NPJ Science of Food最新文献_第6页

Processed dietary fiber partially hydrolyzed guar gum increases susceptibility to colitis and colon tumorigenesis in mice. 部分水解瓜尔胶的加工膳食纤维增加小鼠对结肠炎和结肠肿瘤发生的易感性。

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2025-07-01 DOI: 10.1038/s41538-025-00472-1

Sangshan Tian, Umesh K Goand, Devendra Paudel, Giang V Le, Amit K Tiwari, K Sandeep Prabhu, Vishal Singh

{"title":"Processed dietary fiber partially hydrolyzed guar gum increases susceptibility to colitis and colon tumorigenesis in mice.","authors":"Sangshan Tian, Umesh K Goand, Devendra Paudel, Giang V Le, Amit K Tiwari, K Sandeep Prabhu, Vishal Singh","doi":"10.1038/s41538-025-00472-1","DOIUrl":"10.1038/s41538-025-00472-1","url":null,"abstract":"The vital role of naturally occurring dietary fibers (DFs) in maintaining intestinal health has fueled the incorporation of refined DFs into processed foods. The present study assessed the impact of purified DF partially hydrolyzed guar gum (Phgg) on intestinal inflammation and colitis-associated colon carcinogenesis (CAC). Surprisingly, wild-type mice fed Phgg exhibited more severe dextran sulfate sodium (DSS)-induced colitis than the control group. Additionally, Phgg feeding led to increased colonic expression of genes promoting cell proliferation. Accordingly, extensive colon tumorigenesis was observed in Phgg-fed mice in the azoxymethane (AOM)/DSS model, whereas the control group exhibited no visible tumors. Mice fed low-Phgg (2.5%) diet exhibited more colitis and tumorigenesis than controls, but less than those on regular Phgg diet (7.5%), suggesting a dose-dependent influence of Phgg on colitis and CAC development. Our study reveals that Phgg supplementation exacerbates colitis and promotes colon tumorigenesis, warranting further investigation into the potential gastrointestinal health risks associated with processed Phgg consumption.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"114"},"PeriodicalIF":6.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The novel food evaluation process delays access to food innovation in the European Union. 新的食品评估过程延迟了欧盟食品创新的准入。

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2025-07-01 DOI: 10.1038/s41538-025-00492-x

Jérôme Le Bloch, Marie Rouault, Cédric Langhi, Malorie Hignard, Victoria Iriantsoa, Olivier Michelet

引用次数: 0

Unravelling the human taste receptor interactome: machine learning and molecular modelling insights into protein-protein interactions. 解开人类味觉受体相互作用组：机器学习和分子模型洞察蛋白质-蛋白质相互作用。

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2025-07-01 DOI: 10.1038/s41538-025-00478-9

Harry Zaverdas, Filip Stojceski, Rocío Romero-Zaliz, Lampros Androutsos, Pantelis Makrygiannis, Lorenzo Pallante, Vanessa Martos, Gianvito Grasso, Marco A Deriu, Konstantinos Theofilatos, Seferina Mavroudi

{"title":"Unravelling the human taste receptor interactome: machine learning and molecular modelling insights into protein-protein interactions.","authors":"Harry Zaverdas, Filip Stojceski, Rocío Romero-Zaliz, Lampros Androutsos, Pantelis Makrygiannis, Lorenzo Pallante, Vanessa Martos, Gianvito Grasso, Marco A Deriu, Konstantinos Theofilatos, Seferina Mavroudi","doi":"10.1038/s41538-025-00478-9","DOIUrl":"10.1038/s41538-025-00478-9","url":null,"abstract":"The understanding of the molecular mechanisms that drive taste perception can have broad implications for public health. This study aims to expand the understanding of taste receptor-associated molecular pathways by resolving the taste receptor interactome. To this end, we propose a comprehensive machine learning approach to accurately predict and quantify protein-protein interactions using an ensemble evolutionary algorithm. 1,647,374 positive and 894,213 negative experimentally verified protein-protein interactions were mined and characterized using 61 functional orthology, sequence, co-expression and structural features. The binary classifier significantly improved the accuracy of existing methods, reconstructing the full taste receptor interactome and was combined with a regressor that estimates the binding strength of positive interactions. Molecular dynamics investigation of top-scoring protein-protein interactions verified novel interactions of TAS2R41. The reconstructed TR interactome can catalyze the study of molecular pathophysiological mechanisms related to taste, the development of flavorsome nutrient-dense food products and the identification of personalized nutrition markers.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"113"},"PeriodicalIF":6.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid construction method for a precision pork color scoring model based on standard color board images. 基于标准色板图像的猪肉颜色评分模型快速构建方法。

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2025-07-01 DOI: 10.1038/s41538-025-00447-2

Dongsheng Xiao, Jiabing Gu, Yongkang Li, Zhe Chao, WenYang, ZiMeng, Chengwan Zha, Wangjun Wu, Sanqin Zhao, Yutao Liu

引用次数: 0

Food contact articles as source of micro- and nanoplastics: a systematic evidence map. 食品接触物品作为微塑料和纳米塑料的来源：一个系统的证据图。

