NeuroImage最新文献

{"title":"Unequal allocation alters the benefit of interactive decision-making in novices: A hyperscanning study","authors":"Yinying Hu ,&nbsp;Rongbin Zhang ,&nbsp;Zongyu Duan ,&nbsp;Meihuan Liu ,&nbsp;Xiaojun Cheng","doi":"10.1016/j.neuroimage.2025.121430","DOIUrl":"10.1016/j.neuroimage.2025.121430","url":null,"abstract":"<div><div>Equality is often considered fundamental for effective social interaction, while inequality seems to be counterproductive. Although interaction benefits under equal sharing are well-documented, how unequal reward allocation shapes such benefits and their neural basis remains unclear. This study examined dyads consisting of one “expert” and one “novice” (classified based on individual performance in baseline task) performing a joint dot-location estimation task during simultaneous functional near-infrared spectroscopy (fNIRS) hyperscanning. Three reward conditions were tested: equal reward distribution (ED), unequal distribution-expert advantage (EA), and unequal distribution-novice advantage (NA). Behaviorally, novices benefited from interaction in the ED and NA conditions, but not in EA, while experts showed no gains across conditions. Moreover, dyads compromised more under ED and NA, indicating reflecting greater mutual influence and cooperation. Neurally, inter-brain synchronization (IBS) was highest in EA between experts’ frontal pole (FP) and novices’ right temporoparietal junction (rTPJ) and dorsolateral prefrontal cortex (DLPFC). In contrast, both EA and NA elicited greater IBS than ED in fronto-executive pathways (expert-novice: FP–DLPFC, DLPFC–DLPFC), with NA in particular supporting novice benefit through enhanced coordination. Notably, IBS was lowest in the ED condition, despite behavioral benefits, suggesting that equal allocation may foster more streamlined or efficient neural collaboration. These findings indicate that unequal reward allocation modulates expert-novice neural coupling differently than equal allocation. Crucially, allocation favoring novices preserves behavioral interaction benefits alongside distinct fronto-executive neural synchrony patterns, revealing adaptive social and neural dynamics shaped by reward structures.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"319 ","pages":"Article 121430"},"PeriodicalIF":4.5,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cingulate and frontopolar cortical projections to the cerebellar vermis support prolonged reaction time in identifying negative emotional scenes in women","authors":"Hak Kei Wong ,&nbsp;Shefali Chaudhary ,&nbsp;Yu Chen ,&nbsp;Jaime S. Ide ,&nbsp;Sheng Zhang ,&nbsp;Chiang-Shan R. Li","doi":"10.1016/j.neuroimage.2025.121435","DOIUrl":"10.1016/j.neuroimage.2025.121435","url":null,"abstract":"<div><div>We previously observed sex differences in the association of individual anxiety and reaction time (RT) during identification of negative emotional scenes in a Hariri task. Prolonged RT, an attention marker, in identifying negative (vs. neutral) images correlated with anxiety level in women but not in men. However, the neural circuit that supports this behavioral observation remains unclear. Here, with a larger sample (64 men and 62 women), we employed whole-brain regression on individual differences in RT during matching negative vs. neutral images or RT (negative – neutral) and evaluated the results at a corrected threshold. Women but not men showed a significant correlation between individual anxiety and RT (negative – neutral), with a slope test confirming the sex difference. In women alone the cerebellar vermis showed activity in positive correlation with RT (negative – neutral). Further, Granger causality mapping (GCM) showed multiple brain regions, including the anterior cingulate cortex/frontopolar cortex (ACC/FPC), that provide inputs to the cerebellar vermis in women. Amongst these regions, only the ACC/FPC cluster showed activity (β) in significant correlation with both STAI State score and RT (negative – neutral) in women. GCM also identified a small cluster in the pons, suggesting that the cortical pontine cerebellar circuit may support prolonged RT during identification of negative emotions. Path analyses further characterized the inter-relationships amongst the neural markers, RT, and anxiety. These findings highlight a behavioral and circuit marker of anxiety state in neurotypical women. Studies with different behavioral paradigms are needed to characterize the behavioral and neural mechanisms of male anxiety.