Neuropsychology最新文献

{"title":"Error monitoring in amnestic mild cognitive impairment: Cognitive correlates and relationship to measures of everyday function.","authors":"Carolyn R Pagán, Kayela Arrotta, Reanne Cunningham Chilton, Maureen Schmitter-Edgecombe","doi":"10.1037/neu0000887","DOIUrl":"10.1037/neu0000887","url":null,"abstract":"<p><strong>Objective: </strong>Accurate error monitoring is important for successful completion of everyday tasks and compensatory strategy use. This study examined how error awareness is impacted in amnestic mild cognitive impairment (aMCI) compared to cognitively healthy older adults (HOA). Cognitive correlates of error monitoring and relation to objective and self-reported measurement of everyday function were also evaluated.</p><p><strong>Method: </strong>Twenty-four individuals with aMCI and 24 cognitively HOAs completed standardized cognitive measures (domains: attention, working memory, executive functioning, memory, language, visuospatial abilities); a computerized go-no-go paradigm task that evaluated error monitoring; a naturalistic, performance-based measure of everyday functioning (day-out-task; DOT); and self- and informant-report measures of everyday dysexecutive difficulties (DEX).</p><p><strong>Results: </strong>Participants with aMCI demonstrated significantly poorer error monitoring as compared to the HOA group (Cohen's <i>d</i> = 1.02). Working memory and executive functioning were significantly related to error monitoring for both groups. After accounting for age and global cognitive status, hierarchical regressions revealed error monitoring significantly predicted DOT total time (but not accuracy) as well as both self- and informant-report DEX scores.</p><p><strong>Conclusions: </strong>Compared to HOAs, individuals with aMCI exhibited poorer conscious error awareness. Better error monitoring was associated with higher working memory and executive functioning abilities and predicted better everyday functioning. If individuals with aMCI experience difficulties recognizing performance inaccuracies, they will be unable to correct their errors, leading to mistakes in everyday task completion and difficulty implementing appropriate compensatory strategies. Findings suggest that error monitoring may be a potential target for intervention with individuals with aMCI. (PsycInfo Database Record (c) 2023 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"933-942"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9853967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"But will they use it? Predictors of adoption of an electronic memory aid in individuals with amnestic mild cognitive impairment.","authors":"Catherine Luna, Diane J Cook, Maureen Schmitter-Edgecombe","doi":"10.1037/neu0000898","DOIUrl":"10.1037/neu0000898","url":null,"abstract":"<p><strong>Objective: </strong>Electronic memory aids are being researched and developed widely to assist the everyday functioning of individuals experiencing cognitive decline. Although development studies show promise in the initial use of electronic memory aids, little is known about the factors that influence adoption of these aids after training ends.</p><p><strong>Method: </strong>We analyzed the baseline characteristics (e.g., demographics, cognitive performance) and training usage (e.g., frequency and pattern of use) of 32 older adults experiencing amnestic mild cognitive impairment who participated in a pilot clinical trial with an electronic memory and management aid (EMMA) tablet application. Sixteen participants who were still using EMMA at 3-months posttraining were defined as \"adopters,\" whereas the 16 participants who were not using EMMA at 3-months posttraining were defined as \"nonadopters.\"</p><p><strong>Results: </strong>Adopters scored higher on baseline delayed memory (Cohen's <i>d</i> = .87) and language (Cohen's <i>d</i> = .82) index scores than nonadopters. Adopters also interacted with EMMA more frequently (Cohen's <i>d</i> = 1.34) and in greater quantities (Cohen's <i>d</i> > .87) than nonadopters by Week 2 of training. Stepwise logistic regression revealed that higher baseline language score and increased frequency of use during training significantly predicted classification of adopters at 3-months posttraining.</p><p><strong>Conclusions: </strong>Adoption of this electronic memory aid was enhanced by teaching the aid to individuals who demonstrated average-level language abilities and who used the aid on average eight times per day during training. Encouraging individuals to use the aid early and often during training can increase adoption of electronic memory aids. (PsycInfo Database Record (c) 2023 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"955-965"},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9194136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement and structural invariance of a neuropsychological battery among Middle Eastern/North African, Black, and White older adults.","authors":"Laura B Zahodne, Simon Brauer, Wassim Tarraf, Emily P Morris, Toni C Antonucci, Kristine J Ajrouch","doi":"10.1037/neu0000902","DOIUrl":"10.1037/neu0000902","url":null,"abstract":"<p><strong>Objective: </strong>There is a lack of guidance on common neuropsychological measures among Arabic speakers and individuals who identify as Middle Eastern/North African (MENA) in the United States. This study evaluated measurement and structural invariance of a neuropsychological battery across race/ethnicity (MENA, Black, White) and language (Arabic, English).