Intrasubject variability of sustained attention is associated with elevated self-reported attention deficits in women with a fragile X premutation allele.

IF 2.6 3区 心理学 Q3 NEUROSCIENCES
Neuropsychology Pub Date : 2024-09-01 Epub Date: 2024-06-20 DOI:10.1037/neu0000953
Shira Russell-Giller, Emily G Allen, Jessica Ezzell Hunter, Lisa Shubeck, Veronica J Hinton
{"title":"Intrasubject variability of sustained attention is associated with elevated self-reported attention deficits in women with a fragile X premutation allele.","authors":"Shira Russell-Giller, Emily G Allen, Jessica Ezzell Hunter, Lisa Shubeck, Veronica J Hinton","doi":"10.1037/neu0000953","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Women with a fragile X premutation (PM) self-report higher rates of attention difficulties than women without a PM; however, results of studies using objective measures of attention are inconsistent. The present study assessed whether intrasubject variability during a sustained attention task better predicted functional outcomes in women with a PM than the previously published standard reaction time and accuracy variables.</p><p><strong>Method: </strong>We analyzed continuous performance test, a computerized measure of sustained attention, and the Conners' Adult Attention-Deficit/Hyperactivity Disorder Rating Scale Report (CAARS) data from 273 women with a PM and 175 women without a PM aged 18-50 years. Separate analyses using Pearson correlations and independent t tests were performed on the full range of coefficient of variation (CV) of reaction time scores and the subset of scores that showed higher variability.</p><p><strong>Results: </strong>Performance variability of sustained attention measured by the continuous performance test was associated with functional outcomes measured by the CAARS in women with a PM but not women without a PM. Specifically, the CV in those with higher variability was correlated with two CAARS subscale scores (<i>p</i> = .006). Independent t tests showed significant differences in CV between CAARS scores dichotomized for the presence of subclinical symptoms for two subscales (<i>p</i> ≤ .001-.007). Correlation between the full range of CV scores and the CAARS Inattention/Memory Problems subscale approached significance (<i>p</i> = .012).</p><p><strong>Conclusions: </strong>Findings highlight the importance of including intrasubject variability in analyzing attention in clinical populations as a more sensitive objective measure associated with reported symptoms and to assist in predicting functional outcomes. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuropsychology","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1037/neu0000953","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: Women with a fragile X premutation (PM) self-report higher rates of attention difficulties than women without a PM; however, results of studies using objective measures of attention are inconsistent. The present study assessed whether intrasubject variability during a sustained attention task better predicted functional outcomes in women with a PM than the previously published standard reaction time and accuracy variables.

Method: We analyzed continuous performance test, a computerized measure of sustained attention, and the Conners' Adult Attention-Deficit/Hyperactivity Disorder Rating Scale Report (CAARS) data from 273 women with a PM and 175 women without a PM aged 18-50 years. Separate analyses using Pearson correlations and independent t tests were performed on the full range of coefficient of variation (CV) of reaction time scores and the subset of scores that showed higher variability.

Results: Performance variability of sustained attention measured by the continuous performance test was associated with functional outcomes measured by the CAARS in women with a PM but not women without a PM. Specifically, the CV in those with higher variability was correlated with two CAARS subscale scores (p = .006). Independent t tests showed significant differences in CV between CAARS scores dichotomized for the presence of subclinical symptoms for two subscales (p ≤ .001-.007). Correlation between the full range of CV scores and the CAARS Inattention/Memory Problems subscale approached significance (p = .012).

Conclusions: Findings highlight the importance of including intrasubject variability in analyzing attention in clinical populations as a more sensitive objective measure associated with reported symptoms and to assist in predicting functional outcomes. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

脆性X突变等位基因女性持续注意力的受试者内变异与自我报告的注意力缺陷升高有关。
目的:与没有脆性X突变的女性相比,患有脆性X突变的女性自我报告的注意力困难率更高;然而,使用客观的注意力测量方法进行研究的结果并不一致。本研究评估了持续注意力任务中的受试者内部变异性是否比之前公布的标准反应时间和准确性变量更能预测脆性X突变女性的功能结果:我们分析了273名患有注意力缺陷/多动障碍的女性和175名未患有注意力缺陷/多动障碍的女性(年龄在18-50岁之间)的连续表现测试、计算机化的持续注意力测量和康纳斯成人注意力缺陷/多动障碍评定量表报告(CAARS)数据。使用皮尔逊相关性和独立 t 检验对反应时间分数的全部变异系数 (CV) 和变异性较高的分数子集分别进行了分析:结果:通过连续表现测试测量的持续注意力的表现变异性与通过CAARS测量的功能结果有关。具体来说,变异性较高者的 CV 与 CAARS 的两个分量表得分相关(p = .006)。独立 t 检验显示,在两个分量表中,根据是否存在亚临床症状进行二分的 CAARS 分数之间的 CV 存在明显差异(p ≤ .001-.007)。全部 CV 分数与 CAARS 注意力不集中/记忆问题分量表之间的相关性接近显著性(p = .012):研究结果凸显了在临床人群中分析注意力时纳入受试者内部变异性的重要性,这是一种与报告症状相关的更敏感的客观测量方法,有助于预测功能性结果。(PsycInfo Database Record (c) 2024 APA, 版权所有)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Neuropsychology
Neuropsychology 医学-神经科学
CiteScore
4.10
自引率
4.20%
发文量
132
审稿时长
6-12 weeks
期刊介绍: Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信