npj Biofilms and Microbiomes最新文献_第3页

Enteroendocrine cells: the gatekeepers of microbiome-gut-brain communication. 肠内分泌细胞：微生物群-肠-脑通讯的守门人。

IF 9.2 1区生物学

npj Biofilms and Microbiomes Pub Date : 2025-09-01 DOI: 10.1038/s41522-025-00810-x

Esmée Grundeken, Sahar El Aidy

引用次数: 0

Temporal dynamics, microdiversity, and ecological functions of viral communities during cyanobacterial blooms in Lake Taihu. 太湖蓝藻水华期间病毒群落的时间动态、微多样性和生态功能。

IF 9.2 1区生物学

npj Biofilms and Microbiomes Pub Date : 2025-08-29 DOI: 10.1038/s41522-025-00771-1

Tianyi Chen, Yanxuan Xiong, Jinhong Zhang, Qiue Zhang, Jiang Wu, Nan Xu, Tang Liu

{"title":"Temporal dynamics, microdiversity, and ecological functions of viral communities during cyanobacterial blooms in Lake Taihu.","authors":"Tianyi Chen, Yanxuan Xiong, Jinhong Zhang, Qiue Zhang, Jiang Wu, Nan Xu, Tang Liu","doi":"10.1038/s41522-025-00771-1","DOIUrl":"https://doi.org/10.1038/s41522-025-00771-1","url":null,"abstract":"Harmful cyanobacterial blooms pose severe threats to aquatic ecosystems. Bloom-forming cyanobacteria form cyanobacterial aggregates (CAs) that create a phycosphere supporting diverse microbial interactions. Here, longitudinal metagenomics and metatranscriptomics were employed to explore the temporal variation of CA-attached viral communities throughout cyanobacterial blooms in Lake Taihu. Viral communities, represented by 5613 viral operational taxonomic units, showed increased relative abundance (RPKM) with the expansion of bloom areas. Among 1791 virus‒host linkages, host shifts followed the succession of two dominant cyanobacterial genera, Microcystis and Dolichospermum. Viruses demonstrated high virus‒host abundance ratios within all host genera and showed elevated transcriptional activities infecting Dolichospermum during the late bloom stage. Viruses featured high microdiversity and positively selected replication-associated genes in response to abundant host genera and variable trophic status. This study uncovered diverse active viral auxiliary metabolism associated with photosynthesis, biochemical cycling, and DNA biosynthesis, and highlighted the significant role of phycosphere-associated viruses during cyanobacterial blooms.","PeriodicalId":19370,"journal":{"name":"npj Biofilms and Microbiomes","volume":"11 1","pages":"178"},"PeriodicalIF":9.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiome profiling of Grana Padano and Parmigiano Reggiano cheeses reveals cheese-specific biomarkers, psychobiotic potential, and bioprotective activities. Grana Padano和Parmigiano Reggiano奶酪的微生物组分析揭示了奶酪特异性生物标志物，心理生物学潜力和生物保护活性。

IF 9.2 1区生物学

npj Biofilms and Microbiomes Pub Date : 2025-08-27 DOI: 10.1038/s41522-025-00815-6

Vincenzo Valentino, Raffaele Magliulo, Andrea Balivo, Alicja Monika Krysmann, Chiara Maria Calvanese, Alessia Esposito, Giuseppina Sequino, Alessandro Genovese, Davide Porcellato, Danilo Ercolini, Francesca De Filippis

{"title":"Microbiome profiling of Grana Padano and Parmigiano Reggiano cheeses reveals cheese-specific biomarkers, psychobiotic potential, and bioprotective activities.","authors":"Vincenzo Valentino, Raffaele Magliulo, Andrea Balivo, Alicja Monika Krysmann, Chiara Maria Calvanese, Alessia Esposito, Giuseppina Sequino, Alessandro Genovese, Davide Porcellato, Danilo Ercolini, Francesca De Filippis","doi":"10.1038/s41522-025-00815-6","DOIUrl":"https://doi.org/10.1038/s41522-025-00815-6","url":null,"abstract":"Grana Padano (GP), Trentingrana (TG), and Parmigiano Reggiano (PR) are among the finest Italian Protected Designation of Origin (PDO) cheeses. GP, TG, and PR undergo extensive proteolysis during ripening, where the microbiome metabolizes amino acids, producing flavour and bioactive molecules. We explored the microbiome, volatilome, and metaproteome of PDO GP (n = 42), TG (n = 18), and PR (n = 60). Findings revealed diverse microbial communities enriched in proteolytic microbes, associated with cheese-specific processing technology. Correlations between lactic acid bacteria strains and specific volatile compounds were identified in PR. Importantly, we identified genes involved in the production of neuroactive molecules, suggesting potential connections between cheeses consumption and mental health, along with genes related to bacteriocin biosynthesis, possibly enhancing cheese safety, shelf life, and process sustainability. This study provides novel insights into the functional attributes of long-ripened cheeses microbiome, highlighting their potential as sources of psychobiotics and bioprotective strains.","PeriodicalId":19370,"journal":{"name":"npj Biofilms and Microbiomes","volume":"11 1","pages":"177"},"PeriodicalIF":9.2,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Candida albicans colonization in the human colon correlates with a reduction in acetate- and butyrate-producing bacteria, as simulated using the M-SHIME® model. 使用M-SHIME®模型模拟，白色念珠菌在人类结肠中的定植与产生乙酸和丁酸盐的细菌的减少相关。

