Matti Gärtner, Anne Weigand, Christian Keicher, Marvin Sören Meiering, David Weigner, Luisa Carstens, Rita Hertrampf, Christian Beckmann, Maarten Mennes, Andreas Wunder, Simone Grimm
{"title":"Modulatory Effects of Ketamine and Lamotrigine on Cognition: Emotion Interaction in the Brain.","authors":"Matti Gärtner, Anne Weigand, Christian Keicher, Marvin Sören Meiering, David Weigner, Luisa Carstens, Rita Hertrampf, Christian Beckmann, Maarten Mennes, Andreas Wunder, Simone Grimm","doi":"10.1159/000528315","DOIUrl":"https://doi.org/10.1159/000528315","url":null,"abstract":"<p><strong>Introduction: </strong>Cognition and emotion are fundamentally integrated in the brain and mutually contribute to behavior. The relation between working memory (WM) and emotion is particularly suited to investigate cognition-emotion interaction since WM is an essential component of many higher cognitive functions. Ketamine affects not only WM but also has a profound impact on emotional processing. Effects of acute ketamine challenge are sensitive to modulation by pretreatment with lamotrigine, which inhibits glutamate release. Accordingly, a combination of these approaches should be particularly suited to investigate cognition-emotion interaction.</p><p><strong>Methods: </strong>Seventy five healthy subjects were investigated in a double-blind, placebo-controlled, randomized, single-dose, parallel-group study with three treatment conditions. All subjects underwent two scanning sessions (acute/post 24 h).</p><p><strong>Results: </strong>Compared to placebo, acute ketamine administration induced significant dissociative, psychotomimetic, and cognitive effects, as well as an increase in neural activity during WM for positive stimuli. Inhibition of glutamate release by pretreatment with lamotrigine did not influence ketamine's subjective effects, but significantly attenuated its impact on emotional WM and associated neural activity. There was no effect on these measures 24 h after ketamine administration.</p><p><strong>Conclusion: </strong>Our results demonstrate differential acute effects of modulated glutamate release and a swift restoration of disturbed neurobehavioral homeostasis in healthy subjects.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":"82 2","pages":"91-103"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9238969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Front & Back Matter","authors":"G. Bologna, P. Monteleone, G. Okugawa","doi":"10.1159/000528497","DOIUrl":"https://doi.org/10.1159/000528497","url":null,"abstract":"","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44079516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contents Vol. 81, 2022","authors":"P. Monteleone, G. Okugawa","doi":"10.1159/000528492","DOIUrl":"https://doi.org/10.1159/000528492","url":null,"abstract":"Founded 1975 by J. Mendlewicz (Brussels) Since 1983 integrating ‘International Pharmacopsychiatry’, founded 1968 by F.A. Freyhan (New York), N. Petrilowitsch (Mainz), P. Pichot (Paris) Section Editor ‘Biological Psychiatry’ and Associate Editor 1975–2007 J. Mendlewicz (Brussels) Section Editor ‘Pharmacopsychiatry’ and Associate Editor 1990–2006 B. Saletu (Vienna) Section Editor ‘Biological Psychology/Pharmacopsychology’ and Associate Editor 1990– P. Netter (Giessen) Section Editor ‘Pharmacoelectroencephalography’ and Associate Editor 1990–2002 W.M. Herrmann (Berlin), 2003– T. Kinoshita (Osaka) Official Journal of the International Pharmaco-EEG Society (IPEG)","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":"81 1","pages":"I - VI"},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45718201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Front & Back Matter","authors":"G. Bologna, P. Monteleone, G. Okugawa","doi":"10.1159/000526299","DOIUrl":"https://doi.org/10.1159/000526299","url":null,"abstract":"","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45124351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Front & Back Matter","authors":"T. Fuchs, S. Herpertz, P. Monteleone, G. Okugawa","doi":"10.1159/000525329","DOIUrl":"https://doi.org/10.1159/000525329","url":null,"abstract":"","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42274146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Front & Back Matter","authors":"P. Monteleone, G. Okugawa","doi":"10.1159/000524410","DOIUrl":"https://doi.org/10.1159/000524410","url":null,"abstract":"","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42895867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hanta Bachofner, Konstantin A. Scherer, T. Vanbellingen, S. Bohlhalter, K. Stegmayer, S. Walther
