Neurology India最新文献_第6页

Isolated Abducens Nerve Palsies from COVID-19 Infections: Clinical Features and Outcomes. COVID-19感染引起的孤立外展神经麻痹：临床特征和结局

IF 0.9 3区医学

Neurology India Pub Date : 2025-05-01 Epub Date: 2025-05-23 DOI: 10.4103/neurol-india.Neurol-India-D-24-00411

You-Jiang Tan, Shawn Zhen-Ji Lin

{"title":"Isolated Abducens Nerve Palsies from COVID-19 Infections: Clinical Features and Outcomes.","authors":"You-Jiang Tan, Shawn Zhen-Ji Lin","doi":"10.4103/neurol-india.Neurol-India-D-24-00411","DOIUrl":"10.4103/neurol-india.Neurol-India-D-24-00411","url":null,"abstract":"Background: Isolated abducens nerve palsies from COVID-19 infections are rarely described in literature. Their clinical features are poorly understood, and guidance on their treatment is lacking.Objective: To describe the clinical features of isolated abducens nerve palsies from COVID-19 infection, and provide guidance on their management.Methods: We performed a literature review and analyzed the clinical features of patients with isolated abducens nerve palsy from COVID-19 infections reported in literature.Results: In total, 16 cases from 15 studies published between January 2020 and December 2023 were identified. Their median age was 44 years (range 3-71, including two children). Nearly two-thirds (10/16, 63%) were without medical history. Abducens nerve palsies mostly occurred early with COVID-19 symptoms (median of 5.5 days, range 0-21 days). They were all unilateral, and displayed neither clear gender nor left-right predilections. Brain magnetic resonance imaging scans were often unremarkable (9/13, 69%). More than half (9/16, 56%) received no treatment or symptomatic treatment only, while only two received steroids. Regardless, nearly all experienced clinical of diplopia (14/16, 88%), of which most recovery were either complete or near-complete (at least 10/14, 71%) within a median period of 26 days (range 5-240 days).Conclusion: Isolated abducens nerve palsies are early but uncommon complications of COVID-19, mainly affecting patients with mild infections. Prognosis appears fair even when without corticosteroid treatment, and recovery is significant and early in most. Observation and early outpatient clinical review within a month are reasonable measures. Patients without significant improvement within a month should be re-assessed for other aetiologies.","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 3","pages":"524-528"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurofascin 155, 186 and 140 Antibodies in Patients with Multiple Sclerosis: A Pilot Prospective Exploratory Study. 多发性硬化症患者的神经束蛋白155、186和140抗体：一项前瞻性先导探索性研究

IF 0.9 3区医学

Neurology India Pub Date : 2025-05-01 Epub Date: 2025-05-23 DOI: 10.4103/neurol-india.Neurol-India-D-25-00046

Thomas Mathew, Surabhi Garg, Pritam Majumdar, Shagun Bhardwaj, Sudheeran Kannoth, Annamma Mathai, Sumithra Selvam, Molly George, Uday Murgod, Vikram Kamath, Subhash Kaul, Sindhu V Nambiar, Akshata Huddar, Sonia Shivde, Sagar Badachi, Raghunandan Nadig, Sharath Gg Kumar, Sai Kanth Deepalam, Grk Sarma

{"title":"Neurofascin 155, 186 and 140 Antibodies in Patients with Multiple Sclerosis: A Pilot Prospective Exploratory Study.","authors":"Thomas Mathew, Surabhi Garg, Pritam Majumdar, Shagun Bhardwaj, Sudheeran Kannoth, Annamma Mathai, Sumithra Selvam, Molly George, Uday Murgod, Vikram Kamath, Subhash Kaul, Sindhu V Nambiar, Akshata Huddar, Sonia Shivde, Sagar Badachi, Raghunandan Nadig, Sharath Gg Kumar, Sai Kanth Deepalam, Grk Sarma","doi":"10.4103/neurol-india.Neurol-India-D-25-00046","DOIUrl":"10.4103/neurol-india.Neurol-India-D-25-00046","url":null,"abstract":"Background: Antineurofascin antibodies (ANFA) have been identified in central and peripheral demyelinating disorders. We present the results of pan-ANFA assay targeting neurofascin (NF) 155, 186, and 140, in a cohort of Indian Multiple Sclerosis (MS) patients.Objective: To assess the presence of antineurofascin antibodies (ANFA) 155, 186, and 140 in patients with MS.Methodology: In this multicenter prospective study, we investigated the presence of antibodies targeting NF155, NF186, and NF140 in Indian MS patients satisfying McDonald's 2017 criteria. ANFA was measured by competitive ELISA technique using human neurofascins.Results: During the 11-month period from November 1, 2023, to September 30, 2024, we tested 71 MS patients for ANFA. Of the 71 MS patients, 57 (80.28%) tested positive for at least one antineurofascin antibody and 15 (21.13%) were positive for two antibodies. Isolated ANFA140 was present in 26 (36.62%) patients, isolated ANFA186 in 13 (18.31%), and isolated ANFA155 in 3 (4.23%). Combined ANFA 186/140 was present in 14 (19.72%) patients and combined ANFA 155/140 in 1 (1.41%).Conclusion: Antibodies to at least one of the neurofascin antigens were present in a significant number of Indian MS patients. ANFA to NF140 and NF186 was found to be more prevalent compared with ANFA against NF155. Further immunological and molecular investigations are required to confirm whether these antibodies are truly pathogenic, disease-modifying, or incidental.","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 3","pages":"533-537"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When Cyberattacks Turn Deadly: The Silent Crisis in Healthcare. 当网络攻击变得致命：医疗保健领域无声的危机。