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2025-06-25 DOI: 10.1038/s41538-025-00470-3

Lisa Zimmermann, Birgit Geueke, Lindsey V Parkinson, Christoph Schür, Martin Wagner, Jane Muncke

引用次数: 0

The role of broad bean albumin 1b on GIP and GLP-1 mediated alterations to glucose metabolism in diabetic mice. 蚕豆白蛋白1b在糖尿病小鼠GIP和GLP-1介导的糖代谢改变中的作用。

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2025-06-23 DOI: 10.1038/s41538-025-00486-9

Feifei Han, Lu Jin, Lulu Zhou, Qi Liu, MengLu Ding, Weilin Liu, Jianzhong Han

{"title":"The role of broad bean albumin 1b on GIP and GLP-1 mediated alterations to glucose metabolism in diabetic mice.","authors":"Feifei Han, Lu Jin, Lulu Zhou, Qi Liu, MengLu Ding, Weilin Liu, Jianzhong Han","doi":"10.1038/s41538-025-00486-9","DOIUrl":"10.1038/s41538-025-00486-9","url":null,"abstract":"The biologically active peptides derived from broad bean protein, including broad bean albumin 1b (BA1b), have anti-oxidation and anti-glycation effects. However, the potential for BA1b to improve glucose metabolism and the underlying mechanisms remain unexplored. We examined the effects of BA1b on glucose metabolism in diabetic mice and further studied the effects of BA1b on intestinal cells based on small intestinal organoids (SIOs). The results showed that BA1b significantly reduced blood glucose and serum insulin levels, promoted secretion of glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) in diabetic mice. Similarly, BA1b significantly increased the secretion of GIP and GLP-1 levels in SIOs. Mechanistic studies found that BA1b promoted the secretion of incretin (GIP and GLP-1) by up-regulation of VDAC1 gene expression levels. These findings emphasized the important role of BA1b in improving glucose metabolism and provided a new insight into strategies to explore the effects of functional foods.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"110"},"PeriodicalIF":6.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic exposure to milk odorant might ameliorate the depressive-like behavior of mice through gut-brain axis. 长期暴露于牛奶气味可能通过肠脑轴改善小鼠的抑郁样行为。

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2025-06-23 DOI: 10.1038/s41538-025-00455-2

Yan Jin, Hongze Wang, Ziyao Zhang, Enhui Jin, Can Yang, Jing Meng, Tao Wu, Min Zhang

{"title":"Chronic exposure to milk odorant might ameliorate the depressive-like behavior of mice through gut-brain axis.","authors":"Yan Jin, Hongze Wang, Ziyao Zhang, Enhui Jin, Can Yang, Jing Meng, Tao Wu, Min Zhang","doi":"10.1038/s41538-025-00455-2","DOIUrl":"10.1038/s41538-025-00455-2","url":null,"abstract":"Mental disorders are one of the leading causes of global health burden, while food flavors play a significant role in promoting the appetite and mood of people. This study aimed to investigate the intervention effects of two kinds of pleasant food odorants on depressed mice induced by reserpine. After 6-week exposure, beef odorant and milk odorant could effectively reduced pro-inflammatory cytokines (IL-6, TNF-α), restored hippocampal structure, elevated neurotransmitters (5-HT, DA, NE), and upregulated BDNF/GFAP expression. 16S rRNA sequencing analysis revealed that both odorants could ameliorate the gut microbiota dysbiosis, increasing the relative abundance of Bacteroidetes and reducing Firmicutes. Overall, milk and beef odorants showed reletively positive effect on depressed mice through gut-brain axis, where milk odorant was more pronounced. GC-MS analysis identified oleic acid in milk odorant as a potential active component. These findings highlighted food-derived odors as promising nutritional interventions for depression through neuroinflammation modulation and microbiota-gut-brain axis regulation.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"108"},"PeriodicalIF":6.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From dairy to plant products: Understanding their structural fingerprints with X-rays. 从乳制品到植物产品：用x射线了解它们的结构指纹。

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2025-06-23 DOI: 10.1038/s41538-025-00493-w

Eleonora Olsmats, Adrian R Rennie

{"title":"From dairy to plant products: Understanding their structural fingerprints with X-rays.","authors":"Eleonora Olsmats, Adrian R Rennie","doi":"10.1038/s41538-025-00493-w","DOIUrl":"10.1038/s41538-025-00493-w","url":null,"abstract":"Global interest in milk alternatives increases rapidly due to health awareness, their allergen-friendliness, and concerns about sustainability. While dairy product microstructure and rheology are widely studied, plant-based alternatives remain less understood, with limited comparative studies of different plant sources and brands. This study uses ultra-small, small and wide-angle X-ray scattering (USAXS, SAXS, WAXS) to analyse structural fingerprints of commercial plant-based milk, yoghurt and cream alternatives versus dairy products. These techniques allow characterization across multiple length scales from large oil droplets and aggregated structures to carbohydrate/protein networks and glyceride crystalline phases. Correlations between intensity and fat (USAXS) and carbohydrate content (SAXS) provide structural insights, while SAXS and WAXS data correlated with solid fat and crystal packing are important for melting behaviour and viscosity perception. Light scattering confirmed fat-content-related size trends and revealed larger structures of non-lipid materials in plant-based samples. The study provides a basis for understanding scattering data where structural fingerprint plots, using colour scales to compare intensity and intensity gradient, allow ready data interpretation that will be beneficial for analysis with artificial intelligence (AI) tools. This approach helps optimize plant-based formulations by connecting structure and functionality and demonstrates the potential of scattering techniques in food structure research and design.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"109"},"PeriodicalIF":6.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved gut microbiota by selenium-enriched Bifidobacterium longum DD98 alleviates chemotherapy-induced intestinal mucositis via inhibiting the STING pathway. 富硒长双歧杆菌DD98通过抑制STING途径改善肠道微生物群，缓解化疗诱导的肠黏膜炎。

