Neuropsychobiology最新文献_第8页

Treatment Resistance in Schizophrenia Is Associated with Attention Deficit/Hyperactivity Disorder and Gut Microbiota: A Genetic Correlation and Mendelian Randomization Study. 精神分裂症治疗抵抗与注意缺陷/多动障碍和肠道微生物群相关:遗传相关性和孟德尔随机化研究

IF 3.2 4区心理学

Neuropsychobiology Pub Date : 2023-01-01 DOI: 10.1159/000528316

Bolun Cheng, Shiqiang Cheng, Chun'e Li, Wenming Wei, Li Liu, Peilin Meng, Xuena Yang, Yumeng Jia, Yan Wen, Feng Zhang

{"title":"Treatment Resistance in Schizophrenia Is Associated with Attention Deficit/Hyperactivity Disorder and Gut Microbiota: A Genetic Correlation and Mendelian Randomization Study.","authors":"Bolun Cheng, Shiqiang Cheng, Chun'e Li, Wenming Wei, Li Liu, Peilin Meng, Xuena Yang, Yumeng Jia, Yan Wen, Feng Zhang","doi":"10.1159/000528316","DOIUrl":"https://doi.org/10.1159/000528316","url":null,"abstract":"Introduction: Observational studies highlight associations of common diseases with individual schizophrenia symptoms. However, it is unclear whether these diseases are associated with individual treatment-resistant schizophrenia (TRS). We aimed to explore the genetic associations between common immune diseases, metabolic diseases, psychiatric disorders, gut microbiota and TRS.Methods: Genome-wide association study (GWAS) summary data of European participants (n = ∼456,327) included TRS, 11 psychiatric disorders, 23 immune and metabolic diseases, body mass index, height, and 211 gut microbiota. In this genetic correlation and two-sample Mendelian randomization (MR) study, linkage disequilibrium score (LDSC) regression was applied to infer genetic correlation estimates. Two-sample MR tested potential causal associations of genetic variants associated with common immune diseases, metabolic diseases, psychiatric disorders, and gut microbiota with TRS.Results: LDSC revealed candidate associations between attention deficit/hyperactivity disorder (ADHD), schizophrenia, intestinal infectious diseases, obesity and TRS (genetic correlation range, 0.230-0.702; p < 0.05). Two-sample MR analyses suggested that ADHD was positively associated with TRS (estimate [SE] = 0.204 [0.073], p = 0.005), a finding that remained stable across statistical models. Besides, schizophrenia and genus Barnesiella levels were causally associated with TRS but not consistent across MR approaches.Conclusion: This study reports genetic correlations between ADHD, schizophrenia, intestinal infectious diseases, obesity and TRS. The study also found that genus Barnesiella was associated with TRS. These findings may have clinical implications, highlighting the possible strategy for TRS prevention.","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":"82 1","pages":"24-32"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9227166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Modulatory Effects of Ketamine and Lamotrigine on Cognition: Emotion Interaction in the Brain. 氯胺酮和拉莫三嗪对认知的调节作用:大脑中的情绪相互作用。

IF 3.2 4区心理学

Neuropsychobiology Pub Date : 2023-01-01 DOI: 10.1159/000528315

Matti Gärtner, Anne Weigand, Christian Keicher, Marvin Sören Meiering, David Weigner, Luisa Carstens, Rita Hertrampf, Christian Beckmann, Maarten Mennes, Andreas Wunder, Simone Grimm

{"title":"Modulatory Effects of Ketamine and Lamotrigine on Cognition: Emotion Interaction in the Brain.","authors":"Matti Gärtner, Anne Weigand, Christian Keicher, Marvin Sören Meiering, David Weigner, Luisa Carstens, Rita Hertrampf, Christian Beckmann, Maarten Mennes, Andreas Wunder, Simone Grimm","doi":"10.1159/000528315","DOIUrl":"https://doi.org/10.1159/000528315","url":null,"abstract":"Introduction: Cognition and emotion are fundamentally integrated in the brain and mutually contribute to behavior. The relation between working memory (WM) and emotion is particularly suited to investigate cognition-emotion interaction since WM is an essential component of many higher cognitive functions. Ketamine affects not only WM but also has a profound impact on emotional processing. Effects of acute ketamine challenge are sensitive to modulation by pretreatment with lamotrigine, which inhibits glutamate release. Accordingly, a combination of these approaches should be particularly suited to investigate cognition-emotion interaction.Methods: Seventy five healthy subjects were investigated in a double-blind, placebo-controlled, randomized, single-dose, parallel-group study with three treatment conditions. All subjects underwent two scanning sessions (acute/post 24 h).Results: Compared to placebo, acute ketamine administration induced significant dissociative, psychotomimetic, and cognitive effects, as well as an increase in neural activity during WM for positive stimuli. Inhibition of glutamate release by pretreatment with lamotrigine did not influence ketamine's subjective effects, but significantly attenuated its impact on emotional WM and associated neural activity. There was no effect on these measures 24 h after ketamine administration.Conclusion: Our results demonstrate differential acute effects of modulated glutamate release and a swift restoration of disturbed neurobehavioral homeostasis in healthy subjects.","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":"82 2","pages":"91-103"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9238969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Acknowledgement to Reviewers 审稿人致谢

