NeuroImage最新文献

{"title":"Meditation in the third-person perspective modulates minimal self and heartbeat-evoked potentials","authors":"Hang Yang ,&nbsp;Bruno Herbelin ,&nbsp;Chuong Ngo ,&nbsp;Loup Vuarnesson ,&nbsp;Olaf Blanke","doi":"10.1016/j.neuroimage.2025.121265","DOIUrl":"10.1016/j.neuroimage.2025.121265","url":null,"abstract":"<div><div>Experienced meditation practitioners often report altered states of their sense of self, including decentering and distancing the self from the body and one’s current concerns. Altered states of the sense of self, such as disembodiment and distancing of the self from the body, have also been induced experimentally using virtual reality (VR) and linked neurally to heartbeat-evoked potentials (HEPs). Whereas studies investigated the related neural correlates of such decentering during meditation, none experimentally modulated the sense of self during meditation practice using VR nor determined the potentially associated behavioral changes of the sense of self. Here we determined HEPs and behavioral measures in 23 participants who performed a guided meditation in VR, either from a third-person (3PP) or first-person perspective (1PP) to modulate the sense of self. In the 3PP-vs-1PP meditation condition, we report immediate effects including stronger sensations of detachment and disconnection, reduced salience of the perceived body boundary, and reduced self-identification with the body. HEP analysis revealed a more negative HEP amplitude in the 3PP condition, associated with activation of the posterior cingulate cortex and medial prefrontal cortex. Leveraging a new VR-supported meditation platform and methods, these data link the sense of self in meditation practice to the neuroscience of the bodily self, based on short-term subjective, behavioral, and neural changes. The study provides a foundation for future research on whether manipulating the minimal self in VR can aid in cultivating self-transcendent experiences reported by experienced meditators and whether integrating this manipulation facilitates the cultivation of long-term changes.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"314 ","pages":"Article 121265"},"PeriodicalIF":4.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of automatic MRI segmentation techniques with neuropsychological assessments for early diagnosis and prognosis of Alzheimer’s disease. A systematic review","authors":"Sabrina Bonarota ,&nbsp;Giulia Caruso ,&nbsp;Carlotta Di Domenico ,&nbsp;Sofia Sperati ,&nbsp;Federico Maria Tamigi ,&nbsp;Giovanni Giulietti ,&nbsp;Federico Giove ,&nbsp;Carlo Caltagirone ,&nbsp;Laura Serra","doi":"10.1016/j.neuroimage.2025.121264","DOIUrl":"10.1016/j.neuroimage.2025.121264","url":null,"abstract":"<div><h3>Background</h3><div>This systematic review investigates the integration of automatic segmentation techniques of magnetic resonance imaging (MRI) with neuropsychological assessments for early diagnosis and prognosis of Alzheimer’s Disease (AD).</div></div><div><h3>Objectives</h3><div>Focus on studies that utilise automated MRI segmentation and neuropsychological evaluations across the AD spectrum.</div></div><div><h3>Data sources</h3><div>A literature search was conducted on the PubMed database on 7 November 2024, using key terms related to MRI, segmentation, brain structures, AD, and cognitive decline.</div></div><div><h3>Study Eligibility Criteria</h3><div>Studies including individuals with AD, mild cognitive impairment (MCI), or subjective cognitive decline (SCD), utilising structural MRI, focusing on grey matter and automatic segmentation, and reporting cognitive assessments were included.</div></div><div><h3>Study Appraisal and Synthesis Methods</h3><div>Data were extracted and synthesised focusing on associations between MRI measures and cognitive tests, and discriminative values for diagnosis or prognosis.</div></div><div><h3>Results</h3><div>Seven studies were included, showing a significant association between structural changes in the medial temporal lobe and cognitive decline. The combination of MRI volumetric measures and neuropsychological scores enhanced diagnostic accuracy. Neuropsychological measures demonstrated superiority in the identification of patients with MCI and mild AD in comparison to MRI measures alone.</div></div><div><h3>Limitations</h3><div>Heterogeneity across studies, selection and measurement bias, and lack of non-response data were noted.