NeuroImage最新文献

{"title":"The analyses of structural covariance and structural covariance similarity of cortical morphological measures","authors":"Xi Zhang ,&nbsp;Yanmin Peng ,&nbsp;Dongyue Li ,&nbsp;Ailin Hou ,&nbsp;Meng Liang ,&nbsp;Chunshui Yu","doi":"10.1016/j.neuroimage.2025.121118","DOIUrl":"10.1016/j.neuroimage.2025.121118","url":null,"abstract":"<div><div>Structural covariance refers to the concurrent changes in one morphological measure between two brain regions. Structural covariance of cortical morphological measures such as cortical thickness (CT), surface area (SA), and cortical volume (CV) have been applied to identify brain structural differences between patients with neuropsychiatric disorders and healthy controls. However, the precise relationships between structural covariance patterns of different cortical measures remain largely unknown. Here, we optimized the preprocessing and calculation approaches of structural covariances and investigated both global (whole-brain-level) and regional (brain-region-level) structural covariance similarities between CT, SA, and CV in 35,580 individuals. We found that Pearson correlation outperformed partial correlation due to generating fewer negative correlations of uncertain biological significance and principal component regression outperformed the regressions of total intracranial volume and respective global measures in removing global effects and reducing negative correlations. We observed that both global and regional covariance similarities of SA-CV were much higher than those of CT-CV and CT-SA, although they were influenced by the selection of atlases and covariance values. We also found age and sex effects on structural covariances and age effects on covariance similarities. The higher SA-CV covariance similarities than CT-CV indicates that SA contributes more to CV covariance than CT, although CV is derived from both CT and SA. The lack of CT-SA covariance similarities suggests that CT and SA have different covariance patterns and should be used in combination in structural covariance studies.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121118"},"PeriodicalIF":4.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive mood enhances gender stereotype activation during semantic integration and re-analysis","authors":"Marcin Naranowicz ,&nbsp;Katarzyna Jankowiak","doi":"10.1016/j.neuroimage.2025.121116","DOIUrl":"10.1016/j.neuroimage.2025.121116","url":null,"abstract":"<div><div>Gender stereotypes are deeply rooted in language, and their activation can be influenced by various factors. Behavioural evidence suggests that both positive and negative moods can modulate responses to stereotype-laden linguistic content. Early research also highlights the role of colour–gender associations in language processing. However, the neurocognitive mechanisms underlying the interaction between mood, gender stereotype activation, and colour–gender associations remain underexplored. Here, we provide novel neurocognitive evidence that a positive mood actively facilitates access to stereotype knowledge during the stage of semantic integration and re-analysis. Female participants induced into positive or negative moods made stereotype congruency judgments about sentences that were either congruent or incongruent with gender stereotypes, preceded by gendered (pink/blue circles) or gender-neutral (white circles) visual cues. First, the results showed smaller N200 amplitudes in a positive compared to negative mood only for sentences preceded by gender-neutral cues, suggesting that gender-driven expectancies evoked by gendered cues can override mood effects during early lexico-semantic processing. Second, we found smaller N400 amplitudes in a positive compared to negative mood, indicating overall facilitation of lexico-semantic processing in a positive mood, irrespective of stereotype congruency. Finally, we observed larger Late Positive Complex (LPC) amplitudes for stereotypically incongruent than congruent sentences only in a positive mood, pointing to gender stereotype knowledge modulating semantic integration and reanalysis processes in a positive but not negative mood.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121116"},"PeriodicalIF":4.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical neural activity during responses to mechanical perturbation: Effects of hand preference and hand used","authors":"Kevin Hooks ,&nbsp;Kimia Kiani ,&nbsp;Qiushi Fu","doi":"10.1016/j.neuroimage.2025.121111","DOIUrl":"10.1016/j.neuroimage.2025.121111","url":null,"abstract":"<div><div>Handedness is an important feature of human behavioral lateralization that has often been associated with hemispheric specialization. Existing neuroimaging research on the effect of handedness during motor control has focused on well-practiced or predictable tasks, but not tasks that involve unpredictable perturbations. We examined the extent to which handedness (measured by self-reported hand preference) and whether the dominant hand is used or not influence the motor and neural response during unimanual voluntary corrective actions. The experimental task involved controlling a robotic manipulandum to move a cursor from a center start point to a target presented above or below the start. In some trials, a mechanical perturbation of the hand was randomly applied by the robot either consistent or against the target direction, while electroencephalography (EEG) was recorded. Fourteen left-handers and fourteen right-handers completed the experiment. Left-handed individuals had a greater negative peak in the frontal event-related potential (ERP) during the initial voluntary response stage (N140) than right-handed individuals. Furthermore, left-handed individuals showed more symmetrical ERP distributions between two hemispheres than right-handed individuals in the frontal and parietal regions during the late voluntary response stage (P380). To the best of our knowledge, this is the first evidence to demonstrate the differences in the cortical control of voluntary corrective actions between left-handers and right-handers.