IF 0.9 3区医学

Neurology India Pub Date : 2025-05-01 Epub Date: 2025-05-23 DOI: 10.4103/neurol-india.Neurol-India-D-25-00348

Mazda Turel

引用次数: 0

Bannwarth's Syndrome - Meningoradiculoneuritis Due to European Neuroborreliosis in Kerala. Bannwarth综合征-由欧洲喀拉拉邦神经螺旋体病引起的脑膜根状神经炎。

IF 0.9 3区医学

Neurology India Pub Date : 2025-05-01 Epub Date: 2024-11-29 DOI: 10.4103/ni.ni_1840_20

Boby Varkey Maramattom, Anup Warrier

引用次数: 0

Adult-Onset Leucoencephalopathy with Axonal Spheroids and Pigmented Glia: Report of Two Cases. 成人发病伴轴突球体和色素胶质的白质脑病：附2例报告。

IF 0.9 3区医学

Neurology India Pub Date : 2025-05-01 Epub Date: 2024-11-29 DOI: 10.4103/ni.ni_376_22

Sharath Kumar Goddu Govindappa, Chaitra Parameshwara Adiga, Lakshmikanth N Goolahally, P Prakash

引用次数: 0

Bibliometrics and Visualization Analysis of Neuromuscular Junction Model. 神经肌肉连接模型的文献计量学与可视化分析。

IF 0.9 3区医学

Neurology India Pub Date : 2025-05-01 Epub Date: 2025-05-23 DOI: 10.4103/ni.ni_385_22

Xincheng Du, Wenwen Liu, Jin Geng, Haowen Qiao, Yu Zhou

{"title":"Bibliometrics and Visualization Analysis of Neuromuscular Junction Model.","authors":"Xincheng Du, Wenwen Liu, Jin Geng, Haowen Qiao, Yu Zhou","doi":"10.4103/ni.ni_385_22","DOIUrl":"10.4103/ni.ni_385_22","url":null,"abstract":"Objective: Neuromuscular junctions, which are responsible for voluntary motor function, are the chemical synapses between motor neurons and skeletal muscle fibers. In this study, we performed a scientometric analysis that can be used to construct and visualize networks of neuromuscular junction model (NMJM) using bibliometric methods.Materials and methods: A literature survey for NMJM was conducted using \"TS= (neuromuscular junction model),\" including literature titles, abstracts, and keywords, under the Web of Science Core Collection (WoSCC). Document production was analyzed by document citation, source journals, authors, highly cited documents, countries, organizations, impact factors.Results: A total of 2046 articles published over the past two decades were retrieved and analyzed. Our results showed that the number of publications in NMJM has increased rapidly over the past 20 years. The most productive author in terms of total publications about NMJM was Thomas H. Gillingwater with 27 documents, who worked at the University of Miami. The geographic distribution of publications showed that majority of them were from the USA. In addition, the research hotspot of NMJM was expanding from the establishment of NMJM to mechanistic studies of diseases.Conclusions: This study provides a unique perspective for understanding the evaluative history and future trends of NMJM.","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 3","pages":"506-512"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 0.9 3区医学

Neurology India Pub Date : 2025-05-01 Epub Date: 2024-11-29 DOI: 10.4103/ni.ni_839_21

Madihah Faisal, Rajesh B Iyer, Javeria Nooraine, Sanjeev J Mudakavi, R Jaychandran, S Raghavendra

引用次数: 0

Expanding Phenotype of ATP1A3 Mutation. ATP1A3突变的扩展表型。

IF 0.9 3区医学

Neurology India Pub Date : 2025-05-01 Epub Date: 2024-11-29 DOI: 10.4103/ni.ni_1335_20