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"319 ","pages":"Article 121435"},"PeriodicalIF":4.5,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural changes in the gray matter of the contralateral hemisphere and prognosis of motor function in children with pharmacoresistant epilepsy before and after hemispherotomy","authors":"Yilin Zhao ,&nbsp;Dezhi Cao ,&nbsp;Fengjun Zhu ,&nbsp;Li Chen ,&nbsp;Zeshi Tan ,&nbsp;Turong Chen ,&nbsp;Hongwu Zeng","doi":"10.1016/j.neuroimage.2025.121429","DOIUrl":"10.1016/j.neuroimage.2025.121429","url":null,"abstract":"<div><h3>Objective</h3><div>Hemispherotomy (HS) is an effective treatment option to control seizures for children with pharmacoresistant epilepsy. We aimed to explore the alteration of the gray matter structure before and after surgery and identify the specific brain regions associated with preoperative neuropsychological development and postoperative motor development.</div></div><div><h3>Methods</h3><div>We conducted a retrospective study of magnetic resonance imaging (MRI) results, clinical parameters and follow-up data in 46 children who underwent hemispherotomy (HS) at our hospital between 2018 and 2022, and 32 controls were included. Voxel-based morphometry (VBM) and surface-based morphometry (SBM) techniques were employed to quantify the alteration of the gray matter structure. We used Spearman rank correlation and logistic regression models to analyze the influence of different factors on neuropsychological development and motor outcome.</div></div><div><h3>Results</h3><div>46 children with pharmacoresistant epilepsy undergoing hemispherotomy and 32 control subjects were recruited for this study. The patients were divided into two groups according to their surgical side: 29 patients with the left hemispherotomy (13 females, 17 months [IQR, 26 months]) and 17 patients with the right hemispherotomy (11 females, 19 months [IQR, 27.5 months]). Finally, 36 patients completed 13.80±1.54 months (LHS)/ 11.53±1.73 months (RHS) of follow-up, and 89.0 % remained completely seizure-free (outcome scale class IA). The prefrontal cortex showed a positive correlation with neuropsychological development before surgery. Cortical thickness (CT) of the anterior cingulate gyrus was an independent protective factor [OR=18.19, 95 % CI (1.56–212.43), <em>P</em> = 0.021] for motor function prognosis after surgery, while gray matter volume (GMV) of the temporal pole of the middle temporal gyrus was an independent risk factor [OR=0.07, 95 % CI (0.01–0.85), <em>P</em> = 0.037] after surgery.</div></div><div><h3>Significance</h3><div>Preoperative remodeling of prefrontal cortical gray matter structures in the contralateral hemisphere was performed for functional compensation. After surgery, the prefrontal and cingulate cortices resumed the normal developmental trajectories, with the cingulate cortex determining postoperative motor outcome. However, there is irreversible gray matter damage to the temporal lobe, leading to corresponding functional developmental deficits.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"319 ","pages":"Article 121429"},"PeriodicalIF":4.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontoparietal network activity during a combined action observation and proprioceptive stimulation protocol reveals long-term plasticity in the primary motor cortex","authors":"Ambra Bisio ,&nbsp;Costanza Iester ,&nbsp;Monica Biggio ,&nbsp;Laura Avanzino ,&nbsp;Sabrina Brigadoi ,&nbsp;Simone Cutini ,&nbsp;Laura Bonzano ,&nbsp;Marco Bove","doi":"10.1016/j.neuroimage.2025.121432","DOIUrl":"10.1016/j.neuroimage.2025.121432","url":null,"abstract":"<div><div>The aim of this study was to investigate changes in cortical hemodynamic activity within a frontoparietal network during the administration of an innovative action observation (AO) and proprioceptive stimulation (PS) protocol, and to examine whether this activity