Neurological Sciences最新文献_第7页

Early prediction of refractory myasthenia gravis based on response to treatment within the first year of diagnosis. 早期预测难治性重症肌无力基于治疗反应在诊断的第一年。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-08-01 Epub Date: 2025-04-26 DOI: 10.1007/s10072-025-08196-6

Hee Jo Han, Susung Kim, Hyung Jun Park, Ha Young Shin, Seung Woo Kim

{"title":"Early prediction of refractory myasthenia gravis based on response to treatment within the first year of diagnosis.","authors":"Hee Jo Han, Susung Kim, Hyung Jun Park, Ha Young Shin, Seung Woo Kim","doi":"10.1007/s10072-025-08196-6","DOIUrl":"10.1007/s10072-025-08196-6","url":null,"abstract":"Background: The long lead time required to diagnose refractory myasthenia gravis (MG) can prevent early attempts at new treatments. Herein, we aimed to predict refractory MG by comparing treatment responses during the early stages between patients with refractory and non-refractory MG.Methods: We retrospectively investigated the medical records of patients with acetylcholine receptor antibody-positive generalized MG. Refractory MG was defined as (1) inability to lower prednisolone below 20 mg/day, (2) requiring regular intravenous immunoglobulin or plasmapheresis, or (3) Myasthenia Gravis Activities of Daily Living score ≥ 6 after treatment with corticosteroids and ≥ 1 oral immunosuppressant for ≥ 12 months.Results: Of 133 patients, 29 (21.8%) and 104 (78.2%) had refractory and non-refractory MG, respectively. The median duration from the diagnosis of MG to that of refractory MG was 31 months. During the first year following diagnosis, the proportion of patients who achieved a lowest effective prednisolone dose of ≤ 20 mg was lower in the refractory group than in the non-refractory group (69.0% vs. 92.0%). Conversely, the proportions of patients who initiated oral immunosuppressive therapy (58.6% vs. 22.5%), required rescue interventions (48.3% vs. 22.1%), or experienced a myasthenic crisis (34.5% vs. 14.4%) were significantly higher in the refractory group. The risk of refractory MG was 18.7-fold higher in patients who failed to achieve lowest effective prednisolone dose under 20 mg/day and started oral immunosuppressant during the first year than those with neither of these conditions.Conclusions: The refractory group displayed distinct clinical features during the early disease stages, including frequent crises and higher levels of immunosuppressive treatment. These features can be used for early prediction of refractory MG.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3919-3927"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased expression of proinflammatory cytokines in the cerebrospinal fluid of patients with a history of electrical status epilepticus in sleep. 有睡眠中癫痫持续状态病史的患者脑脊液中促炎细胞因子的表达增加

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-08-01 Epub Date: 2025-05-05 DOI: 10.1007/s10072-025-08217-4

Xing-Guang Ye, Shi-Wei Dong, Ben-Ze Wu, Zhi-Gang Liu

{"title":"Increased expression of proinflammatory cytokines in the cerebrospinal fluid of patients with a history of electrical status epilepticus in sleep.","authors":"Xing-Guang Ye, Shi-Wei Dong, Ben-Ze Wu, Zhi-Gang Liu","doi":"10.1007/s10072-025-08217-4","DOIUrl":"10.1007/s10072-025-08217-4","url":null,"abstract":"Objective: This study was to investigate the cytokine expression profiles in the cerebrospinal fluid (CSF) of Self-limited epilepsy with centrotemporal spikes (SeLECTS) patients with electrical status epilepticus during sleep (ESES) and compare these to other neurological diseases to identify the cytokines that correlate with ESES.Methods: Seven SeLECTS patients with ESES and nine non-ESES controls were included in this study. CSF was centrifuged within one hour and stored at -80 °C; subsequently, High mobility group box 1 (HMGB1), Caspase-1, interleukin (IL)-1β, IL-1α, IL-6, IL-8, IL-10 and tumour necrosis factor-α (TNF-α) were measured with enzyme-linked immunosorbent assay.Results: CSF levels of IL-1β, TNF-α, IL-1α, and Caspase-1 in ESES group were significantly elevated compared with those non-ESES controls. Moreover, IL-1β CSF levels were positively correlated with Caspase-1 and TNF-α whereas it moderately correlated with IL-1α.Conclusions: The present study indicates a close relationship between neuroinflammation and ESES pathogenesis in patients with SeLECTS.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3997-4000"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term safety evaluation of natalizumab during pregnancy and lactation in patients with multiple sclerosis. natalizumab在多发性硬化症患者妊娠和哺乳期的长期安全性评价。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-08-01 Epub Date: 2025-05-07 DOI: 10.1007/s10072-025-08188-6

