NPJ Science of Food最新文献_第10页

Anti-inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitis. 胶原肽的体外抗炎活性及其对溃疡性结肠炎的改善作用。

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2025-01-02 DOI: 10.1038/s41538-024-00367-7

Xuan-Ying Xin, Jing Zhou, Gao-Ge Liu, Mei-Yu Zhang, Xiang-Zi Li, Yan Wang

引用次数: 0

A multiplex microarray lateral flow immunoassay device for simultaneous determination of five mycotoxins in rice 多重微阵列横向流动免疫分析装置同时测定水稻中5种真菌毒素。

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2024-12-31 DOI: 10.1038/s41538-024-00342-2

Saowalak Adunphatcharaphon, Oluwatobi Kolawole, Thanasat Sooksimuang, Waraporn Panchan, Wannee Wasuthep, Anuwut Petdum, Grit Pichayawaytin, Rungroj Jintamethasawat, Narusorn Doljirapisit, Armote Somboonkaew, Prae Noppakuadrittidej, Sudtida Kaew-amdee, Manlika Makornwattana, Julie Meneely, Christopher T. Elliott, Awanwee Petchkongkaew, Nitsara Karoonuthaisiri

{"title":"A multiplex microarray lateral flow immunoassay device for simultaneous determination of five mycotoxins in rice","authors":"Saowalak Adunphatcharaphon, Oluwatobi Kolawole, Thanasat Sooksimuang, Waraporn Panchan, Wannee Wasuthep, Anuwut Petdum, Grit Pichayawaytin, Rungroj Jintamethasawat, Narusorn Doljirapisit, Armote Somboonkaew, Prae Noppakuadrittidej, Sudtida Kaew-amdee, Manlika Makornwattana, Julie Meneely, Christopher T. Elliott, Awanwee Petchkongkaew, Nitsara Karoonuthaisiri","doi":"10.1038/s41538-024-00342-2","DOIUrl":"10.1038/s41538-024-00342-2","url":null,"abstract":"Co-occurrence of multiple mycotoxins is a growing global food safety concern due to their harmful effects on humans and animals. This study developed an eco-friendly sample preparation method and an innovative multiplex microarray-based lateral flow immunoassay, using a novel portable reader for on-site simultaneous determination of five regulated mycotoxins—aflatoxin B1, T-2 toxin, zearalenone, deoxynivalenol, and fumonisin B1 in rice. The eco-friendly and ultrafast extraction procedure utilizes a bio-based solvent. Principally, the microarray signals generated through a novel luminescent organic dye were captured to quantify mycotoxin levels in samples using a portable reader installed with a user-friendly interface. The assay demonstrates accurate detection and quantification of these mycotoxins, with recoveries ranging from 77% to 127%. Detection limits ranged from 0.56 to 1.89 μg/kg, which were well below their regulatory limits, with a relative standard deviation below 25%. This analytical system provides an on-site method for detecting multiple mycotoxins in rice.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":"1-12"},"PeriodicalIF":6.3,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41538-024-00342-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lauric-α-linolenic lipids modulate gut microbiota, preventing obesity, insulin resistance and inflammation in high-fat diet mice 月桂-α-亚麻酸脂质调节肠道微生物群，预防高脂饮食小鼠肥胖、胰岛素抵抗和炎症。

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2024-12-30 DOI: 10.1038/s41538-024-00349-9

Ying Huang, Wangxin Liu, Xianliang Luo, Minjie Zhao, Jing Wang, Sami Ullah, Wei Wei, Fengqin Feng

{"title":"Lauric-α-linolenic lipids modulate gut microbiota, preventing obesity, insulin resistance and inflammation in high-fat diet mice","authors":"Ying Huang, Wangxin Liu, Xianliang Luo, Minjie Zhao, Jing Wang, Sami Ullah, Wei Wei, Fengqin Feng","doi":"10.1038/s41538-024-00349-9","DOIUrl":"10.1038/s41538-024-00349-9","url":null,"abstract":"Medium- and long-chain triacylglycerols (MLCTs) are regarded as healthy premium oils; however, the health benefits of novel MLCTs enriched with lauric and α-linolenic acids are still not fully understood. This study examined the health benefits of lauric-α-linolenic structural lipids (ALSL) and physical mixture (PM) with a similar fatty acid composition in mice with obesity induced by the high-fat diet (HFD). The data indicated that ALSL is more effective than PM in counteracting obesity, insulin resistance, hyperlipidaemia, liver injury, and systemic inflammation in HFD-induced mice. These effects may be associated with the regulation of gut microbiota. ALSL significantly upregulated the abundance of Dubosiella, Lactobacillus, and Bifidobacterium while reducing the abundance of Ileibacterium. Furthermore, ALSL therapy increased the levels of acetic acid, propionic acid, and total short-chain fatty acids. Correlation analysis found that the positive changes in these gut microbes correlated positively with the anti-inflammatory, insulin-sensitizing, and anti-obesity effects of ALSL.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":"1-12"},"PeriodicalIF":6.3,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41538-024-00349-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive effect of Tyr-Pro, a blood-brain barrier transportable dipeptide, on memory impairment in SAMP8 mice 血脑屏障可转运二肽Tyr-Pro对SAMP8小鼠记忆损伤的预防作用