could predict the efficacy of the protocol in evoking M1 plasticity, reflected in significant long-term changes in M1 excitability. AO-PS was composed of 50 bursts of combined stimuli. Each burst consisted of five couples of AO and PS during which participants observed a video showing thumb opposition movements and simultaneously received a mechanical vibration on the extensor pollicis brevis muscle (stimulation frequency 80 Hz). During AO-PS, the hemodynamic activity was measured by means of functional Near-Infrared Spectroscopy. Recruitment curves were assessed using transcranial magnetic stimulation before, immediately, 30 and 60 min after AO-PS, to evaluate changes in M1 excitability. During AO-PS, a significant increase in oxyhemoglobin (HbO) concentration changes was found in the following Brodmann Areas (BA): left and right BA6, BA44, and BA43, left BA3, BA4, BA40 and BA7. The highest increment was found in the left BA4. In left BA7 and BA40 the time-to-peak in HbO concentration changes were reached significantly later than in the other BAs. On average, no significant changes were observed after AO-PS administration in M1 excitability, but HbO concentration changes in the left BA7 correlated with plasticity index. These findings highlight the involvement of sensorimotor and associative fronto-parietal regions during AO-PS. Additionally, the activity of the left BA7 revealed the plasticity induced by AO-PS in M1.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"319 ","pages":"Article 121432"},"PeriodicalIF":4.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive emotions and inhibitory control enhance prosocial sharing behavior in children under unequal resource conditions: An fNIRS study","authors":"Qingfeng Peng ,&nbsp;Jie Zhang ,&nbsp;Gege Liu ,&nbsp;Hong Li","doi":"10.1016/j.neuroimage.2025.121434","DOIUrl":"10.1016/j.neuroimage.2025.121434","url":null,"abstract":"<div><div>Prosocial sharing in unequal contexts is a core issue in children's moral and social development, but the underlying neural mechanisms and the role of emotion regulation and inhibitory control of cognitive structures in them remain under-explored. Leveraging the portability of functional near-infrared spectroscopy (fNIRS), this study measured prefrontal cortex oxyhemoglobin changes during sharing behaviors in children aged 6–9 under unequal resource conditions, and explored the contributions of emotion and cognitive regulation mechanisms. The results showed: (1) Children's sharing behavior significantly increased with age and varied across resource statuses; (2) Children with stronger inhibitory control and higher positive emotions showed greater prosocial tendencies; (3) In disadvantaged conditions, left dorsolateral prefrontal cortex (dlPFC) showed greater increase in HbO concentration than advantaged conditions. At the same time, children aged 8 to 9 also show significant differences in the left medial prefrontal cortex (mPFC) between different conditions; (4) Task-based functional connectivity analysis indicated that children aged 8–9 exhibited stronger connectivity in the right and left dorsolateral prefrontal cortices compared to their counterparts aged 6–7, as well as stronger connectivity in the bilateral medial prefrontal cortices. Moreover, the exploratory analysis revealed that the HbO concentration in the right dlPFC under disadvantageous conditions positively correlated with sharing behavior, while the HbO concentration in the left medial prefrontal cortex negatively correlated with sharing behavior in advantage conditions. In summary, this study provides the important neuroimaging evidence revealing that children's prosocial decision-making in unequal scenarios is jointly influenced by cognitive control and emotional assessment.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"319 ","pages":"Article 121434"},"PeriodicalIF":4.