Giannicola Carrozzo, Federica Pinardi, Alessandra Lugaresi

{"title":"Long-term safety evaluation of natalizumab during pregnancy and lactation in patients with multiple sclerosis.","authors":"Giannicola Carrozzo, Federica Pinardi, Alessandra Lugaresi","doi":"10.1007/s10072-025-08188-6","DOIUrl":"10.1007/s10072-025-08188-6","url":null,"abstract":"Background: Natalizumab (NTZ) is a monoclonal antibody used in treating relapsing forms of multiple sclerosis (MS). However, there is still insufficient information about its long-term safety during pregnancy and lactation. This study aims to provide further insights into the short- and long-term effects of NTZ on mothers with MS and their children exposed to the drug during pregnancy and breastfeeding.Materials and methods: We recruited prospectively and retrospectively 14 women with MS, treated with NTZ, and their 15 children. All women continued NTZ treatment throughout pregnancy, and 10 of them also during breastfeeding. The follow-up period ranged from 1 to 5 years post-delivery, in the group exposed to NTZ both during pregnancy and breastfeeding; from 2 to 10 years post-delivery in the group exposed to NTZ exclusively during pregnancy.Results: During pregnancy, no relapses were reported, suggesting persistent efficacy of NTZ therapy. However, 1 out of 14 mothers experienced postpartum clinical events, without concomitant MRI activity MRI findings, and 2 other patients presented an isolated increase in lesion load, on MRI performed within 1 month after delivery, without clinical relapses. Neonatal outcomes were favorable, with normal birth parameters and absence of infections or developmental delays, with no differences between those exposed or not to NTZ during breastfeeding.Conclusions: NTZ therapy during pregnancy and breastfeeding is associated with favorable maternal and neonatal outcomes up to 10 years follow-up.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3797-3802"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-dose rituximab for the treatment of anti-NMDAR encephalitis in children: a case series study. 低剂量利妥昔单抗治疗儿童抗nmdar脑炎：病例系列研究

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-08-01 Epub Date: 2025-05-15 DOI: 10.1007/s10072-025-08228-1

Haiyan Wu, Fenfen Xu, Yuan Chen, Shanshan Ding, Wei Li, Qiuyue Li, Na Chen, Lin Tang

{"title":"Low-dose rituximab for the treatment of anti-NMDAR encephalitis in children: a case series study.","authors":"Haiyan Wu, Fenfen Xu, Yuan Chen, Shanshan Ding, Wei Li, Qiuyue Li, Na Chen, Lin Tang","doi":"10.1007/s10072-025-08228-1","DOIUrl":"10.1007/s10072-025-08228-1","url":null,"abstract":"Background and purpose: Rituximab is a widely used second-line immune drug for the treatment of anti-NMDAR encephalitis in patients who fail to improve approximately 2 weeks after the initiation of first-line therapies (corticosteroids, intravenous immunoglobulin, plasma exchange). The aim of this study was to investigate the efficacy and safety of low-dose rituximab in the treatment of autoimmune encephalitis in children.Methods: This case series included 6 hospitalized children without tumors with anti-NMDAR encephalitis from January 2018 to December 2020. These children were treated with low-dose rituximab (100 mg, once weekly, according to peripheral blood CD19 + B-cell levels, 3-4 cycles, until CD19 + B cells in peripheral blood were cleared) approximately 2 weeks after the initiation of 2 or more first-line immunotherapies.Results: After 3-4 cycles of low-dose rituximab (100 mg) treatment, the mRS score and CD19 + B-cell count decreased significantly, and the patients maintained stable neurological function (mRS ≤ 2). No adverse events resulting from infusion or other adverse reactions occurred in any patient.Conclusion: In children with autoimmune encephalitis without tumors for whom first-line immunotherapy is ineffective, low-dose rituximab effectively reduces peripheral blood CD19 + B-cell counts, improves the clinical symptoms of patients and reduces hospitalization expenses. RCTs with sufficient sample sizes are needed to firmly establish the value of low-dose rituximab therapy for treating anti-NMDAR encephalitis in children.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3813-3818"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Augusto Tamburini (1848-1918) and Jean-Martin Charcot (1825-1893): the struggle for a scientific approach to Hysteria. 奥古斯托·坦布里尼（1848-1918）和让-马丁·沙科（1825-1893）：为歇斯底里症的科学研究而斗争。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-08-01 Epub Date: 2025-05-13 DOI: 10.1007/s10072-025-08235-2

