NeuroImage最新文献_第3页

AI-based deformable hippocampal mesh reflects hippocampal morphological characteristics in relation to cognition in healthy older adults

IF 4.7 2区医学

NeuroImage Pub Date : 2025-03-21 DOI: 10.1016/j.neuroimage.2025.121145

Wonjung Park , Maria del C. Valdés Hernández , Jaeil Kim , Susana Muñoz Maniega , Fraser N. Sneden , Karen J. Ferguson , Mark E. Bastin , Joanna M. Wardlaw , Simon R. Cox , Jinah Park

{"title":"AI-based deformable hippocampal mesh reflects hippocampal morphological characteristics in relation to cognition in healthy older adults","authors":"Wonjung Park , Maria del C. Valdés Hernández , Jaeil Kim , Susana Muñoz Maniega , Fraser N. Sneden , Karen J. Ferguson , Mark E. Bastin , Joanna M. Wardlaw , Simon R. Cox , Jinah Park","doi":"10.1016/j.neuroimage.2025.121145","DOIUrl":"10.1016/j.neuroimage.2025.121145","url":null,"abstract":"<div><div>Magnetic resonance imaging (MRI)-derived hippocampus measurements have been associated with different cognitive domains. The knowledge of hippocampal structural deformations as we age has contributed to our understanding of the overall aging process. Different morphological hippocampal shape analysis methods have been developed, but it is unclear how their principles relate and how consistent are the published results in relation to cognition in the normal elderly in the light of the new deep-learning-based (DL) state-of-the-art modeling methods. We compared results from analyzing the hippocampal morphology using manually-generated binary masks and a Laplacian- based deformation shape analysis method, with those resulting from analyzing SynthSeg-generated hippocampal binary masks using a DL method based on the PointNet architecture, in relation to different cognitive domains. Whilst most previously reported statistically significant associations were also replicated, differences were also observed due to 1) differences in the binary masks and 2) differences in sensitivity between the methods. Differences in the template mesh, number of vertices of the template mesh, and their distribution did not impact the results.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121145"},"PeriodicalIF":4.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic grouping of ongoing activity in V1 hypercolumns

IF 4.7 2区医学

NeuroImage Pub Date : 2025-03-20 DOI: 10.1016/j.neuroimage.2025.121157

Rui Zhang , Jiayu Wang , Xingya Cai , Rendong Tang , Haidong D. Lu

{"title":"Dynamic grouping of ongoing activity in V1 hypercolumns","authors":"Rui Zhang , Jiayu Wang , Xingya Cai , Rendong Tang , Haidong D. Lu","doi":"10.1016/j.neuroimage.2025.121157","DOIUrl":"10.1016/j.neuroimage.2025.121157","url":null,"abstract":"<div><div>Neurons’ spontaneous activity provides rich information about the brain. A single neuron's activity has close relationships with the local network. In order to understand such relationships, we studied the spontaneous activity of thousands of neurons in macaque V1 and V2 with two-photon calcium imaging. In V1, the ongoing activity was dominated by global fluctuations in which the activity of majority of neurons were correlated. Neurons’ activity also relied on their relative locations within the local functional architectures, including ocular dominance, orientation, and color maps. Neurons with similar preferences dynamically grouped into co-activating ensembles and exhibited spatial patterns resembling the local functional maps. Different ensembles had different strengths and frequencies. This observation was consistent across all hypercolumn-sized V1 locations we examined. In V2, different imaging sites had different orientation and color features. However, the spontaneous activity in the sampled regions also correlated with the underlying functional architectures. These results indicate that functional architectures play an essential role in influencing neurons’ spontaneous activity.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121157"},"PeriodicalIF":4.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibrillar amyloidosis and synaptic vesicle protein expression progress jointly in the cortex of a mouse model with β-amyloid pathology

IF 4.7 2区医学

NeuroImage Pub Date : 2025-03-20 DOI: 10.1016/j.neuroimage.2025.121165

L.H. Kunze , G. Palumbo , J. Gnörich , K. Wind-Mark , R. Schaefer , S. Lindner , F.-J. Gildehaus , S. Ziegler , M. Brendel