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121111"},"PeriodicalIF":4.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural rhythmic speech activates network reorganization with frontal community enhancing communication efficiency in patients with intrinsic brain tumor","authors":"Leyan Gao ,&nbsp;Zhirui Yang ,&nbsp;Yuyao Zhou ,&nbsp;Jingwen Yang ,&nbsp;Qinqin Luo ,&nbsp;Ruiyan Feng ,&nbsp;Keting Ou ,&nbsp;Rui Feng ,&nbsp;Shuo Lu","doi":"10.1016/j.neuroimage.2025.121112","DOIUrl":"10.1016/j.neuroimage.2025.121112","url":null,"abstract":"<div><div>Brain tumors provide unique insights into brain plasticity due to their slow growth compared to acute cerebrovascular diseases. Despite relying on sophisticated functional networks, patients with brain tumors exhibit minimal deficits in higher language functions and demonstrate positive post-injury plasticity; however, the underlying neural mechanisms remain unclear. We utilized high-density electroencephalography to investigate language network plasticity in brain tumor patients without evident language deficits. Natural rhythmic sentences and non-rhythmic sentences with contrasting speech prosodic harmony were employed to examine the impact of task integrativeness on functional network reorganization. Our study reveals that rhythmic speech perception, characterized by higher processing integrativeness, induced inhibited task engagement in the frontal lobe but evoked enhanced hubness and modularity, which supported the generation of new connections and promoted the efficiency of global connectivity. Furthermore, local invasion in the frontal lobe prompted adjacent hubs to generate enriched connections during the early processing phase, facilitating later functional reorganization. Our findings underscore the significant role of global hubs in language network plasticity and reveal the importance of highly integrated tasks for network reorganization in language rehabilitation.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121112"},"PeriodicalIF":4.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain dynamics alterations induced by partial sleep deprivation: An energy landscape study","authors":"Yutong Wu ,&nbsp;Liming Fan ,&nbsp;Wei Chen ,&nbsp;Xing Su ,&nbsp;Simeng An ,&nbsp;Nan Yao ,&nbsp;Qian Zhu ,&nbsp;Zi-Gang Huang ,&nbsp;Youjun Li","doi":"10.1016/j.neuroimage.2025.121108","DOIUrl":"10.1016/j.neuroimage.2025.121108","url":null,"abstract":"<div><div>Partial sleep deprivation (PSD) alters neural activity of intrinsic brain networks involved in cognitive functions. However, the age-related time-varying properties of large-scale brain functional networks after PSD remain unknown. Our study applied energy landscape analysis to resting-state functional magnetic resonance imaging data to characterize the dominant brain activity patterns in 36 healthy young (19 females, 23.53 ± 2.36 years) and 33 healthy older (18 females, 68.81 ± 2.41 years) adults after full sleep (FS) and PSD. Dynamic properties of these patterns, including appearance probability, duration and transitions, were then calculated. Finally, a 10⁵ steps numerical simulation was performed on each energy landscape. We found that the energy landscapes of the younger and older groups had similar hierarchical structures, including two major states and two minor states. The two major states showed complementary spontaneous activation patterns. But the PSD has altered the temporal evolution of these major brain states in younger participants, manifested by significantly higher appearance frequency of the major states and the direct transitions between major states than FS. These changes were not significant in older participants. Additionally, the weaker functional segregation between two modules assigned by two complementary major states was found during PSD than FS in young group. We further demonstrated that such abnormal brain network functional coordination was associated with the atypical brain dynamics and behaviors. These findings suggested a low-dimensional and restricted dynamic landscape of brain activity in young adults after PSD and provided new insight into understand the neural effects of PSD.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121108"},"PeriodicalIF":4.