NeuroImage最新文献

{"title":"Association of spatiotemporal interaction of gamma oscillations with heart rate variability during response inhibition processing in patients with major depressive disorder: An MEG study","authors":"Junling Sheng ,&nbsp;Yi Xia ,&nbsp;Lingling Hua ,&nbsp;Hongliang Zhou ,&nbsp;Qian Liao ,&nbsp;Shui Tian ,&nbsp;Yishan Du ,&nbsp;Xiaoqin Wang ,&nbsp;Rui Yan ,&nbsp;Hao Sun ,&nbsp;Zhijian Yao ,&nbsp;Qing Lu","doi":"10.1016/j.neuroimage.2025.121234","DOIUrl":"10.1016/j.neuroimage.2025.121234","url":null,"abstract":"<div><h3>Background</h3><div>Impairment in response inhibition function is highly prevalent in patients with major depressive disorder (MDD), yet the spatiotemporal neural activity underlying response inhibition and its relationship with the autonomic nervous system (ANS) remains unclear.</div></div><div><h3>Methods</h3><div>35 MDD participants and 35 healthy controls (HC) were included with magnetoencephalography (MEG) and electrocardiogram (ECG) data collecting during a go/no-go task. Heart rate variability (HRV) indices were calculated from the ECG data. Differences in functional connectivity (FC) of gamma oscillations (60–90 Hz) between 0–200 ms, 200–400 ms, and 400–600 ms in the two groups after no-go stimuli were analyzed, and the correlation between FC and HRV indices was examined.</div></div><div><h3>Results</h3><div>The MDD group exhibited poorer task performance and lower HRV indices than the HC group. During the 200–400 ms period, compared to the HC group, the MDD group exhibited decreased FC between the left inferior frontal gyrus (opercular part) and right temporal pole (middle temporal gyrus) (<em>t</em> = 3.62, <em>p</em> &lt; 0.05), and increased FC between the right superior frontal gyrus (orbital part) and right superior occipital gyrus (<em>t</em> = 3.68, <em>p</em> &lt; 0.05). Additionally, a significant positive correlation was found between FC of the left inferior frontal gyrus (opercular part) and right middle temporal gyrus (temporal pole) and the HRV index RMSSD in the MDD group (<em>r</em> = 0.491, <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Abnormal spatiotemporal interactions in gamma oscillations related to response inhibition are observed in MDD patients and abnormal gamma oscillations showed task-dependent covariation with ANS indices, suggesting their potential interplay in MDD pathophysiology.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"312 ","pages":"Article 121234"},"PeriodicalIF":4.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technical considerations for using intravenous gadolinium-based-contrast-agent (GBCA) based MRI approaches to study cerebrospinal fluid (CSF) circulation and clearance","authors":"Jun Hua ,&nbsp;Yuanqi Sun ,&nbsp;Yinghao Li ,&nbsp;Xinyi Zhou ,&nbsp;Yuhan Bian ,&nbsp;Adrian Paez ,&nbsp;Briana Meyer ,&nbsp;Swati Rane Levendovszky","doi":"10.1016/j.neuroimage.2025.121239","DOIUrl":"10.1016/j.neuroimage.2025.121239","url":null,"abstract":"<div><div>Intravenously (IV) administered Gadolinium-based-contrast-agents (GBCAs) can enter the intracranial cerebrospinal-fluid (CSF) space via weak barriers between blood and CSF at multiple locations in the brain. This enables IV-GBCAs to be used as a tracer to study CSF circulation and clearance in the brain. With proper optimization, IV-GBCA induced signal changes can be robustly detected in various brain regions associated with CSF circulation. Nevertheless, whether these signal changes can be attributed to GBCA concentration changes in the CSF space should be interpreted with caution. This review attempts to discuss several technical challenges for using IV-GBCA MRI to study CSF circulation in the brain. First, it is critical to minimize the partial volume effects from the blood compartment as IV-GBCAs can present in both the blood and CSF compartments for a long time. Second, MRI approaches that can provide a quantitative measure of GBCA concentration in the CSF are preferred as raw MR signal intensities can often have a complicated relationship with GBCA concentration. Third, regions with intracranial and extracranial blood supply should be analyzed separately because GBCA distribution in regions with extracranial blood supply may not be a proper indicator for CSF clearance from the brain. Fourth, differences in the cerebrovasculature should be considered when comparing IV-GBCA concentration changes in the CSF in brain diseases. Finally, a proper reference signal needs to be established to calibrate longitudinal post-GBCA signals across sessions. Some of these issues may also apply to intrathecal GBCA MRI studies.