IF 3.2 4区心理学

Neuropsychobiology Pub Date : 2022-12-14 DOI: 10.1159/000528491

引用次数: 0

Prelims 预备考试

IF 3.2 4区心理学

Neuropsychobiology Pub Date : 2022-12-02 DOI: 10.1159/000528194

引用次数: 0

Front & Back Matter 正面和背面事项

IF 3.2 4区心理学

Neuropsychobiology Pub Date : 2022-12-01 DOI: 10.1159/000528497

G. Bologna, P. Monteleone, G. Okugawa

引用次数: 0

Contents Vol. 81, 2022 目录第81卷，2022年

IF 3.2 4区心理学

Neuropsychobiology Pub Date : 2022-12-01 DOI: 10.1159/000528492

P. Monteleone, G. Okugawa

引用次数: 0

Front & Back Matter 正面和背面事项

IF 3.2 4区心理学

Neuropsychobiology Pub Date : 2022-08-01 DOI: 10.1159/000526299

G. Bologna, P. Monteleone, G. Okugawa

引用次数: 0

Front & Back Matter 正面和背面

IF 3.2 4区心理学

Neuropsychobiology Pub Date : 2022-06-01 DOI: 10.1159/000525329

T. Fuchs, S. Herpertz, P. Monteleone, G. Okugawa

引用次数: 0

Front & Back Matter 正面和背面

IF 3.2 4区心理学

Neuropsychobiology Pub Date : 2022-04-01 DOI: 10.1159/000524410

P. Monteleone, G. Okugawa

引用次数: 0

Validation of the Apraxia Screen TULIA (AST) in Schizophrenia 精神分裂症患者精神障碍筛查TULIA（AST）的验证

IF 3.2 4区心理学

Neuropsychobiology Pub Date : 2022-04-01 DOI: 10.1159/000523778

Hanta Bachofner, Konstantin A. Scherer, T. Vanbellingen, S. Bohlhalter, K. Stegmayer, S. Walther

{"title":"Validation of the Apraxia Screen TULIA (AST) in Schizophrenia","authors":"Hanta Bachofner, Konstantin A. Scherer, T. Vanbellingen, S. Bohlhalter, K. Stegmayer, S. Walther","doi":"10.1159/000523778","DOIUrl":"https://doi.org/10.1159/000523778","url":null,"abstract":"Introduction: Deficits in social interaction and community functioning, including impaired use, performance, and perception of hand gestures, are key features in schizophrenia. A well-established tool to assess gesture deficits is the test of upper limb apraxia (TULIA). However, given its time-consuming application based on video analyses, research has proposed the bedside apraxia screen of TULIA (AST). This study aims to test the validity and reliability of the AST to detect gesture abnormalities at bedside in a sample of 27 patients diagnosed with schizophrenia, schizotypal disorder, acute and transient psychotic disorders, or schizoaffective disorder. Methods: Patients completed the 48-item TULIA and the 12-item AST. Two different raters assessed the AST: one at bedside (online) and the other based on the video recordings. Results: The total AST scores demonstrated a high parallel reliability, moderate inter-rater reliability on a single-item level, and good construct validities. Conclusions: The psychometric properties of the AST suggest it can well be used for the clinical assessment of gesture deficits in schizophrenia. However, when detailed information is required, the AST rated from video or conducting the full TULIA is recommended. The findings call for refining the selection of the TULIA items for a psychosis-AST bedside test to increase specificity.","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":"81 1","pages":"311 - 321"},"PeriodicalIF":3.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45215320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1