Neurological Sciences最新文献

{"title":"Unreported collateral pathways in internal carotid artery agenesis.","authors":"Monique Boukobza, Jean-Pierre Laissy","doi":"10.1007/s10072-025-08336-y","DOIUrl":"10.1007/s10072-025-08336-y","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5493-5495"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of neurological manifestation in familial mediterranean fever patients: systematic review & meta-analysis.","authors":"Mohammad Hamad, Tala Mohammad, Mira Bishtawi, Randa Shahwan, Jaber H Jaradat, Wafa' A Hazaymeh, Omar F Jbarah, Ethar Hazaimeh","doi":"10.1007/s10072-025-08351-z","DOIUrl":"10.1007/s10072-025-08351-z","url":null,"abstract":"<p><strong>Background: </strong>Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease worldwide, characterized by recurrent attacks of fever and polyserositis. Several studies have reported FMF cases with neurological conditions. As well as multiple neurological diseases have been reported in multiple studies in patients with FMF.</p><p><strong>Aims: </strong>to summarize the frequency of neurologic manifestations reported among FMF patients.</p><p><strong>Methods: </strong>PubMed, Web of Science, and SCOPUS were searched for studies that reported any neurological manifestation in FMF patients. Studies were screened first by abstract and then by full text, any conflict was resolved by a discussion. The JBI tool was used for assessing the risk of bias in studies. A meta-analysis of the proportions was performed for neurological manifestations in patients with FMF. A random effects model was indicated when I² was greater than 50%, and a fixed model was used otherwise. R version 4.3.2 for performing the analysis.</p><p><strong>Results: </strong>Out of 787 citations, 36 studies (14 case reports, 22 others) were included with a total of 906 FMF patients (14 case reports, 892 others) with neurological manifestations. For case-report studies, the common manifestation was headache (42.9%) followed by Muscle weakness, diplopia (35.7%), Sensory disorders (35.7%) and facial nerve palsy (14.3%), The most common comorbid neurological condition was Multiple sclerosis (28.6%). Regarding Other study types, the Pooled prevalence of the most common manifestation was Neuropathy (0.45 [0.00; 0.99]), then Myalgia (0.27, 95%CI: [0.11; 0.47]), Headache (0.23, 95%CI: [0.12; 0.36]), and visual disorders (0.13 [0.01; 0.37]). The most common comorbid was ADHD (0.31, 95%CI: [0.25; 0.37]). Most studies were evaluated at a low risk of bias.</p><p><strong>Conclusion: </strong>Nearly half of the patients in our review had Neuropathy in this review. ADHD was co-comorbid in 31% of patients. These findings underscore the importance of increased awareness and surveillance for these manifestations in patients with FMF. Further research is needed to better understand the pathogenesis of this manifestation.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"4943-4953"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversible intramyelinic cytotoxic edema in a patient with traumatic brain injury.","authors":"Catalina Barragán, Silvia González-Gómez, Adriana Barrera, Camilo Soler","doi":"10.1007/s10072-025-08338-w","DOIUrl":"10.1007/s10072-025-08338-w","url":null,"abstract":"<p><p>We report a case demonstrating magnetic resonance imaging findings of reversible white matter restriction on diffusion-weighted imaging and apparent diffusion coefficient maps in a patient with traumatic brain injury. A 22-year-old man presented to the emergency department following a severe motor vehicle collision. The magnetic resonance imaging revealed multiple focal hemorrhagic contusions, supratentorial diffuse axonal injury, a left parietotemporal subdural laminar hematoma, and extensive diffusion restriction on diffusion coefficient maps involving the deep white matter of the centrum semiovale bilaterally, as well as the splenium of the corpus callosum. The patient was hospitalized, and follow-up magnetic resonance showed a complete resolution of the diffusion-restricted areas. This case illustrates a traumatic brain injury associated with transient, reversible intramyelinic cytotoxic edema.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5427-5430"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT and MRI findings of intracranial extraskeletal mesenchymal and myxoid chondrosarcoma: report of 3 rare cases and literature review.","authors":"Hongjian Shi, Hui Yi, Ti Wang, Wenwen Xiong, Hong Li, Chengxiao Fu, Xiaodong Wang, Ling Wei","doi":"10.1007/s10072-025-08362-w","DOIUrl":"10.1007/s10072-025-08362-w","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"4993-5001"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing the occurrence and characteristics of white matter hyperintensities on the brain imaging of migraine patients.","authors":"Mahmoud A Farid, Mohamed G Zeinhom, Sherihan Rezk Ahmed, Ehab S Ramadan","doi":"10.1007/s10072-025-08373-7","DOIUrl":"10.1007/s10072-025-08373-7","url":null,"abstract":"<p><strong>Background: </strong>White matter hyperintensities (WMHs) increase the burden of migraine on the patients' lives and leading to migraine-related poor outcomes, so we aim to evaluate the association of different neurophysiological, psychological, and clinical factors with the presence and characteristics of WMHs on the brain imaging of migraine patients.