NeuroImage最新文献_第4页

Contrastive learning of shared spatiotemporal EEG representations across individuals for naturalistic neuroscience 针对自然神经科学的跨个体共享时空脑电图表征的对比学习。

IF 4.7 2区医学

NeuroImage Pub Date : 2024-10-15 DOI: 10.1016/j.neuroimage.2024.120890

{"title":"Contrastive learning of shared spatiotemporal EEG representations across individuals for naturalistic neuroscience","authors":"","doi":"10.1016/j.neuroimage.2024.120890","DOIUrl":"10.1016/j.neuroimage.2024.120890","url":null,"abstract":"<div><div>Neural representations induced by naturalistic stimuli offer insights into how humans respond to stimuli in daily life. Understanding neural mechanisms underlying naturalistic stimuli processing hinges on the precise identification and extraction of the shared neural patterns that are consistently present across individuals. Targeting the Electroencephalogram (EEG) technique, known for its rich spatial and temporal information, this study presents a framework for Contrastive Learning of Shared SpatioTemporal EEG Representations across individuals (CL-SSTER). CL-SSTER utilizes contrastive learning to maximize the similarity of EEG representations across individuals for identical stimuli, contrasting with those for varied stimuli. The network employs spatial and temporal convolutions to simultaneously learn the spatial and temporal patterns inherent in EEG. The versatility of CL-SSTER was demonstrated on three EEG datasets, including a synthetic dataset, a natural speech comprehension EEG dataset, and an emotional video watching EEG dataset. CL-SSTER attained the highest inter-subject correlation (ISC) values compared to the state-of-the-art ISC methods. The latent representations generated by CL-SSTER exhibited reliable spatiotemporal EEG patterns, which can be explained by properties of the naturalistic stimuli. CL-SSTER serves as an interpretable and scalable framework for the identification of inter-subject shared neural representations in naturalistic neuroscience.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural correlates of working memory training: An fMRI meta-analysis 工作记忆训练的神经相关性：fMRI 元分析

IF 4.7 2区医学

NeuroImage Pub Date : 2024-10-11 DOI: 10.1016/j.neuroimage.2024.120885

引用次数: 0

Neuro-immune communication at the core of craving-associated brain structural network reconfiguration in methamphetamine users 神经免疫交流是甲基苯丙胺吸食者渴求相关脑结构网络重组的核心。

IF 4.7 2区医学

NeuroImage Pub Date : 2024-10-09 DOI: 10.1016/j.neuroimage.2024.120883

{"title":"Neuro-immune communication at the core of craving-associated brain structural network reconfiguration in methamphetamine users","authors":"","doi":"10.1016/j.neuroimage.2024.120883","DOIUrl":"10.1016/j.neuroimage.2024.120883","url":null,"abstract":"<div><div>Methamphetamine (MA) use disorder is a chronic neurotoxic brain disease characterized by a high risk of relapse driven by intense cravings. However, the neurobiological signatures of cravings remain unclear, limiting the effectiveness of various treatment methods. Diffusion MRI (dMRI) scans from 62 MA users and 57 healthy controls (HC) were used in this study. The MA users were longitudinally followed up during their period of long-term abstinence (duration of long-term abstinence: 347.52±99.25 days). We systematically quantified the control ability of each brain region for craving-associated state transitions using network control theory from a causal perspective. Craving-associated structural alterations (CSA) were investigated through multivariate group comparisons and biological relevance analysis. The neural mechanisms underlying CSA were elucidated using transcriptomic and neurochemical analyses. We observed that long-term abstinence-induced structural alterations significantly influenced the state transition energy involved in the cognitive control response to external information, which correlated with changes in craving scores (<em>r</em> ∼ 0.35, <em>P</em> <0.01). Our causal network analysis further supported the crucial role of the prefrontal cortex (PFC) in craving mechanisms. Notably, while the PFC is central to the craving, the CSAs were distributed widely across multiple brain regions (<em>P<sub>FDR</sub></em><0.05), with strong alterations in somatomotor regions (<em>P<sub>FDR</sub></em><0.05) and moderate alterations in high-level association networks (<em>P<sub>FDR</sub></em><0.05). Additionally, transcriptomic, chemical compounds, cell-type analyses, and molecular imaging collectively highlight the influence of neuro-immune communication on human craving modulation. Our results offer an integrative, multi-scale perspective on unraveling the neural underpinnings of craving and suggest that neuro-immune signaling may be a promising target for future human addiction therapeutics.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resting state of human brain measured by fMRI experiment is governed more dominantly by essential mode as a global signal rather than default mode network 通过 fMRI 实验测量的人脑静息状态更主要地受作为全局信号的基本模式而非默认模式网络的支配。