IF 9.2 1区生物学

npj Biofilms and Microbiomes Pub Date : 2025-08-26 DOI: 10.1038/s41522-025-00803-w

Benoît Marsaux, Warre d'Hoker, Frédéric Moens, Dries Van Elst, Yorick Minnebo, Massimo Marzorati, Tom Van de Wiele

{"title":"Candida albicans colonization in the human colon correlates with a reduction in acetate- and butyrate-producing bacteria, as simulated using the M-SHIME® model.","authors":"Benoît Marsaux, Warre d'Hoker, Frédéric Moens, Dries Van Elst, Yorick Minnebo, Massimo Marzorati, Tom Van de Wiele","doi":"10.1038/s41522-025-00803-w","DOIUrl":"https://doi.org/10.1038/s41522-025-00803-w","url":null,"abstract":"Candida albicans is a common gut commensal, typically restricted by the resident microbiota. However, microbiome disruption can enable its outgrowth, increasing the risk of life-threatening candidiasis. Restoring key protective microbes offer a therapeutic strategy, though their identification remains challenging. Using the M-SHIME® model simulating the human proximal colon, we investigated C. albicans-bacteriome interactions under eubiotic and dysbiotic conditions. We assessed how clindamycin, ciprofloxacin, and metronidazole modulate C. albicans colonization and evaluated associated microbial and metabolic shifts. The effects were antibiotic- and donor-specific: clindamycin facilitated colonization, ciprofloxacin had no impact, and metronidazole showed variable outcomes. Engraftment did not correlate with total bacterial concentration or α-diversity, but with the loss of specific taxa, notably Lachnospiraceae and Bifidobacterium. These correlations were supported functionally by reductions in acetate and butyrate, suggesting a metabolic mechanism of fungal suppression. This study highlights the role of dysbiosis in C. albicans outgrowth and supports targeted microbiome restoration strategies.","PeriodicalId":19370,"journal":{"name":"npj Biofilms and Microbiomes","volume":"11 1","pages":"176"},"PeriodicalIF":9.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrative microbiome- and metatranscriptome-based analyses reveal diagnostic biomarkers for peri-implantitis. 基于微生物组和亚转录组的综合分析揭示了种植体周围炎的诊断性生物标志物。

IF 9.2 1区生物学

npj Biofilms and Microbiomes Pub Date : 2025-08-26 DOI: 10.1038/s41522-025-00807-6

Amruta A Joshi, Szymon P Szafrański, Matthias Steglich, Ines Yang, Taoran Qu, Paula Schaefer-Dreyer, Xing Xiao, Wiebke Behrens, Jasmin Grischke, Susanne Häussler, Meike Stiesch

