NPJ Science of Food最新文献

Arginine Maillard reaction products recovered damaged immune cells. 精氨酸美拉德反应产物可恢复受损的免疫细胞。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2025-08-01 DOI: 10.1038/s41538-025-00531-7

Yanan Ding, Pingfan Rao, Jianwu Zhou, Huiqin Wang, Ruiyang Wang, Lijing Ke, Guanzhen Gao

{"title":"Arginine Maillard reaction products recovered damaged immune cells.","authors":"Yanan Ding, Pingfan Rao, Jianwu Zhou, Huiqin Wang, Ruiyang Wang, Lijing Ke, Guanzhen Gao","doi":"10.1038/s41538-025-00531-7","DOIUrl":"https://doi.org/10.1038/s41538-025-00531-7","url":null,"abstract":"Instant noodle has been an initiating point for food industry in many countries, and it continues to be a beloved convenient food in the world. However, some products cause discomfort after consumption despite full compliance in both ingredients and processing methods. It has not only resulted in serious consumer misunderstanding but also affect the industry as well. A simple solution possibly lies in nowhere but its soup which uses Maillard reaction products as flavoring agents. Arginine-Glucose Maillard reaction products (Arg-Glc MRPs) have been demonstrated to be antioxidant and anti-inflammatory, which can be useful to remove food caused discomfort. Here we show that Arg-Glc MRPs neither produced significant cytotoxicity nor caused oxidative stress in RAW264.7 macrophages. In theF APPH-induced oxidative damage model, they remarkably reduced cytoplasmic ROS and <math> <msubsup> <mrow> <mrow><mrow><mi>O</mi></mrow> </mrow> </mrow> <mrow><mn>2</mn></mrow> <mrow><mo>⋅</mo> <mo>-</mo></mrow> </msubsup> </math> , and restored the polarization of cytoplasmic membrane potential and mitochondrial membrane potential while enhancing the phagocytic function of normal cells and oxidatively damaged cells. Those in vitro results indicate that the usage of Arg-Glc MRPs in the soup can be a promising solution to discomfort problems.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"164"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silver coated porous silicon microarray SERS platform for detecting aflatoxin B1 fumonisin B1 and ochratoxin A. 镀银多孔硅微阵列SERS平台检测黄曲霉毒素B1伏马毒素B1和赭曲霉毒素A。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2025-08-01 DOI: 10.1038/s41538-025-00532-6

Rohit Kumar Singh, Narsingh R Nirala, Sudharsan Sadhasivam, Divagar Muthukumar, Edward Sionov, Giorgi Shtenberg

{"title":"Silver coated porous silicon microarray SERS platform for detecting aflatoxin B1 fumonisin B1 and ochratoxin A.","authors":"Rohit Kumar Singh, Narsingh R Nirala, Sudharsan Sadhasivam, Divagar Muthukumar, Edward Sionov, Giorgi Shtenberg","doi":"10.1038/s41538-025-00532-6","DOIUrl":"https://doi.org/10.1038/s41538-025-00532-6","url":null,"abstract":"Toxigenic mold contamination in food and agricultural commodities affects a quarter of the world's crops with massive economic losses and consequential health risks. Herein, we present a newly developed nanostructured microarray based on silver-coated porous silicon (Ag-pSi) used as a surface-enhanced Raman scattering (SERS) transducer. The internal porous void and pore morphology were optimized to amplify the SERS effect while achieving an enhancement factor of 1.75 × 107. The optimal structural features were used to analyze three target mycotoxins simultaneously using a portable Raman device. The optical output was inversely proportional to the analyte concentration upon selective biorecognition by the anti-target mycotoxin aptamer-modified scaffold. The Ag-pSi SERS substrate depicted low limits of detection (0.922, 0.547 and 0.008 ppb for ochratoxin A, fumonisin B1 and aflatoxin B1, respectively) within the range of 0.001-1000 ppb. Moreover, the selectivity, reusability, and overall shelf life were meticulously appraised while depicting satisfactory performance values (no interferences with competing mycotoxins, four regeneration cycles and three weeks of stability, respectively). Lastly, the developed SERS microarray was evaluated in different foodstuffs (wheat, maize and rice), with recovery values of 95-104% and RSD below 6.6%. The integrated approach offers a robust, field-deployable solution for a real-time multi-analyte screening platform for food and feed safety monitoring.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"165"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive regulation of cellular heat stress injury by mung bean polyphenols revealed by multi-omics analysis. 多组学分析揭示绿豆多酚对细胞热应激损伤的预防调节作用。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2025-07-31 DOI: 10.1038/s41538-025-00522-8

