Yanyun Wang, Leping Quan, Xiaomin Zheng, Qiang Hu, Xiaoli Huang, Yang Pu, Guangfa Xie, Qi Peng
{"title":"Indole compounds from fermented soybean products activate the aryl hydrocarbon receptor to reduce liver injury.","authors":"Yanyun Wang, Leping Quan, Xiaomin Zheng, Qiang Hu, Xiaoli Huang, Yang Pu, Guangfa Xie, Qi Peng","doi":"10.1038/s41538-025-00404-z","DOIUrl":"10.1038/s41538-025-00404-z","url":null,"abstract":"<p><p>The consumption of stinky tofu, a traditional fermented soybean product from China, elevates the concentrations of indole and trimethylindole in murine feces and increases the levels of indole in serum, as well as indole in the liver. These hepatic compounds act as ligands for the Aryl Hydrocarbon Receptor (AHR), triggering activation of this receptor, which subsequently enhances the expression of the enzyme cytochrome P450 (CYP) 1A1. This upregulation diminishes the levels of pro-inflammatory cytokines, thereby attenuating alcohol-induced liver injury. This study underscores the potential of dietary indole from stinky tofu to mitigate Alcoholic liver disease (ALD), laying a foundation for the development of functional foods and novel treatment strategies for ALD.</p>","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"38"},"PeriodicalIF":6.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuzhuo Wang, Changhui Li, Jiaxiang Huang, Qingkun Zeng, Ling Li, Pan Yang, Pengjie Wang, Min Chu, Jie Luo, Fazheng Ren, Hao Zhang
{"title":"Composition and structural characteristics of lipids in yak, buffalo, and cow colostrum based on untargeted lipidomics.","authors":"Yuzhuo Wang, Changhui Li, Jiaxiang Huang, Qingkun Zeng, Ling Li, Pan Yang, Pengjie Wang, Min Chu, Jie Luo, Fazheng Ren, Hao Zhang","doi":"10.1038/s41538-025-00406-x","DOIUrl":"10.1038/s41538-025-00406-x","url":null,"abstract":"<p><p>Lipids play pivotal roles in supplying energy and promoting gut health. While yak and buffalo milk are known for their high nutritional values, the lipid compositions of yak colostrum (YC) and buffalo colostrum (BC) remain poorly explored. Here, untargeted lipidomics were applied to analyze YC, BC, and cow colostrum (CC). 546, 353, and 417 differential lipids were identified in the comparisons of YC-CC, BC-CC, and YC-BC, respectively. Compared to CC, YC exhibited a higher content of C18:2, while BC was marked by lower levels of saturated fatty acids. Additionally, specific lipid biomarkers were identified: triacylglycerol (TG) (16:0_10:0_22:6), TG (4:0_12:3_16:0), TG (4:0_8:0_18:2), TG (6:0_6:0_22:6), TG (6:0_8:0_22:6), and TG (6:0_8:0_8:0) were more for YC, while ceramide (Cer) (d19:1_24:1), diacylglycerol (DG) (36:2), hexosyl ceramide (Hex1Cer) (d37:1), TG (40:2e), TG (4:0_12:0_18:2), and zymosteryl (ZyE) (24:7) were biomarkers for BC. These findings provide a theoretical basis for optimizing the use of colostrum in various applications.</p>","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"37"},"PeriodicalIF":6.3,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aftab Siddique, Ashish Gupta, Jason T Sawyer, Tung-Shi Huang, Amit Morey
{"title":"Big data analytics in food industry: a state-of-the-art literature review.","authors":"Aftab Siddique, Ashish Gupta, Jason T Sawyer, Tung-Shi Huang, Amit Morey","doi":"10.1038/s41538-025-00394-y","DOIUrl":"10.1038/s41538-025-00394-y","url":null,"abstract":"<p><p>The food industry has experienced rapid growth over the past two decades, driven by technological advancements that have generated vast quantities of complex data. However, the industry's ability to effectively analyze and leverage this data remains limited due to the lack of control over diverse variables. This review addresses a critical gap by exploring how AI-ML-based approaches can be applied to solve key challenges in the food sector.</p>","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"36"},"PeriodicalIF":6.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gwoncheol Park, Katelyn Johnson, Katelyn Miller, Saurabh Kadyan, Saiful Singar, Cole Patoine, Fuhua Hao, Yujin Lee, Andrew D Patterson, Bahram Arjmandi, Penny M Kris-Etherton, Claire E Berryman, Ravinder Nagpal