{"title":"Integrative microbiome- and metatranscriptome-based analyses reveal diagnostic biomarkers for peri-implantitis.","authors":"Amruta A Joshi, Szymon P Szafrański, Matthias Steglich, Ines Yang, Taoran Qu, Paula Schaefer-Dreyer, Xing Xiao, Wiebke Behrens, Jasmin Grischke, Susanne Häussler, Meike Stiesch","doi":"10.1038/s41522-025-00807-6","DOIUrl":"https://doi.org/10.1038/s41522-025-00807-6","url":null,"abstract":"Peri-implantitis is a severe biofilm-associated infection affecting millions worldwide. This cross-sectional study aimed to identify taxonomic and functional biomarkers that reliably indicate peri-implantitis by utilizing paired data from full length 16S rRNA gene amplicon sequencing (full-16S) and metatranscriptomics (RNAseq) in 48 biofilm samples from 32 patients. Both full-16S and RNAseq analyses revealed significant differences between healthy and peri-implantitis samples, with a shift toward anaerobic Gram-negative bacteria in peri-implantitis. Metatranscriptomics identified enzymatic activities and metabolic pathways associated with peri-implantitis and uncovered complex peri-implant biofilm ecology related to amino acid metabolism. Integrating taxonomic and functional data enhanced predictive accuracy (AUC = 0.85) and revealed diagnostic biomarkers including health-associated Streptococcus and Rothia species and peri-implantitis-associated enzymes (urocanate hydratase, tripeptide aminopeptidase, NADH:ubiquinone reductase, phosphoenolpyruvate carboxykinase and polyribonucleotide nucleotidyltransferase). Thus, biofilm profiling at taxonomic and functional levels provides highly predictive disease biomarkers, laying the foundation for novel diagnostic and personalized treatment approaches for peri-implant disease.","PeriodicalId":19370,"journal":{"name":"npj Biofilms and Microbiomes","volume":"11 1","pages":"175"},"PeriodicalIF":9.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Honeybee-Gilliamella synergy in carbohydrate metabolism enhances host thermogenesis in cold acclimation. 在冷驯化中，蜜蜂-吉利亚蝇在碳水化合物代谢中的协同作用增强了宿主产热作用。

IF 9.2 1区生物学

npj Biofilms and Microbiomes Pub Date : 2025-08-25 DOI: 10.1038/s41522-025-00798-4

Min Tang, Chenyi Li, Xinwei Ge, Yu Kuang, Lifei Qiu, Kevin Chun Chan, Zhiwei Chen, Lizhen Guo, Zhunan Zhao, Bingxin Zhang, Shanlin Liu, Xin Zhou

{"title":"Honeybee-Gilliamella synergy in carbohydrate metabolism enhances host thermogenesis in cold acclimation.","authors":"Min Tang, Chenyi Li, Xinwei Ge, Yu Kuang, Lifei Qiu, Kevin Chun Chan, Zhiwei Chen, Lizhen Guo, Zhunan Zhao, Bingxin Zhang, Shanlin Liu, Xin Zhou","doi":"10.1038/s41522-025-00798-4","DOIUrl":"https://doi.org/10.1038/s41522-025-00798-4","url":null,"abstract":"How gut symbionts contribute to host adaptation remains largely elusive. Studying co-diversified honeybees and gut bacteria across climates, we found cold-adapted species (Apis mellifera, A. cerana) exhibit enhanced genomic capacity for glucose, pyruvate, lipid and glucuronate production versus tropical species. Metagenomics revealed Gilliamella as the most enriched gut bacterium in cold-adapted bees. Germ-free honeybees inoculated with the Gilliamella from A. cerana showed increased activity, body temperature and fat storage upon cold exposure. Saccharide metabolomics demonstrated higher hindgut glucose levels in Gilliamella-colonized A. mellifera versus germ-free bees, and in A. cerana versus three sympatric tropical species. Although Gilliamella can hydrolyze β-glucan into glucose, cultural experiments suggest it preferentially degrades glucuronate to pyruvate. In turn, monocolonized bees upregulated hindgut glucose/pyruvate utilization while increasing glucuronate provision, suggesting nutritional complementarity. Gilliamella's transporter genes predominantly target ascorbate (a glucuronate derivative), which is elevated in inoculated hindguts. Accordingly, Gilliamella converts ascorbate to D-xylulose-5P (promoting lipogenesis), while showing reduced growth on glucuronate/ascorbate versus glucose, potentially minimizing glucose competition with hosts. We revealed a highly coordinated host-symbiont metabolic synergy enhancing host energy acquisition for cold adaptation.","PeriodicalId":19370,"journal":{"name":"npj Biofilms and Microbiomes","volume":"11 1","pages":"172"},"PeriodicalIF":9.2,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The resident gut microbiome modulates the effect of synbiotics on the immunogenicity after SARS-COV-2 vaccination in elderly and diabetes patients. 老年人和糖尿病患者接种SARS-COV-2疫苗后，肠道微生物群调节合生剂对免疫原性的影响

IF 9.2 1区生物学

npj Biofilms and Microbiomes Pub Date : 2025-08-25 DOI: 10.1038/s41522-025-00804-9

Lin Zhang, Shilan Wang, Martin C S Wong, Chris K P Mok, Jessica Y L Ching, Joyce W Y Mak, Chunke Chen, Bing Huo, Shuai Yan, Chun Pan Cheung, Emily O L Chiu, Emily Y T Fung, Pui Kuan Cheong, Francis K L Chan, Siew C Ng