</div></div><div><h3>Conclusions and Implications</h3><div>This review emphasises the necessity of integrating automated MRI segmentation with neuropsychological assessments for the diagnosis and prognosis of AD. While MRI is valuable, neuropsychological testing remains essential for early detection. Future studies should focus on developing integrated predictive models and refining neuroimaging techniques.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"314 ","pages":"Article 121264"},"PeriodicalIF":4.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural signatures underlying the effect of social structure on empathy and altruistic behaviors","authors":"Xia Tian ,&nbsp;Zixin Zheng ,&nbsp;Renhui Li ,&nbsp;Yue-Jia Luo ,&nbsp;Chunliang Feng","doi":"10.1016/j.neuroimage.2025.121267","DOIUrl":"10.1016/j.neuroimage.2025.121267","url":null,"abstract":"<div><div>Humans inhabit complex social networks, monitoring social structures that encompass both direct and indirect relationships. However, previous research primarily focused on direct relationships, leaving the neural basis of how social structure influences socioemotional processes understudied. This study addressed this gap by investigating the neural pathways underlying the influence of social structure on empathy and altruistic behaviors. During fMRI scanning, participants viewed painful or non-painful stimulation to innocent strangers who shared preferences with targets who had either treated participants fairly or unfairly. Afterwards, participants rated the pain experienced by these innocents and shared money with other innocents. Participants showed reduced empathic and altruistic responses toward innocents resembling unfair (vs. fair) targets, accompanied by heightened activation in regions crucial for emotion regulation and mentalizing, such as the lateral and medial prefrontal cortex. Furthermore, whole-brain and local neural patterns in the anterior insula and premotor cortex robustly discriminated painful (but not non-painful) stimulation of different innocents, suggesting that social structure altered emotional and sensorimotor aspects of empathy. These alterations might be driven by top-down regulation, as indicated by heightened functional connectivity between the lateral prefrontal cortex and sensorimotor areas, as well as between the anterior insula and subgenual anterior cingulate cortex when witnessing the pain of innocents resembling fair (vs. unfair) targets. Together, our work is the first to uncover the neural underpinnings through which human empathy and altruistic behaviors are shaped by social structure beyond direct self-other relationships.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"315 ","pages":"Article 121267"},"PeriodicalIF":4.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatio-temporal dynamics of sound-induced vestibular processing: insights from stereo-EEG recordings","authors":"Michele Terzaghi ,&nbsp;Piergiorgio d'Orio ,&nbsp;Ivana Sartori ,&nbsp;Veronica Pelliccia ,&nbsp;Flavia Maria Zauli ,&nbsp;Silvia Colnaghi ,&nbsp;Valter Rustioni ,&nbsp;Fausto Caruana ,&nbsp;Maria Del Vecchio ,&nbsp;Maurizio Versino ,&nbsp;Pietro Avanzini","doi":"10.1016/j.neuroimage.2025.121261","DOIUrl":"10.1016/j.neuroimage.2025.121261","url":null,"abstract":"<div><div>Numerous functions rely on the activation of the vestibular system, resulting in widespread activation of cortical brain regions. However, although the topographical organization of vestibular processing is relatively well understood, the temporal dynamics of this information processing remain insufficiently explored.</div><div>In this study, we conducted an in-depth analysis of intracerebral recordings from 107 patients (123 implanted hemispheres) to investigate the cortical response to acoustic and sound-induced vestibular stimuli (SVS), thus unveiling the spatiotemporal dynamics of vestibular processing. Our findings revealed the existence of distinct early components (phasic peak, 20–40 ms) localized in Heschl's area, planum temporale, retroinsula, posterior insular cortex, PFcm, parietal operculum, and structures above the Sylvian fissure. Moreover, we identified later, tonic components (peaking at 50–80 ms) characterized by an extended duration, returning to baseline between 200 and 300 ms. Remarkably, these latter components exclusively involved the perisylvian cortices.</div><div>The findings demonstrated that the early stages of human otolithic vestibular information processing involve both parallel and hierarchical pathways distributed across the perisylvian and peri‑Rolandic regions, rather than being restricted to a single primary cortical area. Furthermore, two distinct streams reminiscent of the dorsal/ventral dichotomy with specific spatio-temporal characteristics were identified.