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2025-06-21 DOI: 10.1038/s41538-025-00473-0

Yu-Shuang Qiu, Chen Ye, Qiao Li, Ling-Chen Jiang, Can-Can Zhou, Hui Fu, Dong-Jie Li, Daijie Chen, Fu-Ming Shen

{"title":"Improved gut microbiota by selenium-enriched Bifidobacterium longum DD98 alleviates chemotherapy-induced intestinal mucositis via inhibiting the STING pathway.","authors":"Yu-Shuang Qiu, Chen Ye, Qiao Li, Ling-Chen Jiang, Can-Can Zhou, Hui Fu, Dong-Jie Li, Daijie Chen, Fu-Ming Shen","doi":"10.1038/s41538-025-00473-0","DOIUrl":"10.1038/s41538-025-00473-0","url":null,"abstract":"Intestinal mucositis, a common chemotherapy side effect, lacks effective treatments. This study evaluated the protective effect of selenium-enriched Bifidobacterium longum DD98 (SeDD98) on irinotecan-induced intestinal mucositis. Irinotecan caused intestinal mucositis, characterized by weight loss, severe diarrhea, damaged intestinal structure, reduced tight junction proteins, and gut dysbiosis. These effects could be inhibited by SeDD98. Additionally, fecal microbiota from SeDD98-treated mice protected against intestinal mucositis. Mechanistically, irinotecan activated the stimulator of interferon genes (STING) / nuclear factor kappa-B (NF-κB) pathway, whereas SeDD98 and fecal microbiota from SeDD98-treated mice suppressed this activation. Furthermore, depletion of gut microbiota by a broad-spectrum antibiotic cocktail (ABX) blunted the protective effect of SeDD98 and its inhibition of the STING/NF-κB pathway. These findings suggest that SeDD98 could protect against intestinal mucositis via inhibiting the STING/NF-κB pathway, likely through improving gut microbiota. Overall, SeDD98 may be a potential therapeutic agent for preventing chemotherapy-induced intestinal mucositis via gut microbiome improvement.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"107"},"PeriodicalIF":6.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sea dragon metabolome and lipidome unveil bioactive functional food candidates with sepsis therapeutic activities. 海龙代谢组和脂质组揭示了具有脓毒症治疗活性的生物活性功能性食品候选物。

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2025-06-19 DOI: 10.1038/s41538-025-00469-w

Huixiang Wu, Miaoyu Li, Lijun Ge, Weibo Lu, Xuewei Shen, Yu Zhang, Zengyan Wu, Jianding Wang, Yonghui Wu, Huijuan Mao, Jianliang Zhang, Qingcheng Wang, Jing Xue, Qing Shen, Yuexing Tu

{"title":"Sea dragon metabolome and lipidome unveil bioactive functional food candidates with sepsis therapeutic activities.","authors":"Huixiang Wu, Miaoyu Li, Lijun Ge, Weibo Lu, Xuewei Shen, Yu Zhang, Zengyan Wu, Jianding Wang, Yonghui Wu, Huijuan Mao, Jianliang Zhang, Qingcheng Wang, Jing Xue, Qing Shen, Yuexing Tu","doi":"10.1038/s41538-025-00469-w","DOIUrl":"10.1038/s41538-025-00469-w","url":null,"abstract":"Sea dragons (Syngnathus) are valuable marine resources with notable interspecific phenotypic similarities and variations in composition and efficacy. This study employed multi-omics technologies to comprehensively analyze and structurally identify the molecular components of six species of Syngnathus, effectively screening interspecific differential markers. Untargeted metabolomics revealed a total of 18 classes and 2264 metabolites, and lipids were found to be the principal differential metabolites. Lipidomics were utilized for in-depth lipid detection, expanding the original 412 lipids detected through metabolomics to 2078 lipids, among which 47 differential metabolites and 138 differential lipids were selected from multi-omics results. The integration of network pharmacology and molecular docking elucidated the multifactorial mechanisms by which Syngnathus exerts anti-sepsis effects, including modulation of inflammatory responses, and regulation of apoptosis, while identifying key targets such as IL6, STAT3, and MAPK14. This study suggests that they may have potential as natural sources for the development of anti-sepsis foods. Further studies on their bioavailability and in vitro and in vivo efficacy are required in the future.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"106"},"PeriodicalIF":6.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0