{"title":"Fibrillar amyloidosis and synaptic vesicle protein expression progress jointly in the cortex of a mouse model with β-amyloid pathology","authors":"L.H. Kunze , G. Palumbo , J. Gnörich , K. Wind-Mark , R. Schaefer , S. Lindner , F.-J. Gildehaus , S. Ziegler , M. Brendel","doi":"10.1016/j.neuroimage.2025.121165","DOIUrl":"10.1016/j.neuroimage.2025.121165","url":null,"abstract":"<div><div>Neurodegeneration, accumulation of β-amyloid (Aβ) plaques, and neuroinflammation are the major hallmarks of Alzheimer's disease. Here, we aimed to investigate the temporal and spatial association between synaptic activity, Aβ plaque load, and neuroinflammation in an Aβ mouse model with limited neurodegeneration.</div><div>26 APPSL70 and 15 C57Bl/6 mice underwent longitudinal PET-scans with [<sup>18</sup>F]UCB-H from plaque onset to levels of strong plaque load (5.3 - 11.0 months of age) to assess the synaptic vesicle protein 2A (SV2A) expression, [<sup>18</sup>F]FBB to determine the fibrillar Aβ plaque load, and [<sup>18</sup>F]GE-180 and [<sup>18</sup>F]F-DED to assess microglial and astroglial (re)activity. Statistical parametric mapping was performed to uncover similarities between the binding patterns of all four tracers.</div><div>We found a continuous increase in Aβ-PET in APPSL70 mice from 5.3 to 11.0 months of age, resulting in a significantly higher [<sup>18</sup>F]FBB PET signal in the cortex, hippocampus, and thalamus of APPSL70 mice compared to C57Bl/6 mice at 11.0 months of age. Parallel increases in SV2A-PET signals were observed in the cortex and thalamus of APPSL70 mice compared to C57Bl/6 mice. Statistical parametric mapping revealed a similar pattern of Aβ- and SV2A-PET differences (dice coefficient 53 %). Patterns of microglia activation showed stronger congruency with SV2A expression (dice coefficient 58 %) than patterns of reactive astrogliosis (dice coefficient 26 %).</div><div>APPSL70 mice with limited neurodegeneration comprise a close temporal and spatial association between SV2A expression, Aβ plaque load, and microglial activation. SV2A PET imaging in APPSL70 mice may facilitate longitudinal monitoring of increased synaptic activity in the earliest phase of AD.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121165"},"PeriodicalIF":4.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theta oscillations between the ventromedial prefrontal cortex and amygdala support dynamic representations of threat and safety

IF 4.7 2区医学

NeuroImage Pub Date : 2025-03-19 DOI: 10.1016/j.neuroimage.2025.121164

Pingping Lu , Dong Chen , Wenran Xia , Si Chen , Zheng Tan , Wenjing Zhou , Liang Wang

{"title":"Theta oscillations between the ventromedial prefrontal cortex and amygdala support dynamic representations of threat and safety","authors":"Pingping Lu , Dong Chen , Wenran Xia , Si Chen , Zheng Tan , Wenjing Zhou , Liang Wang","doi":"10.1016/j.neuroimage.2025.121164","DOIUrl":"10.1016/j.neuroimage.2025.121164","url":null,"abstract":"<div><div>The amygdala exhibits distinct different activity patterns to threat and safety stimuli. Animal studies have demonstrated that the fear (i.e., threat) and extinction (i.e., safety) memory are encoded by the amygdala and its interaction with the ventromedial prefrontal cortex (vmPFC). Recent studies in both animals and humans suggest that the inter-regional interaction between amygdala and vmPFC can be supported by theta oscillations during fear processing. However, the mechanism by which the human vmPFC-amygdala pathway dynamically supports neural representations of the same stimulus remains elusive, as it alternatively reflects threat and safety situations. To investigate this phenomenon, we conducted intracranial EEG recordings in drug-resistant epilepsy patients (n = 8) with implanted depth electrodes who performed a fear conditioning and extinction task. This task was designed with a fixed structure whereby specific CS+ stimulus could be either safe (never paired with US) or threatening (possibly paired with US) based on an implicit rule during fear acquisition. Our findings showed that the stimulus embodying potential threat information was accompanied by increased theta activities in amygdala during both fear acquisition and early extinction. Furthermore, the learning of safety information was associated with enhanced theta-related direction from the vmPFC to the amygdala. This study provided directly electrophysiological evidence supporting the dynamic oscillatory modulation of threat and safety representations in the human amygdala-vmPFC circuit, and suggests that amygdala safety processing depends on theta inputs from the vmPFC in both fear acquisition and extinction.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121164"},"PeriodicalIF":4.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual sensory discrimination of threatening stimuli presenting different durations: A magnetoencephalographic and behavioral study

