NPJ Science of Food最新文献_第7页

BHOD: a bone health optimized dietary pattern designed for osteoporosis prevention. BHOD：为预防骨质疏松症而设计的骨骼健康优化饮食模式。

IF 9.7 1区农林科学

NPJ Science of Food Pub Date : 2026-07-01 DOI: 10.1038/s41538-026-00963-9

Yi Zheng, Yucan Li, Yawen Gao, Xiao Liang, Jincheng Li, Chen Suo, Yanfeng Jiang, Li Jin, Kelin Xu, Xingdong Chen

{"title":"BHOD: a bone health optimized dietary pattern designed for osteoporosis prevention.","authors":"Yi Zheng, Yucan Li, Yawen Gao, Xiao Liang, Jincheng Li, Chen Suo, Yanfeng Jiang, Li Jin, Kelin Xu, Xingdong Chen","doi":"10.1038/s41538-026-00963-9","DOIUrl":"https://doi.org/10.1038/s41538-026-00963-9","url":null,"abstract":"Existing dietary patterns were not specifically designed to target osteoporosis and lack the precision required for effective prevention. We aimed to develop a Bone Health Optimized Diet (BHOD) that is tailored to more precisely reduce the risk of osteoporosis. Using dietary data from 183,092 UK Biobank (UKB) participants, we combined food-wide association analysis with machine learning to develop the BHOD. We identified 10 important osteoporosis-related food groups and integrated them to construct the BHOD. The protective association was observed between BHOD and the risk of osteoporosis, which was validated in both the UKB validation set and the NHANES population. Furthermore, the BHOD showed broad protective associations with other musculoskeletal disorders, such as rheumatoid arthritis and osteoarthritis. Importantly, high adherence to the BHOD mitigated the negative impact of genetic susceptibility on osteoporosis, with particularly pronounced benefits observed among individuals at high genetic risk. The multi-omics analysis identified multiple biomarkers (7 proteins, 66 metabolites, and 5 inflammatory markers) jointly associated with BHOD and osteoporosis risk, highlighting immune-inflammatory regulation and lipid metabolism as key biological pathways linking diet to bone loss.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Building resilient food safety systems through a One Health approach to prepare for the next pandemic. 通过“同一个健康”方针建立有抵御力的食品安全系统，为下一次大流行做好准备。

IF 9.7 1区农林科学

NPJ Science of Food Pub Date : 2026-07-01 DOI: 10.1038/s41538-026-00798-4

Maura Di Martino, Sean Shadomy, Diletta Topazio, Jeffrey T LeJeune

引用次数: 0

Sarcandra glabra alleviates intestinal injury via modulating gut microbiota and suppressing the IL-6/SOCS3 signaling pathway. 赤手杖通过调节肠道菌群和抑制IL-6/SOCS3信号通路减轻肠道损伤。

IF 9.7 1区农林科学

NPJ Science of Food Pub Date : 2026-07-01 DOI: 10.1038/s41538-026-00968-4

Shaowei Huang, Xiaomei Chi, Siting Song, Xinyi Gao, Dedian Yu, Wenbin Huang, Jiayi Wang, Lixia Chen, Hua Li

{"title":"Sarcandra glabra alleviates intestinal injury via modulating gut microbiota and suppressing the IL-6/SOCS3 signaling pathway.","authors":"Shaowei Huang, Xiaomei Chi, Siting Song, Xinyi Gao, Dedian Yu, Wenbin Huang, Jiayi Wang, Lixia Chen, Hua Li","doi":"10.1038/s41538-026-00968-4","DOIUrl":"https://doi.org/10.1038/s41538-026-00968-4","url":null,"abstract":"Ulcerative colitis (UC) is a refractory inflammatory bowel disease characterized by gut microbiota dysbiosis and mucosal barrier disruption. Sarcandra glabra (Sg), a traditional herbal tea and dietary supplement, has been widely used to alleviate intestinal inflammation; however, its gut microbiota-dependent mechanism remains insufficiently clarified. In this study, Sg at 2, 4, and 8 g/kg was found to dose-dependently mitigate dextran sulfate sodium (DSS)-induced colitis in mice, restore mucosal barrier integrity by upregulating tight junction proteins and enhancing mucin secretion, and reduce serum levels of IL-1β, TNF-α, and IL-6. Integrative analysis of full-length 16S rRNA gene sequencing, transcriptomics, and metabolomics data revealed that Sg reshaped gut microbiota, selectively enriching Ligilactobacillus animalis while depleting Escherichia coli and Proteus vulgaris. We identified 8 microbiota-derived metabolites correlated with Ligilactobacillus animalis abundance, among which 2,3-dihydroxybenzoic acid (2,3-DHBA) exhibited the strongest protective effect against DSS-induced NCM460 cell damage. Mechanistic studies indicated that 2,3-DHBA effectively inhibited the IL-6/SOCS3 pathway and restored tight junction protein expression, effects that were reversed by exogenous IL-6. These findings demonstrate that Sg enriches for Ligilactobacillus animalis and its metabolite 2,3-DHBA, which suppresses IL-6-driven inflammation and repairs mucosal damage, supporting its potential as a microbiome-targeted dietary adjunct for UC.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148369026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forged in iron: molecular insights into iron tolerance in Hermetia illucens. 在铁中锻造：对黑墨提亚（Hermetia illucens）铁耐受性的分子洞察。