IF 4.7 2区医学

NeuroImage Pub Date : 2024-10-06 DOI: 10.1016/j.neuroimage.2024.120884

{"title":"Resting state of human brain measured by fMRI experiment is governed more dominantly by essential mode as a global signal rather than default mode network","authors":"","doi":"10.1016/j.neuroimage.2024.120884","DOIUrl":"10.1016/j.neuroimage.2024.120884","url":null,"abstract":"<div><div>Resting-state of the human brain has been described by a combination of various basis modes including the default mode network (DMN) identified by fMRI BOLD signals in human brains. Whether DMN is the most dominant representation of the resting-state has been under question. Here, we investigated the unexplored yet fundamental nature of the resting-state. In the absence of global signal regression for the analysis of brain-wide spatial activity pattern, the fMRI BOLD spatiotemporal signals during the rest were completely decomposed into time-invariant spatial-expression basis modes (SEBMs) and their time-evolution basis modes (TEBMs). Contrary to our conventional concept above, similarity clustering analysis of the SEBMs from 166 human brains revealed that the most dominant SEBM cluster is an asymmetric mode where the distribution of the sign of the components is skewed in one direction, for which we call essential mode (EM), whereas the second dominant SEBM cluster resembles the spatial pattern of DMN. Having removed the strong 1/f noise in the power spectrum of TEBMs, the genuine oscillatory behavior embedded in TEBMs of EM and DMN-like mode was uncovered around the low-frequency range below 0.2 Hz.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The dorsomedial prefrontal cortex promotes self-control by inhibiting the egocentric perspective 背内侧前额叶皮层通过抑制自我中心视角来促进自我控制。

IF 4.7 2区医学

NeuroImage Pub Date : 2024-10-05 DOI: 10.1016/j.neuroimage.2024.120879

{"title":"The dorsomedial prefrontal cortex promotes self-control by inhibiting the egocentric perspective","authors":"","doi":"10.1016/j.neuroimage.2024.120879","DOIUrl":"10.1016/j.neuroimage.2024.120879","url":null,"abstract":"<div><div>The dorsomedial prefrontal cortex (dmPFC) plays a crucial role in social cognitive functions, including perspective-taking. Although perspective-taking has been linked to self-control, the mechanism by which the dmPFC might facilitate self-control remains unclear. Using the multimodal neuroimaging dataset from the Human Connectome Project (Study 1, <em>N</em> =978 adults), we established a reliable association between the dmPFC and self-control, as measured by discounting rate—the tendency to prefer smaller, immediate rewards over larger, delayed ones. Experiments (Study 2, <em>N</em> = 36 adults) involving high-definition transcranial direct current stimulation showed that anodal stimulation of the dmPFC reduces the discounting of delayed rewards and decreases the congruency effect in egocentric but not allocentric perspective in the visual perspective-taking tasks. These findings suggest that the dmPFC promotes self-control by inhibiting the egocentric perspective, offering new insights into the neural underpinnings of self-control and perspective-taking, and opening new avenues for interventions targeting disorders characterized by impaired self-regulation.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strength of activation and temporal dynamics of bioluminescent-optogenetics in response to systemic injections of the luciferin 全身注射荧光素后生物发光-光遗传学的激活强度和时间动态。