IF 4.7 2区医学

NeuroImage Pub Date : 2025-03-19 DOI: 10.1016/j.neuroimage.2025.121158

Luis Carretié , Javier Echegaray , Constantino Méndez-Bértolo

{"title":"Visual sensory discrimination of threatening stimuli presenting different durations: A magnetoencephalographic and behavioral study","authors":"Luis Carretié , Javier Echegaray , Constantino Méndez-Bértolo","doi":"10.1016/j.neuroimage.2025.121158","DOIUrl":"10.1016/j.neuroimage.2025.121158","url":null,"abstract":"<div><div>Whether time exposure influences visual sensory processing of emotional stimulation is an unexplored issue, despite its relevance to understanding affective processing. We recorded magnetoencephalographic (MEG) activity -concretely event-related magnetic fields (ERFs)- from 25 participants while attending to spiders (emotional stimuli) and wheels (neutral) silhouettes they had to categorize. These stimuli were presented during 33.33, 66.66, 133.33, and 266.66 ms, and could appear at the center of the screen (fixation) or in the lower visual field (periphery). Behavioral performance revealed improved detection of negative emotional stimuli at fixation, and this effect did not interact with exposure time. At the neural level, greater amplitudes for spiders than for wheels were observed when presented at fixation in two visual ERF components, M100 and M150, an effect originating in striate and extrastriate visual cortices, respectively. This effect, ocurring later for stimuli presented at the periphery (M210, estimated in the extrastriate cortex), neither interacted with stimulus duration. This threat detection mechanism in the visual cortex independent of stimulus duration points to an all-or-nothing, rather than gradual, sensory discrimination of emotional cues regarding their exposure time.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121158"},"PeriodicalIF":4.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parsimonious EBM: generalising the event-based model of disease progression for simultaneous events.

IF 4.7 2区医学

NeuroImage Pub Date : 2025-03-19 DOI: 10.1016/j.neuroimage.2025.121162

Parker Cs, N P Oxtoby, A L Young, D C Alexander, H Zhang

{"title":"Parsimonious EBM: generalising the event-based model of disease progression for simultaneous events.","authors":"Parker Cs, N P Oxtoby, A L Young, D C Alexander, H Zhang","doi":"10.1016/j.neuroimage.2025.121162","DOIUrl":"https://doi.org/10.1016/j.neuroimage.2025.121162","url":null,"abstract":"<p><p>The event-based model of disease progression (EBM) infers a temporal ordering of biomarker abnormalities, defining different disease stages, from short-term data. A key modelling choice of the EBM is that biomarker abnormalities, termed events, are serially ordered. This enforces a strict equality between the number of input biomarkers and the number of model stages, limiting its ability to infer simple staging systems and latent disease processes. To overcome this, we introduce the parsimonious event-based model of disease progression (P-EBM). The P-EBM generalises the EBM to allow multiple new biomarker abnormalities, termed \"simultaneous events\", at each model stage. We evaluate the P-EBM performance in simulated data to show it accurately estimates orderings with arbitrary event arrangements under realistic experimental conditions. When applied to sporadic AD data from the Alzheimer's Disease Neuroimaging Initiative, the P-EBM estimated a sequence with 7 model stages from a dataset of 12 biomarkers that more closely fitted the data than the EBM. The sets of simultaneous events, such as decreased cerebrospinal fluid total tau and p-tau<sub>181</sub>, correspond closely to latent disease processes. P-EBM patient stages were strongly associated with clinical diagnosis at baseline and future conversion and could be accurately estimated from a smaller number of biomarkers than the EBM. The P-EBM enables the data-driven discovery of simple disease staging systems which could highlight new latent disease processes and suggest practical strategies for patient staging.</p>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":" ","pages":"121162"},"PeriodicalIF":4.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neural representation of body orientation and emotion from biological motion 从生物运动看身体方位和情绪的神经表征。