Yuchao Feng, Shu Zhang, Decheng Suo, Tianxin Fu, Xiaonan Li, Changyuan Wang, Xia Fan

{"title":"Preventive regulation of cellular heat stress injury by mung bean polyphenols revealed by multi-omics analysis.","authors":"Yuchao Feng, Shu Zhang, Decheng Suo, Tianxin Fu, Xiaonan Li, Changyuan Wang, Xia Fan","doi":"10.1038/s41538-025-00522-8","DOIUrl":"10.1038/s41538-025-00522-8","url":null,"abstract":"Based on the Caco-2 cell heat stress model, the study explored the heat stress preventive regulatory mechanisms of key polyphenol fractions in mung bean by metabolomics and transcriptomics association analysis. Results Mung bean polyphenol intervention before heat stress significantly reduced the elevated expression level of heat shock protein 70 (HSP70) caused by 39 °C temperature. At the metabolic level, mung bean polyphenols could play a role in heat stress regulation by alleviating oxidative stress damage. At the gene level, mung bean polyphenols showed regulation of cell proliferation, differentiation, and DNA damage, with DUSP6 and NEURL3 as key regulatory genes. The correlation analysis showed that nucleotide metabolism, and oxidative phosphorylation metabolism were the key pathways in the regulation of mung bean polyphenols by heat stress. Then mung bean polyphenols can exert heat stress preventive activity through the regulation of cellular oxidative damage and energy metabolism. This study provides a good idea for the research and development of dietary intervention products for heat stress.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"163"},"PeriodicalIF":7.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fast and easy edible protein production by nitrogen-supplemented koji fermentation. 补氮曲发酵快速简便生产食用蛋白。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2025-07-31 DOI: 10.1038/s41538-025-00463-2

Junichi Mano

引用次数: 0

Carob Pod Nanoparticles: enhancing physicochemical, antioxidant, and antibacterial properties of innovative functional frozen yogurt. 角豆荚纳米颗粒：增强创新功能冷冻酸奶的理化、抗氧化和抗菌特性。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2025-07-30 DOI: 10.1038/s41538-025-00529-1

Amro Abdelazez, Ghada Abady, Monira Basiony, Atef A Abd El-Rahman, Sally M A El-Shafei, Emad S Shaker, Garsa Alshehry, Eman Algarni, Huda Aljumayi, Amina Mahmoud Hassan

{"title":"Carob Pod Nanoparticles: enhancing physicochemical, antioxidant, and antibacterial properties of innovative functional frozen yogurt.","authors":"Amro Abdelazez, Ghada Abady, Monira Basiony, Atef A Abd El-Rahman, Sally M A El-Shafei, Emad S Shaker, Garsa Alshehry, Eman Algarni, Huda Aljumayi, Amina Mahmoud Hassan","doi":"10.1038/s41538-025-00529-1","DOIUrl":"10.1038/s41538-025-00529-1","url":null,"abstract":"The study investigates the advantages of incorporating carob pod nanoparticles (CPNs) into frozen yogurt production. CPNs, abundant in carbohydrates, polyphenols, and antioxidants, were utilized as a multifunctional ingredient, serving as a sugar substitute, thickening agent, stabilizer, and natural colorant to enhance the manufacturing process of frozen yogurt. The research compared a control group (Ctrl) containing 15% sucrose in plain frozen yogurt with three groups where CPNs partially replaced sucrose at concentrations of 4% (FYC4), 8% (FYC8), and 12% (FYC12). Over a 45-day storage period, the chemical properties remained stable across all groups, with no significant differences observed (p < 0.05). Notably, the CPN-enriched frozen yogurts exhibited enhanced antimicrobial activity and antioxidant capacity, which improved the product's physical microstructure and sensory attributes. The findings suggest that CPNs are a promising functional ingredient and food additive, offering the potential for the development of innovative, health-promoting frozen yogurt products.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"162"},"PeriodicalIF":7.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anthocyanins from blueberry and blackberry ameliorate metabolic syndrome by Prevotella histicola and acetic acid. 蓝莓和黑莓花青素通过历史普氏菌和醋酸改善代谢综合征。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2025-07-29 DOI: 10.1038/s41538-025-00526-4