Ajith Cherian, J Nandana, K P Divya

引用次数: 0

Whole Genome Sequencing-Based Diagnosis of Spinocerebellar Ataxia Type 3 Repeat Expansion Neuromuscular Disorders in an Undiagnosed Patient: Breaking Past Diagnostic Boundaries. 基于全基因组测序的诊断脊髓小脑共济失调3型重复扩张神经肌肉疾病的未确诊患者：打破过去的诊断界限。

IF 0.9 3区医学

Neurology India Pub Date : 2025-05-01 Epub Date: 2025-03-28 DOI: 10.4103/neurol-india.Neurol-India-D-24-00552

Hari Shankar Kumar, Nidhi Shah, Parth Shah, Udhaya Kotecha, Mehul Mistri, Bushra Jarullah

{"title":"Whole Genome Sequencing-Based Diagnosis of Spinocerebellar Ataxia Type 3 Repeat Expansion Neuromuscular Disorders in an Undiagnosed Patient: Breaking Past Diagnostic Boundaries.","authors":"Hari Shankar Kumar, Nidhi Shah, Parth Shah, Udhaya Kotecha, Mehul Mistri, Bushra Jarullah","doi":"10.4103/neurol-india.Neurol-India-D-24-00552","DOIUrl":"10.4103/neurol-india.Neurol-India-D-24-00552","url":null,"abstract":"Background: Spinocerebellar ataxia type 3 (SCA3) is a neuromuscular disorder (NMD) that is a complicated and progressive genetic disorder. SCA3 is predominantly caused by repeat expansions (REs) of short tandem repeats (STRs). SCA3 is caused by a CAG repeat expansion of the ATXN3 gene and is transmitted in an autosomal dominant manner and located on chromosomal position 14q32.Objective: The objective of this study was to identify the ATNX3 gene and assess the clinical accuracy of whole genome sequencing (WGS) in finding REs in previously undiagnosed patients with SCA3 for better management.Methods and materials: Thirty-three referral cases for SCA3 were analyzed using WGS and triplet-repeat PCR (TP-PCR) techniques to detect REs for the ATXN3 gene.Results: A case of SCA3 was discovered to be positive for the ATXN3 gene for 59 CAG REs revealed by WGS and validated by TP-PCR. This mutation was found in a 26-year-old male patient who had previously been undiagnosed by other genetic tests.Conclusion: To identify REs in the ATXN3 gene by validating WGS with previously inconclusive genetic tests, the study propose that WGS could potentially be implemented as the frontline, cost-effective, less turnaround time molecular testing for more accurate diagnoses and better-informed treatment strategies.","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":" ","pages":"513-518"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normative Value of F-wave Minimum Latency in a Tertiary Care Center In Eastern India. 印度东部三级医疗中心f波最小潜伏期的规范值。

IF 0.9 3区医学

Neurology India Pub Date : 2025-05-01 Epub Date: 2025-05-23 DOI: 10.4103/ni.ni_491_21

Alak Pandit, Srimant Pattnaik, Samar Biswas, Bijaya N Naik

{"title":"Normative Value of F-wave Minimum Latency in a Tertiary Care Center In Eastern India.","authors":"Alak Pandit, Srimant Pattnaik, Samar Biswas, Bijaya N Naik","doi":"10.4103/ni.ni_491_21","DOIUrl":"10.4103/ni.ni_491_21","url":null,"abstract":"Background: F-wave normative values may be country- or geographic locality-specific, as shown in various studies. Hence, using the same cut-off value in all laboratories leads to errors. This study attempts to determine the normative value of the F-wave in eastern India.Objective: This study aims to find normative data on F-wave minimum latency in a healthy population in Eastern India and to check the correlation of F-wave minimum latency with height, age, and sex.Methods: Healthy volunteers aged 18-45 participated in the nerve conduction study to determine F-wave minimum latency in the bilateral median, ulnar, and tibial nerves. The height of the volunteers was recorded. This is a descriptive cross-sectional study.Results: A total of 150 healthy volunteers participated (70 females, 80 males). The mean age of the study population was 30.7 ± 8.4 years. The mean height of the participants was 160.5 ± 9.0 cm. The mean values of F-wave minimum latencies are as follows: 24.85 ± 1.87 msec for the median nerve, 25.1 ± 2.01 msec for the ulnar nerve, and 45.56 ± 3.74 msec for the tibial nerve. The most significant effect on latency was by height.Conclusions: The cut-off value for F-wave minimal latency may be kept as follows: right median nerve: 28.57 msec, left median nerve: 28.58 msec, left ulnar nerve: 29.24 msec, right ulnar nerve: 29.01 msec, left tibial nerve: 53.21 msec, and right tibial nerve: 52.85 msec.","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 3","pages":"469-473"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0