{"title":"Validation of the Apraxia Screen TULIA (AST) in Schizophrenia","authors":"Hanta Bachofner, Konstantin A. Scherer, T. Vanbellingen, S. Bohlhalter, K. Stegmayer, S. Walther","doi":"10.1159/000523778","DOIUrl":"https://doi.org/10.1159/000523778","url":null,"abstract":"Introduction: Deficits in social interaction and community functioning, including impaired use, performance, and perception of hand gestures, are key features in schizophrenia. A well-established tool to assess gesture deficits is the test of upper limb apraxia (TULIA). However, given its time-consuming application based on video analyses, research has proposed the bedside apraxia screen of TULIA (AST). This study aims to test the validity and reliability of the AST to detect gesture abnormalities at bedside in a sample of 27 patients diagnosed with schizophrenia, schizotypal disorder, acute and transient psychotic disorders, or schizoaffective disorder. Methods: Patients completed the 48-item TULIA and the 12-item AST. Two different raters assessed the AST: one at bedside (online) and the other based on the video recordings. Results: The total AST scores demonstrated a high parallel reliability, moderate inter-rater reliability on a single-item level, and good construct validities. Conclusions: The psychometric properties of the AST suggest it can well be used for the clinical assessment of gesture deficits in schizophrenia. However, when detailed information is required, the AST rated from video or conducting the full TULIA is recommended. The findings call for refining the selection of the TULIA items for a psychosis-AST bedside test to increase specificity.","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":"81 1","pages":"311 - 321"},"PeriodicalIF":3.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45215320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Zech, M. Reichert, U. Ebner-Priemer, H. Tost, M. Rapp, A. Heinz, R. Dolan, M. Smolka, L. Deserno
{"title":"Mobile Data Collection of Cognitive-Behavioral Tasks in Substance Use Disorders: Where Are We Now?","authors":"H. Zech, M. Reichert, U. Ebner-Priemer, H. Tost, M. Rapp, A. Heinz, R. Dolan, M. Smolka, L. Deserno","doi":"10.1159/000523697","DOIUrl":"https://doi.org/10.1159/000523697","url":null,"abstract":"Introduction: Over the last decades, our understanding of the cognitive, motivational, and neural processes involved in addictive behavior has increased enormously. A plethora of laboratory-based and cross-sectional studies has linked cognitive-behavioral measures to between-subject differences in drinking behavior. However, such laboratory-based studies inevitably suffer from small sample sizes and the inability to link temporal fluctuations in task measures to fluctuations in real-life substance use. To overcome these problems, several existing behavioral tasks have been transferred to smartphones to allow studying cognition in the field. Method: In this narrative review, we first summarize studies that used existing behavioral tasks in the laboratory and self-reports of substance use with ecological momentary assessment (EMA) in the field. Next, we review studies on psychometric properties of smartphone-based behavioral tasks. Finally, we review studies that used both smartphone-based tasks and self-reports with EMA in the field. Results: Overall, studies were scarce and heterogenous both in tasks and in study outcomes. Nevertheless, existing findings are promising and point toward several methodological recommendations: concerning psychometrics, studies show that – although more systematic studies are necessary – task validity and reliability can be improved, for example, by analyzing several measurement sessions at once rather than analyzing sessions separately. Studies that use tasks in the field, moreover, show that power can be improved by choosing sampling schemes that combine time-based with event-based sampling, rather than relying on time-based sampling alone. Increasing sampling frequency can further increase power. However, as this also increases the burden to participants, more research is necessary to determine the ideal sampling frequency for each task. Conclusion: Although more research is necessary to systematically study both the psychometrics of smartphone-based tasks and the frequency at which task measures fluctuate, existing studies are promising and reveal important methodological recommendations useful for researchers interested in implementing behavioral tasks in EMA studies.","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":"81 1","pages":"438 - 450"},"PeriodicalIF":3.2,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44515509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
