Neurology India最新文献

{"title":"A Giant Intracranial Intradural Ethmoidal Mucocele Causing Adult-Onset Seizure.","authors":"M Kodeeswaran, S Chiraag Hiran, Swarna Rekha Narayanan","doi":"10.4103/neurol-india.Neurol-India-D-25-00276","DOIUrl":"10.4103/neurol-india.Neurol-India-D-25-00276","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":" ","pages":"347-349"},"PeriodicalIF":0.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed Vascular Malformation in Brainstem: A Rare Association.","authors":"Manoj Kumar Nayak, Shailesh B Gaikwad, Biswamohan Mishra, Kalyan Sharma, Sarat Chandra","doi":"10.4103/neuroindia.NI_253_22","DOIUrl":"10.4103/neuroindia.NI_253_22","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":" ","pages":"319-321"},"PeriodicalIF":0.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilobed Thoracic Myelocystocele: Rare Presentation.","authors":"Abhijit Acharya, Ashok K Mahapatra, Souvagya Panigrahi, Ram C Deo, Soubhagya R Tripathy, Satya B Senapati, Sumirini Puppala","doi":"10.4103/neurol-india.Neurol-India-D-25-00167","DOIUrl":"10.4103/neurol-india.Neurol-India-D-25-00167","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":" ","pages":"341-342"},"PeriodicalIF":0.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myoclonus Dystonia Look-Alike Syndrome as an Unusual Presenting Manifestation of Systemic Lupus Erythematosus.","authors":"Amina Nasri, Mouna Ben Djebara, Istabrak Abdelkefi, Riadh Gouider","doi":"10.4103/neuroindia.NI_707_19","DOIUrl":"10.4103/neuroindia.NI_707_19","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":" ","pages":"324-329"},"PeriodicalIF":0.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns Regarding Article: 10.4103/ni.ni_800_22: Normative Data of Montreal Cognitive Assessment (MoCA) in Tamil Speaking Adults.","authors":"A P Porrselvi","doi":"10.4103/neurol-india.Neurol-India-D-25-00301","DOIUrl":"10.4103/neurol-india.Neurol-India-D-25-00301","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":" ","pages":"345-346"},"PeriodicalIF":0.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uniportal Endoscopic Versus Microscopic Unilateral Laminotomy for Bilateral Decompression in the Treatment of Lumbar Spinal Stenosis: A Meta-Analysis.","authors":"Ruibin Feng, Cong Pang, Depeng Ji, Yi Zhong, Cairu Chen","doi":"10.4103/neurol-india.Neurol-India-D-25-00298","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-25-00298","url":null,"abstract":"<p><strong>Background: </strong>The effectiveness of uniportal endoscopic and microscopic unilateral laminotomy for bilateral decompression (ULBD) in managing lumbar spinal stenosis (LSS) remains a subject of debate.</p><p><strong>Objective: </strong>This meta-analysis aims to provide evidence-based guidance for clinical decision-making in the treatment of elderly LSS patients.</p><p><strong>Methods: </strong>Databases (PubMed, Scopus, Cochrane, Embase, Web of Science) were searched from inception to September 2024 to identify relevant studies. The primary outcome measures included operative time, estimated blood loss, length of hospital stay, Visual Analog Scale (VAS) pain scores for both back and leg, Oswestry Disability Index (ODI) scores, and complication rates.</p><p><strong>Results: </strong>An analysis of five studies encompassing 349 LSS patients revealed that endoscopic ULBD (Endo-ULBD) provided superior long-term alleviation of back pain compared to microscopic ULBD (Micro-ULBD), although no significant difference was observed during early follow-up periods. Regarding leg pain, both approaches yielded comparable outcomes. Endo-ULBD demonstrated additional advantages, including shorter hospitalization durations, decreased blood loss, and a lower incidence of complications. Furthermore, early functional recovery, as assessed by ODI, was more favorable with Endo-ULBD, despite final functional outcomes being similar between the two techniques.</p><p><strong>Conclusions: </strong>This meta-analysis reveals that Endo-ULBD demonstrates superior long-term back pain relief compared to Micro-ULBD, while also offering significant early functional recovery advantages. Critically, both techniques were found to be equally effective in providing symptomatic relief for radicular leg pain, as measured by VAS leg scores. Although both procedures ultimately yield comparable functional outcomes, Endo-ULBD presents additional benefits, including reduced hospital stay duration, decreased blood loss, and lower complication rates. These findings underscore the distinct advantages of Endo-ULBD in LSS surgical interventions.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 2","pages":"206-214"},"PeriodicalIF":0.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conjunctival Impression Cytology and Dry Eye Parameters in Migraine Patients.","authors":"Mustafa Altas, Pembe Oltulu, Selman Belviranli, Ali Ulvi Uca, Ali Osman Gündogan, Enver Mirza, Ismet Dogru, Refik Oltulu","doi":"10.4103/neurol-india.Neurol-India-D-25-00661","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-25-00661","url":null,"abstract":"<p><strong>Introduction/background: </strong>Migraine is a chronic neurovascular inflammatory disorder involving complex mechanisms such as trigeminovascular system activation and neuroinflammation. In addition to headache, migraine may be associated with ophthalmic manifestations that are often overlooked. Dry eye disease is a multifactorial inflammatory disorder of the ocular surface characterized by tear film instability. Recent evidence suggests a potential association between migraine and dry eye, possibly through shared neurovascular and inflammatory pathways.</p><p><strong>Objective: </strong>In this study, it was aimed to compare ocular surface changes and dry eye parameters between migraine patients and healthy individuals.