IF 9.7 1区农林科学

NPJ Science of Food Pub Date : 2026-07-01 DOI: 10.1038/s41538-026-00962-w

Tomer First, Hunter K Walt, Valentina Ciaravolo, Simona Arena, Andrea Scaloni, Fanis Missirlis, Florencia Meyer, Federico G Hoffmann, Joop J A Van Loon, Dennis G A B Oonincx, Vincenzo Fogliano, Maryia Mishyna

{"title":"Forged in iron: molecular insights into iron tolerance in Hermetia illucens.","authors":"Tomer First, Hunter K Walt, Valentina Ciaravolo, Simona Arena, Andrea Scaloni, Fanis Missirlis, Florencia Meyer, Federico G Hoffmann, Joop J A Van Loon, Dennis G A B Oonincx, Vincenzo Fogliano, Maryia Mishyna","doi":"10.1038/s41538-026-00962-w","DOIUrl":"10.1038/s41538-026-00962-w","url":null,"abstract":"Black soldier fly (BSF) larvae are increasingly valued as a sustainable source of proteins and essential minerals in animal feed and potentially food, yet their physiological response to substrate iron fortification is poorly defined. Here, integrated transcriptomic, proteomic, and tissue iron detection approaches were used to characterize responses of BSF larvae reared on diets containing 323 (control), 1255, and 6970 mg Fe/kg dry matter (DM). Larval growth at day 12 was unaffected, while prepupal emergence after 15 days showed a statistically non-significant increase at the highest iron level, suggesting only subtle developmental effects. Prussian blue staining showed a dose-dependent iron accumulation in the midgut epithelium, consistent with known insect iron responsive regions of entoferritin-based sequestration. An elevated iron signal in the peritrophic matrix indicated a complementary defensive barrier. Multi-omics profiling revealed oxidative stress responses, suppression of mitochondrial and translational pathways, and activation of exoskeleton biosynthesis. Entoferritin levels rose by ~70% for both protein subunits despite insignificant transcript changes, pointing to a post-transcriptional regulation mechanism. These results suggest a gut-centered \"accumulate-and-store\" physiological strategy enabling BSF larvae to tolerate high dietary iron. This entoferritin-based high iron accumulation capacity highlights the potential of this insect as a sustainable source of a protein bound iron in feeds.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3-O-p-coumaroylquinic acid and 4-O-p-coumaroylquinic acid from Hemerocallis citrina Baroni exert antidepressant effects via CA/Dopa/DA/NE and PKA/CREB/BDNF signaling pathways. 3- o -对香豆酰奎宁酸和4- o -对香豆酰奎宁酸通过CA/Dopa/DA/NE和PKA/CREB/BDNF信号通路发挥抗抑郁作用。

IF 9.7 1区农林科学

NPJ Science of Food Pub Date : 2026-07-01 DOI: 10.1038/s41538-026-00934-0

Faying Jiang, Zhengyue Qiu, Juhua Zhong, Tian Ye, Jinghong Liu, Yishuo Zhu, Lewei Zhao, Siyu Chen, Hongbao Chen, Haobo Wang, Lin Kang, Tonghe Yang, Shuai Li, Si Liu, Jianguo Zeng, Zhixing Qing

