Neurology India最新文献

{"title":"When Care Means Letting Go.","authors":"R Girish Menon","doi":"10.4103/neurol-india.Neurol-India-D-26-00555","DOIUrl":"10.4103/neurol-india.Neurol-India-D-26-00555","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 4","pages":"565-566"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of Mild Cognitive Impairment among the Elderly in India: A Systematic Review and Meta-Analysis.","authors":"Thejas Achary, Aninda Debnath, Pritam Halder, Ravneet Kaur, Anubhav Mondal, Vignitha Babu, Athul Sanjeev, Jugal Kishore","doi":"10.4103/neurol-india.Neurol-India-D-25-00766","DOIUrl":"10.4103/neurol-india.Neurol-India-D-25-00766","url":null,"abstract":"<p><strong>Abstract: </strong>Mild cognitive impairment (MCI) represents a transitional state between normal cognitive aging and dementia, with significant implications for public health. The objective of our study was to estimate the pooled prevalence of MCI among Indian elderly individuals (≥60 years). We conducted a systematic review and meta-analysis in accordance with PRISMA-2020 guidelines. Four databases (PubMed, Scopus, Embase, Web of Science) were searched up to January 2025. Twenty-six studies met the eligibility criteria. Random-effects models were used to calculate pooled prevalence with 95% confidence intervals (CIs), stratified by community- and hospital-based settings. Heterogeneity was assessed using I² and τ² statistics. Subgroup and meta-regression analyses examined potential sources of heterogeneity. Publication bias was evaluated using funnel plots, Egger's regression test. The methodological quality of included studies was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Prevalence Studies. The pooled prevalence of MCI was 21% (95% CI: 13%-29%) in community settings and 44% (95% CI: 31%-57%) in hospital-based populations. Higher prevalence was observed among individuals with type 2 diabetes (53%), hypertension (57%), and those undergoing hemodialysis (38%). Diagnostic tool choice significantly influenced prevalence, with MoCA-based assessments yielding higher estimates than MMSE or Petersen criteria. Substantial heterogeneity was present across studies (I² >96%). Publication bias was minimal. MCI is prevalent among India's elderly population, particularly in individuals with chronic conditions. These findings underscore the need to integrate cognitive screening into national noncommunicable disease programs and to adopt standardized, context-appropriate diagnostic protocols for early identification and intervention.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 4","pages":"574-585"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NMDA Receptor-Associated Encephalitis and Renal Failure - A Unique Association.","authors":"Komal Bohra, Rukmini Mridula, Sruthi Kola, Rupam Borgohain","doi":"10.4103/neurol-india.Neurol-India-D-25-00466","DOIUrl":"10.4103/neurol-india.Neurol-India-D-25-00466","url":null,"abstract":"<p><strong>Abstract: </strong>N-methyl-D-aspartate (NMDA) receptor encephalitis stands as the most common form of autoimmune encephalitis in young adults, characterized by a spectrum of distressing symptoms such as seizures, behavioral disruptions, autonomic dysfunction, and memory impairment. We present a noteworthy case involving a young adult male exhibiting seizures and renal failure, initially prompting an evaluation for vasculitis, hyperuricemia-induced acute kidney injury (AKI), and rhabdomyolysis-induced AKI. However, subsequent findings revealed the presence of NMDA receptor antibodies, and a renal biopsy confirmed tubulointerstitial nephritis. This case sheds light on the association between renal failure and NMDA receptor antibody-associated encephalitis, marking a rare instance in our knowledge.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 4","pages":"678-681"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microsurgical Resection of Craniocervical Junction Meningioma via A Far-Lateral (Paracondylar) Approach.","authors":"Ashutosh Carpenter, Prakash Nair, R Gokulvijay, U Jagadishwar, Pooja Choudhary, Syed Yasin Shahtaz Emanee","doi":"10.4103/neurol-india.Neurol-India-D-25-00702","DOIUrl":"10.4103/neurol-india.Neurol-India-D-25-00702","url":null,"abstract":"<p><strong>Abstract: </strong>Craniocervical junction meningiomas compress the ventral medulla and may encase the vertebral artery, making resection challenging. This operative video demonstrates a far-lateral paracondylar approach with C1 laminectomy and dentate-ligament division for broad exposure and safe resection. A far-lateral paracondylar approach (<25% condyle drilling) was performed with C1 laminectomy and extradural mobilization of the V3 segment of the vertebral artery; intradural C1-C2 dentate-ligament division enabled controlled medialization of the spinal cord for circumferential contralateral dissection. Surgical exposure spanned the CN VII-VIII complex superiorly, the paravertebral V3-V4 corridor laterally, the lateral and dorsal aspects of C2 inferiorly, and an intradural corridor between the spinal cord and the ipsilateral vertebral artery extending toward the contralateral vertebral artery and hypoglossal nerve. Gross-total resection was achieved without occipitocervical stabilization, with preservation of the posterior inferior cerebellar artery (PICA), anterior spinal arteries, and lower cranial nerves; single-layer myocutaneous closure limited pseudomeningocele formation. This approach, combining minimal condylar drilling, C1 laminectomy, and dentate-ligament division, affords expansive exposure of foramen magnum meningiomas extending to C2, enabling maximal tumor resection while preserving critical neurovascular structures and maintaining craniocervical stability.