IF 4.7 2区医学

NeuroImage Pub Date : 2024-10-02 DOI: 10.1016/j.neuroimage.2024.120882

{"title":"Strength of activation and temporal dynamics of bioluminescent-optogenetics in response to systemic injections of the luciferin","authors":"","doi":"10.1016/j.neuroimage.2024.120882","DOIUrl":"10.1016/j.neuroimage.2024.120882","url":null,"abstract":"<div><div>BioLuminescent OptoGenetics (“BL-OG”) is a chemogenetic method that can evoke optogenetic reactions in the brain non-invasively. In BL-OG, an enzyme that catalyzes a light producing reaction (i.e., a luciferase) is tethered to an optogenetic element that is activated in response to bioluminescent light. Bioluminescence is generated by injecting a chemical substrate (<em>luciferin</em>, e.g., h-Coelenterazine; h-CTZ) that is catalyzed by the luciferase. By directly injecting the luciferin into the brain, we show that bioluminescent light is proportional to spiking activity, and this relationship scales as a function of luciferin dosage. Here, we build on these previous observations by characterizing the temporal dynamics and dose response curves of bioluminescence generated by luminopsins (LMOs), a proxy of BL-OG effects, to intravenous (IV) injections of the luciferin. We imaged bioluminescence through a thinned skull of mice running on a wheel, while delivering h-CTZ via the tail vein with different dosage concentrations and injection rates. The data reveal a systematic relationship between strength of bioluminescence and h-CTZ dosage, with higher concentration generating stronger bioluminescence. We also found that bioluminescent activity occurs rapidly (< 60 s after IV injection) regardless of concentration dosage. However, as expected, the onset time of bioluminescence is delayed as the injection rate decreases. Notably, the strength and time decay of bioluminescence is invariant to the injection rate of h-CTZ. Taken together, these data show that BL-OG effects are highly consistent across injection parameters of h-CTZ, highlighting the reliability of BL-OG as a minimally invasive neuromodulation method.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of white matter in young adulthood: The speed of brain aging and its relationship with changes in fractional anisotropy 青年期白质的发育：大脑老化的速度及其与分数各向异性变化的关系。

IF 4.7 2区医学

NeuroImage Pub Date : 2024-10-01 DOI: 10.1016/j.neuroimage.2024.120881

{"title":"Development of white matter in young adulthood: The speed of brain aging and its relationship with changes in fractional anisotropy","authors":"","doi":"10.1016/j.neuroimage.2024.120881","DOIUrl":"10.1016/j.neuroimage.2024.120881","url":null,"abstract":"<div><div>White matter (WM) development has been studied extensively, but most studies used cross-sectional data, and to the best of our knowledge, none of them considered the possible effects of biological (vs. chronological) age. Therefore, we conducted a longitudinal multimodal study of WM development and studied changes in fractional anisotropy (FA) in the different WM tracts and their relationship with cortical thickness-based measures of brain aging in young adulthood. A total of 105 participants from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) prenatal birth cohort underwent magnetic resonance imaging (MRI) at the age of 23-24, and the age of 28-30 years. At both time points, FA in the different WM tracts was extracted using the JHU atlas, and brain age gap estimate (BrainAGE) was calculated using the Neuroanatomical Age Prediction using R (NAPR) model based on cortical thickness maps. Changes in FA and the speed of cortical brain aging were calculated as the difference between the respective variables in the late vs. early 20s. We demonstrated tract-specific increases as well as decreases in FA, which indicate that the WM microstructure continues to develop in the third decade of life. Moreover, the significant interaction between the speed of cortical brain aging, tract, and sex on mean FA revealed that a greater speed of cortical brain aging in young adulthood predicted greater decreases in FA in the bilateral cingulum and left superior longitudinal fasciculus in young adult men. Overall, these changes in FA in the WM tracts in young adulthood point out the protracted development of WM microstructure, particularly in men.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analgesic effect of dance movement therapy: An fNIRS study 舞蹈动作疗法的镇痛效果：一项 fNIRS 研究。

IF 4.7 2区医学

NeuroImage Pub Date : 2024-10-01 DOI: 10.1016/j.neuroimage.2024.120880

{"title":"Analgesic effect of dance movement therapy: An fNIRS study","authors":"","doi":"10.1016/j.neuroimage.2024.120880","DOIUrl":"10.1016/j.neuroimage.2024.120880","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to explores the physiological and psychological mechanisms of exercise-induced hypoalgesia (EIH) by combining the behavioral results with neuroimaging data on changes oxy-hemoglobin (HbO) in prefrontal cortex (PFC).</div></div><div><h3>Methods</h3><div>A total of 97 healthy participants were recruited and randomly divided into three groups: a single dance movement therapy (DMT) group, a double DMT group, and control group. Evaluation indicators included the pressure pain threshold (PPT) test, the color-word stroop task (CWST) for wearing functional near-infrared spectroscopy (fNIRS), and the self-assessment manikin (SAM). The testing time is before intervention, after intervention, and one hour of sit rest after intervention.</div></div><div><h3>Results</h3><div>1) Repeated measures ANOVA revealed that, there is a time * group effect on the PPT values of the three groups of participants at three time points. After 30 min of acute dance intervention, an increase in the PPT values of 10 test points occurred in the entire body of the participants in the experimental group with a significant difference than the control group. 2) In terms of fNIRS signals, bilateral DLPFC and left VLPFC channels were significantly activated in the experimental group. 3) DMT significantly awakened participants and brought about pleasant emotions, but cognitive improvement was insignificant. 4) Mediation effect analysis found that the change in HbO concentration in DLPFC may be a mediator in predicting the degree of improvement in pressure pain threshold through dance intervention (total effect β = 0.7140).</div></div><div><h3>Conclusion</h3><div>In healthy adults, DMT can produce a diffuse EIH effect on improving pressure pain threshold, emotional experience but only showing an improvement trend in cognitive performance. Dance intervention significantly activates the left ventrolateral and bilateral dorsolateral prefrontal cortex. This study explores the central nervous system mechanism of EIH from a physiological and psychological perspective.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oscillatory activity in bilateral prefrontal cortices is altered by distractor strength during working memory processing 工作记忆处理过程中，双侧前额叶皮层的振荡活动会因分心物的强度而改变。