</p><p><strong>Method: </strong>Six hundred six older adults (128 MENA-English, 74 MENA-Arabic, 207 Black, 197 White) from the Detroit Area Wellness Network were assessed via telephone. Multiple-group confirmatory factor analyses examined four indicators corresponding to distinct cognitive domains: episodic memory (Consortium to Establish a Registry for Alzheimer's Disease [CERAD] Word List), language (Animal Fluency), attention (Montreal Cognitive Assessment [MoCA] forward digit span), and working memory (MoCA backward digit span).</p><p><strong>Results: </strong>Measurement invariance analyses revealed full scalar invariance across language groups and partial scalar invariance across racial/ethnic groups suggesting a White testing advantage on Animal Fluency; yet this noninvariance did not meet a priori criteria for salient impact. Accounting for measurement noninvariance, structural invariance analyses revealed that MENA participants tested in English demonstrated lower cognitive health than Whites and Blacks, and MENA participants tested in Arabic demonstrated lower cognitive health than all other groups.</p><p><strong>Conclusions: </strong>Measurement invariance results support the use of a rigorously translated neuropsychological battery to assess global cognitive health across MENA/Black/White and Arabic/English groups. Structural invariance results reveal underrecognized cognitive disparities. Disaggregating MENA older adults from other non-Latinx Whites will advance research on cognitive health equity. Future research should attend to heterogeneity within the MENA population, as the choice to be tested in Arabic versus English may reflect immigrant, educational, and socioeconomic experiences relevant to cognitive aging. (PsycInfo Database Record (c) 2023 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"975-984"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9796557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Production of emotions conveyed by voice in Parkinson's disease: Association between variability of fundamental frequency and gray matter volumes of regions involved in emotional prosody.","authors":"Isabella Anzuino,&nbsp;Francesca Baglio,&nbsp;Laura Pelizzari,&nbsp;Monia Cabinio,&nbsp;Federica Biassoni,&nbsp;Martina Gnerre,&nbsp;Valeria Blasi,&nbsp;Maria Caterina Silveri,&nbsp;Sonia Di Tella","doi":"10.1037/neu0000912","DOIUrl":"10.1037/neu0000912","url":null,"abstract":"<p><strong>Objective: </strong>Parkinson's disease (PD) is associated with impairment in producing emotions conveyed by voice which could depend on motor limitations of the vocal apparatus and/or alterations in emotional processing. This study explores the relationship between the standard deviation of fundamental frequency (F0SD) of emotional speech and the volume of specific gray matter regions.</p><p><strong>Method: </strong>Fifteen PD patients and 15 healthy controls (HC) were asked to produce different emotions vocally elicited by reading short stories. For each vocal track, the F0SD was calculated as index of variability. All subjects underwent a structural magnetic resonance imaging and a voxel-based morphometry analysis. An ad hoc mask of brain regions implicated in emotional prosody was constructed to test the relationship between F0SD and the level of brain atrophy.</p><p><strong>Results: </strong>PD patients showed lower F0SD values than HC in the expression of anger. Neuroimaging results showed brain atrophy in PD patients in a widespread bilateral network, including frontal areas, left cingulate cortex, parietal areas as well as occipital cortices. In the PD group, a positive correlation was observed between F0SD values of anger and volumes of the bilateral supramarginal gyrus, left thalamus, right inferior frontal gyrus, and amygdala.</p><p><strong>Conclusions: </strong>The lower F0SD values observed in PD patients in anger production are consistent with their lower ability to express anger effectively through voice compared to HC. Our data demonstrated the involvement of right-lateralized areas, such as the inferior frontal gyrus and amygdala, which are typically involved in emotional prosody. Disturbances in emotion processing might contribute to speech production deficits in PD, probably in addition to the motor impairment of the articulatory system. (PsycInfo Database Record (c) 2023 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"883-894"},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9829647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood maltreatment and midlife cognitive functioning: A longitudinal study of the roles of social support and social isolation.","authors":"Molly Maxfield, Xuechen Li, Cathy Spatz Widom","doi":"10.1037/neu0000911","DOIUrl":"10.1037/neu0000911","url":null,"abstract":"<p><strong>Objective: </strong>Negative consequences of childhood maltreatment have been well-documented, including poorer executive functioning and nonverbal reasoning in midlife. However, not all adults with a history of childhood maltreatment manifest these outcomes, suggesting the presence of risk and protective factors. Based on growing empirical support for the importance of social variables in understanding neuropsychological development and functioning, we examined whether social support and social isolation mediate or moderate the effects of childhood maltreatment on cognitive functioning in midlife.