NPJ Science of Food最新文献_第7页

Phase change material-based antibacterial nanoparticles for short-term preservation of cooked meat during temperature abuse. 基于相变材料的抗菌纳米颗粒，用于在温度滥用期间短期保存熟肉。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2026-04-01 DOI: 10.1038/s41538-026-00808-5

Tong Wu, Yuhe Dong, Wanying Zhu, Zesen Xie, Tao Jiang, Xi Yu, Ying Xiao, Siyao Sui, Tian Zhong

{"title":"Phase change material-based antibacterial nanoparticles for short-term preservation of cooked meat during temperature abuse.","authors":"Tong Wu, Yuhe Dong, Wanying Zhu, Zesen Xie, Tao Jiang, Xi Yu, Ying Xiao, Siyao Sui, Tian Zhong","doi":"10.1038/s41538-026-00808-5","DOIUrl":"https://doi.org/10.1038/s41538-026-00808-5","url":null,"abstract":"To prevent the rapid microbial growth caused by unintended temperature abuse during the handling of cooked meat, such as malfunctioning hot-holding equipment or improper storage, this study developed a smart formulation that can be triggered by high temperature to release antibacterial agents on demand. A mixture of lauric acid and stearic acid was employed as the phase change material (PCM), and cinnamaldehyde (CA) was used as the active substance to fabricate this composite (CA/PCM). At 42 °C, CA/PCM can transit from a solid phase to a molten state, leading to the rapid release of embedded CA. In vitro experiments showed that, compared with the 25 °C group, the CA/PCM-42°C group reduced the colony counts of E. coli and S. aureus by 74.5% and 74.0%, respectively, and also decreased the biofilm absorbance by 92.75% and 82.08%, respectively. Compared with the samples stored at 25 °C, the inoculated meat stored at 42 °C for 24 h exhibited smaller changes in colour (∆E* < 3.5), hardness, pH, TVB-N, and MDA values. Moreover, the microbial counts remained below 5 log CFU·g-1. The results demonstrate that CA/PCM serves as an effective fail-safe strategy, providing targeted antimicrobial protection specifically under temperature-abuse conditions for the preservation of cooked meat.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147593444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synaptic rescue in an Alzheimer's mouse model: low-temperature steam-derived black ginseng oligosaccharides remodel protein S-nitrosylation-NADPH oxidase axis. 阿尔茨海默氏症小鼠模型的突触修复：低温蒸汽源黑参低聚糖重塑s -亚硝基化- nadph氧化酶轴。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2026-03-31 DOI: 10.1038/s41538-026-00812-9

Peng Yu, Jianing Liu, Weiyin Xu, Lu Peng, Yanqi Li, Simeng Shao, Yiru Wang, Zhidong Qiu, Hongmei Yang

{"title":"Synaptic rescue in an Alzheimer's mouse model: low-temperature steam-derived black ginseng oligosaccharides remodel protein S-nitrosylation-NADPH oxidase axis.","authors":"Peng Yu, Jianing Liu, Weiyin Xu, Lu Peng, Yanqi Li, Simeng Shao, Yiru Wang, Zhidong Qiu, Hongmei Yang","doi":"10.1038/s41538-026-00812-9","DOIUrl":"https://doi.org/10.1038/s41538-026-00812-9","url":null,"abstract":"Synaptic loss and aberrant protein S-nitrosylation (SNO) are strongly linked to cognitive decline in both patients and animal models of Alzheimer's disease (AD). Our recent work in an AD mouse model has shed light on the role of oligosaccharides extracted from black ginseng (OSBG) in ameliorating cognitive impairment. However, the precise molecular mechanisms responsible for therapeutic efficacy of OSBG in AD are not well understood. In the present study, we employed an innovative SNOTRAP-based proteomic approach to quantify SNO proteins in the brain of APP/PS1 mice following OSBG intervention. The results revealed that differentially expressed SNO proteins, such as SNO-NOX1 and SNO- NOX5, confirmed by Western blot (WB), are significantly enriched in pathways related to oxidative stress, such as \"Oxidative_stress activation of NADPH oxidase\" and \"Synaptic target recognition\". OSBG treatment significantly alleviated oxidative stress via inhibition of NADPH oxidase activity in APP/PS1 mouse and PC12 cells by WB immunofluorescence (IF) assays. More importantly, upregulation of PSD-95 and SYN1 was detected in the hippocampal tissue of APP/PS1 mice after OSBG intervention, which was further validated by the corresponding mRNA expression levels. Consistently, histopathological analysis revealed the restoration of hippocampal cellular structure. Overall, our findings highlight the synapse-protective effect of OSBG in an AD model through regulating protein SNO levels and inhibiting NADPH oxidase activity, revealing a novel mechanism by which OSBG alleviated oxidative stress injury.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valorizing common pomelo peel by-product via a multi-dimensional framework: a functionally equivalent alternative to a rare botanical for liver health. 通过多维框架评估常见的柚子皮副产品：一种功能等效的肝脏健康稀有植物替代品。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2026-03-31 DOI: 10.1038/s41538-026-00813-8