IF 4.7 2区医学

NeuroImage Pub Date : 2024-09-30 DOI: 10.1016/j.neuroimage.2024.120878

{"title":"Oscillatory activity in bilateral prefrontal cortices is altered by distractor strength during working memory processing","authors":"","doi":"10.1016/j.neuroimage.2024.120878","DOIUrl":"10.1016/j.neuroimage.2024.120878","url":null,"abstract":"<div><div>Working memory (WM) enables the temporary storage of limited information and is a central component of higher order cognitive function. Irrelevant and/or distracting information can have a negative impact on WM processing and suppressing such incoming stimuli is critical to maintaining adequate performance. However, the neural mechanisms and dynamics underlying such distractor inhibition remain poorly understood. In the current study, we enrolled 46 healthy adults (<em>M</em><sub>age</sub>: 27.92, <em>N</em><sub>female:</sub> 28) who completed a Sternberg type WM task with high- and low-distractor conditions during magnetoencephalography (MEG). MEG data were transformed into the time-frequency domain and significant task-related oscillatory responses were imaged to identify the underlying anatomical areas. Whole-brain paired <em>t</em>-tests, with cluster-based permutation testing for multiple comparisons correction, were performed to assess differences between the low- and high-distractor conditions for each oscillatory response. Across conditions, we found strong alpha and beta oscillations (i.e., decreases relative to baseline) and increases in theta power throughout the encoding and maintenance periods. Whole-brain contrasts revealed significantly stronger alpha and beta oscillations in bilateral prefrontal regions during maintenance in high- compared to low-distractor trials, with the stronger beta oscillations being centered on the left dorsolateral prefrontal cortex and right inferior frontal gyrus, while those for alpha being within the right anterior prefrontal cortices and the right middle frontal gyrus. These findings suggest that alpha and beta oscillations in the bilateral prefrontal cortices play a major role in the inhibition of distracting information during WM maintenance. Our results also contribute to prior research on cognitive control and functional inhibition, in which prefrontal regions have been widely implicated.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural mechanisms underlying placebo and nocebo effects in tonic muscle pain 强直性肌肉疼痛的安慰剂效应和免惊厥效应的神经机制。

IF 4.7 2区医学

NeuroImage Pub Date : 2024-09-29 DOI: 10.1016/j.neuroimage.2024.120877

{"title":"Neural mechanisms underlying placebo and nocebo effects in tonic muscle pain","authors":"","doi":"10.1016/j.neuroimage.2024.120877","DOIUrl":"10.1016/j.neuroimage.2024.120877","url":null,"abstract":"<div><div>Pain is a highly subjective and multidimensional experience, significantly influenced by various psychological factors. Placebo analgesia and nocebo hyperalgesia exemplify this influence, where inert treatments result in pain relief or exacerbation, respectively. While extensive research has elucidated the psychological and neural mechanisms behind these effects, most studies have focused on transient pain stimuli. To explore these mechanisms in the context of tonic pain, we conducted a study using a 15-minute tonic muscle pain induction procedure, where hypertonic saline was infused into the left masseter of healthy participants. We collected real-time Visual Analogue Scale (VAS) scores and functional magnetic resonance imaging (fMRI) data during the induction of placebo analgesia and nocebo hyperalgesia via conditioned learning. Our findings revealed that placebo analgesia was more pronounced and lasted longer than nocebo hyperalgesia. Real-time pain ratings correlated significantly with neural activity in several brain regions. Notably, the putamen was implicated in both effects, while the caudate and other regions were differentially involved in placebo and nocebo effects. These findings confirm that the tonic muscle pain paradigm can be used to investigate the mechanisms of placebo and nocebo effects and indicate that placebo analgesia and nocebo hyperalgesia may have more distinct than common neural bases.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0