</p><p><strong>Method: </strong>In the context of a prospective cohort design study, individuals with documented histories of childhood maltreatment (ages 0-11 years) and demographically matched controls were followed up and interviewed in adulthood. Social support and isolation were assessed in young adulthood (<i>M</i>_age = 29), and cognitive functioning was assessed in midlife (<i>M</i>_age = 41). Structural equation modeling was used for mediation and linear regressions for moderation.</p><p><strong>Results: </strong>Childhood maltreatment predicted higher levels of social isolation and lower levels of social support and cognitive functioning. Only social isolation mediated the relationship between childhood maltreatment and midlife cognitive functioning, whereas childhood maltreatment interacted with social support to predict Matrix Reasoning in midlife. Social support was protective for the control group but not for those maltreated.</p><p><strong>Conclusions: </strong>Social isolation and social support play different roles in understanding how childhood maltreatment impacts midlife cognitive functioning. Greater social isolation predicts greater deficits in cognitive functioning overall, whereas the protective effects of social support are limited to those without a documented history of childhood maltreatment. Clinical implications are discussed. (PsycInfo Database Record (c) 2023 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"943-954"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9902347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplemental Material for Multitrial Free Recall for Evaluating Memory","authors":"","doi":"10.1037/neu0000910.supp","DOIUrl":"https://doi.org/10.1037/neu0000910.supp","url":null,"abstract":"","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136112290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The \"when\" matters: Evidence from memory markers in the clinical continuum of Alzheimer's disease.","authors":"Gonzalo Forno, Mario A Parra, Daniela Thumala, Roque Villagra, Mauricio Cerda, Pedro Zitko, Agustín Ibañez, Patricia Lillo, Andrea Slachevsky","doi":"10.1037/neu0000891","DOIUrl":"10.1037/neu0000891","url":null,"abstract":"<p><strong>Objective: </strong>Cognitive assessment able to detect impairments in the early neuropathological stages of Alzheimer's disease (AD) is urgently needed. The visual short-term memory binding task (VSTMBT) and the Free and Cued Selective Reminding Test (FCSRT) have been recommended by the neurodegenerative disease working group as promising tests to aid in the early detection of AD. In this study, we investigated their complementary value across the clinical stages of the AD continuum.</p><p><strong>Method: </strong>One hundred and seventeen older adults with subjective cognitive complaint (SCC), 79 with mild cognitive impairment (MCI), 31 patients with AD dementia (ADD), and 37 cognitively unimpaired (CU) subjects, underwent assessment with the VSTMBT and the picture version of the Spanish FCSRT.</p><p><strong>Results: </strong>After controlling for multiple comparisons, significant differences were found across groups. The VSTMBT was the only test that \"marginally\" differentiated between CU and SCC (<i>d</i> = 0.47, <i>p</i> = .052). Moreover, whereas the FCSRT showed a gradient (CU = SCC) > MCI > ADD, the VSTMBT gradient was CU > SCC > (MCI = ADD) suggesting that conjunctive binding deficits assessed by the latter may be sensitive to the very early stages of the disease.</p><p><strong>Conclusions: </strong>Our results suggest that the VSTMBT and the FCSRT are sensitive to the clinical continuum of AD. Whereas the former detects changes in the early prodromal stages, the latter is more sensitive to the advanced prodromal stages of AD. These novel tests can aid in the early detection, monitor disease progression and response to treatment, and thus support drug development programs. (PsycInfo Database Record (c) 2023 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"753-768"},"PeriodicalIF":2.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9590339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assessment of empathy uncovers defective self-awareness in mild cognitive impairment.","authors":"Davide Quaranta, Chiara Cerami, Naike Caraglia, Emanuele Maria Costantini, Sonia Di Tella, Maria Caterina Silveri, Stefano Cappa, Simona Gaudino, Camillo Marra, Alessandra Dodich","doi":"10.1037/neu0000896","DOIUrl":"10.1037/neu0000896","url":null,"abstract":"<p><strong>Objective: </strong>Self-assessment scales are broadly used to evaluate empathy in neurological patients, but it is conceivable that some discrepancy with caregiver evaluation may emerge as consequence of reduced self-awareness. The aim of the present study was to verify the presence of discrepancies in the self-assessment of empathy in subjects with mild cognitive impairment (MCI) and to explore their neural correlates.</p><p><strong>Method: </strong>Twenty MCI patients and 38 healthy controls (HCs) underwent the Interpersonal Reactivity Index (IRI), exploring the following four aspects of empathy: perspective taking (PT), fantasy, empathic concern, and personal distress. The questionnaire was administered in two modalities: self-administered, and administered to an informant, and the scores were compared. The correlation between discrepancies and regional cortical thickness was assessed.</p><p><strong>Results: </strong>The self-administered version of IRI showed higher PT scores in MCI as compared to HC (<i>p</i> = .017), with no differences detected in the other subscales. The difference between the scores obtained in the self-administered and in the informant-administered IRI-PT was significantly higher in MCI than in HCs (<i>p</i> = .006).