Neurological Sciences最新文献

{"title":"Dimdazenil for the treatment of insomnia: a systematic review and narrative synthesis.","authors":"Shan Ran, Shouhuan Liu, Kewen Yan, Xueyi Li, Min Wu, Hanrui Peng, Tieqiao Liu, Zejun Li","doi":"10.1007/s10072-024-07872-3","DOIUrl":"https://doi.org/10.1007/s10072-024-07872-3","url":null,"abstract":"<p><strong>Background: </strong>Insomnia is a common sleep disorder affecting approximately 10-20% of adults worldwide. Despite various available treatment modalities, significant gaps remain in improving sleep maintenance and reducing functional impairments.</p><p><strong>Objective: </strong>To systematically review and synthesize studies on the efficacy and safety of Dimdazenil for the treatment of insomnia.</p><p><strong>Methods: </strong>A comprehensive search of multiple databases and websites was conducted to identify published and unpublished trials from inception to July 19, 2024. Due to the limited number of studies available, quantitative data were synthesized narratively.</p><p><strong>Results: </strong>This synthesis included four randomized controlled trials. The primary efficacy endpoints of these studies met the predetermined criteria for superiority. Dimdazenil significantly improved certain objective and subjective sleep measures in patients with insomnia, including reduced sleep latency and longer total sleep duration. Importantly, these outcomes were achieved without causing significant excessive daytime drowsiness or impairing daytime functionality. Furthermore, Dimdazenil demonstrated a generally acceptable safety profile and was well tolerated. Most evaluation indicators related to withdrawal symptoms, drug residues, and rebound effects did not show significant statistical differences.</p><p><strong>Limitations: </strong>The number of included studies and sample sizes were small, and there is a lack of data on the long-term efficacy and safety of Dimdazenil.</p><p><strong>Conclusions: </strong>Dimdazenil offers significant benefits in improving sleep onset and maintenance in patients with insomnia. It presents a favorable safety and tolerability profile while preserving daytime functioning. Future studies should extend the duration and scale to assess the long-term efficacy and safety of Dimdazenil across diverse populations.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of transcranial direct current stimulation (tDCS) in treatment of refractory epilepsy: an updated systematic review and meta-analysis of randomized sham-controlled trials.","authors":"Yousef Hawas, Abdallah Abbas, Ibraheem M Alkhawaldeh, Mohamed Abo Zeid, Mohammad Al Diab Al Azzawi, Hamza Khaled Alsalhi, Ahmed Negida","doi":"10.1007/s10072-024-07866-1","DOIUrl":"https://doi.org/10.1007/s10072-024-07866-1","url":null,"abstract":"<p><p>Despite the currently available treatment, one-third of epilepsy patients continue to experience seizures. Transcranial direct current stimulation (tDCS) has emerged as a potential neuromodulation approach for the non-invasive treatment of refractory epilepsy. This study aims to provide a comprehensive investigation of the efficacy and safety of tDCS in patients with drug-resistant epilepsy. The following databases were searched from inception until June 2023; PubMed, Scopus, Embase, WOS, EBSCO, Cochrane Central, and Ovid MEDLINE. Pooled mean difference was calculated for change in seizure frequency (SF), and number of Interictal epileptiform discharges (IEDs) at different follow-up intervals. We included nine parallel randomized sham-controlled trials with a total of 267 patients. Active tDCS patients had a significantly lower SF per month at 4 and 8 weeks (MD = -4.06, 95% CI [-6.01 to -2.12], p < 0.0001), and (MD = -2.66, 95% CI [-5.09 to -0.23], p = 0.03), respectively. However, weekly SF showed no statistically significant results at 4 weeks of follow-up. The IEDs were observed to significantly decline at 2, 4, and 8 weeks of follow-up. The reported adverse events were mild including mild itching and erythematous rash that resolved spontaneously. In conclusion, tDCS significantly reduced monthly SF and the number of IEDs. Future large RCTs with standard clear informed parameters are still required.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based models for prediction of survival in medulloblastoma: a systematic review and meta-analysis.","authors":"Bardia Hajikarimloo, Mohammad Amin Habibi, Mohammadamin Sabbagh Alvani, Sima Osouli Meinagh, Alireza Kooshki, Omid Afkhami-Ardakani, Fatemeh Rasouli, Salem M Tos, Roozbeh Tavanaei, Mohammadhosein Akhlaghpasand, Rana Hashemi, Arman Hasanzade","doi":"10.1007/s10072-024-07879-w","DOIUrl":"https://doi.org/10.1007/s10072-024-07879-w","url":null,"abstract":"<p><strong>Background: </strong>Medulloblastoma (MB) is the pediatric population's most frequent malignant intracranial lesions. Prognostication plays a crucial role in optimizing treatment strategy in the MB setting. Several studies have developed ML-based models to predict survival outcomes in individuals with MB. In this systematic review and meta-analysis study, we aimed to evaluate the role of ML-based models in predicting survival in MB patients.