Neurological Sciences最新文献

{"title":"Wilson disease: time frame for improvement of neurological symptomology may exceed a decade.","authors":"Vinisha Somaya, Marketa Hušáková, Radan Brůha, Petr Dušek","doi":"10.1007/s10072-025-08284-7","DOIUrl":"https://doi.org/10.1007/s10072-025-08284-7","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of physical rehabilitation approaches in improving function and mobility after stroke: comprehensive insights from a cochrane systematic review.","authors":"Chun Dang, Yaoheng Lu, Ying Xiong, Li Feng","doi":"10.1007/s10072-025-08243-2","DOIUrl":"https://doi.org/10.1007/s10072-025-08243-2","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic assessment of dysphagia in Parkinson's disease: a controlled study.","authors":"Büşra Şirin Ahısha, Nur Kesiktaş, Nurdan Paker","doi":"10.1007/s10072-025-08280-x","DOIUrl":"https://doi.org/10.1007/s10072-025-08280-x","url":null,"abstract":"<p><strong>Background: </strong>Swallowing dysfunction is a common but often overlooked symptom in Parkinson's disease (PD), significantly affecting patients' quality of life. Ultrasonography has emerged as a promising, non-invasive, radiation-free, and dynamic assessment tool for evaluating swallowing function in PD.</p><p><strong>Aims: </strong>This study aimed to dynamically assess swallowing function in early- and mid-stage Parkinson's disease patients using ultrasonography and compare the findings with healthy controls.</p><p><strong>Methods: </strong>This cross-sectional study included 30 patients diagnosed with PD and 30 healthy volunteers. Swallowing function was assessed using the Eating Assessment Tool-10 (EAT-10) questionnaire. Ultrasonographic measurements at rest, dry swallowing, and 5 mL water swallowing evaluated tongue thickness, mandible-hyoid distance(MHD), and hyoid displacement. Parkinson's disease severity was assessed using the Modified Hoehn-Yahr (HY) Scale and the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS).</p><p><strong>Results: </strong>EAT-10 scores were significantly higher in the PD group compared to healthy controls (p < 0.001), with 43.33% of patients exhibiting clinically significant dysphagia (EAT-10 ≥ 3). During dry swallowing, minimum MHD was significantly higher (p < 0.05), while hyoid displacement distance (p = 0.013) and percentage (p = 0.002) were significantly lower in PD patients. Similarly, during 5 mL water swallowing, hyoid displacement percentage was significantly lower in the PD group (p = 0.019). No significant correlation was found between ultrasonographic measurements and disease severity (HY staging, MDS-UPDRS scores).</p><p><strong>Conclusion: </strong>Ultrasonography is a valuable tool for assessing swallowing dysfunction in PD, revealing reduced hyoid displacement even in early stages. The high prevalence of dysphagia supports routine swallowing assessments. Ultrasonography integration may aid early detection, improving patient outcomes and reducing aspiration-related risks.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of rapidly progressive juvenile amyotrophic lateral sclerosis associated with a pathogenetic heterozygous de novo variant in the FUS gene.","authors":"Ilaria Orologio, Antonio Russo, Francesca Trojsi, Vincenzo Todisco, Mario Cirillo, Alessandro Tessitore, Marcello Silvestro","doi":"10.1007/s10072-025-08272-x","DOIUrl":"https://doi.org/10.1007/s10072-025-08272-x","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delphi consensus finding on paediatric-adult transition: results from the epilepsy transition working group of the italian league against epilepsy (LICE).","authors":"F Darra, P Biermann Klaus, D Audenino, F Bisulli, A Cossu, M Elia, A La Neve, M Mancardi, C Pastori, J Proietti, F Ragona, R Rizzi, A Rosati, V Sciruicchio, N Specchio, C Stipa, C Zanus, F Villani","doi":"10.1007/s10072-025-08166-y","DOIUrl":"https://doi.org/10.1007/s10072-025-08166-y","url":null,"abstract":"<p><strong>Purpose and rationale: </strong>The care for paediatric and transitional-age epilepsy patients has expanded significantly, addressing the diverse needs of patients with self-limiting to lifelong conditions. Approximately one-third of patients with childhood-onset epilepsy remain dependent on parental care, with transition influenced by factors such as seizure frequency, drug resistance, comorbidities, and developmental disabilities. The Italian League Against Epilepsy (LICE) initiated a Delphi consensus to establish common guidelines for effective transition practices.