Neurology IndiaPub Date : 2025-03-01Epub Date: 2025-04-03DOI: 10.4103/neurol-india.Neurol-India-D-24-00189
Quevedo O Esteban, Binaghi Daniela, Lovaglio Ana, Robla C Javier, Socolovsky Mariano
{"title":"Myositis Ossificans of the Piriformis Muscle: First Reported Case of Non-Traumatic Sciatic Nerve Injury Requiring Surgical Decompression.","authors":"Quevedo O Esteban, Binaghi Daniela, Lovaglio Ana, Robla C Javier, Socolovsky Mariano","doi":"10.4103/neurol-india.Neurol-India-D-24-00189","DOIUrl":"10.4103/neurol-india.Neurol-India-D-24-00189","url":null,"abstract":"<p><p>There are only scarce reports of other presentations of non-traumatic myositis ossificans (MO). We describe the first reported case of non-traumatic MO of the piriformis muscle causing irretractability neuropathic pain in the sciatic nerve territory and signs of severe motor and sensory deficit, requiring surgical decompression. The patient presented a complete resolution of pain and partial resolution of neurological deficits. The surgical images and protocol, imaging tests, and post-surgical follow-up were reviewed, using validated scales and rating systems. We concluded that MO is an infrequent condition, but high suspicion is required because early treatment reduces the development of permanent neurological deficits.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 2","pages":"343-345"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurology IndiaPub Date : 2025-03-01Epub Date: 2025-04-03DOI: 10.4103/neurol-india.Neurol-India-D-25-00139
B Jayanand Sudhir, Azhaganmaadevi K Alagan, G B Akhilesh Gowda, B S V Patnaik
{"title":"Doctor, Will My Aneurysm Rupture?","authors":"B Jayanand Sudhir, Azhaganmaadevi K Alagan, G B Akhilesh Gowda, B S V Patnaik","doi":"10.4103/neurol-india.Neurol-India-D-25-00139","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-25-00139","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 2","pages":"211-212"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurology IndiaPub Date : 2025-03-01Epub Date: 2025-04-03DOI: 10.4103/neurol-india.Neurol-India-D-23-00580
Thangaraj Abiramalatha, Prakash Amboiram, Ananda Kumar Ponnala, Yogeshkumar V Murkunde, Alan Mathew Punnoose, Aravindhan Vivekanandhan, Shonam Tamrakar, Lawrence D Cruze, Anita Mahadevan
{"title":"Development of a New Animal Model for Non-Cystic Periventricular Leukomalacia.","authors":"Thangaraj Abiramalatha, Prakash Amboiram, Ananda Kumar Ponnala, Yogeshkumar V Murkunde, Alan Mathew Punnoose, Aravindhan Vivekanandhan, Shonam Tamrakar, Lawrence D Cruze, Anita Mahadevan","doi":"10.4103/neurol-india.Neurol-India-D-23-00580","DOIUrl":"10.4103/neurol-india.Neurol-India-D-23-00580","url":null,"abstract":"<p><p>Periventricular leukomalacia (PVL) is a major cause of cerebral palsy in preterm neonates. Though many interventions are being explored as therapeutic options in PVL, all these therapies are still in preclinical phase. This emphasizes the need for the development of robust animal models for PVL. We aimed to develop a new animal (rat) model for PVL using natural pattern of perinatal insults as in humans. The animal model was developed using a combination of three insults: prenatal inflammation, prenatal near total ischemia and postnatal recurrent hypoxia. Pathological and immunohistochemical analysis of pup brains was performed on day 28. We had 33 pups in experimental (inflammation, ischemia and hypoxia, LIH) group and 34 normal pups as controls. Histopathological analysis and immunohistochemistry with anti myelin basic protein (MBP) antibody showed myelin loss in corpus callosum or periventricular white matter in all pups in LIH group. Nissl's stain showed focal to generalized cortical disorganization. On functional assessment, LIH pups had prolonged escape latency in morris water maze test suggestive of cognitive/memory impairment. To conclude, we have developed a new animal model for PVL in rat, using a similar pattern of perinatal insults as in human preterm neonates. The model resembles non-cystic PVL in both pathological and functional analysis.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 2","pages":"320-324"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurology IndiaPub Date : 2025-03-01Epub Date: 2025-04-03DOI: 10.4103/neurol-india.Neurol-India-D-24-00101
Sandhya Manorenj, Shashanka Chillapuram
{"title":"I-Beam Sign in Progressive Supranuclear Palsy.","authors":"Sandhya Manorenj, Shashanka Chillapuram","doi":"10.4103/neurol-india.Neurol-India-D-24-00101","DOIUrl":"10.4103/neurol-india.Neurol-India-D-24-00101","url":null,"abstract":"<p><strong>Background: </strong>Postural instability occurs in both progressive supranuclear palsy (PSP) and idiopathic Parkinson's disease (IPD).</p><p><strong>Objective: </strong>Testing for postural instability using a pull test helps to differentiate IPD from PSP based on the presence of an I-beam sign in the latter.</p><p><strong>Methods and materials: </strong>Here, we demonstrate the I-beam sign in a 65-year-old lady who presented with initial marked postural instability.</p><p><strong>Results: </strong>In PSP, postural instability occurs early. Here, we found that in patients with PSP on the backward pull test, they fall without taking a single step, like a building falls without an I-beam. This sign is called I-beam sign. In patients with IPD, this sign is absent as they take one or a few steps before falling. Clinical examination showed mild restriction of upward gaze, and there was radiological evidence of midbrain atrophy. The present case was diagnosed as PSP with a postural instability variant.