Development of diffusion analysis along the perivascular space (DTI-ALPS) index during childhood and adolescence: Evidence from two longitudinal cohorts

IF 4.7 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-06-17 DOI:10.1016/j.neuroimage.2025.121331

Shiwei Lin , Qunjun Liang , Ying Li , Caixue Cheng , Tingting Gong , Yingwei Qiu

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Abstract

Brain glymphatic activity, as indicated by diffusion analysis along the perivascular space (DTI-ALPS) index, has been discovered to participate in the pathogenesis of atypical development. However, little is known about the physiological developmental trajectory of the DTI-ALPS index during childhood and adolescence. Here, we evaluated DTI-ALPS index developmental characteristics and investigated its potential association with sex in 627 participants from two longitudinal cohorts. The global DTI-ALPS (gDTI-ALPS) index showed a positive cross-sectional relationship with age in both cohorts even after adjusting for sex. The annual net increase in the gDTI-ALPS index in both cohorts ranged from 0.003 to 0.005. Increases in the gDTI-ALPS index with age were also observed in the longitudinal analysis. Moreover, regional DTI-ALPS index analysis revealed the increment of DTI-ALPS mainly involved in the anterior brain regions, with the peak value of the regional DTI-ALPS index moving forward with age. Sex had no significant moderating effect on DTI-ALPS index. Our results suggest DTI-ALPS index development is a dynamic process during childhood and adolescence, particularly within the anterior brain regions, which may represent glymphatic system maturation during this critical period. The global and regional DTI-ALPS index could serve as a sensitive biomarker for monitoring this process.

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儿童和青少年时期沿血管周围空间（DTI-ALPS）指数扩散分析的发展：来自两个纵向队列的证据

经沿血管周围间隙弥散分析（DTI-ALPS）指数发现，脑淋巴活性参与了不典型发育的发病机制。然而，关于DTI-ALPS指数在儿童和青少年时期的生理发育轨迹知之甚少。在这里，我们评估了来自两个纵向队列的627名参与者的DTI-ALPS指数发育特征，并调查了其与性别的潜在关联。即使在性别调整后，全球DTI-ALPS （gDTI-ALPS）指数在两个队列中也显示出与年龄正相关的横截面关系。两个队列的gDTI-ALPS指数的年净增长范围为0.003至0.005。在纵向分析中也观察到gDTI-ALPS指数随年龄的增加。此外，区域DTI-ALPS指数分析显示，DTI-ALPS指数的增加主要累及脑前部区域，且区域DTI-ALPS指数的峰值随年龄的增长而向前移动。性别对DTI-ALPS指数无显著调节作用。我们的研究结果表明，DTI-ALPS指数的发展在儿童和青少年时期是一个动态的过程，特别是在大脑前部区域，这可能代表了这个关键时期淋巴系统的成熟。全球和区域DTI-ALPS指数可作为监测这一过程的敏感生物标志物。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.