solution (SPSS) version 25 software. Descriptive analysis was performed using tables, graphs, and charts, whereas inferential statistics were obtained using the Chi-square test of independence or Fisher's exact test, t-test, or analysis of variance (ANOVA). Statistical significance was set at P value < 0.05.</p><p><strong>Results: </strong>The median ages of the SCD patients and their controls were 18 and 23 years, respectively. SCD patients have higher hearing thresholds, with 8.9% conductive loss, 4.5% unilateral mild mixed hearing loss, and 3.3% sensorineural hearing loss (SNHL) (2.0% among the controls; P value of 0.669), and more commonly in the right ear. The overall HL prevalence was 16.7% SCD patients and 8.0% controls (double; P value of 0.067). SNHL is mostly mild and unilateral in nature and affects only adults. Type B tympanogram was only reported in children with SCD.</p><p><strong>Conclusion: </strong>HbSS was the most prevalent genotype, with greater (double) HL than controls, affecting the right ear of males. HL patterns included mild conductive HL, mixed HL, and SNHL. SCD could be a risk factor for OME.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 6","pages":"764-772"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Endotrophin as a Biomarker of Fibrosis in Chronic Liver Diseases.","authors":"H Eruzun, U Avcıoğlu, I Gören, Y C Ürkmez, Ö Küçükdemirci, Bşç Zorlu, E Isgandarov, M Ustaoğlu, T Ayyıldız, B Yıldırım, A Bektaş","doi":"10.4103/njcp.njcp_384_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_384_24","url":null,"abstract":"<p><strong>Background: </strong>Liver fibrosis is a common consequence of most chronic inflammatory liver diseases and results in cirrhosis if left untreated. Therefore, it is important to detect early stages of fibrosis. Endotrophin, the cleavage product of collagen VI, plays a role in renal, cardiac, and hepatic fibrosis. In animal studies, expression of endotrophin results in hepatic inflammation and fibrosis.</p><p><strong>Aim: </strong>We investigated the association between serum endotrophin levels and severity of liver fibrosis in patients with chronic hepatitis B (CHB), autoimmune liver diseases (ALD), and metabolic-associated steatotic liver disease (MASLD).</p><p><strong>Methods: </strong>Blood samples were obtained from treatment-naive patients. Liver fibrosis was evaluated using the modified Knodell scoring system.</p><p><strong>Results: </strong>We included 85 patients (28 with CHB, 32 with ALD and 25 with MASLD). In the combined group endotrophin levels were significantly higher in patients with advanced fibrosis compared to mild fibrosis (P=0.006). However, in the CHB group endotrophin levels were significantly lower compared to the other groups (P<0.001). Further, there was no difference between mild and advanced fibrosis in the individual groups.</p><p><strong>Conclusions: </strong>Our preliminary data showed that endotrophin might be a clinically relevant biomarker for the assessment of liver fibrosis. However, etiology-specific larger-scale clinical studies are needed to determine the true utility of endotrophin as a biomarker in different chronic liver diseases.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 6","pages":"737-743"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Suckling and Swallowing Exercises During the Transition to Oral Feeding in Premature Infants: Randomized Controlled Study.","authors":"E Gökdemir, A K Doğan","doi":"10.4103/njcp.njcp_41_25","DOIUrl":"https://doi.org/10.4103/njcp.njcp_41_25","url":null,"abstract":"<p><strong>Background: </strong>Underdeveloped oral structures of preterm infants cause feeding problems. Therefore, the development of sucking reflexes of premature babies should be supported.</p><p><strong>Aim: </strong>Investigating the effect of suck-swallow exercises during the transition to oral feeding in premature infants was the scope of this study.</p><p><strong>Methods: </strong>This randomized controlled trial study was conducted in the NICU of a public hospital in Istanbul. The study sample consisted of 82 premature infants. Of these infants, 41 were assigned to the intervention group and 41 to the control group. Study data were collected using the Premature Infant Data Collection Form and Early Feeding Skills Assessment Tool. Throughout the study, preterm infants in the intervention group (n = 41) were given suck-swallow exercises for 12 minutes once a day before feeding for 14 days. SPSS22 was used to analyze the data.</p><p><strong>Results: </strong>Male infants constituted 54.9% of the sample group. At enrollment, the gestational age of all infants was 34-37 weeks. Birth weight was 1501-2000 grams in 35.4% of the infants. Evaluation of the 5 sub-parameters of the Early Feeding Assessment Tool revealed that the post-test scores for respiratory regulation, oral motor function, swallowing coordination, feeding participation, and physiological stability were significantly higher in the intervention group than in the control group (P < 0.005).</p><p><strong>Conclusion: </strong>The results of the study showed that sucking and swallowing exercises applied to premature infants improved oral feeding skills and in this context, the use of sucking and swallowing exercises in neonatal intensive care units is recommended.</p><p><strong>Clinicaltrialsgovid: </strong>NCT06371443.