{"title":"Almond snacking modulates gut microbiome and metabolome in association with improved cardiometabolic and inflammatory markers.","authors":"Gwoncheol Park, Katelyn Johnson, Katelyn Miller, Saurabh Kadyan, Saiful Singar, Cole Patoine, Fuhua Hao, Yujin Lee, Andrew D Patterson, Bahram Arjmandi, Penny M Kris-Etherton, Claire E Berryman, Ravinder Nagpal","doi":"10.1038/s41538-025-00403-0","DOIUrl":"10.1038/s41538-025-00403-0","url":null,"abstract":"<p><p>Western-style dietary patterns have been linked with obesity and associated metabolic disorders and gut dysbiosis, whereas prudent dietary and snacking choices mitigate these predispositions. Using a multi-omics approach, we investigated how almond snacking counters gut imbalances linked to adiposity and an average American Diet (AAD). Fifteen adults with overweight or obesity underwent a randomized, crossover-controlled feeding trial comparing a 4-week AAD with a similar isocaloric diet supplemented with 42.5 g/day of almonds (ALD). Almond snacking increases functional gut microbes, including Faecalibacterium prausnitzii, while suppressing opportunistic pathogens, thereby favorably modulating gut microecological niches through symbiotic and microbe-metabolite interactions. Moreover, ALD elevates health-beneficial monosaccharides and fosters bacterial consumption of amino acids, owing to enhanced microbial homeostasis. Additionally, ALD enhances metabolic homeostasis through a ketosis-like effect, reduces inflammation, and improves satiety-regulating hormones. The findings suggest that prudent dietary choices, such as almond snacking, promote gut microbial homeostasis while modulating immune metabolic state.</p>","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"35"},"PeriodicalIF":6.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ki-Uk Kim, Jisu Kim, Hyunjun Jang, Kang Bin Dan, Bo Kyeong Kim, Yong Woo Ji, Dae Yong Yi, Hyeyoung Min
{"title":"Protective effects of human breast milk-derived exosomes on inflammatory bowel disease through modulation of immune cells.","authors":"Ki-Uk Kim, Jisu Kim, Hyunjun Jang, Kang Bin Dan, Bo Kyeong Kim, Yong Woo Ji, Dae Yong Yi, Hyeyoung Min","doi":"10.1038/s41538-025-00400-3","DOIUrl":"10.1038/s41538-025-00400-3","url":null,"abstract":"<p><p>Human breast milk (HBM)-derived exosomes play a crucial role not only in infant nutrition but also in modulating inflammation, immunity, and epithelial cell protection. This study investigated how HBM-derived exosomes regulate immune cell development and function. The exosomes promoted the differentiation of naïve CD4<sup>+</sup> T cells into Treg and Th2 cells while suppressing their differentiation into Th17 and Th1 cells. They also enhanced the proliferation of intestinal epithelial Caco-2 cells and reduced apoptosis in dextran sulfate sodium (DSS)-damaged caco-2 cells. In a DSS-induced colitis mouse model, the exosomes significantly alleviated disease severity, as evidenced by improvements in colon length, disease activity index, and histology grades. Furthermore, the exosomes normalized CD4<sup>+</sup> T cell subsets in the spleen, mesenteric lymph nodes, and colon, restoring levels comparable to controls. These findings suggest that HBM-derived exosomes hold promise as a potential therapeutic strategy for inflammatory bowel disease by modulating T-cell responses and protecting intestinal epithelial cells.</p>","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"34"},"PeriodicalIF":6.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eliot Jan-Smith, Harley Downes, Aaron P Davis, Adam Richard-Bollans, Jeremy Haggar, Daniel Sarmu, Geoffrey C Kite, Melanie-Jayne R Howes