IF 4.7 2区医学

NeuroImage Pub Date : 2025-03-19 DOI: 10.1016/j.neuroimage.2025.121163

Shuaicheng Liu , Lu Yu , Jie Ren , Mingming Zhang , Wenbo Luo

{"title":"The neural representation of body orientation and emotion from biological motion","authors":"Shuaicheng Liu , Lu Yu , Jie Ren , Mingming Zhang , Wenbo Luo","doi":"10.1016/j.neuroimage.2025.121163","DOIUrl":"10.1016/j.neuroimage.2025.121163","url":null,"abstract":"<div><div>The perception of human body orientation and emotion in others provides crucial insights into their intentions. While significant research has explored the brain's representation of body orientation and emotion processing, their possible combined representation remains less well understood. In this study, functional magnetic resonance imaging was employed to investigate this issue. Participants were shown point-light displays and tasked with recognizing both body emotion and orientation. The analysis of functional activation revealed that the extrastriate body area encodesd emotion, while the precentral gyrus and postcentral gyrus encoded body orientation. Additionally, results from multivariate pattern analysis and representational similarity analysis demonstrated that the lingual gyrus, precentral gyrus, and postcentral gyrus played a critical role in processing body orientation, whereas the lingual gyrus and extrastriate body area were crucial for processing emotion. Furthermore, the commonality analysis found that the neural representations of emotion and body orientation in the lingual and precentral gyrus were not interacting, but rather competing. Lastly, a remarkable interaction between hemisphere and body orientation revealed in the connection analysis showed that the coupling between the inferior parietal lobule and the left precentral gyrus was more sensitive to a 90° body orientation, while the coupling between the inferior parietal lobule and the right precentral gyrus was sensitive to 0° and 45° body orientation. Overall, these findings suggest that the conflicted relationship between the neural representation of body orientation and emotion in LING and PreCG when point-light displays were shown, and the different hemispheres play different role in encoding different body orientations.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121163"},"PeriodicalIF":4.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Task-switching and frontal cortex functioning across adulthood: An fNIRS study

IF 4.7 2区医学

NeuroImage Pub Date : 2025-03-18 DOI: 10.1016/j.neuroimage.2025.121160

Michael K. Yeung

{"title":"Task-switching and frontal cortex functioning across adulthood: An fNIRS study","authors":"Michael K. Yeung","doi":"10.1016/j.neuroimage.2025.121160","DOIUrl":"10.1016/j.neuroimage.2025.121160","url":null,"abstract":"<div><div>Switching between tasks is slower and more error-prone than performing a single task. While studies have compared task-switching and associated neural processing between younger and older adults, knowledge of age-related differences in components of task-switching across adulthood, and associated neural mechanisms, remains elusive. In this study, these age differences were investigated using functional near-infrared spectroscopy (fNIRS). A sample of 132 adults aged 18–79 undertook a variant of the Trail Making Test and a task-switching paradigm. Hemodynamic changes in the bilateral frontal cortex during the task-switching paradigm were measured using a 48-channel fNIRS device. Behavioral results showed that age showed a negative linear relationship with time taken to task-switch and a negative quadratic relationship with success in task-switching. In addition, fNIRS results showed that age had a positive linear relationship with activation in the left posterolateral frontal cortex across trial conditions. Among older adults, who had slower and less accurate switch performance than younger adults, greater left posterolateral frontal activation was associated with faster and more accurate switch performance. Therefore, different aspects of task-switching performance exhibit varying patterns of age-related differences across adulthood. Increased engagement of the left posterolateral frontal cortex, which plays a specific role in reconfiguring and implementing relevant task rules, may help older adults compensate for declined switch performance.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121160"},"PeriodicalIF":4.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency- and state-dependent dynamics of EEG microstates during propofol anesthesia 丙泊酚麻醉期间脑电图微状态的频率和状态依赖性动态变化。

IF 4.7 2区医学

NeuroImage Pub Date : 2025-03-18 DOI: 10.1016/j.neuroimage.2025.121159

Yun Zhang , Haidong Wang , Fei Yan , Dawei Song , Qiang Wang , Yubo Wang , Liyu Huang