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel approach of [18F]FDG PET-based individual metabolic radiomics network to predict cognitive impairment in multiple system atrophy","authors":"Daoyan Hu ,&nbsp;Xiaofeng Dou ,&nbsp;Jing Wang ,&nbsp;Chentao Jin ,&nbsp;Ke Liu ,&nbsp;Rui Zhou ,&nbsp;Xiaohui Zhang ,&nbsp;Congcong Yu ,&nbsp;Yan Zhong ,&nbsp;Mei Tian ,&nbsp;Hong Zhang","doi":"10.1016/j.neuroimage.2025.121433","DOIUrl":"10.1016/j.neuroimage.2025.121433","url":null,"abstract":"<div><h3>Purpose</h3><div>Many efforts have been tried to evaluate multiple system atrophy (MSA)-related cognitive impairment, however, there is still lacking of effective approach. In this study, for the first time, we developed the individual metabolic radiomics networks (IMRN) using [¹⁸F]FDG PET imaging to investigate brain metabolic connectivity patterns of MSA and validated the usefulness of IMRN-based predictive model for MSA-related cognitive impairment.</div></div><div><h3>Methods</h3><div>In this retrospective study, we recruited 115 MSA patients with [¹⁸F]FDG PET/CT scans. IMRN was constructed by extracting non-redundant radiomics features from each brain region and computing pairwise Pearson correlation coefficients among these features. The validation of IMRN included assessments of small-world properties, test-retest reliability, and metabolic-genetic correlations. Connectome-based predictive modeling (CPM) was implemented to predict Mini Mental State Examination (MMSE) scores, while network-based statistics (NBS) were compared between MSA patients with cognitive impairment (MSA-CI, <em>n</em> = 58; MMSE &lt; 27) and those with normal cognition (MSA-NC, <em>n</em> = 57; MMSE ≥ 27). A support vector machine (SVM) classifier for detecting MSA-CI was developed using discriminative IMRN edges.</div></div><div><h3>Results</h3><div>IMRN showed small-world properties (σ &gt; 1), high reliability (average edge ICC = 0.754), and a significant correlation with gene expression (<em>r</em> = 0.44, <em>P</em> &lt; 0.001). CPM significantly predicted cognitive scores through IMRN edges (positive network: <em>r</em> = 0.27, <em>P</em> = 0.03; negative network: <em>r</em> = 0.28, <em>P</em> = 0.02). NBS revealed decreased cerebellar-cortical connectivity (73 edges) and increased intra-cerebellar/limbic connectivity (24 edges) in MSA-CI compared to MSA-NC. The IMRN-based SVM outperformed SUVR-based SVM in classifying MSA-CI (accuracy: 73.91% vs 62.61%; AUC: 0.80 vs 0.69).</div></div><div><h3>Conclusion</h3><div>This study established a novel approach of IMRN for assessing whole brain metabolic connectivity, uncovering distinct cerebellar connectivity patterns in MSA-CI, which held promise for facilitating personalized cognitive evaluations in MSA.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"319 ","pages":"Article 121433"},"PeriodicalIF":4.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic brain states during reasoning tasks: a co-activation pattern analysis","authors":"Fatemeh Hasanzadeh ,&nbsp;Christian Habeck ,&nbsp;Yaakov Stern","doi":"10.1016/j.neuroimage.2025.121431","DOIUrl":"10.1016/j.neuroimage.2025.121431","url":null,"abstract":"<div><div>Brain activity exhibits substantial temporal variability during cognitive processes, yet traditional fMRI analyses often fail to capture these dynamic patterns. Co-activation pattern (CAP) analysis has emerged as a promising method to study brain dynamics. CAP analysis provides a powerful framework for capturing transient brain states, however, its application to cognitive tasks remains very limited, with no prior studies specifically investigating its role in reasoning performance. This study investigated CAPs during reasoning tasks, their relationship with cognitive performance, age and other individual differences. We applied CAP analysis to fMRI data from 303 participants performing three reasoning tasks—Matrix Reasoning, Letter Sets, and Paper Folding—along with resting-state data. Using K-means clustering, we identified four distinct CAPs, each exhibiting unique spatial and temporal characteristics. These CAPs were analyzed in relation to predefined resting-state networks, revealing their functional relevance to cognitive task engagement. Key temporal metrics, including fraction occupancy, dwelling time, and transition probabilities, were assessed across reasoning tasks and resting state. The results demonstrate that CAP2 and CAP3 are predominantly engaged during reasoning tasks, with CAP2 strongly overlapping with the visual network and CAP3 