</p><p><strong>Conclusion: </strong>The self-assessment of empathy in subjects with MCI may be misleading because of a tendency toward an overestimation of the PT ability, typically considered as a cognitive component of empathy. Our results may reflect a particular aspect of reduced self-awareness in MCI subjects. (PsycInfo Database Record (c) 2023 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"837-845"},"PeriodicalIF":2.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9500539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further evaluation of narrative description as a measure of cognitive function in Alzheimer's disease.","authors":"Stephanie M Reeves, Victoria Williams, Deborah Blacker, Russell L Woods","doi":"10.1037/neu0000884","DOIUrl":"10.1037/neu0000884","url":null,"abstract":"<p><strong>Objective: </strong>The narrative description (ND) test objectively measures the ability to understand and describe visual scenes. As subtle differences in speech occur early in cognitive decline, we analyzed linguistic features for their utility in detecting cognitive impairment and predicting downstream decline.</p><p><strong>Method: </strong>Participants (<i>n</i> = 52) with normal cognition to mild dementia performed the ND test (watched twenty 30-s video clips and described the visual content). Cognitive function was followed for up to 5 years. We computed simple linguistic features such as content efficiency, speech rate, and part of speech and unique word counts. We examined (a) relationships between cognitive status and ND score and linguistic features; (b) ability to discriminate early cognitive impairment from normal cognition using ND score and linguistic features; and (c) whether ND score and linguistic features were associated with future cognitive functional decline.</p><p><strong>Results: </strong>Many of the linguistic-feature metrics were related to cognitive status. Many of the linguistic features could distinguish between the cognitively normal group and the mild cognitive impairment (MCI) and Dementia groups. The area under the curve (AUC) for ND score alone was 0.74, with a nonsignificant increase to 0.78 when adding mean word length. Among participants with subjective cognitive decline (SCD) at the first visit, a smaller number of words plus more interjections or a lower ND score at baseline were predictive of future cognitive decline.</p><p><strong>Conclusions: </strong>While many linguistic features were associated with cognitive status, and some were able to detect early cognitive impairment or predictive of future cognitive decline, all the features we tested seem to have been captured by the ND score. Thus, adding linguistic measures to the ND test score did not add to its value in assessing current or predicting future cognitive status. (PsycInfo Database Record (c) 2023 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"801-812"},"PeriodicalIF":2.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10065542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autocorrection if→of function words in reading aloud: A novel marker of Alzheimer's risk.","authors":"Tamar H Gollan, Alena Stasenko, Chuchu Li, Denis S Smirnov, Douglas Galasko, David P Salmon","doi":"10.1037/neu0000829","DOIUrl":"10.1037/neu0000829","url":null,"abstract":"<p><strong>Objective: </strong>The present study investigated cognitive mechanisms underlying the ability to stop \"autocorrect\" errors elicited by unexpected words in a read-aloud task, and the utility of autocorrection for predicting Alzheimer's disease (AD) biomarkers.</p><p><strong>Method: </strong>Cognitively normal participants (total <i>n</i> = 85; <i>n</i> = 64 with cerebrospinal fluid [CSF] biomarkers) read aloud six short paragraphs in which 10 critical target words were replaced with autocorrect targets, for example, <i>The player who scored that final [paint] for the local team reported [him] experience</i>. Autocorrect targets either replaced the most expected/<i>dominant</i> completion (i.e., <i>point</i>) or a less expected/<i>nondominant</i> completion (i.e., <i>basket</i>), and within each paragraph half of the autocorrect targets were content words (e.g., <i>point/paint</i>) and half were function words (e.g., <i>his/him</i>). Participants were instructed to avoid autocorrecting.</p><p><strong>Results: </strong>Participants produced more autocorrect errors in paragraphs with dominant than with nondominant targets, and with function than with content targets. Cognitively normal participants with high CSF Tau/Aβ42 (i.e., an AD-like biomarker profile) produced more autocorrect total errors than those below the Tau/Aβ42 threshold, an effect also significant with dominant-function targets alone (e.g., saying <i>his</i> instead of <i>him</i>). A logistic regression model with dominant-function errors and age showed errors as the stronger predictor of biomarker status (sensitivity 83%; specificity 85%).</p><p><strong>Conclusions: </strong>Difficulty stopping autocorrect errors is associated with biomarkers indicating preclinical AD, and reveals promise as a diagnostic tool. Greater vulnerability of function over content words to autocorrection in individuals with AD-like biomarkers implicates monitoring and attention (rather than semantic processing) in the earliest of cognitive changes associated with AD risk. (PsycInfo Database Record (c) 2023 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"813-826"},"PeriodicalIF":2.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10655781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}