{"title":"3-O-p-coumaroylquinic acid and 4-O-p-coumaroylquinic acid from Hemerocallis citrina Baroni exert antidepressant effects via CA/Dopa/DA/NE and PKA/CREB/BDNF signaling pathways.","authors":"Faying Jiang, Zhengyue Qiu, Juhua Zhong, Tian Ye, Jinghong Liu, Yishuo Zhu, Lewei Zhao, Siyu Chen, Hongbao Chen, Haobo Wang, Lin Kang, Tonghe Yang, Shuai Li, Si Liu, Jianguo Zeng, Zhixing Qing","doi":"10.1038/s41538-026-00934-0","DOIUrl":"https://doi.org/10.1038/s41538-026-00934-0","url":null,"abstract":"The ancient text \"Compendium of Materia Medica\" records that Hemerocallis citrina Baroni (daylily) was used for antidepressant, but its active components and mechanisms remain unknown. In this study, the H. citrina extract was initially fractionated into three parts, and only the 35% HCW (35% ethanol-eluted fraction of Hemerocallis citrina water extract, LILYANTIDEPRES®) demonstrated significant antidepressant activity, notably increasing the levels of dopamine (DA), norepinephrine (NE), and brain-derived neurotrophic factor (BDNF) in the brain of depressed mice. It's also significantly reducing the IL-6 (Interleukin-6) and MDA (Malondialdehyde) levels, and improving the gut microbiota. The main components of the 35% HCW were identified as 3-O-p-coumaroylquinic acid (1) and 4-O-p-coumaroylquinic acid (2), which were also chemically synthesized. Both compounds exhibited significant antidepressant activity by increasing the levels of DA, NE, and BDNF in the brain of depressed mice and significantly reducing the levels of IL-6 and TNF-α (Tumor Necrosis Factor-α). A potential mechanism to elevate DA and NE levels in the depressed mice brain via the CA (coumaroylquinic acid)/Dopa/DA/NE pathway. Additionally, compounds 1 and 2 significantly increase BDNF levels through the PKA (Protein Kinase A)/CREB (cAMP Response Element-Binding Protein)/BDNF signaling pathway. This study provides the first elucidation of the antidepressant components of H. citrina and the mechanisms, laying the foundation for the development of antidepressant products and the high-value utilization of H. citrina resources.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148369434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium ascorbate and gold core silver shell nanoparticles enhance chitosan starch films for grape preservation. 抗坏血酸钙和金核银壳纳米颗粒增强了壳聚糖淀粉膜对葡萄的保鲜作用。

IF 9.7 1区农林科学

NPJ Science of Food Pub Date : 2026-06-30 DOI: 10.1038/s41538-026-00971-9

Xin Chen, Jun Lv, Lixuan Cong, Ai Nasi, Fengzhi Lyu, Lin Qin, Yiming Zhao, Donghui Xu, Ming Yang, Junmei Liu, Bining Jiao, Guangyang Liu

{"title":"Calcium ascorbate and gold core silver shell nanoparticles enhance chitosan starch films for grape preservation.","authors":"Xin Chen, Jun Lv, Lixuan Cong, Ai Nasi, Fengzhi Lyu, Lin Qin, Yiming Zhao, Donghui Xu, Ming Yang, Junmei Liu, Bining Jiao, Guangyang Liu","doi":"10.1038/s41538-026-00971-9","DOIUrl":"10.1038/s41538-026-00971-9","url":null,"abstract":"While chitosan-based films are widely studied for food preservation, their practical application is often limited by inherent limitations in stability of the material, antibacterial efficacy, and long-term preservation capability. Here, we present an innovative one-pot fabrication of a multifunctional, biodegradable food packaging film based on a chitosan-potato starch matrix synergistically enhanced by calcium ascorbate (CA) and Au@Ag. CA acts as both an ionic crosslinker and an active antimicrobial/antioxidant additive, while the embedded Au@Ag nanoparticles synergistically reinforce the functional performance of the composite film. The resulting exhibits considerably improved mechanical strength (tensile strength increased from 7.58 to 8.76 MPa) and enhanced water barrier properties (WVTR reduced from 0.312 to 0.271 g·m-2·h-1). Notably, it demonstrates high water stability, nearly complete UV-blocking (≈99%), and the composite film exhibits considerably enhanced ABTS and DPPH radical-scavenging activities compared to the control CS/PS film (p > 0.05). Antibacterial testing shows 100% inhibition against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). In practical preservation tests, the lower water contact angle (WCA) of CS/PS/CA/Au@Ag film promotes strong adhesion to the grape surface, which enhances contact-active antimicrobial efficacy and results in a longer shelf life than commercial polyethylene (PE) wrap. Combined with excellent biosafety and soil-degradability, this rationally engineered composite represents a sustainable, high-performance alternative to conventional petroleum-based packaging for food preservation.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DHA and EPA alleviate atherosclerosis by synergistically regulating the aorta-liver axis via miRNA networks. DHA和EPA通过miRNA网络协同调节主动脉-肝轴减轻动脉粥样硬化。