Yuliang Liu, Mengmeng Sun, Qizhong Lian, Jianan Wang, Xianghe Meng, Davron Dekhkonov, Hilola Ahunova, Komiljon Tojibaev, Min He, Dong Li

{"title":"Valorizing common pomelo peel by-product via a multi-dimensional framework: a functionally equivalent alternative to a rare botanical for liver health.","authors":"Yuliang Liu, Mengmeng Sun, Qizhong Lian, Jianan Wang, Xianghe Meng, Davron Dekhkonov, Hilola Ahunova, Komiljon Tojibaev, Min He, Dong Li","doi":"10.1038/s41538-026-00813-8","DOIUrl":"https://doi.org/10.1038/s41538-026-00813-8","url":null,"abstract":"Turning agricultural and food processing by-products into health-promoting ingredients is pivotal for developing sustainable food systems. This study developed an integrated multi-dimensional evaluation framework to assess whether the common pomelo peel by-product (Citrus grandis (L.) Osbeck, CGO) can serve as a functionally equivalent alternative to the rare Citrus grandis 'Tomentosa' (CGT) for functional food ingredient development. The framework combined comparative metabolomics and delayed luminescence profiling to characterize chemical and physical properties, alongside multi-parametric in vivo bioactivity and safety assessment in a diet-induced vertebrate model. Analyzes confirmed CGO and CGT as distinct chemotypes and physicotypes, with differential enrichment in bioactive pathways like phenylpropanoid biosynthesis. Crucially, both extracts demonstrated statistically equivalent efficacy in alleviating hepatic steatosis, oxidative stress, and inflammation in a high-cholesterol diet-induced zebrafish model, and modulated key genes related to lipid metabolism, antioxidant response, and inflammation. Safety assessment revealed CGO's significantly wider safety margin. Data integration across dimensions demonstrates that despite compositional differences, the net bioactivity converges on similar beneficial outcomes for liver metabolic health. This work provides a validated strategy for transforming underutilized residues into a multi-target, dietary-relevant ingredient, offering a replicable framework for resource-efficient development of sustainable functional crops and food supply chains.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147593482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The future of digital innovation in transforming food safety systems in the developing world. 数字创新在改变发展中国家食品安全系统中的未来。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2026-03-31 DOI: 10.1038/s41538-026-00809-4

Gabor Molnar

引用次数: 0

Integrated metabolomics analysis of pigment metabolite accumulation and color development of fresh Dendrobium officinale juice after processing. 鲜铁皮石斛加工后汁液色素代谢物积累与颜色发育的综合代谢组学分析。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2026-03-30 DOI: 10.1038/s41538-026-00810-x

Weifeng Ni, Zhongqi Zhou, Shu Mao, Zhaolian Li, Meichen Liu, Daqing Zhao, Liwei Sun, Daian Pan, Shichao Liu, Yiqiu Yin, Siming Wang

引用次数: 0

The regulation mechanism of α-linolenic acid bioavailability by flaxseed lignan macromolecules in O/W emulsions. 亚麻籽木脂素大分子对O/W乳剂中α-亚麻酸生物利用度的调节机制

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2026-03-30 DOI: 10.1038/s41538-026-00814-7