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 6","pages":"708-715"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thirty-Year-Old Rhinolith in a Female Adult at a Tertiary Institution.","authors":"R B Mgbe, A G Adekanye, M E Offiong, B C Onwughalu","doi":"10.4103/njcp.njcp_850_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_850_24","url":null,"abstract":"<p><p>Rhinoliths are concrete salts of calcium, aluminum, and magnesium that form around exogenous or endogenous foreign bodies in the nasal cavity. Rhinoliths are most commonly asymptomatic and misdiagnosed. When symptomatic, they can present with nasal obstruction, foul breath, and bloody rhinorrhea. Rhinoscopy is the mainstay for rhinolith diagnosis. Plain radiographs or computerized tomography (CT) imaging aids in rhinolith diagnosis to determine their proper orientation. The definitive treatment is removal via manual or endoscopic maneuvers. We report the case of a 32-year-old female who was diagnosed with nasal polyps by a general practitioner because of persistent left-sided nasal obstruction, foul breath, and rhinorrhea for 6 months. The rhinolith was diagnosed via nasendoscopy and CT tomography of the paranasal sinuses, and its removal was performed under general anesthesia with the aid of an endoscope. The procedure was uneventful. The index patient was asymptomatic for 30 years, and was misdiagnosed with nasal polyps by a general practitioner. To the best of our knowledge, this is the first reported case of a rhinolith at our center.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 6","pages":"773-775"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Normal Pancreatic Stiffness Using 3T Magnetic Resonance Elastography.","authors":"L Karakaş, S Poçan, A Y Karkaş, Ş Şahin","doi":"10.4103/njcp.njcp_192_25","DOIUrl":"https://doi.org/10.4103/njcp.njcp_192_25","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to establish the normal range of pancreatic stiffness in adults using 3T magnetic resonance elastography (MRE) and investigate how factors such as age, sex, pancreatic diameter, and anthropometric characteristics influence pancreatic stiffness.</p><p><strong>Aim: </strong>We aimed to provide data to the literature in determining the stiffness values of normal pancreatic tissue with 3T MRE.</p><p><strong>Methods: </strong>Patient demographic data, including age, sex, and body mass index (BMI), were collected. magnetic resonance imaging (MRI) and MRE parameters were extracted from the hospital's radiology database. Medical history, including liver or pancreatic conditions, was obtained from the patients and confirmed through electronic medical records.</p><p><strong>Results: </strong>The study included 54 patients, comprising 31 males (57.4%) and 23 females (42.6%), with a mean age of 35.8 ± 9.18 years. The average BMI was 24.73 ± 1.83 kg/m². The pancreatic diameters were 20.80 ± 2.13 cm (CC) and 19.93 ± 3.29 cm (AP). The mean pancreatic stiffness was 1587.09 ± 114.90 Pascals (Pa). No significant correlations were found between pancreatic stiffness and age (r = -0.128, P = 0.358), sex (r = -0.051, P = 0.716), BMI (r = -0.026, P = 0.850), pancreatic CC diameter (r = -0.090, P = 0.519), or AP diameter (r = 0.054, P = 0.701).</p><p><strong>Conclusion: </strong>This study provides reliable baseline values for normal pancreatic stiffness (1587.09 ± 114.90 Pa) using 3T MRE, which is essential for distinguishing normal from pathological tissue. These findings suggest that demographic and anatomical factors have little impact on pancreatic stiffness, supporting the potential of MRE in evaluating pancreatic diseases.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 6","pages":"751-757"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Imaging Assessment of Rectal and Vascular Changes Following Radiotherapy in Prostate Cancer Patients.","authors":"F Karaca, S Keskin, S Menteş, H Akkaya, B Gülek","doi":"10.4103/njcp.njcp_107_25","DOIUrl":"https://doi.org/10.4103/njcp.njcp_107_25","url":null,"abstract":"<p><strong>Background and aims: </strong>Radiotherapy is the preferred treatment method for early-stage prostate cancer. The objective of this study was to evaluate the alterations that take place in the vascular structures of non-operated prostate cancer patients following the administration of curative radiotherapy.</p><p><strong>Methods: </strong>In total, 102 male patients who underwent curative external radiotherapy for prostate cancer were included in the study. A contrast-enhanced magnetic resonance imaging (CE-MRI) examination was performed on these patients both prior to and 3 months after the radiotherapy sessions. CE-MRI images were evaluated based on the measurements performed for the internal and external diameters of the rectum and the diameters of the bilateral iliac and femoral arteries. All measurements were done by the utilization of the centimeter (cm) scale.</p><p><strong>Results: </strong>No statistically significant differences were found between the pre- and post-radiotherapeutic measurements of the rectal internal and external diameters, right and left external iliac artery diameters, right and left femoral artery diameters, Gleason scores, and total and free prostate-specific antigen (TPSA and FPSA) levels, in terms of pathological stagings. The mean values of the rectal external diameter, right external iliac artery diameter, and the right and left femoral artery diameters, together with the TPSA and FPSA levels, were found to have been diminished at measurements done 3 months after the radiotherapy (P = 0.001).