Neurology India最新文献

{"title":"Neuromyelitis Optica Spectrum Disorders (NMOSD), Its Effects on Pregnancy and the Effects of Pregnancy on NMOSD. A Mini-Review.","authors":"Reshma S Shaik, Sireesha Yareeda","doi":"10.4103/neurol-india.Neurol-India-D-23-00647","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-23-00647","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Study of Clinical Spectrum and Outcome of Pure Midbrain Strokes.","authors":"S Sheetal, Reji Thomas, P Byju, Aswathy Sasidharan, Finu Mathew, M Madhusudanan","doi":"10.4103/neurol-india.NI_270_20","DOIUrl":"https://doi.org/10.4103/neurol-india.NI_270_20","url":null,"abstract":"<p><strong>Background: </strong>Pure mesencephalic infarcts are uncommon, the main clinical manifestations being oculomotor signs and ataxia.</p><p><strong>Objectives: </strong>Primary objective was to determine the incidence of pure midbrain strokes. We also evaluated the clinical spectrum, syndromes, arterial territories involved, risk factors, and outcome at 3 months.</p><p><strong>Settings and design: </strong>This cross-sectional study was conducted at the Neurology department of a tertiary teaching hospital in Kerala.</p><p><strong>Methods and material: </strong>We recorded clinical examination and radiological details of all the patients who presented with isolated midbrain strokes from December 2014 to December 2019. The clinical spectrum and outcomes of the patients at 3 months were analyzed.</p><p><strong>Results: </strong>Of the 520 posterior circulation stroke patients, 48 (9.2%) had isolated mesencephalic infarcts. Clinical manifestations included gait ataxia in 40 patients (83.3%), third nerve palsy in 29 (60.41%), fourth nerve palsy in 4 (8.3%), internuclear ophtalmoplegia in 9 (18.8%), upgaze paresis in 3 (6.3%), hemiparesis in 4 (8.3%), and cheiro-oral paraesthesia in 4 (8.3%). Of the 48 patients, 21 (43.8%) had Claude syndrome, 9 (18.8%) had Wernekink commisure syndrome, 6 (12.5%) had ataxic hemiparesis, 3 (6.3%) had Parinaud syndrome, 3 (6.3%) had Weber syndrome, 4 (8.3%) had Nothnagel syndrome, and 1 patient had a pure sensory stroke (2.1%). The anteromedial territory was frequently affected, in 37 (77%), characterized by oculomotor manifestations and ataxia. Posterior lesions were noted in three (6.3%), anterolateral lesions in three (6.3%), and lateral lesion in one (2.1%) patient. Combined lesions in posterior and paramedian territory were seen in four (8.3%). At the end of 3 months, 30 patients (62.5%) had a modified Rankin score of one.</p><p><strong>Conclusions: </strong>Our study provides the incidence of midbrain stroke over 5 years. It also highlights the heterogeneity of clinical features of pure midbrain infarcts.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Patient Diagnosed With Rare Central Neurocytoma: A Case Report.","authors":"Bilal Ertuğrul, Bekir Akgün, Ismail Akçin, Fatih S Erol","doi":"10.4103/neurol-india.Neurol-India-D-23-00667","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-23-00667","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awake Brain Mapping.","authors":"Sohel S Kazi, Bipin Chaurasia","doi":"10.4103/neurol-india.Neurol-India-D-24-00298","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-24-00298","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CSF Pulsation Artifact Mimicking Intraventricular Pathology.","authors":"Rama Krishna Narra","doi":"10.4103/neurol-india.Neurol-India-D-24-00309","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-24-00309","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Gadolinium Pancake-Like Spinal Cord Enhancement in Spondylotic Cervical Compressive Myelopathy.","authors":"Varsha P Rangankar, Prajwal M Rao, Sanika K Deshmukh","doi":"10.4103/neurol-india.Neurol-India-D-24-00311","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-24-00311","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolactin Secreting Pituitary Carcinoma and the Role of Peptide Receptor Radionuclide Therapy: A Brief Report.","authors":"Nitish Agarwal, Satish Kumar Verma, Vikram Raj Gopinathan, Mehar Chand Sharma, Anima Sharma, Sarat P Chandra","doi":"10.4103/neurol-india.Neurol-India-D-24-00529","DOIUrl":"10.4103/neurol-india.Neurol-India-D-24-00529","url":null,"abstract":"<p><p>Pituitary carcinoma is a rare entity comprising 0.1-0.2% of all pituitary tumors and presents significant diagnostic and therapeutic challenges. Intraspinal drop metastasis in these tumors is even rarer. We report a case of a prolactin secreting