Chen Cheng, Xiao Yu, Lei Wang, Shuyi Li, Xu Chen, Qianchun Deng, Zhenzhou Zhu

{"title":"The regulation mechanism of α-linolenic acid bioavailability by flaxseed lignan macromolecules in O/W emulsions.","authors":"Chen Cheng, Xiao Yu, Lei Wang, Shuyi Li, Xu Chen, Qianchun Deng, Zhenzhou Zhu","doi":"10.1038/s41538-026-00814-7","DOIUrl":"https://doi.org/10.1038/s41538-026-00814-7","url":null,"abstract":"Enhanced α-linolenic acid (ALA) intake effectively alleviates population sub-health status through dietary pattern modification, demonstrating substantial implications for promoting national health advancement. In this study, the multi-targeted regulation on ALA micellization, absorption, and lymphatic transport by natural flaxseed lignan macromolecules (FLM) and its thermal treatment products (FLM 150) was systematically investigated in an emulsion delivery system. In vitro Caco-2 transport assays revealed that ALA absorption was enhanced by 95% with the addition of FLM 150. Moreover, in vivo rat mesenteric lymph cannulation proved that FLM 150-enriched emulsion elevated ALA absorption by 493%, while significantly reducing lipid oxidation. Besides, lipidomic profiling indicated that FLM 150 enhanced triglyceride resynthesis during lipid resynthesis in intestinal epithelial cells, as well as promoted metabolism of ALA. Therefore, these findings established FLM 150 as a multi-target regulator optimizing ALA bioavailability through concurrent mucosal barrier reinforcement, oxidative stress mitigation, and lipid metabolic pathway redirection. These insights highlighted the potential of engineered emulsion systems to lipid absorption kinetics and intestinal metabolic outcomes, offering novel strategies for enhancing the bioavailability of ALA.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extensively drug-resistant and heat-resistant Enterococcus faecalis and Enterococcus faecium in ready-to-eat meat products. 即食肉制品中广泛耐药和耐热的粪肠球菌和粪肠球菌。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2026-03-27 DOI: 10.1038/s41538-026-00790-y

Sara Abdelnaby Sallam, Samir Mohammed Abd-Elghany, Khalid Ibrahim Sallam

{"title":"Extensively drug-resistant and heat-resistant Enterococcus faecalis and Enterococcus faecium in ready-to-eat meat products.","authors":"Sara Abdelnaby Sallam, Samir Mohammed Abd-Elghany, Khalid Ibrahim Sallam","doi":"10.1038/s41538-026-00790-y","DOIUrl":"10.1038/s41538-026-00790-y","url":null,"abstract":"The presence of extensively drug-resistant and heat-resistant Enterococcus faecalis and Enterococcus faecium in ready-to-eat meat products poses a significant public health risk due to their ability to survive thermal processing, persist in the food chain, and disseminate antimicrobial resistance, thereby increasing the risk of foodborne transmission and limiting treatment options. This study evaluated the prevalence, heat-resistance, virulence, and antimicrobial resistance profile of Enterococcus isolated from ready-to-eat (RTE) meat products in Mansoura, Egypt. All (100%, 135/135) examined RTE samples (45 each of shawarma sandwiches, Hawawshi, and pastrami slices) were contaminated with Enterococcus. PCR targeting the sodA gene verified that 63.3% (171/270) of Enterococcus isolates were E. faecium and 36.7% (99/270) were E. faecalis. The gelE and ace virulent genes were detected in 71.1% and 65.2% of Enterococcus isolates, respectively. Absolute resistance (100%) of enterococcal isolates was found towards penicillin and imipenem, while 86.7%, 85.6%, and 41.9% were resistant to rifampin, vancomycin, and amoxicillin, respectively. All isolates were resistant to at least 4 antibiotics, and 96.3% were resistant to at least 6 antibiotics, with an average MAR index of 0.604. Interestingly, Enterococcus in RTE meat samples passed thermal microwave deactivation for 5 minutes, indicating a potent heat stability of this microorganism. The threat caused by virulent, heat-tolerant, vancomycin-resistant enterococci contaminating meat products highlights the risk associated with these pathogens. This emphasizes the urgent need for preventive measures and global strategies to control these emerging foodborne threats.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147531289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of transcriptomics and gut microbiomics reveals walnut septum polyphenols alleviate HFD-induced lipid disorders. 转录组学和肠道微生物组学的整合显示核桃隔多酚可减轻hfd诱导的脂质紊乱。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2026-03-26 DOI: 10.1038/s41538-026-00801-y

Yue-Xiu Pan, Lei Peng, Xia Hu, Jin-Lian Chen, Min Su, Jing-Jing Dai, Jun Sheng, Zi-Shan Hong, Jing Xie, Yang Tian

{"title":"Integration of transcriptomics and gut microbiomics reveals walnut septum polyphenols alleviate HFD-induced lipid disorders.","authors":"Yue-Xiu Pan, Lei Peng, Xia Hu, Jin-Lian Chen, Min Su, Jing-Jing Dai, Jun Sheng, Zi-Shan Hong, Jing Xie, Yang Tian","doi":"10.1038/s41538-026-00801-y","DOIUrl":"https://doi.org/10.1038/s41538-026-00801-y","url":null,"abstract":"Walnut septum, an underutilized agricultural by-product, exhibits anti-obesity potential. However, the in vivo hypolipidemic mechanisms of walnut septum polyphenols (WSP) remain unexplored. We investigated the effects of WSP on lipid metabolism in high-fat diet (HFD)-fed mice using integrated transcriptomic and gut microbiomic analyses. The results indicated that WSP inhibited lipid accumulation in HFD mice and ameliorated HFD-induced oxidative stress, inflammation, and gut barrier impairment. Further studies revealed that WSP positively regulated FoxO1 expression by suppressing the PI3K/AKT signaling pathway, which in turn inhibited hepatic lipid synthesis in HFD mice. Furthermore, WSP concurrently remodeled gut microbiota via selective enrichment of beneficial Akkermansia and depletion of inflammation-associated norank_f__Desulfovibrionaceae. This microbial shift correlated with enhanced intestinal barrier integrity, reduced endotoxemia, and a predicted upregulation of propanoate metabolism. This study provides the first evidence of the synergistic regulation of the PI3K/AKT/FoxO1 pathway and gut microbiota restructuring by WSP, establishing a scientific foundation for valorizing walnut-processing waste into nutraceuticals against obesity.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality evaluation, authentication, and redundancy analysis of wild and farmed silver carp based on amino acid profiles. 基于氨基酸谱的野生和养殖鲢鱼质量评价、鉴定和冗余分析。