</p><p><strong>Conclusion: </strong>Vessel and rectal lumens were found to have been narrowed following radiotherapy, on CE-MRI examinations performed 3 months after the radiotherapy sessions.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 6","pages":"744-750"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of ECG Interpretation Among Undergraduate Medical Students at Universities in Makkah Region, Saudi Arabia: A Cross-Sectional Study.","authors":"A J Mandourah, K A Basamih, G A Alghamdi, R M Almatrafi, S Y Hazra, F A Alghamdi, Y M Alraffah","doi":"10.4103/njcp.njcp_261_24","DOIUrl":"https://doi.org/10.4103/njcp.njcp_261_24","url":null,"abstract":"<p><strong>Background: </strong>Electrocardiogram (ECG) Interpretation is one of the most important and critical skills for various medical specialists. It is essential for diagnosing and managing many cardiac diseases, including life-threatening conditions.</p><p><strong>Aim: </strong>To evaluate competency in ECG interpretation skills among medical students in the Makkah region and the associated factors.</p><p><strong>Methods: </strong>Medical students from all Makkah region medical schools were asked to complete a web-based survey containing questions on 17 ECG strips. There were questions on primary ECG parameters (rate, rhythm, and axis), emergencies, and common ECG abnormalities. Multiple logistic regression analysis was used to determine factors associated with their performance. A P value of < 0.05 was considered as significant.</p><p><strong>Results: </strong>We enrolled 1239 medical students from medical schools in the Makkah region completed the questionnaire. The participants' ECG interpretation competency scores were generally low, with a median of 35.29% (IQR 17.65%-52.94%). Fifth and sixth-year students demonstrated significantly higher ECG competency scores compared students in the earlier years (P < 0.001). Logistic regression analysis showed that being in clinical years (OR: 1.65, 95% CI: 1.18-2.30, P = 0.003), self-study as primary source of ECG knowledge (OR: 0.58, 95% CI: 0.43-0.79, P = 0.001), and using both online and face-to-face learning methods (OR: 1.44, 95% CI: 1.00-2.07, P = 0.049) were significantly associated with higher odds of adequate ECG interpretation competency.</p><p><strong>Conclusion: </strong>The study showed a significant need for improvement in ECG interpretation skills among medical students in the Makkah region. The findings underscore the importance of integrating practical ECG interpretation training throughout the medical curriculum, with emphasis on clinical exposure, self-study, and blended learning approaches.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 6","pages":"695-707"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orofacial Manifestations and Oral Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus.","authors":"F Akkoca, F Basibuyuk, E Koyuncu, G Ilhan, M E Arayici, M Ozdede, G Sen","doi":"10.4103/njcp.njcp_166_25","DOIUrl":"https://doi.org/10.4103/njcp.njcp_166_25","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated orofacial manifestations and oral health-related quality of life in patients with systemic lupus erythematosus (SLE) in the Turkish population. It also aims to investigate the relationship between these findings and disease activity and other associated factors.</p><p><strong>Methods: </strong>Patients referred from the rheumatology clinic and SLE-diagnosed patients were evaluated in the oral diagnosis clinic. Orofacial manifestations were assessed through clinical examinations, and oral health status was evaluated using the Decayed-Missing-Filled Teeth (DMFT) index. Disease activity was measured using the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), while oral health-related quality of life was assessed with the Oral Health Impact Profile-14 (OHIP-14). Statistical analyses, including Pearson correlation and Kruskal-Wallis tests, were performed to evaluate associations among disease activity, oral health status, and quality of life.</p><p><strong>Results: </strong>The study included 70 SLE patients (67 females, 3 males; mean age: 46.3 ± 13.5 years). Orofacial lesions were present in 25.7% of the patients, and the cheek mucosa was the most commonly affected site. Bruxism was detected in 42.9% of patients, while burning mouth syndrome was observed in 11.4% of patients. Disease activity assessment showed that 45.7% had no activity, and 47.1% had mild severity. The OHIP-14 analysis indicated that psychological discomfort was the most affected domain (2.8 ± 2.26), whereas handicap had the least impact (0.97 ± 1.32). Although significant correlations were found between the OHIP-14 subscales, no significant correlation was observed between SLEDAI-2K scores and OHIP-14 subscales (P > 0.05).</p><p><strong>Conclusion: </strong>Orofacial lesions in SLE patients were relatively common and varied in presentation. Although no direct relationship was found between disease activity and oral health-related quality of life, significant associations existed between different domains of OHIP-14. These findings highlight the need for a multidisciplinary approach to managing oral health in SLE patients to improve their overall quality of life.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 6","pages":"730-736"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}