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2024-12-29 DOI: 10.1038/s41538-024-00360-0

Xixi Li, Yuka Ichiba, Takuya Watanabe, Atsuko Yoshino, Lihong Cheng, Yuki Nagasato, Fuyuko Takata, Shinya Dohgu, Katsunori Iwasaki, Mitsuru Tanaka, Toshiro Matsui

{"title":"Preventive effect of Tyr-Pro, a blood-brain barrier transportable dipeptide, on memory impairment in SAMP8 mice","authors":"Xixi Li, Yuka Ichiba, Takuya Watanabe, Atsuko Yoshino, Lihong Cheng, Yuki Nagasato, Fuyuko Takata, Shinya Dohgu, Katsunori Iwasaki, Mitsuru Tanaka, Toshiro Matsui","doi":"10.1038/s41538-024-00360-0","DOIUrl":"10.1038/s41538-024-00360-0","url":null,"abstract":"In a series of studies on blood-brain barrier transportable peptides, a soybean dipeptide, Tyr-Pro, penetrated the mouse brain parenchyma after oral intake and improved short and long memory impairment in acute Alzheimer’s model mice. Here, we aimed to clarify the anti-dementia effects of this peptide administered to SAMP8 mice prior to dementia onset. At the end of the 25-week protocol in 16-week-old SAMP8 mice, Tyr-Pro (10 mg/kg/day) significantly improved the reduced spatial learning ability compared with that in the control and amino acid (Tyr + Pro) groups as indicated by the results of Morris water maze tests conducted for five consecutive days. The hippocampus and cortex regions of SAMP8 harvested after the test showed lower amyloid ß (Aß) accumulation in the Tyr-Pro group than those in the control and amino acid groups. Consistent with the lower level of Aß, decreased expression of ß-secretase (BACE1) and markedly increased expression (4-times higher) of insulin degrading enzyme (IDE) were obtained compared to those in the control group. Collectively, we demonstrated that long-term daily intake of the dipeptide Tyr-Pro in SAMP8 mice may be sufficient for maintaining cognitive ability by preventing excess Aß accumulation through downregulated BACE1 and particularly upregulated IDE.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":"1-8"},"PeriodicalIF":6.3,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41538-024-00360-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brassica rapa L. polysaccharide mitigates hypobaric hypoxia-induced oxidation and intestinal damage via microbiome modulation 芥蓝多糖通过调节微生物群减轻低氧诱导的氧化和肠道损伤

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2024-12-27 DOI: 10.1038/s41538-024-00365-9

Wei Liu, Zhenjiang Liu, Xueni Fan, Diantong Li, Tingting Zhao, Yuanlin Niu, Yangjin Baima, Dongxu Wen, Bin Li, Xiaodan Huang

{"title":"Brassica rapa L. polysaccharide mitigates hypobaric hypoxia-induced oxidation and intestinal damage via microbiome modulation","authors":"Wei Liu, Zhenjiang Liu, Xueni Fan, Diantong Li, Tingting Zhao, Yuanlin Niu, Yangjin Baima, Dongxu Wen, Bin Li, Xiaodan Huang","doi":"10.1038/s41538-024-00365-9","DOIUrl":"10.1038/s41538-024-00365-9","url":null,"abstract":"The high-altitude, low-pressure, and hypoxia environment poses a significant threat to human health, particularly causing intestinal damage and disrupting gut microbiota. This study investigates the protective effects of Brassica rapa L. crude polysaccharides (BRP) on intestinal damage in mice exposed to hypobaric hypoxic conditions. Results showed that oxidative stress and inflammation levels were elevated in the hypoxia group, while BRP intervention significantly increased antioxidant enzyme activities (SOD, GSH-Px, T-AOC) and reduced inflammatory markers (IL-6, IL-1β, TNF-α). BRP also restored intestinal barrier function by enhancing claudin-1, occludin, and ZO-1 expression. Notably Chromatographic and metagenomic analyses revealed that BRP enriched butyrate levels, promoted beneficial bacteria like Akkermansia muciniphila and Leuconostoc lactis, and upregulated L-arginine biosynthesis II and L-methionine biosynthesis III pathways to enhance antioxidant activity. Fecal microbiota transfer experiments confirmed the role of gut microbiota in mediating BRP’s protective effects, providing valuable insights into prebiotic-based therapeutic strategies for hypobaric hypoxia-induced intestinal damage.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":"1-14"},"PeriodicalIF":6.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41538-024-00365-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilization of plant-based foods for effective prevention of chronic diseases: a longitudinal cohort study 利用植物性食物有效预防慢性疾病：一项纵向队列研究

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2024-12-27 DOI: 10.1038/s41538-024-00362-y

Jie Liang, Yanchao Wen, Jinzhu Yin, Guiming Zhu, Tong Wang

引用次数: 0

Sex differences in CYP450-based sodium dehydroacetate metabolism and its metabolites in rats 大鼠基于cyp450的脱氢乙酸钠代谢及其代谢物的性别差异