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 4","pages":"586-589"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lt. Col. (Dr.) Prahlad Kumar Sethi: A Pioneer in Indian Neurology and Military Medicine (Oct 14th 1939 to March 24th 2026).","authors":"S Venkatraman","doi":"10.4103/neurol-india.Neurol-India-D-26-00504","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-26-00504","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 4","pages":"764-766"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148654160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and Operative Utility of Bilateral Inferior Petrosal Sinus Sampling in ACTH-Dependent Cushing Syndrome using Vasopressin.","authors":"Shubham Gupta, Ashok Gandhi, Naman Purohit, Arvind Sharma, Surendra Jain, Trilochan Srivastava","doi":"10.4103/neurol-india.Neurol-India-D-25-00836","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-25-00836","url":null,"abstract":"<p><strong>Background: </strong>Accurate localization of adrenocorticotropic hormone (ACTH) secretion is crucial for the surgical management of ACTH-dependent Cushing's syndrome. While magnetic resonance imaging (MRI) and biochemical testing aid diagnosis, bilateral inferior petrosal sinus sampling (BIPSS) remains a reference standard in diagnostically challenging cases. In the absence of corticotropin-releasing hormone (CRH), vasopressin may serve as an effective alternative corticotroph stimulant during BIPSS; however, its additional benefit in lateralizing corticotroph adenomas remains uncertain.</p><p><strong>Objective: </strong>To evaluate the diagnostic utility of BIPSS using vasopressin in selected patients with ACTH-dependent Cushing's syndrome and compare its accuracy with the high-dose dexamethasone suppression test (HDDST) and MRI in localization and lateralization.</p><p><strong>Methods: </strong>Fourteen patients with biochemically confirmed ACTH-dependent Cushing's syndrome underwent HDDST, pituitary MRI, and BIPSS with Vasopressin as a corticotroph stimulant. BIPSS was performed to confirm a central source of ACTH secretion and assess lateralization. Transsphenoidal surgery (TSS) was performed in selected patients based primarily on MRI findings.</p><p><strong>Results: </strong>Of 14 patients, 13 were diagnosed with Cushing's disease (CD) and one with ectopic ACTH secretion. BIPSS correctly identified a pituitary source in all Cushing's disease cases, while HDDST yielded false negatives in three cases (sensitivity 76.9%). Concordance lateralization between BIPSS and MRI was observed in eight of 13 CD cases (61.5%). Among nine patients who underwent TSS, five achieved remissions; four of these had concordant BIPSS and MRI lateralization.</p><p><strong>Conclusion: </strong>BIPSS is a valuable adjunct and remains a diagnostic tool for confirming pituitary origin in ACTH-dependent Cushing's syndrome, particularly when MRI and HDDST findings are inconclusive. Although vasopressin-stimulated BIPSS did not improve lateralization in this cohort, a higher proportion of patients achieving remission demonstrated concordant MRI and BIPSS findings; however, this observation should be interpreted cautiously due to the small sample size. BIPSS should not be used routinely but should be reserved for carefully selected cases with persistent diagnostic uncertainty.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 4","pages":"597-603"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Management After Transsphenoidal Resection of Pituitary Tumors.","authors":"Jeffrey L Nadel, Jihad Abdelgadir, Karol P Budohoski, Robert C Rennert, Sarah T Menacho, William T Couldwell","doi":"10.4103/neurol-india.Neurol-India-D-25-00992","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-25-00992","url":null,"abstract":"<p><strong>Abstract: </strong>The postoperative period after transsphenoidal resection of a pituitary tumor is critical for the detection and management of endocrine, visual, and cerebrospinal fluid (CSF)-related complications. We describe the structured approach tailored to patients undergoing microscope-assisted transsphenoidal resection used at our institution. This step-by-step postoperative protocol, refined over years of multidisciplinary care in a high-volume pituitary surgery practice, emphasizes early recognition of diabetes insipidus, management of hormonally active tumors, careful CSF leak monitoring, and clear discharge planning.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 4","pages":"653-656"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Case of Neisseria Subflava Meningitis After Ventriculostomy: Insights into Post-Surgical Infection and Antibiotic Resistance.","authors":"Kalpana Kuntal, Prashant Gupta, Tanya Sachan, Rajat Verma","doi":"10.4103/neurol-india.Neurol-India-D-25-00318","DOIUrl":"10.4103/neurol-india.Neurol-India-D-25-00318","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 4","pages":"705-707"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prof. (Dr.) Sureswar Mohanty.","authors":"Sunil K Gupta","doi":"10.4103/neurol-india.Neurol-India-D-26-00509","DOIUrl":"10.4103/neurol-india.Neurol-India-D-26-00509","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 4","pages":"761-763"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The German Neurologist Joachim Bodamer Who Should Be Remembered and His Legacy to Neurology: \"Prosopagnosia\".","authors":"Hayriye Dilek Akdoğan, Ali Çağlar Turgut, Yaren Akdoğan, Fuyou Guo","doi":"10.4103/neurol-india.Neurol-India-D-25-00972","DOIUrl":"10.4103/neurol-india.Neurol-India-D-25-00972","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"74 4","pages":"666-669"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}