{"title":"The resident gut microbiome modulates the effect of synbiotics on the immunogenicity after SARS-COV-2 vaccination in elderly and diabetes patients.","authors":"Lin Zhang, Shilan Wang, Martin C S Wong, Chris K P Mok, Jessica Y L Ching, Joyce W Y Mak, Chunke Chen, Bing Huo, Shuai Yan, Chun Pan Cheung, Emily O L Chiu, Emily Y T Fung, Pui Kuan Cheong, Francis K L Chan, Siew C Ng","doi":"10.1038/s41522-025-00804-9","DOIUrl":"https://doi.org/10.1038/s41522-025-00804-9","url":null,"abstract":"The study aims to tackle the seed and soil microbiome and mechanisms that contribute to the effect of synbiotics in enhancing immunogenicity after SARS-CoV-2 vaccination in elderly and diabetic patients. Among 369 subjects who received 3 months of SIM01, a gut microbiota-derived synbiotic formula of three Bifidobacterium strains (B. adolescentis, B. bididum, and B. longum) or a placebo after the SARS-CoV-2 vaccines (mRNA vaccine BNT162b2 (Pfizer-BioNTech) or the inactivated vaccine Sinovac-CoronaVac), we performed metagenomic sequencing in stool samples of 280 vaccinees collected at baseline and 3-month postvaccination and metabonomic sequencing in 276 vaccinees collected at baseline and 1-month postvaccination. The open niche of autochthonous gut microbiota (lower levels of Bifidobacterium and decreased functional potential for carbohydrate metabolism) was associated with enhancing SIM01-contained species. The enrichment of three bifidobacterial species after 3 months of SIM01 intervention (BABBBL_fc) was positively correlated with the level of neutralizing antibodies to the BNT162b2 vaccine at 6-month postvaccination. The fold change of benzoic acid was positively correlated with BABBBL_fc in the BNT162b2 vaccinees, which was also implicated with SARS-CoV-2 surrogate virus neutralization test (sVNT)% levels at 1-month postvaccination. Importantly, SIM01 strain engraftment assessed by StrainPhlAn (A metagenomic strain-level population genomics tool) was associated with a higher fold change of three bifidobacterial species and could be predicted based on the baseline gut microbiome. Therefore, the resident gut microbiome affected the SIM01 engraftment, which was associated with the immunogenicity of SARS-CoV-2 BNT162b2 vaccines.","PeriodicalId":19370,"journal":{"name":"npj Biofilms and Microbiomes","volume":"11 1","pages":"171"},"PeriodicalIF":9.2,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing dual-channel probiotics to synergistically correct intestinal and vaginal dysbiosis after antibiotic disruption. 利用双通道益生菌协同纠正抗生素中断后肠道和阴道生态失调。

IF 9.2 1区生物学

npj Biofilms and Microbiomes Pub Date : 2025-08-25 DOI: 10.1038/s41522-025-00813-8

Xuanqi Zhao, Qifa Huang, Yujuan Liu, Xia He, Weijun Chen, Yan Liu, Lihong Gan, Jing Wei, Hongyan Zhang, Tingtao Chen

{"title":"Harnessing dual-channel probiotics to synergistically correct intestinal and vaginal dysbiosis after antibiotic disruption.","authors":"Xuanqi Zhao, Qifa Huang, Yujuan Liu, Xia He, Weijun Chen, Yan Liu, Lihong Gan, Jing Wei, Hongyan Zhang, Tingtao Chen","doi":"10.1038/s41522-025-00813-8","DOIUrl":"https://doi.org/10.1038/s41522-025-00813-8","url":null,"abstract":"Antibiotics are widely used to treat infectious diseases, yet antibiotic therapy has been shown to disrupt symbiotic microbiota. Notably, the dosage and duration of antibiotic use for specific infections may exert detrimental effects on microbiota in non-infected sites. Here, we propose a dual-channel probiotic delivery strategy to address gut and vaginal dysbiosis caused by antibiotic therapies. In a Helicobacter pylori infection model, oral administration of Limosilactobacillus reuteri NCU-15 alleviated gastritis and protected the intestinal barrier and microbiota. In a vaginal dysbiosis model, intravaginal delivery of Lactobacillus crispatus NCU-23 reduced local inflammation and apoptosis, restoring vaginal microbial homeostasis. In the entero-vaginal disordered mice, dual-channel probiotic therapy produced synergistic effects by reducing inflammation, inhibiting apoptosis, and reestablishing microbial balance. These findings demonstrate the potential of dual-channel probiotic intervention to modulate gut-vaginal microbiota interactions and offer a scientific basis for developing strategies to prevent or treat antibiotic-induced dysbiosis.","PeriodicalId":19370,"journal":{"name":"npj Biofilms and Microbiomes","volume":"11 1","pages":"174"},"PeriodicalIF":9.2,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The microbiome is associated with obesity-related metabolome signature in the process of aging. 在衰老过程中，微生物组与肥胖相关的代谢组特征有关。