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A potential role for the middle temporal gyrus in mediating pain rumination in patients with chronic pain","authors":"Eri Shinto ,&nbsp;Sushuang Yang ,&nbsp;Atsushi Shinto ,&nbsp;Jiro Kurata","doi":"10.1016/j.neuroimage.2025.121106","DOIUrl":"10.1016/j.neuroimage.2025.121106","url":null,"abstract":"<div><div>Perception of pain offset is essential to free one from any aftereffects of nociception. Because patients with chronic pain show impaired temporal contrast of pain, we tested whether they show slower perception of pain offset after the end of a nociceptive stimulus compared with pain-free subjects. We sought for cerebral correlates for offset and aftereffects of pain using functional magnetic resonance imaging (fMRI). In 19 patients with chronic pain and 15 pain-free subjects, we gave 10 blocks of pain stimuli by a Peltier-type thermal stimulator on the left volar forearm and recorded pain intensity continuously by a visual analogue scale (VAS), while performing whole-brain fMRI. We measured latency to reach “no pain” after stimulus offset (VAS End Latency). We analyzed fMRI signal changes during cessation of pain and made a between-group comparison. Individual parameters were sought for correlations with the rumination score from the Pain Catastrophizing Scale. Patients showed a longer VAS End Latency, and a larger after-pain activity in the left middle temporal gyrus, the right parietal lobule and, after small-volume correction, the right dorsolateral prefrontal cortex than pain-free subjects. Both VAS End Latency and after-pain activity were positively correlated with the rumination score. Psychophysiological interaction analysis revealed that higher rumination scores were associated with weaker coupling between the middle temporal and prefrontal cortices in patients and pain-free subjects with positive rumination scores. We suggest a possible role for the middle temporal gyrus in mediating pain aftereffects and rumination, and its modulation by the prefrontal-temporal network.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121106"},"PeriodicalIF":4.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UTE MRI for assessing demyelination in an mTBI mouse model: An open-field low-intensity blast study","authors":"Yajun Ma ,&nbsp;Qingbo Tang ,&nbsp;Xin Cheng ,&nbsp;Jiyo S. Athertya ,&nbsp;David Coughlin ,&nbsp;Eric Y. Chang ,&nbsp;Catherine E. Johnson ,&nbsp;Jiankun Cui ,&nbsp;Zezong Gu ,&nbsp;Jiang Du","doi":"10.1016/j.neuroimage.2025.121103","DOIUrl":"10.1016/j.neuroimage.2025.121103","url":null,"abstract":"<div><div>Mild traumatic brain injury (mTBI) is a leading cause of long-term disability. Following mTBI, secondary chemical cascades and neuroinflammation can result in myelin damage, significantly impairing cognitive function. This study aims to assess demyelination in mice with mTBI induced by open-field low-intensity blast (LIB) using a novel three-dimensional short repetition time adiabatic inversion recovery UTE (3D STAIR-UTE) magnetic resonance imaging (MRI) sequence. Thirty male C57BL/6 mice, with 15 experiencing mTBI and 15 serving as sham controls, were included in this study. Behavioral tests were performed starting at 5 days post-injury to assess motor activity and anxiety-like responses followed by STAIR-UTE imaging using a pre-clinical 3T MRI scanner. Additionally, a proton density-weighted UTE sequence was scanned alongside the STAIR-UTE for quantification of myelin proton fraction (MPF). Luxol fast blue (LFB) staining was performed to evaluate myelin changes between the mTBI group and the control group. The behavioral tests indicated decreased motor activity in the center zone and increased anxiety-like response in the mTBI mice compared to sham controls. The STAIR-UTE sequence revealed significantly lower MPFs in the corpus callosum of mTBI mice (8.4 ± 0.4 % vs. 8.7 ± 0.4 %; <em>P</em> = 0.003), consistent with the myelin reduction observed in the LFB staining (0.77 ± 0.22 vs. 1.09 ± 0.15; <em>P</em> = 0.004). Our findings demonstrate that the STAIR-UTE sequence facilitates quantitative myelin imaging at 3T MRI, enabling the detection of demyelination in the white matter of the mouse brain associated with alterations in motor and anxiety domains post-LIB exposure.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121103"},"PeriodicalIF":4.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White-Matter fiber tract and resting-state functional connectivity abnormalities in young children with autism spectrum disorder","authors":"Jia Wang ,&nbsp;Natasha Y.S. Kawata ,&nbsp;Xuan Cao ,&nbsp;Jie Zhang ,&nbsp;Takashi X. Fujisawa ,&nbsp;Xinyi Zhang ,&nbsp;Lili Fan ,&nbsp;Wei Xia ,&nbsp;Lijie Wu ,&nbsp;Akemi Tomoda","doi":"10.1016/j.neuroimage.2025.121109","DOIUrl":"10.1016/j.neuroimage.2025.121109","url":null,"abstract":"<div><div>Autism spectrum disorder (ASD) is a complex developmental disorder characterized by difficulties in social interaction and communication and repetitive behaviors. Although abnormal brain development has been shown to exist in children with ASD, the link between structural brain abnormalities and resting-state functional connectivity (rsFC) disruptions in children with ASD remains understudied. To address this limitation, we utilized the population-based bundle-to-region connectome, providing a detailed understanding of the connectivity between cortical regions and white matter (WM) tracts. By precisely indexing WM-Gray Matter (GM) interactions, we investigated the rsFC of the cortex-associated ROIs to explore the association between structural and rsFC abnormalities and clinical symptoms in young children with ASD. This MRI study identified significant differences in WM structure and rsFC between children with ASD (<em>n</em> = 34) and typically developing children (TD, <em>n</em> = 43). Our results showed that decreased