{"title":"Metabolomic insights into the Arabica-like flavour of stenophylla coffee and the chemistry of quality coffee.","authors":"Eliot Jan-Smith, Harley Downes, Aaron P Davis, Adam Richard-Bollans, Jeremy Haggar, Daniel Sarmu, Geoffrey C Kite, Melanie-Jayne R Howes","doi":"10.1038/s41538-025-00398-8","DOIUrl":"10.1038/s41538-025-00398-8","url":null,"abstract":"<p><p>Stenophylla coffee, an undomesticated species from Upper West Africa, is of commercial interest due to its high heat tolerance and Arabica-like flavour. To investigate the chemical basis of flavour similarity, we analysed unroasted coffee bean samples using liquid chromatography-mass spectrometry (LC-MS) and applied metabolomics approaches to compare chemical profiles. We report similarities between Arabica and stenophylla in the relative levels of several key compounds linked to coffee flavour, including caffeine, trigonelline, sucrose and citric acid. Differences in their chemical profiles were also observed, especially in their diterpenoid and hydroxycinnamic acid profiles. We report the additional novel finding that theacrine occurs in stenophylla, which is the first record of this alkaloid in coffee beans. For stenophylla, the dissimilarities in chemical compound composition (compared to Arabica) may offer opportunities for a better understanding of the chemical basis of high-quality coffee and sensory diversification.</p>","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"33"},"PeriodicalIF":6.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kirsten Schulz, Martin Bachmann, Jens Raila, Ruth Schmitt, Rudolf Staufenbiel, Heiko Scholz, Monika Wensch-Dorendorf, Sebastian Ptok, Anke Weissenborn, Robert Pieper
{"title":"Vitamin A concentration in bovine liver and milk does not only depend on characteristics of the farming system.","authors":"Kirsten Schulz, Martin Bachmann, Jens Raila, Ruth Schmitt, Rudolf Staufenbiel, Heiko Scholz, Monika Wensch-Dorendorf, Sebastian Ptok, Anke Weissenborn, Robert Pieper","doi":"10.1038/s41538-025-00397-9","DOIUrl":"10.1038/s41538-025-00397-9","url":null,"abstract":"<p><p>The study examined the vitamin A status in commercially managed suckler cows and lactating dairy cows and identified primary influencing factors. Liver retinyl ester concentrations were higher in multiparous than primiparous cows (p < 0.01). Pasture availability was associated with higher β-carotene concentrations (p < 0.001). In dairy cows, pasture access during the dry period did not affect any of the parameters assayed. β-Carotene and retinol in milk increased with parity. No vitamin A deficiency or hypervitaminosis A was detected. Liver and milk retinol and retinyl ester concentrations that were analysed in the present study and data from a recent German total diet study were used to estimate the exposure to preformed vitamin A in vulnerable groups (children, 0.5-5 years). 95th percentiles of preformed vitamin A intake do not exceed tolerable upper intake levels in individuals between 1 year and 5 years, but in infants 6 to 12 months of age.</p>","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"32"},"PeriodicalIF":6.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tianzhen Yin, Yankun Peng, Kuanglin Chao, Yongyu Li
{"title":"Emerging trends in SERS-based veterinary drug detection: multifunctional substrates and intelligent data approaches.","authors":"Tianzhen Yin, Yankun Peng, Kuanglin Chao, Yongyu Li","doi":"10.1038/s41538-025-00393-z","DOIUrl":"10.1038/s41538-025-00393-z","url":null,"abstract":"<p><p>Veterinary drug residues in poultry and livestock products present persistent challenges to food safety, necessitating precise and efficient detection methods. Surface-enhanced Raman scattering (SERS) has been identified as a powerful tool for veterinary drug residue analysis due to its high sensitivity and specificity. However, the development of reliable SERS substrates and the interpretation of complex spectral data remain significant obstacles. This review summarizes the development process of SERS substrates, categorizing them into metal-based, rigid, and flexible substrates, and