Serum Cytokine 6, 10 and α-Tumour Necrosis Factor Levels in Alzheimer's Disease Subjects Treated with Donepezil Plus Vitamin B12.

IF 0.9 3区 医学 Q4 NEUROSCIENCES
Neurology India Pub Date : 2025-05-01 Epub Date: 2025-05-23 DOI:10.4103/neuroindia.NI_1615_20
Neelam Yeram, Shubhangi M Dalvi, Vinayak P Kale, Vinayak W Patil, Ranjit Mankeshwar, Kamlesh Jagiasi, Leela G Abichandani
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引用次数: 0

Abstract

Background: Neuroinflammation is a key feature of Alzheimer's disease (AD) pathology.

Objectives: The aim of this study was to investigate the serum levels of Cytokine 6 (Cyto-6), Cytokine 10 (Cyto-10), and alpha-tumor necrosis factor (α-TNF) in Alzheimer's disease patients and observe the effects of donepezil plus vitamin B12 (VB12) treatment on these cytokines.

Methods and materials: Seventy-one AD cases and 70 controls with age more than 60 years. Cyto-6, Cyto-10, and α-TNF were measured using the Chemiluminescence Immulite 1000 system, Siemens. Alzheimer's disease subjects were treated with donepezil (5 mg/day) plus VB12 (1.5 mg/day) supplement for 6 months, and serum cytokine levels were reinvestigated. Statistical analysis was done using SPSS software.

Result: Cyto-6, Cyto-10, and α-TNF values were raised in Alzheimer's disease as compared to controls (P < 0.001) [AD (Cyto-6: 10.27 ± 2.76 pg/ml; Cyto-10: 6.2 ± 1.48 pg/ml; α-TNF: 26.49 ± 6.85 pg/ml) and Control (Cyto-6: 3.29 ± 0.77 pg/ml; Cyto-10: 8.213 ± 0.787 pg/ml; α-TNF: 5.18 ± 1.65 pg/ml)]. After 6 months, a significant decrease (P < 0.01) was observed in Cyto-6 (7.95 ± 2.21 pg/ml), Cyto-10 (4.77 ± 1.12 pg/ml), and α-TNF (22.67 ± 7.00 pg/ml) levels in AD.

Conclusion: We conclude that serum Cyto-6, Cyto-10, and α-TNF play an inflammatory role in Alzheimer's disease progression. Combined therapy of donepezil and VB12 supplement showed a beneficial effect in reducing inflammation. This study might benefit further research along with molecular follow-up studies for development of novel therapeutic strategies in Alzheimer's disease.

多奈哌齐加维生素B12治疗阿尔茨海默病患者血清细胞因子6、10和α-肿瘤坏死因子水平
背景:神经炎症是阿尔茨海默病(AD)病理的一个关键特征。目的:研究阿尔茨海默病患者血清细胞因子6 (cell -6)、细胞因子10 (cell -10)、α-肿瘤坏死因子(α-TNF)水平,观察多奈哌齐联合维生素B12 (VB12)治疗对这些细胞因子的影响。方法与材料:老年痴呆71例,60岁以上70例。细胞-6、细胞-10和α-TNF采用化学发光Immulite 1000系统,西门子。多奈哌齐(5mg /天)加VB12 (1.5 mg/天)治疗阿尔茨海默病患者6个月,并重新调查血清细胞因子水平。采用SPSS软件进行统计分析。结果:与对照组相比,阿尔茨海默病患者的细胞-6、细胞-10和α-TNF值升高(P < 0.001) [AD](细胞-6:10.27±2.76 pg/ml;Cyto-10: 6.2±1.48 pg/ml;α-TNF: 26.49±6.85 pg/ml)和对照组(Cyto-6: 3.29±0.77 pg/ml;cell -10: 8.213±0.787 pg/ml;α-TNF: 5.18±1.65 pg/ml)。6个月后,AD患者细胞-6(7.95±2.21 pg/ml)、细胞-10(4.77±1.12 pg/ml)、α-TNF(22.67±7.00 pg/ml)水平显著降低(P < 0.01)。结论:血清细胞-6、细胞-10和α-TNF在阿尔茨海默病的进展中起炎症作用。多奈哌齐和维生素b12联合治疗对减轻炎症有良好的效果。这项研究可能有助于进一步的研究和分子随访研究,以开发新的治疗策略。
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来源期刊
Neurology India
Neurology India 医学-神经科学
CiteScore
1.60
自引率
70.40%
发文量
434
审稿时长
2 months
期刊介绍: Neurology India (ISSN 0028-3886) is Bi-monthly publication of Neurological Society of India. Neurology India, the show window of the progress of Neurological Sciences in India, has successfully completed 50 years of publication in the year 2002. ‘Neurology India’, along with the Neurological Society of India, has grown stronger with the passing of every year. The full articles of the journal are now available on internet with more than 20000 visitors in a month and the journal is indexed in MEDLINE and Index Medicus, Current Contents, Neuroscience Citation Index and EMBASE in addition to 10 other indexing avenues. This specialty journal reaches to about 2000 neurologists, neurosurgeons, neuro-psychiatrists, and others working in the fields of neurology.
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