Francesco Brigo

{"title":"Augusto Tamburini (1848-1918) and Jean-Martin Charcot (1825-1893): the struggle for a scientific approach to Hysteria.","authors":"Francesco Brigo","doi":"10.1007/s10072-025-08235-2","DOIUrl":"10.1007/s10072-025-08235-2","url":null,"abstract":"This article explores the scientific relationship between Augusto Tamburini (1848-1918) and Jean-Martin Charcot (1825-1893) through a detailed analysis of archival documents. It also investigates Tamburini's conception of hypnotism based on the complex interplay between the Salpêtrière and Nancy schools of hypnotism, which is emblematic of Charcot's influence on Italian medicine at the turn of the nineteenth century. Tamburini, a leading Italian psychiatrist, was instrumental in modernizing asylum care, integrating experimental psychology into clinical practice, and advancing psychiatric research. We examine Tamburini's connection with Charcot and present two significant historical documents: the account of Charcot's 1881 visit to the San Lazzaro asylum, directed by Tamburini, and the obituary he wrote in 1893 to honor the French master. Charcot's visit reinforced San Lazzaro's prominence in psychiatric research, particularly in hysteria and hypnosis, and affirmed Tamburini's methodological alignment with the French neurologist. Both scholars utilized photography as a tool for psychiatric documentation, reflecting their commitment to empirical inquiry. Initially following Charcot's neuropathological model of hypnosis, Tamburini later proposed a more integrative theory, incorporating elements of the psychological perspective proposed by Hippolyte Bernheim (1840-1919). His evolving stance illustrated the broader scientific debates of the time while maintaining a strong foundation in experimental methods. Tamburini's obituary for Charcot emphasized his admiration for the French neurologist's scientific rigor and lasting contributions to neurology and psychiatry. Ultimately, Tamburini's work exemplifies how Italian psychiatry, while influenced by Charcot, established its own distinct and respected identity.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"4023-4027"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Miliary brain tuberculosis: a rare case report. 军人脑结核一例罕见报告。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-08-01 Epub Date: 2025-04-12 DOI: 10.1007/s10072-025-08181-z

Vuk Aleksić, Nenad Lalović, Milija Mijajlović

引用次数: 0

Vegetative state in two Italian residential facilities: study of prognosis for subjects and related caregivers. 意大利两家居住机构的植物人状态：受试者和相关护理人员预后的研究。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-08-01 Epub Date: 2025-04-30 DOI: 10.1007/s10072-025-08205-8

Elisabetta Pupillo, Andrea Magnoni, Lorenzo Tinti, Serena Sassi, Ambrogio Monti, Jessica Barbieri, Andrea Millul, Maria Rita Aldeghi, Elisa Bianchi

{"title":"Vegetative state in two Italian residential facilities: study of prognosis for subjects and related caregivers.","authors":"Elisabetta Pupillo, Andrea Magnoni, Lorenzo Tinti, Serena Sassi, Ambrogio Monti, Jessica Barbieri, Andrea Millul, Maria Rita Aldeghi, Elisa Bianchi","doi":"10.1007/s10072-025-08205-8","DOIUrl":"10.1007/s10072-025-08205-8","url":null,"abstract":"Background: Vegetative state (VS) is a severe disturbance of consciousness, often caused by cerebral insults, with limited long-term prognosis data.Study objective: to provide a detailed picture of a cohort of patients treated at 2 long-term care facilities in Lombardy starting from 2014.Methods: Multicentric observational study. Subjects who met the diagnostic criteria for VS were admitted. A caregiver was identified for each patient and filled two questionnaires to evaluate quality of life (SF-36) and need for psychological support (FSQ-30).Results: The study included 146 patients (median age: 61.8 years at admission, 60.4 at the event that caused VS). Non-traumatic cerebral hemorrhage was the leading cause of VS (41%), followed by traumatic (19%) and anoxic brain injury (17%), and ischemic stroke (6.8%). The cumulative mortality was 10% at 1 year, 24% at 2 years, 43% at 5 years, 69% at 10 years, and 88% at 15 years after the event that caused VS, with age (HR 1.03) and ischemic stroke (HR 2.86) as risk factors. Among 24 caregivers, 50% had FSQ-30 score suggesting recommended psychological support (R area), 33% were in the SR area (strongly recommended), and 13% in the U area (urgent need). Females had worse FSQ-30 and SF-36 scores than males, particularly in the mental health index (median 60 vs. 74) and mental component scale (45.3 vs. 53.2).Conclusions: Hemorrhages were found to be the most common cause of VS, differing from previous studies that identified trauma as the primary cause. Caregivers exhibited significant psychological distress.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3899-3907"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-varying association between blood pressure and malignant brain edema after large hemispheric infarction: a prospective cohort study. 大半球梗死后血压与恶性脑水肿的时变关系：一项前瞻性队列研究。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-08-01 Epub Date: 2025-03-29 DOI: 10.1007/s10072-025-08147-1