IF 9.7 1区农林科学

NPJ Science of Food Pub Date : 2026-06-29 DOI: 10.1038/s41538-026-00920-6

Junli Feng, Yiran Jin, Yu Zhang, Yibin Mei, Yibin Pan, Qing Shen, Chunlai Zeng, Yong Cui, Ning Huangfu

{"title":"DHA and EPA alleviate atherosclerosis by synergistically regulating the aorta-liver axis via miRNA networks.","authors":"Junli Feng, Yiran Jin, Yu Zhang, Yibin Mei, Yibin Pan, Qing Shen, Chunlai Zeng, Yong Cui, Ning Huangfu","doi":"10.1038/s41538-026-00920-6","DOIUrl":"10.1038/s41538-026-00920-6","url":null,"abstract":"The anti-atherosclerotic effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are well-documented, yet the underlying molecular mechanisms, particularly via cross-organ crosstalk, remain unclear. Here, a high-fat diet-induced atherosclerosis (AS) model in ApoE-/- mice was constructed. Compared with controls, AS mice exhibited elevated serum total cholesterol, triglyceride and low-density lipoprotein cholesterol levels, along with reduced high-density lipoprotein cholesterol levels, impaired hepatic and cardiac function, enlarged aortic plaque area, and pronounced hepatic steatosis and cardiac lipid deposition. DHA/EPA intervention reversed these biochemical and histopathological abnormalities, and conferred superior hepatoprotection than Atorvastatin. Transcriptomics identified 1453 and 1663 differentially expressed genes in liver and aorta of AS mice, respectively. DHA/EPA up-regulated genes related to hepatic cholesterol metabolism and bile acid synthesis, and aortic genes encoding ABC transporters and PPAR signaling components. Conversely, they suppressed hepatic IL-17 signaling and endothelial adhesion molecules. MicroRNA quantification showed significant modulation of aortic miR-33a, miR-146a-3p, miR-155 and miR-223-3p levels, implicating regulation of lipid metabolism and inflammation. Collectively, these data indicate that DHA and EPA exert synergistic anti-atherosclerotic effects via the aorta-liver axis, regulating lipid metabolism, inflammation and vascular remodeling via a miR-30a/146a-3p/223-3p mediated network. These findings provide experimental and mechanistic supports for nutritional intervention of AS.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aligning patient and planetary health: planetary health diet adherence and inflammatory bowel disease prognosis across Western and Eastern cohorts. 调整患者和全球健康：全球健康饮食依从性和炎症性肠病预后在西方和东方队列

IF 9.7 1区农林科学

NPJ Science of Food Pub Date : 2026-06-29 DOI: 10.1038/s41538-026-00959-5

Lintao Dan, Haiting Shu, Yuhao Sun, Judith Wellens, Yang Chen, Minzi Deng, Jialu Yao, Xixian Ruan, Henit Yanai, Xue Li, Britta Siegmund, Xiaoyan Wang, Fernando Magro, Jie Chen

{"title":"Aligning patient and planetary health: planetary health diet adherence and inflammatory bowel disease prognosis across Western and Eastern cohorts.","authors":"Lintao Dan, Haiting Shu, Yuhao Sun, Judith Wellens, Yang Chen, Minzi Deng, Jialu Yao, Xixian Ruan, Henit Yanai, Xue Li, Britta Siegmund, Xiaoyan Wang, Fernando Magro, Jie Chen","doi":"10.1038/s41538-026-00959-5","DOIUrl":"10.1038/s41538-026-00959-5","url":null,"abstract":"This study aims to evaluate whether planetary health diet (PHD) could be a potential tool to achieve sustainability in IBD management. We included 1455 IBD participants from the UK Biobank (UKB) and 205 from the ONE-IBD cohort. Dietary intake was captured through validated questionnaires and seven PHD adherence algorithms were evaluated. Environmental impact was estimated using dietary carbon footprints. Outcomes included IBD-related surgery, colorectal cancer, and all-cause mortality in the UKB, while readmission and recurrence in ONE-IBD. Cox models estimated hazard ratios (HRs) with 95% confidence intervals (CIs). During a median 10.5-year follow-up, 191 surgeries, 78 CRC, and 232 deaths occurred. Adherence to PHD were inversely associated with surgery risk (HRper SD 0.67-0.80). All algorithms were linked to lower dietary carbon footprints (r -0.061 to -0.468). A modified-Knuppel algorithm provided similar protection (HRper SD = 0.73, 95% CI 0.60-0.89) and environmental correlation (r = -0.244). In ONE-IBD, the modified algorithm was associated with lower readmission risk (HRper SD = 0.80, 95% CI 0.65-1.00). Proteomics data suggest potential benefits through improved intestinal barrier integrity and reduced fibrosis. To conclude, higher PHD adherence is associated with better IBD outcomes and lower environmental burden, supporting that the PHD may represent a promising and sustainable dietary pattern in IBD management.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circling the sandwich: measuring food waste and its drivers in UK prepared sandwich manufacture. 绕着三明治转一圈：衡量英国预制三明治制造中的食物浪费及其驱动因素。