IF 9.2 1区生物学

npj Biofilms and Microbiomes Pub Date : 2025-08-25 DOI: 10.1038/s41522-025-00811-w

Dana Binyamin, Sondra Turjeman, Nofar Asulin, Ron Schweitzer, Omry Koren

{"title":"The microbiome is associated with obesity-related metabolome signature in the process of aging.","authors":"Dana Binyamin, Sondra Turjeman, Nofar Asulin, Ron Schweitzer, Omry Koren","doi":"10.1038/s41522-025-00811-w","DOIUrl":"https://doi.org/10.1038/s41522-025-00811-w","url":null,"abstract":"Aging involves changes in the gut microbiome impacting health and longevity; however, the roles of specific microbial metabolites remain understudied. Here, we examine the microbial contribution to the metabolic profile in aged mice. Fecal samples were collected from female Swiss-Webster mice raised conventionally (Conv) or germ free (GF), at 8 weeks (young) and 18 (aged) months of age, and the microbiome and metabolome were characterized. Significant differences were observed in bacterial composition and its predicted functional activity between young and aged mice. Interestingly, we found more age-related differences in metabolite abundances among Conv mice than GF mice, highlighting the contribution of the microbiome to aging. Moreover, microbiome-associated metabolites, predominantly lipids, were higher in aged mice, with linoleic acid metabolism enriched in this group. Our study underscores a microbiome-dependent component to age-related metabolic changes in mice, particularly in lipid-associated pathways, and contributes to the growing body of literature linking gut microbiota to host metabolism in aging.","PeriodicalId":19370,"journal":{"name":"npj Biofilms and Microbiomes","volume":"11 1","pages":"173"},"PeriodicalIF":9.2,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virome characteristics of small mammals and their associated environments in pastoral areas on the Qinghai-Tibet Plateau.

IF 9.2 1区生物学

npj Biofilms and Microbiomes Pub Date : 2025-08-22 DOI: 10.1038/s41522-025-00814-7

Xiang Lu, Qing Zhang, Haisheng Wu, Likai Ji, Yongshun Wang, Juan Xu, Jia Liu, Jiamin Pan, Xiaojie Jiang, Yuan Xi, Shixing Yang, Quan Shen, Xiaochun Wang, Ping Wu, Yuwei Liu, Xiao Ma, Chenglin Zhou, Tongling Shan, Wen Zhang

{"title":"Virome characteristics of small mammals and their associated environments in pastoral areas on the Qinghai-Tibet Plateau.","authors":"Xiang Lu, Qing Zhang, Haisheng Wu, Likai Ji, Yongshun Wang, Juan Xu, Jia Liu, Jiamin Pan, Xiaojie Jiang, Yuan Xi, Shixing Yang, Quan Shen, Xiaochun Wang, Ping Wu, Yuwei Liu, Xiao Ma, Chenglin Zhou, Tongling Shan, Wen Zhang","doi":"10.1038/s41522-025-00814-7","DOIUrl":"https://doi.org/10.1038/s41522-025-00814-7","url":null,"abstract":"The Qinghai-Tibet Plateau (QTP), known for its rich biodiversity and unique ecological niche, harbors numerous endemic species and serves as a reservoir for both established human pathogens and numerous poorly characterized pathogens. Despite certain advances, virological research on small mammals in this region is still limited. In this study, we investigated the diversity and evolution of viral communities in plateau voles, plateau pikas, and their associated environmental samples collected near pastoral settlements on the QTP. Our findings revealed 291,165 species-level viral operational taxonomic units, highlighting a diverse array of bacteriophages. In addition, we further characterized 774 novel eukaryotic viral genomes, primarily classified into 22 established viral families. Among them, 95.5% shared less than 80% amino acid sequence identity with known viruses, some of which may represent new genera or species. Furthermore, some eukaryotic viruses display distinct tissue distribution patterns in these small mammals. Notably, we identified 32 mammalian viruses capable of cross-species transmission, among which 22 are considered potential spillover risks, and most of them were detected for the first time in plateau pikas and plateau voles. Overall, this study expands the viral spectrum of small mammals on the QTP and broadens the host range of previously identified viruses, emphasizing the need for further research into their potential public health implications.","PeriodicalId":19370,"journal":{"name":"npj Biofilms and Microbiomes","volume":"11 1","pages":"168"},"PeriodicalIF":9.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0