Xindi Song, Yanan Wang, Wen Guo, Meng Liu, Yilun Deng, Ming Liu

{"title":"Time-varying association between blood pressure and malignant brain edema after large hemispheric infarction: a prospective cohort study.","authors":"Xindi Song, Yanan Wang, Wen Guo, Meng Liu, Yilun Deng, Ming Liu","doi":"10.1007/s10072-025-08147-1","DOIUrl":"10.1007/s10072-025-08147-1","url":null,"abstract":"Aim: To investigate the time-varying association between blood pressure (BP) and malignant brain edema (MBE) risk after large hemispheric infarction (LHI).Methods: We prospectively enrolled LHI patients (CT hypodensity > 1/3 middle cerebral artery territory within 6 h or > 1/2 within 6-48 h of onset) from registry cohort. BP was recorded hourly and analyzed for 24 h and in two 12-hour epochs after onset: 1-12 h and 13-24 h. MBE was defined as neurological deterioration symptoms with midline shift ≥ 5 mm. Generalized estimating equation (GEE) compared BP patterns by MBE occurrence. Logistic regression and restricted cubic splines (RCS) assessed dose-response associations.Results: Among 414 included LHI patients (mean age 69 ± 14y, median onset-to-admission interval 3 h [interquartile range, IQR 2-5]), 117(28.3%) developed MBE with a median post-onset interval of 29 h (IQR 15-56). No significant difference in BP level was observed during 1-12 h. Systolic BP (SBP) was significantly higher in MBE group over time during 13-24 h (GEE P = 0.027). The 24-hour mean SBP exhibited a U-shaped association with MBE risk (nonlinear test, P = 0.029), with no significance in 1-12 h and a positive correlation between mean SBP in 13-24 h and MBE risk (aOR 1.02[1.00-1.04]). A threshold effect for 24-hour mean diastolic BP (DBP) was identified (non-linear test, P = 0.039), with DBP increase above 70 mmHg associated with higher MBE risk (aOR 1.03 [1.00-1.07]). Similarly, elevated mean DBP > 75mmHg during 1-12 h was associated with higher MBE risk.Conclusion: In LHI patients, 24-hour mean SBP demonstrated a U-shaped association with MBE risk, with no significant effect during 1-12 h and a positive linear correlation during 13-24 h after onset. DBP exhibited a threshold effect, primarily influencing MBE risk during 1-12 h after onset.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3727-3734"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum sirtuin 3 levels and multimodal abnormalities in brain structure and function in Parkinson's disease patients with depression. 帕金森病伴抑郁患者血清sirtuin 3水平与脑结构和功能多模态异常

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-08-01 Epub Date: 2025-04-21 DOI: 10.1007/s10072-025-08170-2

Zonghan She, Xuelin Qi, Xiaoxue Shi, Haoran Peng, Jinhua Zheng, Jianjun Ma, Yunfei Sun, Mengyan Zhang, Yingyun Wang, Qing Xu, Qi Gu, Siyuan Chen, Xue Li

