COVID-19感染引起的孤立外展神经麻痹:临床特征和结局

IF 0.9 3区 医学 Q4 NEUROSCIENCES
Neurology India Pub Date : 2025-05-01 Epub Date: 2025-05-23 DOI:10.4103/neurol-india.Neurol-India-D-24-00411
You-Jiang Tan, Shawn Zhen-Ji Lin
{"title":"COVID-19感染引起的孤立外展神经麻痹:临床特征和结局","authors":"You-Jiang Tan, Shawn Zhen-Ji Lin","doi":"10.4103/neurol-india.Neurol-India-D-24-00411","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Isolated abducens nerve palsies from COVID-19 infections are rarely described in literature. Their clinical features are poorly understood, and guidance on their treatment is lacking.</p><p><strong>Objective: </strong>To describe the clinical features of isolated abducens nerve palsies from COVID-19 infection, and provide guidance on their management.</p><p><strong>Methods: </strong>We performed a literature review and analyzed the clinical features of patients with isolated abducens nerve palsy from COVID-19 infections reported in literature.</p><p><strong>Results: </strong>In total, 16 cases from 15 studies published between January 2020 and December 2023 were identified. Their median age was 44 years (range 3-71, including two children). Nearly two-thirds (10/16, 63%) were without medical history. Abducens nerve palsies mostly occurred early with COVID-19 symptoms (median of 5.5 days, range 0-21 days). They were all unilateral, and displayed neither clear gender nor left-right predilections. Brain magnetic resonance imaging scans were often unremarkable (9/13, 69%). More than half (9/16, 56%) received no treatment or symptomatic treatment only, while only two received steroids. Regardless, nearly all experienced clinical of diplopia (14/16, 88%), of which most recovery were either complete or near-complete (at least 10/14, 71%) within a median period of 26 days (range 5-240 days).</p><p><strong>Conclusion: </strong>Isolated abducens nerve palsies are early but uncommon complications of COVID-19, mainly affecting patients with mild infections. Prognosis appears fair even when without corticosteroid treatment, and recovery is significant and early in most. Observation and early outpatient clinical review within a month are reasonable measures. Patients without significant improvement within a month should be re-assessed for other aetiologies.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 3","pages":"524-528"},"PeriodicalIF":0.9000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Isolated Abducens Nerve Palsies from COVID-19 Infections: Clinical Features and Outcomes.\",\"authors\":\"You-Jiang Tan, Shawn Zhen-Ji Lin\",\"doi\":\"10.4103/neurol-india.Neurol-India-D-24-00411\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Isolated abducens nerve palsies from COVID-19 infections are rarely described in literature. Their clinical features are poorly understood, and guidance on their treatment is lacking.</p><p><strong>Objective: </strong>To describe the clinical features of isolated abducens nerve palsies from COVID-19 infection, and provide guidance on their management.</p><p><strong>Methods: </strong>We performed a literature review and analyzed the clinical features of patients with isolated abducens nerve palsy from COVID-19 infections reported in literature.</p><p><strong>Results: </strong>In total, 16 cases from 15 studies published between January 2020 and December 2023 were identified. Their median age was 44 years (range 3-71, including two children). Nearly two-thirds (10/16, 63%) were without medical history. Abducens nerve palsies mostly occurred early with COVID-19 symptoms (median of 5.5 days, range 0-21 days). They were all unilateral, and displayed neither clear gender nor left-right predilections. Brain magnetic resonance imaging scans were often unremarkable (9/13, 69%). More than half (9/16, 56%) received no treatment or symptomatic treatment only, while only two received steroids. Regardless, nearly all experienced clinical of diplopia (14/16, 88%), of which most recovery were either complete or near-complete (at least 10/14, 71%) within a median period of 26 days (range 5-240 days).</p><p><strong>Conclusion: </strong>Isolated abducens nerve palsies are early but uncommon complications of COVID-19, mainly affecting patients with mild infections. Prognosis appears fair even when without corticosteroid treatment, and recovery is significant and early in most. Observation and early outpatient clinical review within a month are reasonable measures. Patients without significant improvement within a month should be re-assessed for other aetiologies.</p>\",\"PeriodicalId\":19429,\"journal\":{\"name\":\"Neurology India\",\"volume\":\"73 3\",\"pages\":\"524-528\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurology India\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4103/neurol-india.Neurol-India-D-24-00411\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurology India","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/neurol-india.Neurol-India-D-24-00411","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/23 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

