NeuroImagePub Date : 2025-03-28DOI: 10.1016/j.neuroimage.2025.121180
Ruhuiya Aili , Siyuan Zhou , Xinran Xu , Xiangyu He , Chunming Lu
{"title":"The cortical architecture representing the linguistic hierarchy of the conversational speech","authors":"Ruhuiya Aili , Siyuan Zhou , Xinran Xu , Xiangyu He , Chunming Lu","doi":"10.1016/j.neuroimage.2025.121180","DOIUrl":"10.1016/j.neuroimage.2025.121180","url":null,"abstract":"<div><div>Recent studies demonstrate that the brain parses natural language into smaller units represented in lower-order regions and larger units in higher-order regions. Most of these studies, however, have been conducted on unidirectional narrative speech, leaving the linguistic hierarchy and its cortical representation in bidirectional conversational speech unexplored. To address this gap, we simultaneously measured brain activity from two individuals using functional near-infrared spectroscopy (fNIRS) hyperscanning while they engaged in a naturalistic conversation. Using a Pre-trained Language Model (PLM) and Representational Similarity Analysis (RSA), we demonstrated that conversational speech, jointly produced by two interlocutors in a turn-taking manner, exhibits a linguistic hierarchy, characterized by a boundary effect between linguistic units and an incremental context effect. Furthermore, a gradient pattern of shared cortical representation of the linguistic hierarchy was identified at the dyadic rather than the individual level. Interpersonal neural synchronization (INS) in the left superior temporal cortex was associated with turn representation, whereas INS in the medial prefrontal cortex was linked to topic representation. These findings further validated the distinctiveness of linguistic units of different sizes. Together, our results provide original evidence for the linguistic hierarchy and the underlying cortical architecture during a naturalistic conversation, extending the hierarchical nature of natural language from unidirectional narrative speech to bidirectional conversational speech.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"311 ","pages":"Article 121180"},"PeriodicalIF":4.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unveiling complex brain dynamics during movie viewing via deep recursive autoencoder model.","authors":"Kexin Wang, Limei Song, Zhaowei Li, Liting Wang, Xiaowei He, Yudan Ren, Jinglei Lv","doi":"10.1016/j.neuroimage.2025.121177","DOIUrl":"https://doi.org/10.1016/j.neuroimage.2025.121177","url":null,"abstract":"<p><p>Naturalistic stimuli have become an effective tool to uncover the dynamic functional brain networks triggered by cognitive and emotional real-life experiences through multimodal and dynamic stimuli. However, current research predominantly focused on exploring dynamic functional connectivity generated via chosen templates under resting-state paradigm, with relatively limited investigation into the dynamic functional interactions among large-scale brain networks. Moreover, these studies might overlook the longer time-scale adaptability and information transmission that occur over extended periods during naturalistic stimuli. In this study, we introduced an unsupervised deep recursive autoencoder (DRAE) model combined with a sliding window approach, effectively capturing the brain's long-term temporal dependencies, as measured in functional magnetic resonance imaging (fMRI), when subjects viewing a long-duration and emotional film. The experimental results revealed that naturalistic stimuli can induce dynamic large-scale brain networks, of which functional interactions covary with the development of the film's narrative. Furthermore, the dynamic interactions among brain networks were temporally synchronized with specific features of the movie, especially with the emotional arousal and valence. Our study provided novel insight to the underlying neural mechanisms of dynamic functional interactions among brain regions in an ecologically valid sensory experience.</p>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":" ","pages":"121177"},"PeriodicalIF":4.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novelty Modulates Proactive and Reactive Cognitive Control Modes: Evidence from ERP and EEG Data.","authors":"Qianqian Li, Tianlong Chen, Lixia Wang, Hongshan Gu, Bi Ying Hu, Chuanhua Gu, Zongkui Zhou","doi":"10.1016/j.neuroimage.2025.121178","DOIUrl":"https://doi.org/10.1016/j.neuroimage.2025.121178","url":null,"abstract":"<p><p>Novelty refers to the quality of an idea or product that is new or unusual. It has been shown to influence a broad range of cognitive processes, such as increasing arousal and facilitating working memory. However, no studies have directly investigated the effects of novelty on cognitive control, particularly on the trade-off between proactive and reactive cognitive control. The present study employed an adapted AX Continuous Performance Task (AX-CPT) combined with electroencephalography (EEG) to investigate the impact of novelty on proactive and reactive control modes. The behavioral results showed that reaction times in BX trials were longer under novel conditions than common conditions, indicating that participants may rely more on reactive control and/or rely less on proactive control when influenced by novelty. The EEG results showed smaller effects of cue-P3 and cue-locked theta-ERS under novelty, suggesting that novelty might decrease proactive control, including the decreased maintenance and utilization of contextual information. Moreover, in the novel conditions, the effect of probe-locked theta-ERS was greater, while the effect of probe-P3 was smaller. This indicates that novelty may enhance reactive control, including increased conflict monitoring and reduced response inhibition cost. The findings suggest that exposure to novelty can influence how individuals balance proactive and reactive control, potentially causing a bias towards reactive control.