exhibiting concurrent default mode and sensorimotor network activations. CAP1, primarily dominant during rest, showed prolonged engagement in older individuals, while CAP4 appeared to function as a transitional state facilitating network reorganization. Regression analyses link longer dwelling times and higher fraction occupancy of CAP2 and CAP3 to superior reasoning performance, whereas excessive transitions to CAP4 negatively impacted cognitive task outcomes. Additionally, aging was associated with reduced engagement in task-relevant CAPs and an increased tendency to transition into baseline-like states. These findings underscore the critical role of dynamic brain state reconfigurations in supporting cognition specifically reasoning and highlight CAP analysis as a powerful tool for studying transient brain function and individual cognitive differences.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"319 ","pages":"Article 121431"},"PeriodicalIF":4.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of the dorsomedial and the dorsolateral reach-to-grasp pathways’ roles in response to virtual visual perturbations of object goal","authors":"Mariusz P. Furmanek ,&nbsp;Luis F. Schettino ,&nbsp;Mathew Yarossi ,&nbsp;Sergei V. Adamovich ,&nbsp;Eugene Tunik","doi":"10.1016/j.neuroimage.2025.121428","DOIUrl":"10.1016/j.neuroimage.2025.121428","url":null,"abstract":"<div><div>Traditional research approaches to the reach-to-grasp movement have employed real-world perturbations involving physical objects. Recent technological advances provide new avenues for the investigation of sensorimotor control including the use of Virtual Reality Environments (VE). In this study, we used an immersive VE to produce compelling perturbations of target object size and position and Transcranial Magnetic Stimulation (TMS) to probe the neural bases of compensatory responses during grasping movements. Extensive research has identified a Dorsolateral (DL) and a Dorsomedial (DM) pathway as the likely neural bases for the sensorimotor coordination underlying grasping movements. In order to test the causal involvement of the parietal and premotor nodes of both pathways, we implemented visual perturbations of object size and distance at two different latencies (100 and 300 ms after movement onset) with concurrent TMS in a fully randomized design. The kinematic profiles of the grasping movements exhibited clear effects of the visual perturbations, particularly the late ones. We found that TMS stimulation of aIPS during the late perturbation of object size modified the timing of aperture closing. Similarly, TMS to PMv during the late perturbation of object distance reduced transport velocity during the compensatory double-peak. Our results support the involvement of the DL pathway when quick modifications including complex digit control are required. Against our expectations, sudden changes in target position did not elicit activity in the DM pathway. This study supports the notion that VE can be successfully employed for the study of the neural substrates of motor control.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"319 ","pages":"Article 121428"},"PeriodicalIF":4.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The somatosensory side of the affordance: How seeing an object influences touch","authors":"M. Galigani ,&nbsp;M. Romeo ,&nbsp;V. Bruno ,&nbsp;B. Forster ,&nbsp;F. Garbarini","doi":"10.1016/j.neuroimage.2025.121427","DOIUrl":"10.1016/j.neuroimage.2025.121427","url":null,"abstract":"<div><div>Object perception is inherently multisensory, as the brain integrates information across sensory modalities to facilitate the interaction with them. This intrinsic ‘action potential’ of objects is described by the concept of affordance, which refers to the opportunities for interaction that an object offers to an organism, depending on both the object’s physical characteristics and the organism’s sensorimotor abilities. Converging evidence demonstrated that seeing affordable objects modulates motor activity. Coherently, viewing graspable objects can also induce a somatosensory activation associated with their tactile manipulation. Yet, little is known about the representation of affordances in the somatosensory system. Here, we investigated whether visual perception of affordable objects modulates somatosensory evoked activity. Participants viewed images of affordable and non-affordable objects, while concomitantly probing the somatosensory system with tactile stimuli delivered to both index fingers. We found that viewing graspable objects enhances somatosensory processing, as indicated by higher somatosensory evoked potentials to tactile stimuli when paired with images of affordable objects compared to non-affordable objects.