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2024-12-24 DOI: 10.1038/s41538-024-00361-z

Meng Zhang, Pengfei Du, Yirong Xiao, Hao Liu, Meixue Wang, Yumei Zhang, Xin Chen

{"title":"Sex differences in CYP450-based sodium dehydroacetate metabolism and its metabolites in rats","authors":"Meng Zhang, Pengfei Du, Yirong Xiao, Hao Liu, Meixue Wang, Yumei Zhang, Xin Chen","doi":"10.1038/s41538-024-00361-z","DOIUrl":"10.1038/s41538-024-00361-z","url":null,"abstract":"Sodium dehydroacetate (DHA-Na), a widely used preservative, can induce sex-differentiated coagulation disorders primarily resulting from its metabolism. However, the underlying mechanisms remain poorly understood. Here, we identified several Cytochrome P450 (CYP450) sub-enzymes involved in sex differences related to DHA-Na metabolism, along with two related DHA-Na metabolites. CYP1A2, CYP3A2, and CYP2D1 were primarily responsible for DHA-Na metabolism, which was stronger in male rats than in female rats. Inhibition of these isoforms separately resulted in the DHA-Na metabolic capacity in male rats becoming equal to, or even weaker than, that in female rats. Furthermore, Cyp1a2, Cyp3a2, Cyp2d1, and Cyp2c11 expression was higher in male rats than in female rats, suggesting these enzymes are related to exhibited sex differences in DHA-Na metabolism. Moreover, 3-glycoloyl-6-methy-2,3-dihydropyran-2,4-dione (C8H8O5) and 3-imino-6-methyl-2,3-dihydropran-2,4dione (C6H5O3N) were identified as the two main DHA-Na metabolites. These findings provide crucial insights into potential mechanisms underlying sex differences in DHA-Na metabolism and its metabolites in rats.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":"1-12"},"PeriodicalIF":6.3,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41538-024-00361-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress tolerance 食材艾叶促进寿命和抗逆性的分子机制

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2024-12-24 DOI: 10.1038/s41538-024-00358-8

Jinsong Wang, Deyan Zhu, Hailin Cui, Yan Xu, Shuyou Shang, Yuanxin Miao, Zhimin Xu, Rong Li

引用次数: 0

It is time to reevaluate the lard in glucose homeostasis and diabetes pathogenesis 现在是重新评估葡萄糖稳态和糖尿病发病机制的时候了

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2024-12-24 DOI: 10.1038/s41538-024-00357-9

Fangrui Guo, Xiaoran wu, Sisi Yan, Xiangyan Liu, Xiaowen Li, Lixin Wen, Ji wang

引用次数: 0

Conditioned serum-free culture medium accomplishes adhesion and proliferation of bovine myogenic cells on uncoated dishes 条件无血清培养基实现牛肌原细胞在无涂层培养皿上的粘附和增殖

IF 6.3 1区农林科学

NPJ Science of Food Pub Date : 2024-12-23 DOI: 10.1038/s41538-024-00355-x

Takashi Morikura, Katsuhisa Sakaguchi, Ryu-ichiro Tanaka, Azumi Yoshida, Hironobu Takahashi, Kiyotaka Iwasaki, Tatsuya Shimizu

{"title":"Conditioned serum-free culture medium accomplishes adhesion and proliferation of bovine myogenic cells on uncoated dishes","authors":"Takashi Morikura, Katsuhisa Sakaguchi, Ryu-ichiro Tanaka, Azumi Yoshida, Hironobu Takahashi, Kiyotaka Iwasaki, Tatsuya Shimizu","doi":"10.1038/s41538-024-00355-x","DOIUrl":"10.1038/s41538-024-00355-x","url":null,"abstract":"To establish a sustainable cultured meat technology, a low-cost culture medium must be developed without expensive biological materials such as serum and coating substances. However, even adhering bovine myogenic cells to uncoated culture dishes in the serum-free medium is challenging. We found that serum-free culture medium conditioned by HepG2 and NIH/3T3 cells not only accomplished the cell adhesion on uncoated culture dishes (the serum-containing medium : the serum-free medium : the conditioned medium = 6722 ± 1500 : 2210 ± 319 : 5985 ± 1558 cells/cm2), but also induced proliferation comparable to that observed in a serum-containing medium (the serum-containing medium : the serum-free medium : the conditioned medium = 10,050 ± 2814 : 2200 ± 707 : 8998 ± 3890 cells/cm2). Interestingly, although the nutrient composition of the developed medium differed significantly from that of the serum-containing medium, it tended to coordinate the expression of cell adhesion, proliferation, and myogenic differentiation markers as serum-containing medium. Component analysis and validation experiments suggested that pyridoxamine, asparagine, and glutamic acid contributed to the acquisition of the culture function of the developed medium. Our study paves the way to realize a low-cost and sustainable cultured meat technology.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":"1-13"},"PeriodicalIF":6.3,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41538-024-00355-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0