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"312 ","pages":"Article 121239"},"PeriodicalIF":4.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predominant white matter microstructural changes over gray matter in tinnitus brain","authors":"Qianhui Xu ,&nbsp;Tingting Chai ,&nbsp;Jun Yao ,&nbsp;Chunhua Xing ,&nbsp;Xiaomin Xu ,&nbsp;Xindao Yin ,&nbsp;Fei Zhao ,&nbsp;Richard Salvi ,&nbsp;Yu-Chen Chen ,&nbsp;Yuexin Cai","doi":"10.1016/j.neuroimage.2025.121235","DOIUrl":"10.1016/j.neuroimage.2025.121235","url":null,"abstract":"<div><h3>Introduction</h3><div>To explore microstructure changes across brain white matter and gray matter in tinnitus patients and its effect on neuropsychological performance.</div></div><div><h3>Methods</h3><div>The cross-sectional study used Multi-shell Diffusion Weighted Imaging data and neuropsychological assessment from 48 tinnitus patients and 48 healthy controls. Microstructural features across over white matter and gray matter based on Diffusion Tensor Imaging (DTI) and Neurite Orientation Dispersion and Density Imaging (NODDI) model using Tract-Based Spatial Statistics (TBSS) and Gray Matter-Based Spatial Statistics (GBSS), as well as topological properties were derived from an advanced tractography model in subjects. Brain-neuropsychological performance correlations were analyzed.</div></div><div><h3>Results</h3><div>Tinnitus patients showed decreased axial diffusivity in forceps minor and right corticospinal tract, increased orientation dispersion in forceps minor, decreased connection strength between the right caudate and pericalcarine, right caudate and superior temporal lobe, and left putamen and cuneus. Global network efficiency and local network efficiency were significantly less in tinnitus patients while feeder connection strength was significantly less in tinnitus patients. The orientation dispersion value mediated the relationship between tinnitus status and Trail Making Test–Part B scores. However, no obvious microstructural changes in gray matter were observed.</div></div><div><h3>Conclusion</h3><div>Leveraging multi-shell DWI data, the current study indicated that fiber disruption and internal connectivity organizational changes in brain white matter, rather than gray matter, were more susceptible in tinnitus patients. These microstructural changes in white matter could be associated with changes in cognitive function in tinnitus patients.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"312 ","pages":"Article 121235"},"PeriodicalIF":4.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual differences in resting alpha band power and changes in theta band power during sustained pain are correlated with the pain-relieving efficacy of alpha HD-tACS on SM1","authors":"Xingang Qi ,&nbsp;Tianzhe Jia ,&nbsp;Baijintao Sun ,&nbsp;Jiahui Xia ,&nbsp;ChenXi Wang ,&nbsp;Zilong Hong ,&nbsp;Yi Zhang ,&nbsp;Hanfeng Yang ,&nbsp;Chuan Zhang ,&nbsp;Jixin Liu","doi":"10.1016/j.neuroimage.2025.121237","DOIUrl":"10.1016/j.neuroimage.2025.121237","url":null,"abstract":"<div><div>High-definition transcranial alternating current stimulation (HD-tACS) targeting alpha rhythms (8–13 Hz) shows promise as a pain-relieving intervention, but individual responses vary widely. Understanding the neurobiological mechanism behind this variability is crucial for optimizing HD-tACS parameters to enhance its efficacy in pain relief. In a double-blind, within-subject, sham-controlled experimental study, 34 healthy participants were recruited. We investigated how individual differences in brain oscillations during rest and capsaicin-induced sustained pain states influence the efficacy of alpha HD-tACS. Participants underwent EEG assessments at rest and during capsaicin-induced sustained pain. They then received either sham or active HD-tACS on the sensorimotor cortex (SM1) or dorsolateral prefrontal cortex (DLPFC). We found significant reductions in delta and theta band power at the C4 electrode during sustained pain correlated with individual pain intensity. Additionally, stimulating the SM1 and DLPFC significantly relieved sustained pain. Resting alpha band power and changes in theta band power during sustained pain (the difference in theta band power between sustained pain and rest) at the C4 electrode were both significantly correlated with the pain-relieving efficacy of alpha HD-tACS on SM1. Notably, changes in theta band power mediated the relationship between resting alpha band power and pain-relieving efficacy. These results were not found with alpha HD-tACS on DLPFC. Our results suggest that the variations in theta band power during sustained pain may be crucial for understanding the variability in the efficacy of alpha HD-tACS targeting SM1. The factors influencing the efficacy of alpha HD-tACS on the DLPFC might be multifaceted.