</p><p><strong>Methods: </strong>The consensus process included a literature review, thematic analysis, and iterative surveys using the Delphi Technique. The surveys involved 15 clinicians from LICE centres, forming the Epilepsy Transition Working Group (ETWG), and external experts. The surveys gathered expert opinions, with questions designed from evidence-based thematic areas.</p><p><strong>Results: </strong>The Delphi rounds revealed several findings. Effective pediatric-to-adult transition in epilepsy requires a multidisciplinary approach, including child and adolescent neuropsychiatrists, continuous training for healthcare providers, and active involvement of caregivers. The transition process should start at variable ages depending on the type of epilepsy and associated comorbidities, and it should mitigate risk factors and address psychological stress for patients and caregivers. Items related to transition tools did not reach consensus, highlighting the need for standardized screening questionnaires and measurable outcomes.</p><p><strong>Conclusions: </strong>This study emphasizes the necessity of an organized transition model involving various specialists and a tailored timeline. The consensus underscores the importance of caregiver involvement and unified educational curricula for all epileptologists to ensure effective care transition. The ETWG is building and improving a network of epilepsy centres to implement the organizational model derived from this study.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in diagnostic technologies for postoperative central nervous system infections: a review.","authors":"Junan Hu, Wei Yu, Jiating Cui, Lun Zhang, Wangfang Yu","doi":"10.1007/s10072-025-08279-4","DOIUrl":"https://doi.org/10.1007/s10072-025-08279-4","url":null,"abstract":"<p><p>Postoperative central nervous system infections (PCNSIs), including meningitis, cerebral abscesses, and implant-associated infections, represent critical complications following neurosurgical procedures. These infections pose significant risks to patient outcomes due to delayed diagnosis, escalating antimicrobial resistance, and limited therapeutic efficacy. Conventional diagnostic approaches, such as cerebrospinal fluid (CSF) analysis, microbial cultures, and neuroimaging, exhibit notable limitations in sensitivity, specificity, and rapidity. This review highlights transformative technologies reshaping PCNSI diagnostics, including molecular assays (e.g., quantitative PCR, digital droplet PCR), metagenomic next-generation sequencing (mNGS), CRISPR-based pathogen detection platforms, metabolomics, and advanced molecular imaging modalities. Furthermore, we address translational challenges in clinical adoption, including cost barriers, standardization gaps, and the need for interdisciplinary collaboration. Emerging artificial intelligence (AI)-driven strategies are proposed to optimize pathogen identification, predict antimicrobial resistance profiles, and tailor personalized therapeutic regimens.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibromuscular dysplasia: Challenges for the current classification.","authors":"Marialuisa Zedde, Maria Simona Stoenoiu, Alexandre Persu, Rosario Pascarella","doi":"10.1007/s10072-025-08281-w","DOIUrl":"https://doi.org/10.1007/s10072-025-08281-w","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of continuous subcutaneous ND0612 Infusion compared to oral and alternative regimens in managing motor fluctuations in Parkinson's disease: a systematic review and meta-analysis.","authors":"Abdallah Abunamoos, Mohammad Moayad Ahmad Alghaniem, Fares A Qtaishat, Yumna Aljazi, Leen Omar Al-Omari, Izere Salomon, Bara M Hammadeh, Khaled Moghib","doi":"10.1007/s10072-025-08257-w","DOIUrl":"https://doi.org/10.1007/s10072-025-08257-w","url":null,"abstract":"<p><strong>Background: </strong>Continuous subcutaneous infusion of levodopa/carbidopa (ND0612) is a promising alternative to oral therapy for Parkinson's disease. Motor fluctuations and \"off time\" significantly impact the quality of life in advanced diseases. This meta-analysis evaluates the effectiveness of ND0612 in reducing \"off time,\" improving the overall quality of life, and enhancing sleep quality.