</p><p><strong>Method: </strong>Literature records were retrieved on May 14th, 2024, using the relevant key terms without filters in PubMed, Embase, Scopus, and Web of Science. Records were screened according to the eligibility criteria, and the data from the included studies were extracted. The quality assessment was performed using the QUADAS-2 tool. The meta-analysis and sensitivity analysis were conducted using R software.</p><p><strong>Results: </strong>Six studies were included, with 2771 patients ranging from 46 to 1759 individuals. A total of 23 ML and DL models were developed, 20 of which were ML and three DL. Random forest (RF) was the most frequent classifier, as it was utilized in nine models, followed by support vector machine (SVM). Eight models were included in the meta-analysis. Our meta-analysis revealed a pooled AUC of 0.77 (95% CI: 0.75-0.80). In addition, the radionics-based and genomics-based models had a pooled AUC of 0.77 (95% CI: 0.76-079) and 0.76 (0.63-0.88), respectively (P = 0.77).</p><p><strong>Conclusion: </strong>Our results suggested that ML-based models, especially ML algorithms, could play a vital and efficient role in the prediction of survival of patients based on radiomics and genomics.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of upper extremity robotic rehabilitation on respiratory parameters, functional capacity and dyspnea in patients with stroke: a randomized controlled study.","authors":"Büşra Okumuş, Buket Akıncı, Güzin Kaya Aytutuldu, Mehmet Salih Baran","doi":"10.1007/s10072-024-07868-z","DOIUrl":"https://doi.org/10.1007/s10072-024-07868-z","url":null,"abstract":"<p><strong>Background: </strong>Stroke leads to reduced mobility and functional capacity, also negatively affects respiratory functions and muscle strength.</p><p><strong>Aim: </strong>To examine the effects of adding upper extremity robotic rehabilitation to conventional treatment on respiratory parameters, functional capacity, mobility, and dyspnea.</p><p><strong>Method: </strong>Thirty-four stroke patients aged 18-65/years were randomized into Conventional Rehabilitation (CR) or Upper Extremity Robotic Rehabilitation (RR) groups. Both groups received conventional treatment for 5 days/week, for 6 weeks. Additionally, the RR group participated in upper extremity robotic rehabilitation (ExoRehab X, Houston Bionics) twice/week. Respiratory muscle strength (Maximum Inspiratory Pressure-MIP and Maximum Expiratory Pressure-MEP) and respiratory functions (forced expiratory flow first second (FEV1)), forced vital capacity (FVC), FEV1/FVC, peak expiratory flow (PEF), and forced expiratory flow-25-75% (FEF 25-75%) were assessed. Functional capacity was evaluated with 6-minute walk test (6-MWT), mobility was assessed with Timed Up and Go (TUG) test, and dyspnea was measured using Dyspnea-12 test.</p><p><strong>Results: </strong>Both groups showed improvements in MIP, MEP, 6MWT and TUG scores. Additionally, significant increases were observed in PEF in the CR group and in FVC, FEV1, %FEF 25-75, and reduced dyspnea in the RR group (all p < 0.05). The groups were similar in terms of mean changes, except for FVC (p = 0.004) and FEV1 (p = 0.002), which were significantly higher in RR group.</p><p><strong>Conclusion: </strong>Combining upper extremity robotic rehabilitation with conventional rehabilitation in stroke patients led to similar improvements in respiratory muscle strength, functional capacity, and mobility while also improving some respiratory parameters and reducing the perception of dyspnea.</p><p><strong>Trial registration number: </strong>NCT05550311.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KLHL11-associated rhomboencephalitis presenting as clippers-like syndrome.","authors":"Jin Li, Ling Bai, Yushan Yuan, Jianzhao Zhai, Minjin Wang","doi":"10.1007/s10072-024-07858-1","DOIUrl":"https://doi.org/10.1007/s10072-024-07858-1","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurological, psychological, psychosocial complications of long-COVID and their management.","authors":"Sareesh Naduvil Narayanan, Sreeshma Padiyath, Krishnapriya Chandrababu, Lima Raj, Baby Chakrapani P S, George Abraham Ninan, Ajith Sivadasan, Alexander Ryan Jacobs, Yan Wa Li, Anand Bhaskar","doi":"10.1007/s10072-024-07854-5","DOIUrl":"https://doi.org/10.1007/s10072-024-07854-5","url":null,"abstract":"<p><p>Since it first appeared, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has had a significant and lasting negative impact on the health and economies of millions of individuals all over the globe. At the level of individual health too, many patients are not recovering fully and experiencing a long-term condition now commonly termed 'long-COVID'. Long-COVID is a collection of symptoms which must last more than 12 weeks following initial COVID infection, and which cannot be adequately explained by alternate diagnoses. The neurological and psychosocial impact of long-COVID is itself now a global health crisis and therefore preventing, diagnosing, and managing these patients is of paramount importance. This review focuses primarily on: neurological functioning deficits; mental health impacts; long-term mood problems; and associated psychosocial issues, among patients suffering from long-COVID with an eye towards the neurological basis of these symptoms. A concise account of the clinical relevance of the neurological and psychosocial impacts of long-COVID, the effects on long-term morbidity, and varied approaches in managing patients with significant chronic neurological symptoms and conditions was extracted from the literature, analysed and reported. A comprehensive account of plausible pathophysiological mechanisms involved in the development of long-COVID, its management, and future research needs have been discussed.