Modulatory Effects of Ketamine and Lamotrigine on Cognition: Emotion Interaction in the Brain.

IF 2.3 4区心理学 Q3 NEUROSCIENCES

Neuropsychobiology Pub Date : 2023-01-01 DOI:10.1159/000528315

Matti Gärtner, Anne Weigand, Christian Keicher, Marvin Sören Meiering, David Weigner, Luisa Carstens, Rita Hertrampf, Christian Beckmann, Maarten Mennes, Andreas Wunder, Simone Grimm

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引用次数: 3

Abstract

Introduction: Cognition and emotion are fundamentally integrated in the brain and mutually contribute to behavior. The relation between working memory (WM) and emotion is particularly suited to investigate cognition-emotion interaction since WM is an essential component of many higher cognitive functions. Ketamine affects not only WM but also has a profound impact on emotional processing. Effects of acute ketamine challenge are sensitive to modulation by pretreatment with lamotrigine, which inhibits glutamate release. Accordingly, a combination of these approaches should be particularly suited to investigate cognition-emotion interaction.

Methods: Seventy five healthy subjects were investigated in a double-blind, placebo-controlled, randomized, single-dose, parallel-group study with three treatment conditions. All subjects underwent two scanning sessions (acute/post 24 h).

Results: Compared to placebo, acute ketamine administration induced significant dissociative, psychotomimetic, and cognitive effects, as well as an increase in neural activity during WM for positive stimuli. Inhibition of glutamate release by pretreatment with lamotrigine did not influence ketamine's subjective effects, but significantly attenuated its impact on emotional WM and associated neural activity. There was no effect on these measures 24 h after ketamine administration.

Conclusion: Our results demonstrate differential acute effects of modulated glutamate release and a swift restoration of disturbed neurobehavioral homeostasis in healthy subjects.

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氯胺酮和拉莫三嗪对认知的调节作用:大脑中的情绪相互作用。

认知和情感在大脑中是基本整合的，并相互促进行为。由于工作记忆是许多高级认知功能的重要组成部分，因此工作记忆与情绪之间的关系特别适合于研究认知-情绪相互作用。氯胺酮不仅影响WM，而且对情绪加工有深远的影响。急性氯胺酮刺激对拉莫三嗪预处理的调节作用敏感，拉莫三嗪可抑制谷氨酸释放。因此，这些方法的组合应该特别适合于调查认知-情感的相互作用。方法:对75名健康受试者进行双盲、安慰剂对照、随机、单剂量、平行组研究，共有3种治疗条件。结果:与安慰剂相比，急性氯胺酮给药引起了显著的解离、拟精神和认知效应，并且在WM期间积极刺激的神经活动增加。拉莫三嗪预处理抑制谷氨酸释放不影响氯胺酮的主观效应，但显著减弱其对情绪WM和相关神经活动的影响。氯胺酮给药24 h后对这些指标均无影响。结论:我们的研究结果表明，在健康受试者中，调节谷氨酸释放和迅速恢复受干扰的神经行为稳态有不同的急性效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychobiology 医学-精神病学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.