Lanlan Du, Xiaoqin Ding, Weichen Zhang, Lushi Huang, Han Lü, Tunyu Jian, Jing Li, Yanan Gai, Xiuhua Meng, Guanting Niu, Jian Chen, Weilin Li

{"title":"Anthocyanins from blueberry and blackberry ameliorate metabolic syndrome by Prevotella histicola and acetic acid.","authors":"Lanlan Du, Xiaoqin Ding, Weichen Zhang, Lushi Huang, Han Lü, Tunyu Jian, Jing Li, Yanan Gai, Xiuhua Meng, Guanting Niu, Jian Chen, Weilin Li","doi":"10.1038/s41538-025-00526-4","DOIUrl":"10.1038/s41538-025-00526-4","url":null,"abstract":"Metabolic syndrome (MetS) is a globally prevalent disorder and poses a significant threat to human health and social harmony. Consumption of anthocyanins has been proven to improve disrupted gut microbiota and obesity in mice and humans. However, the potential specific gut microbiota and metabolites that might mediate these beneficial effects on MetS remain unknown. Here, the MetS-mice model, induced by a high-fat diet (HFD), was employed to investigate the specific effects of ACNs. Additionally, 16S rRNA sequencing and targeted metabolomics analysis of short-chain fatty acids (SCFAs) were utilized to evaluate the influence on gut microbiota composition and SCFAs levels. More importantly, we also utilized antibiotics to construct a pseudo-germ-free mouse model for fecal microbiota transplantation (FMT) to further confirm the regulation of gut microbiota by ACNs and demonstrating that the related effects on MetS could be transferable through FMT. Our data demonstrated that the amelioration of MetS by ACNs might be achieved through modulation of the gut microbiota, which was validated through FMT, and the related benefits could be transferable by FMT. Furthermore, acetic acid and Prevotella histicola might be key microbial metabolites and bacteria, respectively, in this process. These findings highlight the diet-gut-metabolites-diseases system crosstalk and provide new research perspectives for plant-derived ingredients with poor bioavailability.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"158"},"PeriodicalIF":7.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monobutyrin can alleviate hepatic lipid dysmetabolism and improve liver mitochondrial ultrastructure and autophagy in high-fat diet mice. 单丁胺素能减轻高脂饮食小鼠肝脏脂质代谢异常，改善肝脏线粒体超微结构和自噬。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2025-07-29 DOI: 10.1038/s41538-025-00524-6

Yuqing Zhang, Xiaoteng Li, Haidong Wang, Kexin Zhang, Ji Qiu, Minyao Zhou, Minqi Wang

{"title":"Monobutyrin can alleviate hepatic lipid dysmetabolism and improve liver mitochondrial ultrastructure and autophagy in high-fat diet mice.","authors":"Yuqing Zhang, Xiaoteng Li, Haidong Wang, Kexin Zhang, Ji Qiu, Minyao Zhou, Minqi Wang","doi":"10.1038/s41538-025-00524-6","DOIUrl":"10.1038/s41538-025-00524-6","url":null,"abstract":"The incidence of non-alcoholic fatty liver disease has proportionally escalated alongside the global epidemic of obesity. Monobutyrin (MB), a food additive found in butter and cod liver oil, possesses lipid-regulating properties. This study aimed to explore the alleviating effect of MB on liver oxidative injury and lipid metabolism in obese mice induced by a high-fat diet (HFD). The results showed that MB administration (1 or 2 g/kg body weight (BW)) for 8 weeks significantly reduced body weight, improved hepatic lipid metabolism via activation of the peroxisome proliferator-activated receptor α (PPARα) signaling pathway, and stabilized liver mitochondrial ultrastructure to alleviate oxidative liver injury by triggering mitochondrial autophagy through regulation of microtubule-associated protein 1A/1B-light chain 3 (LC3) and ubiquitin-binding protein (P62) in mice. Moreover, MB might increase the abundance of beneficial bacteria, promote short-chain fatty acid levels, and alleviate high-fat induced obesity via the gut-liver axis. These findings provide a novel insight into MB as an intervention strategy for hepatic metabolic disorders.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"159"},"PeriodicalIF":7.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhizobium biostimulation of blackberry modulates survival pathways in Caenorhabditis elegans across biological kingdoms. 黑莓根瘤菌的生物刺激调节秀丽隐杆线虫的生存途径。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2025-07-29 DOI: 10.1038/s41538-025-00525-5