IF 9.7 1区农林科学

NPJ Science of Food Pub Date : 2026-06-27 DOI: 10.1038/s41538-026-00948-8

Alexander Moores, Dimitris Charalampopoulos, Adrian Williams, Kerry Whiteside, Paul Buxton, Ximena Schmidt Rivera

{"title":"Circling the sandwich: measuring food waste and its drivers in UK prepared sandwich manufacture.","authors":"Alexander Moores, Dimitris Charalampopoulos, Adrian Williams, Kerry Whiteside, Paul Buxton, Ximena Schmidt Rivera","doi":"10.1038/s41538-026-00948-8","DOIUrl":"10.1038/s41538-026-00948-8","url":null,"abstract":"Food waste reduction and reutilisation is paramount to meeting national Waste Directives and achieving the Sustainable Development agenda. Implementing Circular Economy principles provides opportunities for cost savings, new revenue streams, and sustainable resource management. Applying the Food Loss and Waste (FLW) Accounting and Reporting Standard, this study identifies and measures sources of FLW in the manufacture of prepared sandwiches, and explores reduction and reutilisation from a Circular Economy perspective. The examined process contributes to circularity, with a loss rate of 13%, of which 97% is valorised. Waste hotspots include product assembly and ingredient preparation, while operational reductions, design changes, and stakeholder collaboration for high-value side-stream management would further reduce FLW impact. Examining a complex food item at the product-level for the first time, this study provides an evidence base for FLW reduction through inventory and hotspot analysis, contextualising the current extent of circularity and suggesting areas for further development.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148339372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urea supplementation is associated with holistic changes in suprathreshold non-volatile flavour perception through oral microbiome carbon metabolism. 尿素补充与通过口服微生物组碳代谢的超阈值非挥发性风味感知的整体变化有关。

IF 9.7 1区农林科学

NPJ Science of Food Pub Date : 2026-06-27 DOI: 10.1038/s41538-026-00951-z

Shuyuan Zhang, Adrien Le Guennec, Saeed Shoaie, Guy H Carpenter

{"title":"Urea supplementation is associated with holistic changes in suprathreshold non-volatile flavour perception through oral microbiome carbon metabolism.","authors":"Shuyuan Zhang, Adrien Le Guennec, Saeed Shoaie, Guy H Carpenter","doi":"10.1038/s41538-026-00951-z","DOIUrl":"10.1038/s41538-026-00951-z","url":null,"abstract":"Urea is a small inorganic compound, readily available in saliva, that can be metabolised by the oral microbiome. We hypothesised that dietary supplementation with urea would increase salivary levels, alter microbial metabolism and, potentially, modify suprathreshold non-volatile flavour perception. A semi-trained panel of 20 participants completed taste evaluations using visual analogue scales for nine tastants, both before and during a 5-day urea supplementation regimen. System-level analysis revealed a significant shift in suprathreshold non-volatile flavour perception during supplementation (PERMANOVA, p = 0.008) even though none of the nine tastants showed significant changes (p > 0.05 or an absolute percentage change greater than 10%) during the intervention. Functional gene completeness analysis, together with 13C NMR, suggested that the oral microbiome primarily utilises carbon dioxide generated from urease-mediated urea metabolism. Overall, urea supplementation was associated with changes in microbiome carbon-related metabolic pathways and induce holistic level changes in suprathreshold non-volatile flavour perception.","PeriodicalId":19367,"journal":{"name":"NPJ Science of Food","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148339322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0