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"312 ","pages":"Article 121237"},"PeriodicalIF":4.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter hyperintensity tissue property spatial variations as a function of cognitive status in Parkinson’s disease","authors":"Mariyemuguli Reheman ,&nbsp;Sagar Buch ,&nbsp;Naying He ,&nbsp;Pei Huang ,&nbsp;Qiurong Yu ,&nbsp;Xinhui Wang ,&nbsp;Yu Liu ,&nbsp;Youmin Zhang ,&nbsp;Zhijia Jin ,&nbsp;Yan Li ,&nbsp;Peng Liu ,&nbsp;Shengdi Chen ,&nbsp;E. Mark Haacke ,&nbsp;Fuhua Yan","doi":"10.1016/j.neuroimage.2025.121236","DOIUrl":"10.1016/j.neuroimage.2025.121236","url":null,"abstract":"<div><h3>Background and purpose</h3><div>The pathological relationship between white matter hyperintensities (WMH) and cognitive impairment in Parkinson's disease (PD) remains unclear due to their variable locations, heterogeneity, and limited assessment of underlying tissue properties. This study integrates T2-FLAIR and quantitative MRI (qMRI) to investigate burden, spatial distribution, and extent of tissue alterations in WMH, aiming to elucidate their role in cognitive decline among PD patients.</div></div><div><h3>Methods</h3><div>A total of 122 age- and sex-matched PD patients and 65 healthy controls (HC) were recruited, with PD patients grouped by Montreal Cognitive Assessment (MoCA) score including normal, mild cognitive impairment (MCI) or PD with dementia (PDD). WMH burden was compared across groups and cognitive status. Water content, T1, and T2* measures were derived from qMRI data and tissue property heatmaps and periventricular distance profiles were constructed for all groups to visualize location-dependent tissue alterations of WMH relative to the lateral ventricles. In addition, voxel-wise analysis was performed to examine the correlation between WMH lesion tissue properties and MoCA scores.</div></div><div><h3>Results</h3><div>WMH volume was significantly higher in PDD compared to other groups (<em>p</em> &lt; 0.05) and negatively correlated with MoCA scores (<em>r</em> = −0.352, <em>p</em> &lt; 0.001). WMH appeared predominantly around the lateral ventricles, with anterior horn involvement common to all groups and posterior horn involvement specific to PDD. qMRI measures were significantly elevated in WMH compared to normal appearing white matter (NAWM) (<em>p</em> &lt; 0.001), with heatmaps showing a negative gradient of tissue property changes from the lateral ventricles to the NAWM. Voxel-wise analysis revealed a significant negative correlation between the qMRI tissue properties of periventricular WMH and MoCA scores, with the strongest association observed in the periventricular WM situated just beyond the boundary of the lateral ventricles.</div></div><div><h3>Conclusion</h3><div>Over and above volume differences, the spatial distribution and tissue property variations of WMH were closely linked to cognitive impairment in PD patients, with distinct patterns across different cognitive stages.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"312 ","pages":"Article 121236"},"PeriodicalIF":4.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CVAE-based generative model for generalized B1 inhomogeneity corrected chemical exchange saturation transfer MRI at 5 T","authors":"Ruifen Zhang ,&nbsp;Qiyang Zhang ,&nbsp;Yin Wu","doi":"10.1016/j.neuroimage.2025.121202","DOIUrl":"10.1016/j.neuroimage.2025.121202","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has emerged as a powerful tool to image endogenous or exogenous macromolecules. CEST contrast highly depends on radiofrequency irradiation &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;B&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt; level. Spatial inhomogeneity of &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;B&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt; field would bias CEST measurement. Conventional interpolation-based &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;B&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt; correction method required CEST dataset acquisition under multiple &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;B&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt; levels, substantially prolonging scan time. The recently proposed supervised deep learning approach reconstructed &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;B&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt; inhomogeneity corrected CEST effect at the identical &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;B&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt; as of the training data, hindering its generalization to other &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;B&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt; levels. In this study, we proposed a Conditional Variational Autoencoder (CVAE)-based generative model to generate &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;B&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt; inhomogeneity corrected Z spectra from single CEST acquisition. The model was trained from pixel-wise source–target paired Z spectra under multiple &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;B&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt; with target &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;B&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt; as a conditional variable. Numerical simulation and healthy human brain imaging at 5 T were respectively performed to evaluate the performance of proposed model in &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;B&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt; inhomogeneity corrected CEST MRI. Results showed that the generated &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;B&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt;-corrected Z spectra agreed well with the reference averaged from regions with subtle &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;B&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt; inhomogeneity. Moreover, the performance of the proposed model in correcting &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;B&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt; inhomogeneity in APT CEST effect, as measured by both &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;M&lt;/mi&gt;&lt;mi&gt;T&lt;/mi&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;R&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mi&gt;a&lt;/mi&gt;&lt;mi&gt;s&lt;/mi&gt;&lt;mi&gt;y&lt;/mi&gt;&lt;mi&gt;m&lt;/mi&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt; and &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;M&lt;/mi&gt;&lt;mi&gt;T&lt;/mi&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;R&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;R&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mi&gt;e&lt;/mi&gt;&lt;mi&gt;x&lt;/mi&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt; at 3.5 ppm, were superior over conventional Z/contrast-&lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;B&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt;&lt;/mrow","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"312 ","pages":"Article 121202"},"PeriodicalIF":4.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationships of resting-state brain entropy (BEN), ovarian hormones and behavioral inhibition and activation systems (BIS/BAS)","authors":"Donghui Song ,&nbsp;Ze Wang","doi":"10.1016/j.neuroimage.2025.121226","DOIUrl":"10.1016/j.neuroimage.2025.121226","url":null,"abstract":"<div><div>Brain entropy (BEN) quantifies irregularity, disorder and uncertainty of brain activity. Recent studies have linked BEN, derived from resting-state functional magnetic resonance imaging (rs-fMRI), to cognition, task activation, neuromodulation, and pharmacological interventions. However, it remains unknown whether BEN can reflect the effects of hormonal fluctuations. Furthermore, ovarian hormones are known to modulate behavioral traits, such as inhibitory control and impulsivity, as measured by the Behavioral Inhibition and Activation Systems (BIS/BAS). In this study, we investigated how ovarian hormones influence BEN and BIS/BAS in young adult women.