pituitary carcinoma with intracranial metastasis and multiple intraspinal drop metastasis. This is the first case where 68Gallium labelled [1,4,7,10 - tetraazacyclododecane - 1,4,7,10 - tetraacetic acid] -1- NaI3 - octreotide (68Ga-DOTANOC) whole-body positron emission tomography-computed tomography (PET-CT) has been used in a case of malignant prolactinoma, in an attempt to ascertain the somatostatin receptor (SSTR) expression on tumor cells. Through this paper, we suggest that SSTR targeted radionuclide therapy could have a potential role in aggressive pituitary tumors and pituitary carcinomas similar to the promising role of lutetium-labelled peptides in inoperable or metastasized gastroentero-pancreatic neuroendocrine tumors (GEP-NETs).</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis on the Effectiveness of Radiotherapy and Temozolomide Treatment With or Without Bevacizumab in Patients With Glioblastoma Multiforme.","authors":"Fu Yang, Liuli Wang, Wei Zhao, Shuai Wang, Jinxing Li, Aigang Sun, Mingguang Wang, Zengyong Wang, Zi Chen, Xueyuan Heng","doi":"10.4103/neurol-india.Neurol-India-D-23-00346","DOIUrl":"10.4103/neurol-india.Neurol-India-D-23-00346","url":null,"abstract":"<p><p>Glioblastoma multiforme (GBM) is the most frequent primary brain malignancy in adults. Despite improvements in imaging and therapy, the prognosis remains poor. To evaluate and compare the impact of combining bevacizumab with temozolomide and radiotherapy on progression-free survival (PFS) and overall survival (OS) in patients diagnosed with GBM. A comprehensive search was conducted across multiple databases, including PubMed, Embase, Scopus, and The Cochrane Library, covering the period from their inception to December 2022. The collected data underwent analysis employing appropriate statistical methods. Six articles were included in this systematic review and meta-analysis. The addition of bevacizumab to the combination of temozolomide/radiotherapy did not increase the OS in GBM patients. The pooled odds ratio (OR) was 0.843 (95% CI: 0.615-1.156, P = 0.290). The addition of bevacizumab to radiotherapy/temozolomide did not increase the PFS in patients with GBM. The pooled OR was 0.829 (95% CI: 0.561-1.224, P = 0.346). The funnel plot demonstrated the absence of the alleged pleiotropic effects by showing no evidence of observable variability across the estimations. This study does not support the benefit of the addition of bevacizumab to temozolomide and radiotherapy in improving OS and PFS in GBM patients.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant Arachnoid Granulation.","authors":"Liyan Chen, Lili Zhao","doi":"10.4103/neurol-india.Neurol-India-D-24-00403","DOIUrl":"https://doi.org/10.4103/neurol-india.Neurol-India-D-24-00403","url":null,"abstract":"","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Prognostic Value of m6A-Related Genes in Glioblastoma.","authors":"Ping Zheng, Xiaoxue Zhang, Dabin Ren, Qingke Bai","doi":"10.4103/neurol-india.ni_1166_21","DOIUrl":"https://doi.org/10.4103/neurol-india.ni_1166_21","url":null,"abstract":"<p><strong>Background: </strong>N6-methyladenosine (m6A) is one of the most common forms of mRNA modification, which is dynamically regulated by the m6A-related genes; however, its effect in glioblastoma (GBM) is still unknown.</p><p><strong>Objective: </strong>We sought to investigate the association between m6A-related genes (m6A-RGs) and GBM.</p><p><strong>Methods: </strong>Transcriptome data and the relevant clinical data were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. The m6A-RGs were identified from differently expressed genes, and COX and lasso regression models were applied to locate the prognosis-related genes.</p><p><strong>Results: </strong>We identified 15 out of 19 m6A-RGs differentially expressed between GBM and nontumor tissues. We identified two subgroups of GBM (clusters 1 and 2) by applying consensus clustering. Compared with the cluster 1 subgroup, the cluster 1 subgroup correlates with a poorer prognosis, and most of the 19 m6A-RGs are higher expressed in cluster 1. Through univariate Cox and lasso regression model, we identified three m6A-RGs, namely HNRNPC, ALKBH5, and FTO, which were used to construct a Cox regression risk model to predict the prognosis of GBM patients.</p><p><strong>Conclusion: </strong>We identified a valuable m6A model for predicting the prognosis of GBM patients, which can provide useful epigenetic biomarkers.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}