</div><div>Collectively, our study uncovers a complex and interconnected cortical network that underlies vestibular processing, shedding light on the temporal dynamics of this essential sensory system. These findings pave the way for a deeper understanding of the functional organization of the vestibular system and its implications for sensory perception and motor control.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"314 ","pages":"Article 121261"},"PeriodicalIF":4.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential neural responses to body image-related cyberbullying in adolescent females","authors":"Taliah Prince ,&nbsp;Jacob M. Levenstein ,&nbsp;Christina Driver ,&nbsp;Kate E. Mulgrew ,&nbsp;Lia Mills ,&nbsp;Amanda Boyes ,&nbsp;Zack Shan ,&nbsp;Larisa T. McLoughlin ,&nbsp;Daniel F. Hermens","doi":"10.1016/j.neuroimage.2025.121266","DOIUrl":"10.1016/j.neuroimage.2025.121266","url":null,"abstract":"<div><div>Body image-related cyberbullying (BRC), which targets an individual’s body shape, weight, and/or size, is associated with body dissatisfaction and maladaptive eating behaviours among adolescent females. However, its neurobiological mechanisms remain unclear. Using functional magnetic resonance imaging, we examined neural responses to BRC stimuli in 26 females (14–18 years; Mage = 15.54) from the Longitudinal Adolescent Brain Study. BRC stimuli elicited greater BOLD responses in regions implicated in emotional regulation (insula, anterior cingulate cortex), visual processing (lateral occipital cortex, fusiform gyrus), and social cognition (temporal pole, angular gyrus). Adolescents with recent cyberbullying experiences exhibited greater BOLD responses in the parahippocampal gyrus and lateral occipital cortex, whereas those without body dissatisfaction showed greater responses in the caudate and amygdala. Longitudinally, increased cyberbullying perpetration was associated with greater BOLD responses in the angular and middle temporal gyri. These findings provide insights into neurobiological pathways through which BRC may influence adolescent brain function and mental health.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"314 ","pages":"Article 121266"},"PeriodicalIF":4.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic blue light exposure induced spatial anxiety in an adolescent mouse model: Per2 upregulation and altered brain resting-state functional activity","authors":"Yu-Lin Hsieh ,&nbsp;Sheng-Min Huang ,&nbsp;Sebastian Yu ,&nbsp;Tzu-Ning Chao ,&nbsp;Chia-Wen Chiang ,&nbsp;Yu-Yu Kan ,&nbsp;Ying-Shuang Chang ,&nbsp;Li-Wei Kuo ,&nbsp;Hsin-Su Yu","doi":"10.1016/j.neuroimage.2025.121259","DOIUrl":"10.1016/j.neuroimage.2025.121259","url":null,"abstract":"<div><h3>Background</h3><div>Blue light (BL) is the primary component of light emitted from 3C devices. The use of 3C (computers, consumer electronics, and communication) devices has been increasing among all age groups. How social interaction and spatial cognition are affected in adolescents after long-term 3C device usage at night remains unclear.</div></div><div><h3>Methods</h3><div>Five-week-old mice were exposed to BL. Subsequently, these mice were subjected to social behavior tests, functional magnetic resonance imaging, and histopathologic analyses.</div></div><div><h3>Results</h3><div>BL exposure increased spatial anxiety but did not affect sociability, social novelty, or motor coordination. Also, BL exposure altered brain connectivity in the hippocampus (Hip), thalamus, and striatum, and it reduced brain activity in the retrosplenial cortex and dorsal part of the Hip. Spatial anxiety was associated with brain alterations. Although BL exposure reduced the size of retinal oligodendrocytes and increased the expression of the Period 2 circadian protein, it did not result in brain inflammation, at least not in the Hip.</div></div><div><h3>Conclusion</h3><div>Our findings highlight that long-term BL exposure in adolescents induces spatial anxiety. The underlying mechanisms include changes in brain activity and connectivity and the disruption of the circadian rhythm.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"314 ","pages":"Article 121259"},"PeriodicalIF":4.