</p>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":" ","pages":"121178"},"PeriodicalIF":4.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroImagePub Date : 2025-03-27DOI: 10.1016/j.neuroimage.2025.121175
Ray Lee, Paul Sajda, Nim Tottenham
{"title":"An Interaction-Centric Approach for Quantifying Eye-to-eye Reciprocal Interaction.","authors":"Ray Lee, Paul Sajda, Nim Tottenham","doi":"10.1016/j.neuroimage.2025.121175","DOIUrl":"https://doi.org/10.1016/j.neuroimage.2025.121175","url":null,"abstract":"<p><p>This study presents an interaction-centric framework for analytically investigating brain-to-brain dynamics during eye contact, advancing beyond the traditional spectator model. The foundation of the interactor approach is to delineate the interaction. To achieve this, simultaneous brain activity engaged in eye contact was captured using hyperscanning fMRI. The BOLD responses were first divided into eye-to-eye reciprocal interaction and eye-to-face non-reciprocal communication based on the experimental design; then the reciprocal interaction response was further differentiated into sensory-based (exogenous) and mind-based (endogenous) components to characterize agentic interaction. The proposed interactor approach not only determines interaction from dyadic brain states but also computes emergent interactive brain states arising from the interaction. To achieve these, reciprocal interactive fMRI responses were quantified into an interaction matrix, from which interaction-induced communication channels were identified using Correspondence Analysis, and information flow within those channels was measured with Mutual Information. The advantage of the interactor approach is its ability to reveal emergent dyadic brain states that a spectator approach cannot fully unravel. When applied to parent-child eye contact, this method confirmed existing developmental findings, clarified previous inconsistencies, and uncovered new insights into how reciprocal social engagement shapes brain function.</p>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":" ","pages":"121175"},"PeriodicalIF":4.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroImagePub Date : 2025-03-26DOI: 10.1016/j.neuroimage.2025.121176
Su Shu, Wenwen Ou, Mohan Ma, Hairuo He, Qianqian Zhang, Mei Huang, Wentao Chen, Aoqian Deng, Kangning Li, Zhenman Xi, Fanyu Meng, Hui Liang, Sirui Gao, Yilin Peng, Mei Liao, Li Zhang, Mi Wang, Jin Liu, Bangshan Liu, Yumeng Ju, Yan Zhang
{"title":"Altered brain network dynamics during rumination in remitted depression.","authors":"Su Shu, Wenwen Ou, Mohan Ma, Hairuo He, Qianqian Zhang, Mei Huang, Wentao Chen, Aoqian Deng, Kangning Li, Zhenman Xi, Fanyu Meng, Hui Liang, Sirui Gao, Yilin Peng, Mei Liao, Li Zhang, Mi Wang, Jin Liu, Bangshan Liu, Yumeng Ju, Yan Zhang","doi":"10.1016/j.neuroimage.2025.121176","DOIUrl":"https://doi.org/10.1016/j.neuroimage.2025.121176","url":null,"abstract":"<p><p>Rumination is a known risk factor for depression relapse. Understanding its neurobiological mechanisms during depression remission can inform strategies to prevent relapse, yet the temporal dynamics of brain networks during rumination in remitted depression remain unclear. Here, we collected rumination induction fMRI data from 42 patients with remitted depression and 41 healthy controls (HCs). Using an energy landscape approach, we investigated the temporal dynamics of brain networks during rumination. The appearance frequency (AF) and transition frequency (TF) metrics were defined to quantify the dynamic properties of brain states. Patients during remission showed higher levels of rumination than HCs. Both groups exhibited four brain states during rumination, which consisted of complementary network group activation (states 1 and 2, states 3 and 4). In patients, the AFs of and reciprocal TFs between states 1 and 2 during rumination were significantly increased, while AFs of states 3 and 4 and reciprocal TFs involving states 1-3, 1-4, 2-3, and 2-4 were decreased, both when compared to HCs and relative to patients themselves during distraction. Moreover, we found that for patients, the AF of state 1 was negatively correlated with rumination levels and marginally positively associated with attention, while the AF of state 2 was negatively associated with performance on attention tasks. Our study revealed altered dynamic characteristics of brain states composed of network groups during rumination in remitted depression. Additionally, the findings suggest that heightened self-focus linked to rumination may impair the brain's ability to efficiently allocate attentional resources.</p>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":" ","pages":"121176"},"PeriodicalIF":4.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroImagePub Date : 2025-03-26DOI: 10.1016/j.neuroimage.2025.121147