highlighting the emerging trend of multifunctional substrates. The diverse application scenarios and detection requirements for these substrates are also discussed, with a focus on their use in veterinary drug detection. Furthermore, the integration of deep learning techniques into SERS-based detection is explored, including substrate structure design optimization, optical property prediction, spectral preprocessing, and both qualitative and quantitative spectral analyses. Finally, key limitations are briefly outlined, such as challenges in selecting reporter molecules, data imbalance, and computational demands. Future trends and directions for improving SERS-based veterinary drug detection are proposed.</p>","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"31"},"PeriodicalIF":6.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tomáš Siatka, Marek Mát'uš, Monika Moravcová, Patrícia Harčárová, Zuzana Lomozová, Kateřina Matoušová, Chaweewan Suwanvecho, Lenka Kujovská Krčmová, Přemysl Mladěnka
{"title":"Biological, dietetic and pharmacological properties of vitamin B<sub>9</sub>.","authors":"Tomáš Siatka, Marek Mát'uš, Monika Moravcová, Patrícia Harčárová, Zuzana Lomozová, Kateřina Matoušová, Chaweewan Suwanvecho, Lenka Kujovská Krčmová, Přemysl Mladěnka","doi":"10.1038/s41538-025-00396-w","DOIUrl":"10.1038/s41538-025-00396-w","url":null,"abstract":"<p><p>Humans must obtain vitamin B<sub>9</sub> (folate) from plant-based diet. The sources as well as the effect of food processing are discussed in detail. Industrial production, fortification and biofortification, kinetics, and physiological role in humans are described. As folate deficiency leads to several pathological states, current opinions toward prevention through fortification are discussed. Claimed risks of increased folate intake are mentioned as well as analytical ways for measurement of folate.</p>","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"30"},"PeriodicalIF":6.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yingnan Zhou, Airong Zhang, Rieks Dekker van Klinken, Darren Jones, Junxiu Wang
{"title":"Consumers' perspectives on antibiotic use and antibiotic resistance in food animals: a systematic review.","authors":"Yingnan Zhou, Airong Zhang, Rieks Dekker van Klinken, Darren Jones, Junxiu Wang","doi":"10.1038/s41538-025-00381-3","DOIUrl":"10.1038/s41538-025-00381-3","url":null,"abstract":"<p><p>Inappropriate antibiotic use in food animals is considered a significant contributor to increasing antibiotic resistance. Consumers can play a critical role in reducing it through purchasing choices, demand, and policy advocacy. This systematic review aimed to synthesize all published literature investigating consumers' perspectives (i.e., knowledge, perceptions, and attitudes) on antibiotic use and antibiotic resistance in food animals. We conducted a comprehensive literature search in PubMed, Web of Science, Scopus, and Google Scholar on November 14, 2022, and an updated search on April 30, 2024. We limited findings to original peer-reviewed journal articles published up to 2023 (inclusive), were written in English, and focused on knowledge/perceptions/attitudes of antibiotic use and antibiotic resistance in food animals. Of the 3815 articles identified, 39 were included. The findings suggested that consumers were concerned about antibiotic use in food animals, thus they were willing to pay more for food products with antibiotic-free or reduced-antibiotic use. However, consumers lacked deep understanding of antibiotic use practice and antibiotic stewardship in food animals as well as transmission risks of antibiotic-resistant bacteria. These findings offer valuable insights for policymakers and livestock industries to implement policy and practice changes to ensure responsible antibiotic use in food animals.</p>","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":"9 1","pages":"29"},"PeriodicalIF":6.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}