{"title":"Serum sirtuin 3 levels and multimodal abnormalities in brain structure and function in Parkinson's disease patients with depression.","authors":"Zonghan She, Xuelin Qi, Xiaoxue Shi, Haoran Peng, Jinhua Zheng, Jianjun Ma, Yunfei Sun, Mengyan Zhang, Yingyun Wang, Qing Xu, Qi Gu, Siyuan Chen, Xue Li","doi":"10.1007/s10072-025-08170-2","DOIUrl":"10.1007/s10072-025-08170-2","url":null,"abstract":"Background: Depression is a common nonmotor symptom in patients with Parkinson's disease (PD). Currently, few studies have investigated the relationships between serum markers and neuroimaging changes associated with depression in PD patients.Objective: To explore the correlations among depression, serum SIRT3 levels, and brain structural and functional alterations in PD patients.Methods: The Hamilton Depression Scale-17 (HAMD-17) was used to assess depression. Serum SIRT3 levels were measured using an enzyme-linked immunosorbent assay (ELISA). Voxel-based morphometry (VBM) and resting-state functional magnetic resonance imaging (rs-fMRI) were used to examine structural and functional alterations.Results: Compared to healthy individuals, serum SIRT3 levels were lower in PD patients, especially in those with depression. PD patients with depression had lower total gray matter volume/total intracranial volume (GMV/TIV) ratio, and GMVs of the right amygdala, lower fractional amplitude of low-frequency fluctuations (fALFF) values of the left middle frontal gyrus (MidFG.L) and left superior parietal lobule (SPL.L), and altered functional connectivity(FC) primarily involving the Salience Network (SN) and the default Mode Network (DMN) compared to those without depression. Serum SIRT3 levels, total GMV/TIV ratios, and fALFF values of the MidFG.L and SPL.L have diagnostic value for PD patients with depression, and their combination can improve predictive accuracy.Conclusions: Depression in PD patients is associated with lower serum SIRT3 levels, right amygdala atrophy, decreased spontaneous activity in MidFG.L and SPL.L, and altered FC in the DMN and SN.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3663-3676"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eye movement abnormalities in Parkinson's disease motor subtypes: a video-oculographic study. 帕金森氏病运动亚型的眼动异常：一项视频眼摄影研究

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-08-01 Epub Date: 2025-04-21 DOI: 10.1007/s10072-025-08184-w

Jolanda Buonocore, Alessio Facchin, Marianna Crasà, Giulia Sgrò, Alessia Cristofaro, Aldo Quattrone, Andrea Quattrone

{"title":"Eye movement abnormalities in Parkinson's disease motor subtypes: a video-oculographic study.","authors":"Jolanda Buonocore, Alessio Facchin, Marianna Crasà, Giulia Sgrò, Alessia Cristofaro, Aldo Quattrone, Andrea Quattrone","doi":"10.1007/s10072-025-08184-w","DOIUrl":"10.1007/s10072-025-08184-w","url":null,"abstract":"Introduction: Eye movement dysfunction has been described in Parkinson's disease (PD), but differences between tremor-dominant (TD) and postural instability/gait difficulty (PIGD) PD motor subtypes remain poorly understood. The aim of this study was thus to compare video-oculographic (VOG) features between PD motor subtypes.Methods: Two hundred and four PD patients and 55 age-matched healthy control subjects (HC) were enrolled in this study. PD patients were stratified into PIGD and TD motor subtype groups. VOG amplitude, peak velocity of upward, downward, and vertical saccades, and square wave jerks (SWJ) number and amplitude were compared across groups. Multivariate linear models also investigated associations between VOG parameters and motor severity, gait/balance disturbances, dopaminergic treatment, and cognitive function.Results: The final cohort included 180 PD patients classified as PIGD (n = 121) or TD subtype (n = 59) and 55 HC. Both PD subtypes showed reduced upward and downward amplitude compared to HC, with normal peak velocity. PIGD patients exhibited significantly decreased upward saccadic amplitude compared to TD patients, with no differences in other VOG parameters. Moreover, the upward saccadic amplitude was associated with motor severity, particularly slowness of gait and bradykinesia/rigidity scores, as well as with levodopa equivalent daily dose (LEDD) in the PIGD group.Discussion: This study provides evidence of greater saccadic hypometria in PIGD than in TD patients in upward gaze, contributing to a better understanding of oculomotor impairment in PD. The association of saccadic amplitude with bradykinesia/rigidity severity and LEDD may suggest a role of underlying dopaminergic deficits in ocular dysfunction in PD patients.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3677-3684"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0