Rocío Roca-Couso, José David Flores-Félix, Begoña Ayuda-Durán, Rebeca Ferreras-Charro, Ignacio García-Estévez, Paula García-Fraile, Raúl Rivas

{"title":"Rhizobium biostimulation of blackberry modulates survival pathways in Caenorhabditis elegans across biological kingdoms.","authors":"Rocío Roca-Couso, José David Flores-Félix, Begoña Ayuda-Durán, Rebeca Ferreras-Charro, Ignacio García-Estévez, Paula García-Fraile, Raúl Rivas","doi":"10.1038/s41538-025-00525-5","DOIUrl":"10.1038/s41538-025-00525-5","url":null,"abstract":"Endophytic Rhizobium species represent promising bioinoculants for enhancing crop performance and nutritional profiles. This study investigated the impact of Rhizobium sp. CRRU65 inoculation on blackberry (Rubus sp.) plants, with emphasis on fruit phytochemical composition and cross-kingdom bioactivity. Inoculated plants exhibited a significant increase in yield and elevated levels of phenolic compounds, notably sanguiin H6 and cyanidin-3-O-glucoside, as quantified by HPLC-DAD-MS. Antioxidant functionality was evaluated using Caenorhabditis elegans under oxidative stress. Extracts from inoculated fruits significantly improved nematode survival, accompanied by transcriptional upregulation of skn-1 and hsp-16, genes involved in stress response and proteostasis. These findings demonstrate that Rhizobium sp. CRRU65 enhances not only agronomic traits but also the nutraceutical quality of blackberry fruits, with beneficial effects extending across biological kingdoms. This work underscores the potential of endophytic bacteria to contribute to sustainable agriculture and functional food innovation through molecular and physiological modulation in both plants and animal models.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"160"},"PeriodicalIF":7.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postmortem muscle proteomics reveals breed specific responses to environmental enrichment and broiler meat quality. 死后肌肉蛋白质组学揭示了品种对环境富集和肉鸡肉品质的特异性反应。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2025-07-29 DOI: 10.1038/s41538-025-00530-8

Seren Yigitturk, Ingrid C de Jong, Sjef Boeren, Martin Alewijn, Shai Barbut, Vincenzo Fogliano, Sara W Erasmus

{"title":"Postmortem muscle proteomics reveals breed specific responses to environmental enrichment and broiler meat quality.","authors":"Seren Yigitturk, Ingrid C de Jong, Sjef Boeren, Martin Alewijn, Shai Barbut, Vincenzo Fogliano, Sara W Erasmus","doi":"10.1038/s41538-025-00530-8","DOIUrl":"10.1038/s41538-025-00530-8","url":null,"abstract":"The meat industry faces growing pressure to adopt sustainable and welfare-friendly practices. This study used mass spectrometry-based proteomics to examine the effects of genetics and on-farm environmental enrichment on broiler performance and meat quality. Slower-growing (SG; Hubbard S757N) and faster-growing (FG; Hubbard JA787) broilers were raised in enriched and non-enriched environments within higher-welfare systems. The SG broilers showed higher expression of detoxification and cytoskeletal proteins, supporting robust muscle architecture, higher protein content and reduced moisture retention. Enriched environments further enhanced immune function, metabolic resilience and physical health in SG broilers. Conversely, FG broilers prioritised anabolic pathways, driving rapid muscle growth and intramuscular fat accumulation. Growing in enriched conditions led to reduced breast yield in FG broilers, likely due to higher proteasome activity. These findings highlight the importance of breed-specific strategies to support sustainable farming, as only SG broilers benefited from environmental enrichment, potentially improving meat quality while supporting welfare outcomes.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"161"},"PeriodicalIF":7.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing microbial risk assessment: perspectives from the evolution of detection technologies. 推进微生物风险评估：从检测技术发展的角度。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2025-07-28 DOI: 10.1038/s41538-025-00527-3

Linlin Xiao, Zhao Li, Xin Dou, Yulin Long, Zhuosi Li, Yangtai Liu, Qingli Dong

引用次数: 0