Neurology India最新文献

{"title":"Paroxysmal Third Nerve Palsy due to an Aberrant Vascular Loop.","authors":"Divya Davison, Asish Vijayaraghavan, Adarsh A Kumar, Kiren G Koshy","doi":"10.4103/neurol-india.Neurol-India-D-26-00035","DOIUrl":"10.4103/neurol-india.Neurol-India-D-26-00035","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":" ","pages":"945-946"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demystifying Suprasellar Arachnoid Cysts.","authors":"Ranjith K Moorty","doi":"10.4103/neurol-india.Neurol-India-D-26-00683","DOIUrl":"10.4103/neurol-india.Neurol-India-D-26-00683","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 5","pages":"862-863"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgery for Drug Resistant Epilepsy with Malformations of Cortical Development: Role of Non-Invasive Pre-Surgical Evaluation, Surgical Strategy and Seizure Outcome Prediction.","authors":"Malla Bhaskara Rao, Ajinkya Rewatkar, Ajay Asranna, Binukumar Bhaskarapillai, Arivazhagan Arimappamagan, Ravindu Tiwari, Karthik Kulanthaivelu, L G Vishwanathan, Jitender Chaturvedi, G C Sandeep, Nishanth Sadashiva, Ravindranadh M Chowdary, Anita Mahadevan, Raghavendra Kenchaiah, Jitender Saini, Rose D Bharath, Sandhya Mangalore, Jamuna Rajeswaran, Parthasarathy Satishchandra, Sanjib Sinha","doi":"10.4103/neurol-india.Neurol-India-D-26-00225","DOIUrl":"10.4103/neurol-india.Neurol-India-D-26-00225","url":null,"abstract":"<p><strong>Objective: </strong>Selecting patients for surgery for drug resistant epilepsy (DRE) with malformations of cortical development (MCD) by non-invasive evaluation is challenging. Optimizing surgical strategy and predicting seizure outcomes are also difficult. We analyzed the data of patients with DRE and MCD over a 12-year period at a single institution to assess the role of non-invasive pre-surgical evaluation, surgical strategy, and predictors of seizure outcome.</p><p><strong>Methods: </strong>Between April 2011 and March 2022, 584 patients with DRE underwent pre-surgical evaluation and surgery at our institution. During the study period, a total of 93 patients underwent surgery for DRE and MCD. Six patients who underwent invasive evaluation, and another six patients with incomplete data were excluded from the study. We have analyzed the clinical profile, pre-surgical evaluation data, surgical strategy, histopathology, and seizure outcome and have identified the predictors of the seizure outcome.</p><p><strong>Results: </strong>The cohort consists of 81 patients (males = 47) with a mean age of seizure onset of 6.85 years and mean age at surgery of 16.54 years. The mean duration of epilepsy before surgery was 9.75 years. The mean follow-up period was 8.66 years. In this study, 63 patients achieved international league against epilepsy (ILAE) class 1 outcome and 18 patients achieved class 2-6 outcome. Of the patients who had complete resection of the lesion, 86.2% had ILAE class 1 outcome, and those with incomplete resection had 55.17%. We found that factors such as fewer anti-seizure medications and complete resection of the lesion were associated with a favorable outcome on multivariable analysis.</p><p><strong>Conclusions: </strong>Based upon these predictors, we conclude that patients with stereotypical habitual seizures, who were on fewer anti seizure medications (ASM) preoperatively and who have undergone complete resection of the lesion can expect a favorable post-operative seizure outcome. Lack of concordant findings on pre-surgical evaluation did not independently predict poor outcome in this study, suggesting that discordant findings should not per se exclude patients with MCD from undergoing epilepsy surgery.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 5","pages":"877-884"},"PeriodicalIF":0.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Vibration-based Neuromodulation on Freezing of Gait in Parkinson's Disease: A Pilot Study.","authors":"Nitish Kamble, Amey Desai, Ravi Yadav, Basundhara Bansal, Kanishk Khanduri, Ria Rajput, Samit Chakrabarty, Vikram V Holla, Pramod Kumar Pal","doi":"10.4103/neurol-india.Neurol-India-D-26-00015","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-26-00015","url":null,"abstract":"<p><strong>Background: </strong>Freezing of gait (FOG) is an enigmatic phenomenon observed in patients with advanced Parkinson's disease (PD).</p><p><strong>Objectives: </strong>We present a novel wearable device, Wearable Assisted Locomotor Kinesthesia (WALK), that delivers vibration-based stimulation and test its effectiveness in PD patients with FOG.</p><p><strong>Methods: </strong>This prospective, nonrandomized, single-center, single-blinded study included 20 PD patients with FOG. Clinical assessments with and without the WALK device were done in the medication OFF state under two conditions: (a) walking and (b) walking + cognitive dual task. A 12-item FOG scale was used to measure FOG across six FOG-provoking tasks. These were assessed at baseline using a placebo device and an active interventional device (WALK).</p><p><strong>Results: </strong>The active device WALK reduced FOG severity by an average of 10.2 points, surpassing the minimal clinically important difference of 4.28 scale points, and participants experienced fewer FOG episodes (a mean of 7.15 fewer episodes). Participants experiencing total akinetic phases (>30s) were able to complete the task with WALK, whereas those receiving a placebo did not. Task completion duration improved by an average of 27.37% across different activities. WALK reduced FOG scores and freezing duration, particularly when navigating through narrow spaces. WALK was also effective in mitigating FOG severity across all Hoehn and Yahr stages.