</p><p><strong>Method: </strong>A comprehensive search of 549 studies was performed, and five eligible studies (n = 327) were included after intense screening. The ROB2 tool and ROBINS1 were used to assess the quality of the included studies. The outcomes assessed included reductions in \"off time\" (hours), quality of life (PDQ-39 scores), and sleep quality (PDSS scores). Statistical heterogeneity was assessed using the I² and tau² statistics.</p><p><strong>Results: </strong>The meta-analysis showed a significant reduction in OFF time for ND0612 compared to oral regimens, with a standardized mean difference (SMD) of -0.53 (95% CI: -0.76, -0.30), and compared to placebo with an SMD of -0.30 (95% CI: -1.05, 0.44). For improvement in quality of life, a favorable effect of ND0612 was shown compared to oral regimens (SMD = -0.31, 95% CI: -0.54, -0.08) and placebo (SMD = 0.44, 95% CI: 1.19, -0.32). Sleep quality (PDSS scores) demonstrated a slight improvement compared with oral regimens (SMD = -0.21, 95% CI: -0.44, 0.02) and a more significant improvement compared with placebo (SMD = -0.42, 95% CI: -0.87, 0.03). Overall, ND0612 provided consistent benefits in reducing OFF time and enhancing both quality of life and sleep in patients with Parkinson's disease.</p><p><strong>Conclusion: </strong>ND0612 significantly reduced \"off time\" and improved quality of life among Parkinson's disease patients experiencing motor fluctuations. However, its effect on sleep quality was inconsistent, with no clear, robust benefit demonstrated. Overall, this analysis supports ND0612 as an effective therapeutic option in patients with advanced Parkinson's disease.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudoaneurysm of the middle meningeal artery as a delayed complication of head trauma.","authors":"Nicola Romano, Annapaola Truono, Antonio Castaldi","doi":"10.1007/s10072-025-08273-w","DOIUrl":"https://doi.org/10.1007/s10072-025-08273-w","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review: Resting state functional MRI as a biomarker for non-invasive brain stimulation in upper limb recovery post-stroke.","authors":"Mudasar Aziz, Sheharyar Baig, Wen Hai, Ali Ali, Arshad Majid, Li Su","doi":"10.1007/s10072-025-08224-5","DOIUrl":"https://doi.org/10.1007/s10072-025-08224-5","url":null,"abstract":"<p><strong>Background: </strong>Stroke is a leading cause of adult-onset disability. Non-invasive brain stimulation (NIBS) techniques such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and transcutaneous vagus nerve stimulation (tVNS) may improve arm weakness after stroke. Resting-state functional MRI (rs-fMRI) and near-infrared spectroscopy (rs-fNIRS) assess brain connectivity. Identifying the effect of NIBS on rs-fMRI/rs-fNIRS may illuminate the post-stroke recovery process. This systematic review assesses NIBS effects on clinical and rs-fMRI/rs-fNIRS outcomes in stroke survivors with arm weakness.</p><p><strong>Methods: </strong>Systematic searches were conducted in EMBASE and MEDLINE. Articles involving adults with arm weakness from stroke, treated with more than one session of NIBS (TMS/tDCS/tVNS) and reporting clinical and rs-fMRI/rs-fNIRS outcomes at baseline and post-intervention were included. The Cochrane Risk of Bias tool was used to assess the methodological quality of included studies. Data extraction and narrative synthesis were performed.</p><p><strong>Results: </strong>Twelve articles containing 393 participants were included. Nine studies assessed TMS, two studies assessed tDCS, and one study used dual-mode stimulation (TMS and tDCS). All studies showed significant improvements in clinical measures of arm function compared to baseline following NIBS. All studies showed changes in functional connectivity post-intervention. Enhanced interhemispheric connectivity, particularly between primary motor cortices, was positively correlated with functional outcomes.</p><p><strong>Discussion: </strong>Both TMS and tDCS are promising adjunctive therapies for arm weakness post-stroke. Rs-fMRI, particularly interhemispheric connectivity, may provide a valid biomarker of restitution of function with NIBS. Future research should involve.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}