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2026-03-25 DOI: 10.1038/s41538-026-00796-6

Lang Zhang, Liting Ye, Feng Zhang, Xiaoyun Zhou, Ziwei Song, Yinzhe Zhang, Yutong Wang, Yu Fang, Qi Bai, Meiping Lan, Yali Yu, Hui Zhang

{"title":"Quality evaluation, authentication, and redundancy analysis of wild and farmed silver carp based on amino acid profiles.","authors":"Lang Zhang, Liting Ye, Feng Zhang, Xiaoyun Zhou, Ziwei Song, Yinzhe Zhang, Yutong Wang, Yu Fang, Qi Bai, Meiping Lan, Yali Yu, Hui Zhang","doi":"10.1038/s41538-026-00796-6","DOIUrl":"https://doi.org/10.1038/s41538-026-00796-6","url":null,"abstract":"Elucidating quality disparities between farmed and wild fish is essential for the formulation of quality standards and the fulfillment of consumer expectations. In this study, wild and farmed silver carp (Hypophthalmichthys molitrix) were systematically collected across 12 sampling sites. Significant differences in amino acid composition were identified, with amino acids such as Ala being more abundant in wild silver carp compared to farmed ones. The results revealed that the EAAI of farmed silver carp was relatively high. PCA and OPLS-DA further corroborated the amino acid differences between farmed and wild silver carp. Notably, Arg demonstrates potential as a biomarker for differentiating the farmed versus wild silver carp, with an AUC of 0.918, and achieved a 90% accuracy rate in validation. RDA showed links between amino acids and aquatic environments (e.g., His correlates positively with Cu). Research highlights the nutritional differences between farmed and wild silver carp, aiding ecological protection and market regulation.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Driving impact of organic acids on microbial community dynamics and fermentation performance in Huangjiu. 有机酸对黄酒微生物群落动态及发酵性能的驱动影响

IF 7.8 1区农林科学

NPJ Science of Food Pub Date : 2026-03-24 DOI: 10.1038/s41538-026-00786-8

Shuangqi Cheng, Leping Quan, Huihui Zhou, Xiaoyan Jiang, Guochang Sun, Zhifang Yu, Jiandi Zhou, Lan Wang, Huan Ren, Jianjiang Wu, Guangfa Xie, Qi Peng

{"title":"Driving impact of organic acids on microbial community dynamics and fermentation performance in Huangjiu.","authors":"Shuangqi Cheng, Leping Quan, Huihui Zhou, Xiaoyan Jiang, Guochang Sun, Zhifang Yu, Jiandi Zhou, Lan Wang, Huan Ren, Jianjiang Wu, Guangfa Xie, Qi Peng","doi":"10.1038/s41538-026-00786-8","DOIUrl":"https://doi.org/10.1038/s41538-026-00786-8","url":null,"abstract":"Huangjiu, a traditional Chinese rice wine, relies on microbial communities for its quality, but the role of organic acids during fermentation is unclear. This study uses flavoromics and metatranscriptomics to explore how organic acids shape microbial composition and metabolism. Comparing samples with high (H) and low (L) organic acid content, 44 flavor compounds were identified, revealing significant group differences. Organic acids altered fungal communities: succinic acid positively correlated with Saccharomyces and Thermomyces, while lactic and tartaric acids showed negative correlations. Simulated fermentations and sequencing demonstrated that succinic acid enhanced Saccharomyces cerevisiae growth, upregulated sugar-metabolism genes, and boosted ethanol production. Understanding endogenous organic acids' regulatory effects may inform potential approaches to modulate microbial community structure, optimize fermentation performance, and potentially improve Huangjiu flavor. These insights could provide a reference for precision fermentation management in similar traditional beverage systems, pending further validation.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0