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of sleep deprivation on fractal and oscillatory spectral measures of the sleep EEG: A window on basic regulatory processes","authors":"Csenge G․ Horváth,&nbsp;Róbert Bódizs","doi":"10.1016/j.neuroimage.2025.121260","DOIUrl":"10.1016/j.neuroimage.2025.121260","url":null,"abstract":"<div><div>Sleep is vital for sustaining life; therefore, reliable measurement of its regulatory processes is of significant importance in research and medicine. Here we examine the effect of extended wakefulness on the putative indicators of fundamental sleep regulatory processes (spectral slope and spindle frequency) proposed by the Fractal and Oscillatory Adjustment model of sleep regulation by involving a healthy young adult sample in a 35-hour long sleep deprivation protocol. Wearable headband EEG-derived results revealed that NREM sleep electroencephalogram (EEG) spectral slope estimated in the 2–48 Hz range is an accurate indicator of the predicted changes in sleep depth induced by sleep deprivation (steepened slopes in recovery sleep) or by the overnight dissipation of sleep pressure (flattening slopes during successive sleep cycles). While the baseline overnight dynamics of the center frequency of the sleep spindle oscillations followed a U-shaped curve, and the timing of its minimum (the presumed phase indicator) correlated with questionnaire-based chronotype metrics as predicted, a different picture emerged during recovery sleep. Advanced recovery sleep advanced the timing of the minima of the oscillatory spindle frequency, reduced considerably its relationship with chronotype, but retained partially its U-shaped overnight evolution. Overall, our study supports the use of the spectral slope of the sleep EEG as a homeostatic marker of wake-sleep regulation, in addition, encourages further research on the EEG-derived measure of the circadian rhythm, primarily focusing on its interaction with the homeostatic process.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"314 ","pages":"Article 121260"},"PeriodicalIF":4.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From simulation to clinic: Assessing the required channel count for effective clinical use of OPM-MEG systems","authors":"Bing Yan ,&nbsp;Yuming Peng ,&nbsp;Yixiang Zhang,&nbsp;Yun Zhang,&nbsp;Haonan Zhang,&nbsp;Yifu Cao,&nbsp;Chang Sun,&nbsp;Ming Ding","doi":"10.1016/j.neuroimage.2025.121262","DOIUrl":"10.1016/j.neuroimage.2025.121262","url":null,"abstract":"<div><div>The channel count in an Optically Pumped Magnetometer Magnetoencephalography (OPM-MEG) system plays a pivotal role in determining its overall performance. While existing research consistently highlights that a greater number of channels enhances system capabilities, practical constraints such as sensor placement on the head, inter-channel interference, and cost-efficiency impose limitations on channel scalability. Additionally, the optimal channel count required for clinical applications of OPM-MEG remains unclear. In this study, we systematically investigate the impact of channel count on OPM-MEG performance by integrating simulations, phantom experiments, and human MEG experiments. Four configurations with varying channel counts (16, 32, 64, and 128) are evaluated. Specifically, systems with fewer channels (e.g., 16 channels) encounter significant challenges in meeting the demands of clinical MEG applications. In contrast, a 64-channel OPM-MEG system demonstrates performance metrics—such as signal-to-noise ratio (SNR) and localization accuracy—that are comparable to those of a 306-channel Superconducting Quantum Interference Device MEG (SQUID-MEG) system. Notably, a 128-channel OPM-MEG system surpasses the 306-channel SQUID-MEG system, achieving superior results. This work provides a detailed exploration of the relationship between channel count and OPM-MEG system performance, analyzing how many channels of the OPM-MEG system are suitable for clinical applications. By combining simulation-based evaluations with empirical measurements, we found that it is crucial to carefully select the appropriate number of channels based on the specific usage requirements in clinical applications.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"314 ","pages":"Article 121262"},"PeriodicalIF":4.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo cortical microstructure mapping using high-gradient diffusion MRI accounting for intercompartmental water exchange effects","authors":"Tanxin Dong ,&nbsp;Hong-Hsi Lee ,&nbsp;Han Zang ,&nbsp;Hansol Lee ,&nbsp;Qiyuan Tian ,&nbsp;Liang Wan ,&nbsp;Qiuyun Fan ,&nbsp;SusieY. Huang","doi":"10.1016/j.neuroimage.2025.121258","DOIUrl":"10.1016/j.neuroimage.2025.121258","url":null,"abstract":"<div><div>In recent years, mapping tissue microstructure in the cortex using high gradient diffusion MRI has received growing attention. The Soma And Neurite Density Imaging (SANDI) explicitly models the soma compartment in the cortex assuming impermeable membranes. As such, it does not account for diffusion time dependence due to water exchange in the estimated microstructural properties, as neurites in gray matter are much less myelinated than in white matter.