</div><div>The forty-four participants (mean age = 22.61 ± 2.14 years) were obtained from OpenNeuro in the study. Ovarian hormones including estradiol (E2), progesterone (PROG) and BIS/BAS were acquired before scanning. The voxel-wise BEN maps were calculated from the preprocessed rs-fMRI images. Pearson’s correlation and mediation analyses were used to assess the relationships between BEN and ovarian hormones as well as BIS/BAS.</div><div>Our results revealed a negative correlation between BEN and PROG in frontoparietal network (FPN), including the dorsolateral prefrontal cortex (DLPFC) and posterior parietal cortex (PPC), as well as in the limbic network, encompassing the amygdala, hippocampus, and parahippocampal cortex. In contrast, BEN showed a positive correlation with impulsivity traits measured by the BAS-drive subscale of BAS in the left DLPFC. Additionally, PROG was negatively correlated with impulsivity traits measured by BAS-drive. Results from mediation analysis demonstrated that PROG reduces impulsivity, as measured by BAS-drive, by decreasing BEN in the left DLPFC and subsequently increasing functional connectivity (FC) within this region.</div><div>These findings provide the first evidence that BEN reflects the influence of PROG on brain function and behavior. Furthermore, they elucidate the neural mechanisms through which PROG modulates impulsivity traits measured by BAS-drive: PROG enhances the temporal coherence (decreased entropy) of neural activity in the left DLPFC, which in turn increases temporal synchronization (increased FC) within this region during resting-state, and then enhances executive control functions, thereby negatively regulating impulsivity. These findings provide new insights into our understanding of the effects of ovarian hormones on the brain and behavior in women.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"312 ","pages":"Article 121226"},"PeriodicalIF":4.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study on the detection and localization of interictal epileptiform discharges in magnetoencephalography using optically pumped magnetometers versus superconducting quantum interference devices","authors":"Jiechuan Ren ,&nbsp;Ming Ding ,&nbsp;Yuming Peng ,&nbsp;Chang Sun ,&nbsp;Chunqing Yang ,&nbsp;Shuxian Zhou ,&nbsp;Jiayin Tian ,&nbsp;Qun Wang ,&nbsp;Zhimei Li","doi":"10.1016/j.neuroimage.2025.121232","DOIUrl":"10.1016/j.neuroimage.2025.121232","url":null,"abstract":"<div><h3>Background</h3><div>Superconducting quantum interference device (SQUID)-based magnetoencephalography (MEG) holds substantial clinical value in epilepsy examination but is limited by the high costs. The optically pumped magnetometer (OPM)-based MEG appears promising in overcoming these limitations. This study aims to explore the consistency of interictal epileptiform discharge (IED) detection and source localization between OPM-MEG and SQUID-MEG in a large cohort of patients with epilepsy.</div></div><div><h3>Methods</h3><div>Patients with epilepsy underwent SQUID-MEG and 128-channel whole-scalp OPM-MEG examinations. IED detection, amplitude, signal-to-noise ratio (SNR), sensor-scalp distance, and source localization results were compared between OPM-MEG and SQUID-MEG through statistical analysis.</div></div><div><h3>Results</h3><div>The cohort comprised 46 patients with epilepsy (mean age, 23.7 ± 8.7 [SD] years; 29 male). McNemar <em>χ</em>² test indicated no significant difference for IED detection between two systems. OPM-MEG achieved a detection accuracy of 91.3 % compared with SQUID-MEG; a Gwet's first-order agreement coefficient (AC₁) of 0.892 suggested good consistency. Among 39 patients with IEDs detected by both systems, OPM-MEG demonstrated closer sensor-scalp distance (<em>p</em> &lt; 0.001), higher IED amplitude (<em>p</em> &lt; 0.001) and SNR (<em>p</em> = 0.003) compared with SQUID-MEG. At the sublobar level, OPM-MEG and SQUID-MEG exhibited nearly consistent source localization results. Among 24 patients with single dipole clusters, the average centroid distance between dipole clusters of OPM-MEG and SQUID-MEG was 12.16 ± 5.90 mm.</div></div><div><h3>Conclusion</h3><div>This real-world study demonstrated that OPM-MEG had comparable applicability in IED detection and source localization, compared with SQUID-MEG. Additionally, OPM-MEG performed better in terms of IED amplitude and SNR. Lower costs and user-friendly features highlight the clinical potential of OPM-MEG in epilepsy assessments.