{"title":"Frequency- and state-dependent dynamics of EEG microstates during propofol anesthesia","authors":"Yun Zhang , Haidong Wang , Fei Yan , Dawei Song , Qiang Wang , Yubo Wang , Liyu Huang","doi":"10.1016/j.neuroimage.2025.121159","DOIUrl":"10.1016/j.neuroimage.2025.121159","url":null,"abstract":"<div><div>Electroencephalography microstate analysis has emerged as a powerful tool for investigating brain dynamics during anesthesia-induced unconsciousness. However, existing studies typically analyze EEG signals across broad frequency bands, leaving the frequency-specific temporal characteristics of microstates poorly understood. In this study, we investigated frequency-specific EEG microstate features in the delta (0.5–4 Hz) and EEG-without-delta (4–30 Hz) frequency bands during propofol anesthesia. Sixty-channel EEG recordings were collected from 18 healthy male participants during wakefulness and propofol-induced unconsciousness. Microstate analysis was conducted separately for delta and EEG-without-delta frequency bands and microstate features were compared across frequency bands and conscious states. Our results revealed eight consistent microstate classes (MS1–MS8) with high topographic similarity across frequency bands, while global explained variance (GEV), mean duration (MeanDur), occurrence (Occ), and coverage (Cov) exhibited significant frequency- and state-dependent variations during propofol anesthesia. In the delta band, propofol-induced unconsciousness was associated with significantly longer MeanDur for microstate classes of MS4, MS5, and MS6 (<em>p</em> < 0.05). In the EEG-without-delta band, GEV, Cov, and Occ significantly increased for MS1 and MS3 (<em>p</em> < 0.01) and decreased for MS2 and MS4 (<em>p</em> < 0.05) during unconsciousness. Notably, microstate features in the EEG-without-delta band showed better sensitivity for discriminating conscious states, achieving a classification accuracy of 0.944. These findings emphasize the importance of frequency-specific microstate analysis in unraveling the neural dynamics of anesthesia-induced unconsciousness and highlight its potential clinical applications for improving anesthesia depth monitoring.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121159"},"PeriodicalIF":4.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White matter integrity of hearing and cognitive impairments in healthy aging

IF 4.7 2区医学

NeuroImage Pub Date : 2025-03-18 DOI: 10.1016/j.neuroimage.2025.121135

Samaneh Nemati , Meisam Arjmandi , Jean Neils-Strunjas , Roger D. Newman-Norlund , Sarah E. Newman-Norlund , Laura Droege , Leonardo Bonilha , Julius Fridriksson

{"title":"White matter integrity of hearing and cognitive impairments in healthy aging","authors":"Samaneh Nemati , Meisam Arjmandi , Jean Neils-Strunjas , Roger D. Newman-Norlund , Sarah E. Newman-Norlund , Laura Droege , Leonardo Bonilha , Julius Fridriksson","doi":"10.1016/j.neuroimage.2025.121135","DOIUrl":"10.1016/j.neuroimage.2025.121135","url":null,"abstract":"<div><div>Age-Related Hearing Loss (ARHL), or presbycusis, affects two-thirds of U.S. adults over 70 and is linked to cognitive decline and an increased risk of dementia. This study examines associations between white matter integrity and hearing and cognitive function in healthy aging using diffusion tensor imaging (DTI).</div><div>We recruited 126 participants (92 female) aged 20–79 years (<span><math><mrow><mi>M</mi><mi>e</mi><mi>a</mi><mi>n</mi><mo>=</mo><mn>51</mn><mo>.</mo><mn>34</mn><mo>,</mo><mi>S</mi><mi>D</mi><mo>=</mo><mn>20</mn><mo>.</mo><mn>54</mn></mrow></math></span>) from the Aging Brain Cohort Study at the University of South Carolina (ABC@UofSC). Cognitive performance was assessed using the Montreal Cognitive Assessment (MoCA), and hearing was evaluated through pure-tone thresholds (PTT) and words-in-noise (WIN) thresholds. White matter integrity was measured with fractional anisotropy (FA) and mean diffusivity (MD), and analyses examined relationships between these DTI metrics and hearing and cognitive scores using the region-of-interest regression analysis.</div><div>Results showed significant associations between lower FA and higher MD values and poorer hearing and cognitive performance, particularly in the anterior and superior corona radiata, corpus callosum, and superior longitudinal fasciculus. Additionally, ANOVA comparisons between older adults with and without hearing impairments revealed significant MD differences in several regions, indicating specific microstructural changes linked to auditory impairment.</div><div>This study contributes to the understanding of the neural bases of hearing and cognitive impairments, underscoring the potential of DTI as a complementary tool to gray matter-based studies in exploring reliable imaging evidence of hearing and cognitive impairments in healthy aging across adulthood.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121135"},"PeriodicalIF":4.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0