Andrea I Costantino, Benjamin O Turner, Mark A Williams, Matthew J Crossley
{"title":"Partial information transfer from peripheral visual streams to foveal visual streams may be mediated through local primary visual circuits.","authors":"Andrea I Costantino, Benjamin O Turner, Mark A Williams, Matthew J Crossley","doi":"10.1016/j.neuroimage.2025.121147","DOIUrl":"https://doi.org/10.1016/j.neuroimage.2025.121147","url":null,"abstract":"<p><p>Visual object recognition is driven through the what pathway, a hierarchy of visual areas processing features of increasing complexity and abstractness. The primary visual cortex (V1), this pathway's origin, exhibits retinotopic organization: neurons respond to stimuli in specific visual field regions. A neuron responding to a central stimulus won't respond to a peripheral one, and vice versa. However, despite this organization, task-relevant feedback about peripheral stimuli can be decoded in unstimulated foveal cortex, and disrupting this feedback impairs discrimination behavior. The information encoded by this feedback remains unclear, as prior studies used computer-generated objects ill-suited to dissociate different representation types. To address this knowledge gap, we investigated the nature of information encoded in periphery-to-fovea feedback using real-world stimuli. Participants performed a same/different discrimination task on peripherally displayed images of vehicles and faces. Using fMRI multivariate decoding, we found that both peripheral and foveal V1 could decode images separated by low-level perceptual models (vehicles) but not those separated by semantic models (faces). This suggests the feedback primarily carries low-level perceptual information. In contrast, higher visual areas resolved semantically distinct images. A functional connectivity analysis revealed foveal V1 connections to both peripheral V1 and later-stage visual areas. These findings indicate that while both early and late visual areas may contribute to information transfer from peripheral to foveal processing streams, higher-to-lower area transfer may involve information loss.</p>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":" ","pages":"121147"},"PeriodicalIF":4.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ensemble network using oblique coronal MRI for Alzheimer's disease diagnosis.","authors":"Cunhao Li, Zhongjian Gao, Xiaomei Chen, Xuqiang Zheng, Xiaoman Zhang, Chih-Yang Lin","doi":"10.1016/j.neuroimage.2025.121151","DOIUrl":"https://doi.org/10.1016/j.neuroimage.2025.121151","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a primary degenerative brain disorder commonly found in the elderly, Mild cognitive impairment (MCI) can be considered a transitional stage from normal aging to Alzheimer's disease. Therefore, distinguishing between normal aging and disease-induced neurofunctional impairments is crucial in clinical treatment. Although deep learning methods have been widely applied in Alzheimer's diagnosis, the varying data formats used by different methods limited their clinical applicability. In this study, based on the ADNI dataset and previous clinical diagnostic experience, we propose a method using oblique coronal MRI to assist in diagnosis. We developed an algorithm to extract oblique coronal slices from 3D MRI data and used these slices to train classification networks. To achieve subject-wise classification based on 2D slices, rather than image-wise classification, we employed ensemble learning methods. This approach fused classification results from different modality images or different positions of the same modality images, constructing a more reliable ensemble classification model. The experiments introduced various decision fusion and feature fusion schemes, demonstrating the potential of oblique coronal MRI slices in assisting diagnosis. Notably, the weighted voting from decision fusion strategy trained on oblique coronal slices achieved accuracy rates of 97.5% for CN vs. AD, 100% for CN vs. MCI, and 94.83% for MCI vs. AD across the three classification tasks.</p>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":" ","pages":"121151"},"PeriodicalIF":4.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroImagePub Date : 2025-03-25DOI: 10.1016/j.neuroimage.2025.121172
Mohammad Aliramezani , Balbir Singh , Christos Constantinidis , Mohammad Reza Daliri