</p><p><strong>Conclusions: </strong>The WALK device significantly reduced FOG in patients with PD by providing vibration-based stimulation. This noninvasive neuromodulation-based intervention appeared effective and safe in this pilot study, with no adverse events, highlighting its potential in the management of FOG.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Vitamin D3 Supplementation on Sleep Quality in Deficient Adults: A Randomized Controlled Trial.","authors":"Lakshmi Priya Lalitha, Pradeep Rangaiah, Anish Mehta, Mahendra Javali, Purushottam T Acharya, Shivaraj Nallur Somanna","doi":"10.4103/neurol-india.Neurol-India-D-26-00162","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-26-00162","url":null,"abstract":"<p><strong>Background: </strong>Emerging evidence suggests a link between serum vitamin D3 deficiency and poor sleep quality, but the optimal dosing frequency to improve sleep quality remains unclear. This study investigates the impact of daily versus weekly vitamin D3 supplementation on sleep quality in adults with vitamin D3 deficiency.</p><p><strong>Methods: </strong>This single-center, prospective, single-blinded, randomized controlled trial randomized vitamin D3-deficient adults in a 1:1 ratio to receive either daily supplementation (6000 IU/day for 8 weeks) or weekly supplementation (60,000 IU/week for 8 weeks). Subjective sleep quality was evaluated with the Pittsburg Sleep Quality Index (PSQI) questionnaire at baseline and after 8 weeks. The Wilcoxon signed-rank test and Mann-Whitney U test were used to compare both groups.</p><p><strong>Results: </strong>This study enrolled 87 patients, with 45 in the weekly arm and 42 in the daily arm. The mean age was 39.26 [11.03] years, and 71% (n = 62) were female. On follow-up, the daily arm showed significant improvements in \"duration of sleep\" (0.93 [0.65] vs 1.55 [0.75], P = 0.002) and \"daytime dysfunction due to sleep\" (0.67 [0.57] vs 1.11 [1.15], P = 0.007). In contrast, the weekly arm performed better in the \"need medication to sleep\" parameter (0.13 [0.50] vs 0.37 [0.54], P = 0.034). However, the daily supplementation arm showed a favorable trend in the PSQI total score (8.46 [3.14] vs 9.93 [2.68], P = 0.024).</p><p><strong>Conclusion: </strong>Daily vitamin D3 supplementation is more effective than weekly supplementation in improving overall sleep quality, sleep duration, and daytime dysfunction in vitamin D3-deficient adults.</p><p><strong>Trial registration: </strong>Clinical Trial Registry of India (CTRI/2024/01/061970) on 29.1.2024.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concordance Between Immunohistochemistry and Sanger Sequencing for IDH1 and IDH2 Mutation Detection in South Indian Adult-type Glioblastoma Patients.","authors":"Megha S Uppin, Kaushik Puranam, Y Gayathri Devi","doi":"10.4103/neurol-india.Neurol-India-D-26-00372","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-26-00372","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plaque Steepness is Associated with Hemodynamics in Patients with Atherosclerotic Middle Cerebral Artery Stenosis.","authors":"Mi Wang, Bin Jiang, Danfeng Zhang","doi":"10.4103/neurol-india.Neurol-India-D-26-00273","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-26-00273","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the relationship between plaque steepness and hemodynamics in middle cerebral artery (MCA) stenosis based on high-resolution magnetic resonance imaging and computational fluid dynamics.</p><p><strong>Methods: </strong>Eighty consecutive patients accompanying with unilateral atherosclerotic MCA stenosis (50%-99%) were prospectively recruited. All patients underwent a cross-sectional scan of the stenotic MCA vessel wall. The parameters and features of the plaque, vessel wall, translesional wall shear stress ratio (WSSR), wall shear stress in stenosis (WSSs), and translesional pressure ratio (RP) were obtained. The patients were divided into the DWI-positive group and the DWI-negative group. The differences in plaque, vessel wall, and hemodynamics were compared between the two groups. Correlations between the plaque steepness and hemodynamics were calculated.</p><p><strong>Results: </strong>The DWI-positive group (31 cases) had a smaller lumen area (LA) (P = 0.024), larger plaque area (PA) (P < 0.001) and normal wall index (NWI) (P = 0.009), higher WSSR (P = 0.009) and WSSs (P = 0.018), and larger plaques' height (P = 0.039) and radio of height/width (P = 0.014) at the most stenotic site. The DWI-positive group had more enhanced plaques (24 vs 13, P = 0.03), positive remodeling patients (23 vs 20, P < 0.001) than the DWI-negative group (49 cases). The height of plaque (r = 0.805, P < 0.001) and ratio of height/width (r = 0.879, P < 0.001) showed positive correlation with WSSR, respectively.</p><p><strong>Conclusion: </strong>Steepness is an important feature of atherosclerotic plaques; individuals with steep plaques might be more prone to stroke.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pure Right Conjugate Horizontal Gaze Palsy due to Isolated Abducens Nuclear Infarction.","authors":"Bhadra Sajeev Nair, Boby Varkey Maramattom","doi":"10.4103/neurol-india.Neurol-India-D-26-00232","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-26-00232","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crossed Cerebellar Diaschisis Following an Acute Stroke.","authors":"Shreyashi Ganguly, Divya Nagabushana, Rashmi Devaraj, Mohan P Channappanavar","doi":"10.4103/neurol-india.Neurol-India-D-26-00130","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-26-00130","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding Bilateral Chronic Subdural Hematoma in an Infant: Key Neuroimaging Findings.","authors":"Srishti Dixit, Swarjith Nimmakayala, Ved P Maurya","doi":"10.4103/neurol-india.Neurol-India-D-26-00335","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-26-00335","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}