背景:文献中很少描述COVID-19感染引起的孤立外展神经麻痹。人们对其临床特征了解甚少,缺乏治疗指导。目的:了解COVID-19感染孤立性外展神经麻痹的临床特点,为其治疗提供指导。方法:回顾文献,分析文献报道的COVID-19感染孤立性外展神经麻痹患者的临床特点。结果:从2020年1月至2023年12月发表的15项研究中共确定了16例病例。他们的中位年龄为44岁(范围3-71岁,包括两个孩子)。近三分之二(10/16,63%)无病史。展神经麻痹多发生在COVID-19症状早期(中位5.5天,范围0-21天)。它们都是单侧的,既没有明确的性别,也没有左右偏好。脑磁共振成像扫描通常不显著(9/13,69%)。一半以上(9/16,56%)未接受治疗或仅接受对症治疗,而只有两人接受类固醇治疗。无论如何,几乎所有患者均出现复视(14/16,88%),其中大多数患者在26天(5-240天)内完全或接近完全恢复(至少10/14,71%)。结论:孤立性外展神经麻痹是新型冠状病毒感染的早期少见并发症,以轻度感染为主。即使在没有皮质类固醇治疗的情况下,预后也很好,大多数患者恢复明显且早期。观察和一个月内早期门诊临床复查是合理的措施。一个月内无明显改善的患者应重新评估其他病因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Isolated Abducens Nerve Palsies from COVID-19 Infections: Clinical Features and Outcomes.

Background: Isolated abducens nerve palsies from COVID-19 infections are rarely described in literature. Their clinical features are poorly understood, and guidance on their treatment is lacking.

Objective: To describe the clinical features of isolated abducens nerve palsies from COVID-19 infection, and provide guidance on their management.

Methods: We performed a literature review and analyzed the clinical features of patients with isolated abducens nerve palsy from COVID-19 infections reported in literature.

Results: In total, 16 cases from 15 studies published between January 2020 and December 2023 were identified. Their median age was 44 years (range 3-71, including two children). Nearly two-thirds (10/16, 63%) were without medical history. Abducens nerve palsies mostly occurred early with COVID-19 symptoms (median of 5.5 days, range 0-21 days). They were all unilateral, and displayed neither clear gender nor left-right predilections. Brain magnetic resonance imaging scans were often unremarkable (9/13, 69%). More than half (9/16, 56%) received no treatment or symptomatic treatment only, while only two received steroids. Regardless, nearly all experienced clinical of diplopia (14/16, 88%), of which most recovery were either complete or near-complete (at least 10/14, 71%) within a median period of 26 days (range 5-240 days).

Conclusion: Isolated abducens nerve palsies are early but uncommon complications of COVID-19, mainly affecting patients with mild infections. Prognosis appears fair even when without corticosteroid treatment, and recovery is significant and early in most. Observation and early outpatient clinical review within a month are reasonable measures. Patients without significant improvement within a month should be re-assessed for other aetiologies.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Neurology India
Neurology India 医学-神经科学
CiteScore
1.60
自引率
70.40%
发文量
434
审稿时长
2 months
期刊介绍: Neurology India (ISSN 0028-3886) is Bi-monthly publication of Neurological Society of India. Neurology India, the show window of the progress of Neurological Sciences in India, has successfully completed 50 years of publication in the year 2002. ‘Neurology India’, along with the Neurological Society of India, has grown stronger with the passing of every year. The full articles of the journal are now available on internet with more than 20000 visitors in a month and the journal is indexed in MEDLINE and Index Medicus, Current Contents, Neuroscience Citation Index and EMBASE in addition to 10 other indexing avenues. This specialty journal reaches to about 2000 neurologists, neurosurgeons, neuro-psychiatrists, and others working in the fields of neurology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信