{"title":"Low-frequency local field potentials reveal integration of spatial and non-spatial information in prefrontal cortex","authors":"Mohammad Aliramezani , Balbir Singh , Christos Constantinidis , Mohammad Reza Daliri","doi":"10.1016/j.neuroimage.2025.121172","DOIUrl":"10.1016/j.neuroimage.2025.121172","url":null,"abstract":"<div><div>The prefrontal cortex (PFC) is critical for various aspects of executive functions, particularly working memory. The debate over whether the dorsal and ventral PFC should be viewed as unitary or heterogeneous in working memory has been ongoing. This study explored the specialization of the posterior dorsal, medial dorsal, and posterior ventral subdivisions of the lateral PFC in two macaque monkeys, focusing on the processing of the location and shape of stimuli during working memory tasks. In contrast to previous studies that focused on spike activity analysis, this article employed local field potential (LFP) power analysis. Results revealed that during the working memory periods, both the dorsal and ventral PFC exhibited significantly higher LFP power for feature stimuli compared to spatial stimuli in the low-frequency bands (∼2–23 Hz). Additionally, the impact of matching versus non-matching stimuli was consistent with repetition suppression in the medial dorsal and posterior ventral regions during the working memory period within the same frequency range. The major modulation of LFP power linked to incorrect decisions made by the monkeys was a sharp reduction in low-frequency LFP power. The similar LFP power patterns in the PFC subdivisions for spatial and feature stimuli throughout the analysis suggested that spatial and non-spatial inputs are integrated by the PFC, revealed by the low-frequency components of the LFP.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121172"},"PeriodicalIF":4.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroImagePub Date : 2025-03-24DOI: 10.1016/j.neuroimage.2025.121170
Dong-ni Pan , CuiZhu Lin , Ma Xin , Oliver T. Wolf , Gui Xue , Xuebing Li
{"title":"Understanding episodic memory dynamics: Retrieval and updating mechanisms revealed by fMRI and tDCS","authors":"Dong-ni Pan , CuiZhu Lin , Ma Xin , Oliver T. Wolf , Gui Xue , Xuebing Li","doi":"10.1016/j.neuroimage.2025.121170","DOIUrl":"10.1016/j.neuroimage.2025.121170","url":null,"abstract":"<div><div>This study investigates brain mechanisms in memory preservation and alteration using a three-phase design: memory encoding (Day 1), interference under fMRI (Day 2), and testing (Day 3). Thirty-one participants completed the core experiment, supplemented by a tDCS study (<em>n</em> = 118) targeting the visual cortex. Original memories were more susceptible to incorrect updating during old-background/new-object interference compared to relearning and no-retrieval conditions. Interference trials elicited heightened activation in the Inferior Parietal Lobe (IPL), Dorsolateral Prefrontal Cortex (DLPFC), and Dorsal Anterior Cingulate Gyrus (dACC) versus no-retrieval controls, and increased frontoparietal and Occipital Fusiform Gyrus (OFG) activation versus relearning. Analyzing interference trials by Day 3 outcomes revealed preserved memories correlated with stronger cingulo-opercular and frontoparietal activation (indicating effective conflict resolution), whereas updated memories showed elevated OFG activity (suggesting new sensory integration). Crucially, IPL/DLPFC activation during interference positively correlated with original memory accuracy, while OFG activation showed negative correlation. tDCS stimulation of the occipital cortex during memory reactivation significantly enhanced memory updating, confirming visual cortex involvement in contextual distortion. Findings demonstrate distinct neural profiles underlie memory outcomes: preserved memories require efficient conflict processing networks, while perceptual interference during reactivation promotes updates through sensory integration systems. This supports targeted neuromodulation approaches for memory modification, highlighting intervention potential through visual cortex engagement during critical memory phases.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121170"},"PeriodicalIF":4.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroImagePub Date : 2025-03-24DOI: 10.1016/j.neuroimage.2025.121173
Kitti Bán, Ádám Nárai, Noémi Báthori, Éva M Bankó, Adél Bihari, Vivien Tomacsek, Tibor Kovács, Béla Weiss, Petra Hermann, Péter Simor, Zoltán Vidnyánszky
{"title":"Slow-wave sleep is associated with nucleus accumbens volume in elderly adults.","authors":"Kitti Bán, Ádám Nárai, Noémi Báthori, Éva M Bankó, Adél Bihari, Vivien Tomacsek, Tibor Kovács, Béla Weiss, Petra Hermann, Péter Simor, Zoltán Vidnyánszky","doi":"10.1016/j.neuroimage.2025.121173","DOIUrl":"https://doi.org/10.1016/j.neuroimage.2025.121173","url":null,"abstract":"<p><p>Slow-wave sleep (SWS) is essential for restorative neural processes, and its decline is associated with both healthy and pathological ageing. Building on previous rodent research, this longitudinal study identified a significant association between nucleus accumbens (NAcc) volume and SWS duration in cognitively unimpaired older adults, whilst no significant link was observed between NAcc volume and N2 or rapid eye movement (REM) sleep percentage. Our findings support the involvement of the NAcc in ageing-related modulation of SWS and thus suggest the NAcc as a potential neural marker or therapeutic target for improving SWS.</p>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":" ","pages":"121173"},"PeriodicalIF":4.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}