Neurology India最新文献_第10页

A Systematic Review and Meta-Analysis on the Effectiveness of Radiotherapy and Temozolomide Treatment With or Without Bevacizumab in Patients With Glioblastoma Multiforme. 关于多形性胶质母细胞瘤患者接受放疗和替莫唑胺治疗联合或不联合贝伐珠单抗疗效的系统性综述和元分析。

IF 0.9 3区医学

Neurology India Pub Date : 2024-07-01 Epub Date: 2024-08-31 DOI: 10.4103/neurol-india.Neurol-India-D-23-00346

Fu Yang, Liuli Wang, Wei Zhao, Shuai Wang, Jinxing Li, Aigang Sun, Mingguang Wang, Zengyong Wang, Zi Chen, Xueyuan Heng

{"title":"A Systematic Review and Meta-Analysis on the Effectiveness of Radiotherapy and Temozolomide Treatment With or Without Bevacizumab in Patients With Glioblastoma Multiforme.","authors":"Fu Yang, Liuli Wang, Wei Zhao, Shuai Wang, Jinxing Li, Aigang Sun, Mingguang Wang, Zengyong Wang, Zi Chen, Xueyuan Heng","doi":"10.4103/neurol-india.Neurol-India-D-23-00346","DOIUrl":"10.4103/neurol-india.Neurol-India-D-23-00346","url":null,"abstract":"Glioblastoma multiforme (GBM) is the most frequent primary brain malignancy in adults. Despite improvements in imaging and therapy, the prognosis remains poor. To evaluate and compare the impact of combining bevacizumab with temozolomide and radiotherapy on progression-free survival (PFS) and overall survival (OS) in patients diagnosed with GBM. A comprehensive search was conducted across multiple databases, including PubMed, Embase, Scopus, and The Cochrane Library, covering the period from their inception to December 2022. The collected data underwent analysis employing appropriate statistical methods. Six articles were included in this systematic review and meta-analysis. The addition of bevacizumab to the combination of temozolomide/radiotherapy did not increase the OS in GBM patients. The pooled odds ratio (OR) was 0.843 (95% CI: 0.615-1.156, P = 0.290). The addition of bevacizumab to radiotherapy/temozolomide did not increase the PFS in patients with GBM. The pooled OR was 0.829 (95% CI: 0.561-1.224, P = 0.346). The funnel plot demonstrated the absence of the alleged pleiotropic effects by showing no evidence of observable variability across the estimations. This study does not support the benefit of the addition of bevacizumab to temozolomide and radiotherapy in improving OS and PFS in GBM patients.","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"72 4","pages":"700-707"},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant Arachnoid Granulation. 巨型蛛网膜肉芽肿

IF 0.9 3区医学

Neurology India Pub Date : 2024-07-01 Epub Date: 2024-08-31 DOI: 10.4103/neurol-india.Neurol-India-D-24-00403

Liyan Chen, Lili Zhao

引用次数: 0

Identification and Prognostic Value of m6A-Related Genes in Glioblastoma. 胶质母细胞瘤中 m6A 相关基因的鉴定和预后价值

IF 0.9 3区医学

Neurology India Pub Date : 2024-07-01 Epub Date: 2024-08-31 DOI: 10.4103/neurol-india.ni_1166_21

Ping Zheng, Xiaoxue Zhang, Dabin Ren, Qingke Bai

{"title":"Identification and Prognostic Value of m6A-Related Genes in Glioblastoma.","authors":"Ping Zheng, Xiaoxue Zhang, Dabin Ren, Qingke Bai","doi":"10.4103/neurol-india.ni_1166_21","DOIUrl":"https://doi.org/10.4103/neurol-india.ni_1166_21","url":null,"abstract":"Background: N6-methyladenosine (m6A) is one of the most common forms of mRNA modification, which is dynamically regulated by the m6A-related genes; however, its effect in glioblastoma (GBM) is still unknown.Objective: We sought to investigate the association between m6A-related genes (m6A-RGs) and GBM.Methods: Transcriptome data and the relevant clinical data were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. The m6A-RGs were identified from differently expressed genes, and COX and lasso regression models were applied to locate the prognosis-related genes.Results: We identified 15 out of 19 m6A-RGs differentially expressed between GBM and nontumor tissues. We identified two subgroups of GBM (clusters 1 and 2) by applying consensus clustering. Compared with the cluster 1 subgroup, the cluster 1 subgroup correlates with a poorer prognosis, and most of the 19 m6A-RGs are higher expressed in cluster 1. Through univariate Cox and lasso regression model, we identified three m6A-RGs, namely HNRNPC, ALKBH5, and FTO, which were used to construct a Cox regression risk model to predict the prognosis of GBM patients.Conclusion: We identified a valuable m6A model for predicting the prognosis of GBM patients, which can provide useful epigenetic biomarkers.","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"72 4","pages":"830-836"},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphometric Study of the Intracranial Fluid Spaces in Schizophrenia. 精神分裂症患者颅内液间隙形态计量学研究

IF 0.9 3区医学

Neurology India Pub Date : 2024-07-01 Epub Date: 2024-08-31 DOI: 10.4103/neurol-india.ni_552_21