</p><p><strong>Methods and materials: </strong>The participants of the present cross-sectional comparative study are 30 migraine patients and 31 age and gender matched healthy individuals. The demographic and clinical data of migraine patients were recorded. Ocular surface changes were evaluated using Schirmer I test, tear break-up time (TBUT), Ocular Surface Disease Index (OSDI) scores and conjunctival impression cytology (CIC) grades were assessed and results were compared between the two groups.</p><p><strong>Results: </strong>CIC degrees of the migraine patients were higher than the control group (p<0.001). CIC assessment of the migraine group revealed that ten patients (33.3%) were of grade II-III, whereas the CIC assessment of two (6.5%) participants in the control group was grade II. Grade III CIC was not determined in the control group. TBUT in the migraine group was lower compared to the control group (p=0.023) and Schirmer I was (p=0.013) lower and OSDI score higher (p<0.001). In the migraine group, there was an inverse correlation between CIC grade, Schirmer I test (p=0.001, p=-0.559) and TBUT (p<0.001, p=-0.778).</p><p><strong>Conclusion: </strong>Objective signs and subjective symptoms of dry eye are common in patients with migraine. Abnormal CIC evaluation findings such as morphological changes in the bulbar conjunctiva, goblet cell loss, and squamous metaplasia suggest the presence of inflammation. These findings too, support the hypothesis that dry eye and changes in the ocular surface may play a role in the pathogenesis of migraine.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 2","pages":"249-255"},"PeriodicalIF":0.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fever Triggered Early-Onset Dystonia, Parkinsonism, and Striatal Degeneration: Think of DYT-PRKRA.","authors":"A Roshwanth, Ramandeep Singh, Balachandar Vellingiri, Madhu Gaddigoudar, Arvinder Wander","doi":"10.4103/neurol-india.Neurol-India-D-25-00566","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-25-00566","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 2","pages":"367-368"},"PeriodicalIF":0.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Myoclonic Epilepsies - A Pragmatic Review.","authors":"Ajith Cherian, K P Divya","doi":"10.4103/neurol-india.Neurol-India-D-25-00075","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-25-00075","url":null,"abstract":"<p><strong>Introduction: </strong>Progressive Myoclonus Epilepsy (PME) is a rare and complex group of inherited neurodegenerative disorders characterized by progressively worsening myoclonus, cognitive impairment, tonic-clonic seizures and ataxia. The clinical features and genetic underpinnings of PME are diverse, with approximately 80% of individuals now able to receive a molecular diagnosis. This review outlines the clinical phenotypes, genotypes, and management strategies for PME. Literature search for publications on PME in the preceding 20 years, with emphasis for the past one decade, performed using Medline, JSTOR (journal storage) and PubMed databases.</p><p><strong>Discussion: </strong>In PME progression of symptoms can vary widely among patients, with some experiencing rapid deterioration while others may have a slower rate of decline. Lafora Disease, characterized by the presence of Lafora bodies in tissues, Unverricht-Lundborg Disease (EPM1), caused by mutations in the CSTB gene, Myoclonic Epilepsy with Ragged-Red Fibers (MERRF), a mitochondrial disorder and Neuronal Ceroid Lipofuscinoses (NCL) make up the major chunk of PME syndromes. In the workup of PME, certain clinical and electroencephalogram (EEG) findings can help differentiate the specific etiologies. Valproic acid, perampanel, phenobarbitone and zonisamide are frequently prescribed as a treatment for various seizure types associated with PME. They are effective for managing both myoclonic and generalized tonic-clonic seizures. However, patients often have a progressive course and may find their myoclonus resistant to treatment.</p><p><strong>Conclusion: </strong>This review explores the clinical features and genetic factors associated with the more prevalent as well as recently described forms of PME for effective clinical evaluation, and suggests management strategies for this challenging condition.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 2","pages":"175-183"},"PeriodicalIF":0.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance-Guided Focused Ultrasound (MRgFUS) for Movement Disorders: A Practical Guide for Neurologists.","authors":"Sandhya Manorenj, S Sravan Kumar","doi":"10.4103/neurol-india.Neurol-India-D-25-00354","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-25-00354","url":null,"abstract":"<p><strong>Abstract: </strong>Magnetic resonance-guided focused ultrasound (MRgFUS) is a novel, noninvasive therapeutic approach that shows potential in treating movement disorders, such as essential tremor, Parkinson's disease, and dystonia. This technique combines high-intensity focused ultrasound with real-time magnetic resonance imaging, allowing for accurate targeting and thermal ablation of deep brain areas without incisions or exposure to ionizing radiation. MRgFUS provides precise lesioning with intraoperative feedback, enabling immediate assessment of symptoms. Clinical trials and initial clinical applications have shown significant enhancements in motor symptoms and quality of life, boasting a favorable safety profile with fewer adverse effects compared to traditional surgical methods like deep brain stimulation (DBS). For patients who are not candidates for surgery or who prefer less invasive treatments, MRgFUS represents a valuable alternative. This brief overview serves as a useful resource for general neurologists.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 2","pages":"184-193"},"PeriodicalIF":0.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}