</div><div>These findings suggest that the observation of affordable objects triggers somatosensory responses associated with potential actions, supporting the view that object perception is a dynamic multisensory process. In everyday interactions, objects like cups are consistently grasped, leading to the formation of strong multisensory associations between objects’ visual features and tactile afferences. Once well-established, these associations may allow vision alone to activate stored tactile representations, enhancing somatosensory engagement, as observed in our study.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"319 ","pages":"Article 121427"},"PeriodicalIF":4.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putamen vascularization on high-resolution 7T MRI is associated with perfusion and cognitive performance in cerebral small vessel disease","authors":"Philipp Arndt ,&nbsp;Stefanie Boewe ,&nbsp;Jascha Brüggemann ,&nbsp;Berta Garcia-Garcia ,&nbsp;Renat Yakupov ,&nbsp;Niklas Vockert ,&nbsp;Anne Maas ,&nbsp;Malte Pfister ,&nbsp;Valentina Perosa ,&nbsp;Marwa Al Dubai ,&nbsp;Robin Jansen ,&nbsp;Sven G. Meuth ,&nbsp;Marc Dörner ,&nbsp;Patrick Müller ,&nbsp;Solveig Henneicke ,&nbsp;Frank Schreiber ,&nbsp;Katja Neumann ,&nbsp;Hendrik Mattern ,&nbsp;Stefanie Schreiber","doi":"10.1016/j.neuroimage.2025.121426","DOIUrl":"10.1016/j.neuroimage.2025.121426","url":null,"abstract":"<div><h3>Objective</h3><div>In cerebral small vessel disease (CSVD), compromised arterial supply to the deep gray matter contributes to cognitive decline. While CSVD frequently involves lenticulostriate arteries supplying the putamen, the functional consequences of altered putaminal vascular architecture remain unclear. We hypothesized that a less homogeneous arterial network in the putamen is associated with impaired perfusion and worse cognitive performance in CSVD.</div></div><div><h3>Methods</h3><div>We enrolled 16 CSVD patients with cerebral microbleeds and 21 age‑matched controls (mean age 71 years; 38 % female). High-resolution 7 T time‑of‑flight angiography was used to segment all visible intraputaminal vessels. For each voxel in the putamen, the distance to its nearest segmented vessel was computed to generate a vessel distance map; the mean vessel distance reflects the homogeneity of the arterial network. Putaminal perfusion was quantified via multi‑inversion time pulsed arterial spin labeling (ASL) at 3 T, and CSVD severity was scored on clinical 3 T MRI. All participants completed a comprehensive neuropsychological battery to derive a global cognition composite score.</div></div><div><h3>Results</h3><div>Linear regression revealed that higher CSVD MRI scores predicted larger mean vessel distance, reflecting a sparser arterial network, in both the right (B = 0.12, β = 0.42, p = 0.010) and left putamen (B = 0.13, β = 0.43, p = 0.014). Across all participants, increased vessel distance was also associated with prolonged arterial transit time in the right (B = 0.044, β = 0.50, p = 0.009) and left putamen (B = 0.042, β = 0.49, p = 0.009). Finally, in a multivariable linear regression adjusting for demographics, vascular risk factors, and CSVD severity, greater vessel distance in the right putamen was associated with lower global cognitive performance (B = –1.26, β = –0.34, p = 0.012).</div></div><div><h3>Conclusion</h3><div>This study demonstrates the impact of an impaired arterial network in the putamen on blood supply and cognitive function across the continuum of CSVD.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"319 ","pages":"Article 121426"},"PeriodicalIF":4.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}