</p><p><strong>Conclusion: </strong>The presence of the I-beam sign in patients with Parkinsonism suggests PSP.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 2","pages":"330-331"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dural Arteriovenous Fistulas in Spontaneous Intracranial Hypotension.","authors":"Enrico Ferrant, Michele Trimboli, Cristina Erminio, Luca Quilici, Oreste Marsico, Mirko Maria Ferrante","doi":"10.4103/neurol-india.Neurol-India-D-23-00575","DOIUrl":"10.4103/neurol-india.Neurol-India-D-23-00575","url":null,"abstract":"<p><p>The occurrence of dural arteriovenous fistulas (DAVFs) in patients with spontaneous intracranial hypotension (SIH) is exceptionally rare. While DAVF is a known complication of cerebral venous thrombosis (CVT), the role of CVT as one of the early events in the genesis of DAVFs is still debated. This is because only a small number of patients with CVT develop DAVFs, and not all DAVFs are associated with CVT. Although several hypotheses have been proposed to explain the link between CVT and DAVFs, the relationship between DAVFs and SIH in the absence of CVT remains unclear. To delineate the association between DAVFs and SIH. We reviewed the medical records of 460 SIH patients who were observed and treated over the past several years, looking specifically for cases of SIH complicated by DAVFs. We also reviewed all published case reports reporting patients with SIH and DAVFs. Of the 460 SIH patients reviewed, two (0.4%) were also diagnosed with DAVFs. Both patients had orthostatic headache, diffuse pachymeningeal enhancement, and brain sagging on brain magnetic resonance imaging, which are typical neuroimaging findings of SIH. Patient n.1 reported DAVF caused by left transverse/sigmoid sinus thrombosis, while patient n.2 presented DAVF as a complication of SIH in the absence of CVT. We speculate that SIH, even without CVT, might represent the start of a cascade of events leading to DAVFs. The pathogenic mechanism involved in DAVF formation in SIH patients could be explained by the opening of preexisting microscopic vascular channels within the dura mater, secondary to extreme venodilation related to SIH.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 2","pages":"332-338"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurology IndiaPub Date : 2025-03-01Epub Date: 2025-04-03DOI: 10.4103/neurol-india.Neurol-India-D-24-00119
Jun Ha Hwang, Hong Bum Kim, Su Hee Cho, Kuhyun Yang
{"title":"Spontaneous Angiographic Disappearance of an Intracranial Aneurysm: A Systematic Review of Cases in the Last Ten Years and Two Cases from Our Institution.","authors":"Jun Ha Hwang, Hong Bum Kim, Su Hee Cho, Kuhyun Yang","doi":"10.4103/neurol-india.Neurol-India-D-24-00119","DOIUrl":"10.4103/neurol-india.Neurol-India-D-24-00119","url":null,"abstract":"<p><p>Spontaneous disappearances of intracranial aneurysms have been reported previously, but because of their rarity, discussing their pathophysiology has been difficult. This study aims to investigate cases of spontaneous angiographic disappearance of intracranial aneurysms over the past 10 years, including two additional cases from our hospital, and determine their clinical significance. PubMed was searched for articles on the spontaneous disappearance of intracranial aneurysms published within the last ten years. Data on patient demographics, characteristics of the aneurysms (ruptured or unruptured, location, size, and shape), and the time to the disappearance, recurrence, with or without vasospasm, and treatment were collected. Additionally, two cases from our hospital (Cases A and B) were analyzed. In total, 11 articles with 12 cases of spontaneous aneurysm disappearance were chosen for analysis. Of these cases, 10 occurred in females, and the age of the affected patients ranged from 7 months to 72 years. Eight cases involved unruptured aneurysms, which were larger and took longer to disappear. Three patients experienced a recurrence during the observation period. Several differences were found between the characteristics of the previous cases and those of our case XIII in Table 1 (Case A). In conclusion, spontaneous angiographic disappearance involves complex interactions between thrombosis, vasospasm, and endothelial remodeling. Exceptions were noted, emphasizing the need for nuanced considerations in elucidating the mechanisms behind aneurysm disappearance. The recurrence of aneurysms that had disappeared highlights the importance of the following treatment, if clinically indicated, urgent neurosurgical intervention should be considered; otherwise, thorough angiographic monitoring at least.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 2","pages":"238-243"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurology IndiaPub Date : 2025-03-01Epub Date: 2024-11-29DOI: 10.4103/neurol-india.Neurol-India-D-24-00566
Ashutosh V Dudhatra, Ronak K Arora, Fali F Poncha
{"title":"Diagnostic Crossroads: Coexistence of Myotonic Dystrophy Type 1 and Hirayama Disease in a Case Report.","authors":"Ashutosh V Dudhatra, Ronak K Arora, Fali F Poncha","doi":"10.4103/neurol-india.Neurol-India-D-24-00566","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-24-00566","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 2","pages":"368-370"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}