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"312 ","pages":"Article 121232"},"PeriodicalIF":4.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint resting state and structural networks characterize pediatric bipolar patients compared to healthy controls: a multimodal fusion approach","authors":"Xiaoping Yi ,&nbsp;Mingzhao Ma ,&nbsp;Xueying Wang ,&nbsp;Jinfan Zhang ,&nbsp;Feifei Wu ,&nbsp;Haimiao Huang ,&nbsp;Qian Xiao ,&nbsp;An Xie ,&nbsp;Peng Liu ,&nbsp;Alessandro Grecucci","doi":"10.1016/j.neuroimage.2025.121225","DOIUrl":"10.1016/j.neuroimage.2025.121225","url":null,"abstract":"<div><div>Pediatric bipolar disorder (PBD) is a highly debilitating condition, characterized by alternating episodes of mania and depression, with intervening periods of remission. Limited information is available about the functional and structural abnormalities in PBD, particularly when comparing type I with type II subtypes. Resting-state brain activity and structural grey matter, assessed through MRI, may provide insight into the neurobiological biomarkers of this disorder. In this study, Resting state Regional Homogeneity (ReHo) and grey matter concentration (GMC) data of 58 PBD patients, and 21 healthy controls matched for age, gender, education and IQ, were analyzed in a data fusion unsupervised machine learning approach known as transposed Independent Vector Analysis. Two networks significantly differed between BPD and HC. The first network included fronto- medial regions, such as the medial and superior frontal gyrus, the cingulate, and displayed higher ReHo and GMC values in PBD compared to HC. The second network included temporo-posterior regions, as well as the insula, the caudate and the precuneus and displayed lower ReHo and GMC values in PBD compared to HC. Additionally, two networks differ between type-I vs type-II in PBD: an occipito-cerebellar network with increased ReHo and GMC in type-I compared to type-II, and a fronto-parietal network with decreased ReHo and GMC in type-I compared to type-II. Of note, the first network positively correlated with depression scores. These findings shed new light on the functional and structural abnormalities displayed by pediatric bipolar patients.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"312 ","pages":"Article 121225"},"PeriodicalIF":4.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural substrates of attack event prediction in video games: the role of ventral posterior cingulate cortex and theory of mind network","authors":"Zhiwei Ye ,&nbsp;Chenyu Lv ,&nbsp;Hui Zhou ,&nbsp;Yanmeng Bao ,&nbsp;Tiantian Hong ,&nbsp;Qinghua He ,&nbsp;Yuzheng Hu","doi":"10.1016/j.neuroimage.2025.121228","DOIUrl":"10.1016/j.neuroimage.2025.121228","url":null,"abstract":"<div><div>Action anticipation, the ability to observe actions and predict the intent of others, plays a crucial role in social interaction and fields such as electronic sports. However, the neural mechanisms underlying the inference of purpose from action observation remain unclear. In this study, we conducted an fMRI experiment using video game combat scenarios to investigate the neural correlates of action anticipation and its relationship with task performance. The results showed that the higher level of ability to infer the purpose from action observation during experiment associates with higher level of proficiency in real world electric gaming competition. The action anticipation task activates visual streams, fronto-parietal network, and the ventral posterior cingulate cortex (vPCC), a key hub in the theory of mind network. The strength of vPCC activation during action anticipation, but not movement direction judgment, was positively correlated with gaming proficiency. Finite impulse response analysis revealed distinct dynamic response profiles in the vPCC compared to other theory of mind regions. These findings suggest that theory of mind ability may be an important factor influencing individual competitive performance, with the vPCC serving as a core neural substrate for inferring purpose from action observation.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"312 ","pages":"Article 121228"},"PeriodicalIF":4.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}