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and functional outcomes of pediatric Guillain-Barré syndrome admitted to the Neuro-intensive care unit: a decade-long retrospective observational study.","authors":"Rohini M Surve, Prachi Sharma, Roshan Nisal, Dhritiman Chakrabarti, K Raghavendra, Girish B Kulkarni, Sriganesh Kamath","doi":"10.1007/s10072-024-07862-5","DOIUrl":"https://doi.org/10.1007/s10072-024-07862-5","url":null,"abstract":"<p><strong>Background: </strong>Guillain-Barré Syndrome (GBS) remains a significant contributor to acute flaccid paralysis in pediatric patients worldwide. Despite its impact, studies focusing on pediatric GBS requiring intensive care unit (ICU) management are limited. This study aimed to address this gap by exploring the clinical and outcome characteristics of pediatric GBS necessitating ICU care.</p><p><strong>Methods: </strong>This retrospective observational study, spanning a decade, analyzed the records of 75 pediatric GBS patients admitted to the Neuro-ICU of a tertiary care center in South India. Data included demographics, prodromal symptoms, clinical features, investigations, treatment modalities, and outcomes.</p><p><strong>Results: </strong>The majority (55/75) of patients were male, with a median age of 12 years. The highest incidence of GBS requiring ICU admission was in the monsoon season. Prodromal symptoms were observed in 56%. Most patients (93.33%) presented with typical GBS symptoms, and 40% had respiratory distress on ICU admission. Acute motor axonal neuropathy (AMAN) was the most common subtype. Approximately 80% required mechanical ventilation, with a median duration of 22.5 days. No in-hospital mortality was recorded. At discharge, most patients had a GBS disability score of 4, improving to 2 at a median follow -up of 228 days.</p><p><strong>Conclusions: </strong>Pediatric GBS patients requiring ICU care exhibit distinctive characteristics, including a higher prevalence of AMAN subtype, seasonal clustering, and favorable outcomes with intensive treatment. The absence of in-hospital mortality underscores the effectiveness of prompt ICU admission and dedicated Neuro-intensive care.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical progression of benign fasciculation syndrome: a systematic literature review.","authors":"Camilla Mattiuzzi, Giuseppe Lippi","doi":"10.1007/s10072-024-07867-0","DOIUrl":"https://doi.org/10.1007/s10072-024-07867-0","url":null,"abstract":"<p><strong>Objectives: </strong>Benign fasciculation syndrome (BFS) is a challenging clinical condition that causes great concern to patients, as the sudden onset of fasciculations often raises suspicion of the presence or future development of motor neuron diseases. This article hence aims to provide a systematic literature review of clinical studies that investigated the clinical progression of BFS over time.</p><p><strong>Methods: </strong>We conducted an electronic search of PubMed, Scopus, and Web of Science using the keyword \"benign fasciculation syndrome\" in article title, abstract, and keywords, with no time or language restrictions, to identify all possible studies with a minimum number of 10 patients that examined the clinical progression of BFS over time.</p><p><strong>Results: </strong>Three articles with 180 patients, predominantly men (140/180; 78%), could be included in our analysis. In 98.3% of all patients fasciculations persisted over a period of 8 months to several years after the initial diagnosis of BFS, but no patient developed motor neuron dysfunction at follow-up. In the two studies providing details on clinical evolution of symptoms, fasciculations improved in 51.7% of patients and worsened in 4.1%. These results confirm the almost benign nature of BFS, with progression to overt motor neuron disease described only in specific case reports.</p><p><strong>Conclusion: </strong>Despite its benign nature, BFS does not appear to resolve over time, as fasciculations persist in the vast majority of BFS cases, albeit with some improvements in more than half of patients.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing ChatGPT accuracy in pediatric epilepsy.","authors":"Alejandro García-Rudolph, David Sanchez-Pinsach, Eloy Opisso, Celeste Aparicio-López, Antonia Enseñat","doi":"10.1007/s10072-024-07851-8","DOIUrl":"https://doi.org/10.1007/s10072-024-07851-8","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-induced liver injury during valproic acid and cenobamate coadministration: a direct consequence or an unforeseen event?","authors":"Thomas Giannelli, Giovanni Falcicchio","doi":"10.1007/s10072-024-07864-3","DOIUrl":"https://doi.org/10.1007/s10072-024-07864-3","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}