Mete Ozdikici

{"title":"Morphometric Study of the Intracranial Fluid Spaces in Schizophrenia.","authors":"Mete Ozdikici","doi":"10.4103/neurol-india.ni_552_21","DOIUrl":"https://doi.org/10.4103/neurol-india.ni_552_21","url":null,"abstract":"Background: The intracranial fluid spaces (IFS), also known as \"the extra-axial spaces,\" consist of the superficial cerebral sulci, the Sylvian fissures, the basal cisterns, the third ventricle, the fourth ventricle, and the two lateral ventricles. In diseases such as schizophrenia, Alzheimer's, Parkinson's, and especially hydrocephalus, IFS' enlargements are observed.Objective: Our study aimed to determine the mean values of IFS measurements in patients with schizophrenia and compare them with healthy controls.Material and methods: This work has been carried out on 188 cases, out of which 88 schizophrenia patients (56 men and 32 women) met the diagnostic criteria according to DSM-5 for schizophrenia and 100 healthy controls (50 men and 50 women). The 10 parameters have been used to evaluate IFS on magnetic resonance imaging (MRI) scans.Results: The parameters showing statistically significant differences were higher in favor of the individual with schizophrenia. Except for the bifrontal index and Evan's index, most parameters (the bicaudate index, the fourth ventricle width, the fourth ventricle index, the maximum width of the anterior interhemispheric fissure, the maximum width of the right frontal subarachnoid space, the maximum width of the left frontal subarachnoid space, the maximum width of the right Sylvian fissure, and the maximum width of the left Sylvian fissure) were obtained statistically highly significant differences between the examined and control groups.Conclusions: In schizophrenia, it is more practical to evaluate brain atrophy using some parameters, especially the width of the Sylvian fissure and the bicaudate index.","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"72 4","pages":"817-823"},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Posterior Fossa Craniopharyngioma Arising from the Inferior Medullary Velum. 后窝颅咽管瘤源自髓质下静脉。

IF 0.9 3区医学

Neurology India Pub Date : 2024-07-01 Epub Date: 2024-08-31 DOI: 10.4103/neurol-india.NI_366_20

Dimble Raju, Chandramouli Mukherjee, Sayan Das, Sugat Sanyal, Prasad Krishnan

引用次数: 0

Syncope and Seizure-Clash of the Two Titans in Geriatrics. 晕厥与癫痫发作--老年医学中的两大难题。

IF 0.9 3区医学

Neurology India Pub Date : 2024-07-01 Epub Date: 2024-08-31 DOI: 10.4103/neurol-india.Neurol-India-D-24-00010

Debabrata Chakraborty

引用次数: 0

Laser-Cut Stent-Assisted Coiling of Wide-Necked Giant Cavernous ICA Aneurysm: Inviting a Catastrophe. 激光切割支架辅助夹闭宽颈巨大腔隙性 ICA 动脉瘤：引来一场灾难

IF 0.9 3区医学

Neurology India Pub Date : 2024-07-01 Epub Date: 2024-08-31 DOI: 10.4103/neurol-india.Neurol-India-D-23-00368

Parth Jani, Sukalyan Purkayastha

引用次数: 0

Neurocysticercosis by Autoinfection. 自身感染引起的神经囊虫病。

IF 0.9 3区医学

Neurology India Pub Date : 2024-07-01 Epub Date: 2024-08-31 DOI: 10.4103/neurol-india.Neurol-India-D-24-00078

Ashok Narendrakumar, Amol Raheja, Ayush Agarwal, Ajay Garg, Kanwaljeet Garg, Vivek Tandon

引用次数: 0

Spinal Arachnoid Web Presenting as Noncompressive Polyradiculoneuropathy. 表现为非压迫性多脊髓神经病的脊髓蛛网膜。

IF 0.9 3区医学

Neurology India Pub Date : 2024-07-01 Epub Date: 2024-08-31 DOI: 10.4103/neurol-india.Neurol-India-D-24-00147

Rahil Arora, Manish Bahrtia, Vinny W Pulikottil, Arindam Mukherjee, Bharat Hosur

引用次数: 0

Which Acute Stroke Patients can Walk while Returning Home? Factors Predicting Ambulation. 哪些急性中风患者可以在回家后步行？行走能力的预测因素。

IF 0.9 3区医学

Neurology India Pub Date : 2024-07-01 Epub Date: 2024-08-31 DOI: 10.4103/neurol-india.ni_188_22

Kirac Unal Zeynep, Cankurtaran Damla, Umay Ebru

{"title":"Which Acute Stroke Patients can Walk while Returning Home? Factors Predicting Ambulation.","authors":"Kirac Unal Zeynep, Cankurtaran Damla, Umay Ebru","doi":"10.4103/neurol-india.ni_188_22","DOIUrl":"https://doi.org/10.4103/neurol-india.ni_188_22","url":null,"abstract":"Purpose: Regaining gait is the primary goal in stroke rehabilitation. In this study, we aimed to investigate the effect of premorbid features of acute stroke patients on the ambulatory level.Methods: The study included 174 patients who applied to our rehabilitation clinic within the first month after the onset of stroke. Demographic characteristics of patients, pre-stroke symptoms, and stroke characteristics were questioned from patient files and historical data. The ambulation levels of patients before and after rehabilitation were evaluated with the functional ambulation category. The relationship between demographic characteristics, pre-stroke symptoms, stroke characteristics, and ambulation levels of patients before and after rehabilitation was examined.Results: The presence of coronary heart diseases, atrial fibrillation, and nausea/vomiting before stroke were independent negative risk factors on both pre- and post-rehabilitation ambulation levels (P < 0.05). Additionally, advanced age, oxygen, and mechanical ventilation requirement were other negative independent risk factors on post-rehabilitation ambulation levels (P < 0.05).Conclusions: Knowing some of the pre-stroke characteristics of patients while applying rehabilitation programs may be useful in estimating the ambulatory levels on returning home.","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"72 4","pages":"824-829"},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0