Micah J Savin, Desiree Byrd, Lucette Cysique, Sean Rourke, Steven P Verney, Kylie Radford, Tedd Judd, Maral Aghvinian, Cara Crook, Denise Oleas, Alex Slaughter, Richard Armenta, Donald Franklin, Thomas Marcotte, Heining Cham, Monica Rivera Mindt
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引用次数: 0
摘要
目的：本研究描述了美国印第安人/阿拉斯加原住民（AI/AN）成年人中感染和未感染艾滋病毒者的认知衰老轨迹以及免疫衰老的作用：本研究描述了感染和未感染艾滋病毒的美国印第安人/阿拉斯加原住民（AI/AN）成年人的认知衰老轨迹以及免疫衰老的纵向作用：我们对美国六个研究地点的 333 名美国印第安人/阿拉斯加原住民和 309 名非西班牙裔白人（NHW）成年人的认知衰老轨迹进行了长达 20 年的纵向追踪。我们使用具有自回归 Lag-1 结构和异质残差的生长曲线模型来评估种族身份和 HIV 群体对认知衰老轨迹下降的作用：与感染艾滋病毒的非华裔成人相比，感染艾滋病毒的亚裔美国人/印第安人在处理速度、注意力/工作记忆计时任务、执行功能和精神运动速度等任务上的认知老化正常轨迹下降更早、更快。与感染艾滋病毒的同龄人相比，感染艾滋病毒和感染艾滋病毒的免疫抑制人群的认知衰老轨迹明显加剧，这主要是由于免疫衰老的作用：结论：美国印第安人/美洲印第安人在认知衰老轨迹上的差异是显而易见的，而且很可能是由包括免疫衰老在内的生物心理社会文化因素相互作用造成的。(PsycInfo Database Record (c) 2024 APA, all rights reserved）。
Disparate trajectories of cognitive aging among American Indian and Alaskan Native people with and without HIV.
Objective: This study describes trajectories of cognitive aging among American Indian/Alaskan Native (AI/AN) adults with and without HIV and the role of immunosenescence longitudinally.
Method: We characterized trajectories of cognitive aging in a sample of 333 AI/AN and 309 non-Hispanic White (NHW) adults who were followed longitudinally for up to 20 years by the HIV Neurobehavioral Research Program (HNRP) across six U.S. research sites. We used growth curve modeling with autoregressive Lag-1 structures and heterogeneous residual variances to assess the role of ethnoracial identity and HIV grouping upon decline in trajectories of cognitive aging.
Results: HIV- AI/AN adults demonstrated earlier and steeper decline in normative trajectories of cognitive aging on tasks of processing speed, timed tasks of attention/working memory, executive function, and psychomotor speed in comparison to HIV- NHW adults. Accentuated trajectories of cognitive aging were evident in both HIV+ and HIV+ immunosuppressed groups in comparison to HIV- peers and were primarily driven by the role of immunosenescence.
Conclusions: AI/AN disparities in trajectories of cognitive aging are evident and are likely explained by the interplay of biopsychosociocultural factors, including immunosenescence. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
期刊介绍：
Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.
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