fractional anisotropy (FA) and increased mean diffusivity (MD) and radial diffusivity (RD) in ASD WM tracts compared to TD, particularly in left hemisphere tracts (anterior thalamic radiation [ATR], cingulum, inferior fronto-occipital fasciculus [IFOF], inferior longitudinal fasciculus [ILF], superior longitudinal fasciculus [SLF], and uncinate fasciculus [UF]). Abnormal rsFC was observed in GM areas connected by ATR, cingulum, IFOF, ILF, and SLF. Furthermore, abnormalities in the structural and functional connectivity index (SFCI) within the SLF and cingulum were identified. An association has been observed between these abnormalities and clinical symptoms. Specifically, SLF structural and functional connectivity appear to be associated with repetitive and restrictive behavior (RRB), while cingulum connectivity is associated with communication abilities. In conclusion, young children with ASD exhibit abnormal WM tract structures and associated rsFC abnormalities. These differences highlight significant disruptions in rsFC mapped from WM tracts to cortical areas in ASD, correlating with the severity of ASD symptoms, and suggest the importance of multi-modal imaging in capturing these variations.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121109"},"PeriodicalIF":4.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinguishing the roles of edge, color, and other surface information in basic and superordinate scene representation","authors":"Liansheng Yao ,&nbsp;Qiufang Fu ,&nbsp;Chang Hong Liu ,&nbsp;Jianyong Wang ,&nbsp;Zhang Yi","doi":"10.1016/j.neuroimage.2025.121100","DOIUrl":"10.1016/j.neuroimage.2025.121100","url":null,"abstract":"<div><div>The human brain possesses a remarkable ability to recognize scenes depicted in line drawings, despite that these drawings contain only edge information. It remains unclear how the brain uses this information alongside surface information in scene recognition. Here, we combined electroencephalogram (EEG) and multivariate pattern analysis (MVPA) methods to distinguish the roles of edge, color, and other surface information in scene representation at the basic category level and superordinate naturalness level over time. The time-resolved decoding results indicated that edge information in line drawings is both sufficient and more effective than in color photographs and grayscale images at the superordinate naturalness level. Meanwhile, color and other surface information are exclusively involved in neural representation at the basic category level. The time generalization analysis further revealed that edge information is crucial for representation at both levels of abstraction. These findings highlight the distinct roles of edge, color, and other surface information in dynamic neural scene processing, shedding light on how the human brain represents scene information at different levels of abstraction.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121100"},"PeriodicalIF":4.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stimulation of the anterior thalamus modulates behavior in multiple cognitive domains","authors":"Ha Neul Song ,&nbsp;Yu Jin Rah ,&nbsp;Ik Hyun Ryu ,&nbsp;Jung Han Shin ,&nbsp;Seunghoon Lee ,&nbsp;Young-Min Shon ,&nbsp;Sang Ah Lee","doi":"10.1016/j.neuroimage.2025.121101","DOIUrl":"10.1016/j.neuroimage.2025.121101","url":null,"abstract":"<div><h3>Background</h3><div>Deep Brain Stimulation (DBS) of the ATN (Anterior Thalamic Nuclei) has been used to treat refractory epilepsy. Despite the fact that the ATN plays a crucial role in various cognitive functions, including emotional processing, memory, and spatial navigation, there is limited understanding of the effects of ATN-DBS across multiple cognitive domains.</div></div><div><h3>Objective</h3><div>In order to gain insight into the variability in the cognitive outcome of DBS across tasks and individuals, we investigated effects of ATN-DBS on multiple cognitive functions within the same patients and stimulation parameters.</div></div><div><h3>Methods</h3><div>Eleven patients with refractory epilepsy performed four cognitive behavioral tasks: Emotional Attention Network, Emotional Face Categorization, Word Recognition, and Head Direction. In each task, reaction time, emotional response, or accuracy was measured under on- and off-DBS conditions. Volumes of tissue activated (VTA) were also estimated to investigate target-specific effects on cognition.</div></div><div><h3>Results</h3><div>ATN-DBS facilitated attention following the presentation of a negative visual stimulus and increased the inclination to perceive a face as expressing an emotion. Furthermore, ATN-DBS disrupted the precision of head direction in the absence of visual cues. Although overall word recognition memory appeared unaffected by ATN-DBS, individual performance changes depended on the location of VTAs. Interestingly, modulation in one cognitive domain did not consistently result in changes in other domains.</div></div><div><h3>Conclusions</h3><div>ATN-DBS can influence human behavior across multiple cognitive domains, but with varying degrees of individual difference across tasks. The findings emphasize the complexity of the ATN in its involvement in human cognition and provide novel insight into individualized methods for neuromodulation.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121101"},"PeriodicalIF":4.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}