</div><div>In this work, we performed a systematic evaluation of an extended SANDI model for <em>in vivo</em> human cortical microstructural mapping that accounts for water exchange effects between the neurite and extracellular compartments using the anisotropic Kärger model. We refer to this model as <em>in vivo</em> SANDIX, adapting the nomenclature from previous publications. As in the original SANDI model, the soma compartment is modeled as an impermeable sphere due to the much smaller surface-to-volume ratio compared to the neurite compartment. A Monte Carlo simulation study was performed to examine the sensitivity of the <em>in vivo</em> SANDIX model to sphere radii, compartment fractions, and water exchange times. The simulation results indicate that the proposed <em>in vivo</em> SANDIX framework can account for the water exchange effect and provide measures of intra-soma and intra-neurite signal fractions without spurious time-dependence in estimated parameters, whereas the measured water exchange times need to be interpreted with caution. The model was then applied to <em>in vivo</em> diffusion MRI data acquired in 13 healthy adults on the 3-Tesla Connectome MRI scanner equipped with 300 mT/m gradients. The <em>in vivo</em> results exhibited patterns that were consistent with corresponding anatomical characteristics in both cortex and white matter. In particular, the estimated water exchange times in gray and white matter were distinct and differentiated between the two tissue types.</div><div>Our results show the SANDIX approach applied to high-gradient diffusion MRI data achieves cortical microstructure mapping of the <em>in vivo</em> human brain with the evaluation of water exchange effects. This approach potentially provides a more appropriate description of <em>in vivo</em> cortical microstructure for improving data interpretation in future neurobiological studies.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"314 ","pages":"Article 121258"},"PeriodicalIF":4.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of experimental inflammation on the neuronal processing of cardiac interoceptive signals and heart rate variability in humans","authors":"Vera Flasbeck ,&nbsp;Manfred Schedlowski ,&nbsp;Martin Brüne ,&nbsp;Harald Engler","doi":"10.1016/j.neuroimage.2025.121257","DOIUrl":"10.1016/j.neuroimage.2025.121257","url":null,"abstract":"<div><div>Interoception, or the perception of internal somatic states, is crucial for signaling the individual to take care of the body when needed. It enables behavioral adaptations to sickness states, which further impact autonomic nervous system (ANS) activity. Whether acute inflammation affects interoceptive processing and how this relates to sickness behavior remains unknown. Therefore, we investigated interoceptive processing in participants undergoing experimental endotoxemia. In neuroimaging research, heartbeat-evoked potentials (HEP) - defined as event-related potentials time-locked to electrocardiogram (ECG) R-waves during electroencephalogram (EEG) recordings - have emerged as a promising metric for cardiac interoceptive processing. We analyzed the effects of intravenous administration of lipopolysaccharide (LPS; 0.4 ng/kg) or placebo, on HEP amplitudes and ANS functioning in healthy, female participants (<em>n</em> = 52) during 8 min resting-state EEG and ECG recordings before and 2 h after injections. Our results showed increased cortisol and cytokine levels in the LPS group, along with increased sympathetic and decreased parasympathetic activity 2 h after injections compared to the placebo group. Placebo-injected participants exhibited lower post injection-baseline differences in HEP amplitudes in an early timeframe (255–455 ms), indicating lower HEPs 2 h after administrations. Moreover, post-injection HEP amplitudes differed between groups, suggesting that while participants in the placebo group showed altered HEP amplitudes after injection, HEPs remained unresponsive to LPS administration. These findings are discussed in the context of predictive processing, expectation violation and attention direction to external and interoceptive cues. Future research should further investigate the role of LPS dose and explore behavioral measures of interoception under experimental inflammation.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"314 ","pages":"Article 121257"},"PeriodicalIF":4.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}