</p><p><strong>Methods: </strong>Our study included 300 migraine patients who underwent clinical, psychological, and neurophysiological assessment, including P300, which represented an event-related potential (ERP) component elicited in the decision-making process. The goal was to evaluate the association of these factors with the presence and characteristics of WMHs on the brain imaging of migraine patients.</p><p><strong>Results: </strong>older age (OR, 1.213; 95% CI, 1.149 to 1.787; P-value 0.02), P300 Fz latency (OR, 1.852; 95% CI, 1.374 to 2.314; P-value < 0.001), P300 Pz latency (OR, 1.823; 95% CI, 1.397 to 4.237; P-value < 0.001), migraine with aura (OR, 7.115; 95% CI, 3.874 to 14.254; P-value 0.01), chronic migraine (OR, 6.105; 95% CI, 3.364 to 8.057; P-value < 0.001), and Montreal cognitive assessment (MoCA) (OR, 0.543; 95% CI, 0.169 to 0.723; P-value < 0.001) were associated with developing WMHs on the brain MRI of migraine patients.</p><p><strong>Conclusion: </strong>Prolonged P300 latency, older age, lower MoCA score, chronic migraine, and migraine with aura were associated with the presence of WMHs on the brain imaging of migraine patients. In addition, longer P300 latency was positively correlated with WMH diameter, number, and Schelten's score. In contrast, higher P300 amplitude and higher MoCA score were negatively correlated with WMH diameter, number, and Schelten's score in migraine patients.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5253-5262"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central nervous system demyelination associated with biological agents used in the treatment of rheumatologic diseases: a retrospective cohort study.","authors":"Doruk Arslan, Basak Sayinalp-Arslan, Emre Bilgin, Pinar Acar-Ozen, Rahsan Gocmen, Ihsan Ertenli, Sedat Kiraz, Rana Karabudak, Umut Kalyoncu, Asli Tuncer","doi":"10.1007/s10072-025-08354-w","DOIUrl":"10.1007/s10072-025-08354-w","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the annual incidence rate and clinical characteristics of central nervous system (CNS) demyelinating disease in patients who receive biologic agents for rheumatic diseases.</p><p><strong>Methods: </strong>Patients who received biologic agents due to rheumatic diseases were identified in a retrospective manner and data of the patients who developed CNS demyelinating disease were recorded.</p><p><strong>Results: </strong>4838 out of 5926 patients who attended regular follow-up visits, were included in the study. CNS demyelinating disease was observed in 7 patients for 19.391 patient-years. 4 of 7 were diagnosed with multiple sclerosis (MS). 6 out of 7 were under anti-TNF therapy and mean duration was 13 months under causative drugs. While annual incidence rate of CNS demyelinating disease was 36.1/100000 (95% CI: 17-75), annual multiple sclerosis incidence rate in rheumatologic patients exposed to biologic agents was 19.6/100000 (95% confidence interval 7-52).</p><p><strong>Conclusion: </strong>When compared with the data obtained in our cohort with annual incidence rates of multiple sclerosis in Europe, it is possible to conclude that there is an increase in the incidence of demyelinating events. Therefore, clinicians must be aware of neurological signs and symptoms in patients who receive biologic agents.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5279-5286"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral MAPT methylation as a biomarker in FTD: potential, pitfalls, and future directions.","authors":"Syed Muhammad Ali, Javed Iqbal, Brijesh Sathian, Ramya Kundayi Ravi, Mian Zahid Jan Kakakhel","doi":"10.1007/s10072-025-08326-0","DOIUrl":"10.1007/s10072-025-08326-0","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5467-5468"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Missing information and selective reporting confounds the literature on the association between spinal manipulation and vertebral artery dissection.","authors":"Andrea K Albertson, Anna-Marie Ziegler, Jordan A Gliedt, Ronald J Farabaugh","doi":"10.1007/s10072-025-08394-2","DOIUrl":"10.1007/s10072-025-08394-2","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5507-5508"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Converging pathologies in neurodegeneration: the mechanistic interplay between α-Synuclein and Tau in Alzheimer's and Parkinson's.","authors":"Jeyaram Bharathi Jeyabalan, Vignesh Pandi A, Sankar Veintramuthu, Ramasamy Sivasamy, Muralikrishnan Dhanasekaran, Antony Justin","doi":"10.1007/s10072-025-08421-2","DOIUrl":"10.1007/s10072-025-08421-2","url":null,"abstract":"<p><p>Alzheimer's and Parkinson's disease are the most prevalent neurodegenerative disorders globally, each characterized by distinct pathological hallmarks; primarily tau neurofibrillary tangles and amyloid-beta plaques in AD, and alpha-synuclein (α-Syn) Lewy bodies in PD. However, evidence suggests a complex interplay between these proteins, particularly α-Syn and tau, which may contribute to the progression of both diseases. Recent observations demonstrate the co-occurrence of α-Syn and tau pathologies in both AD and PD patients. At the molecular level, both proteins exhibit prion-like propagation properties and can undergo cross-seeding, where one misfolded protein species induces the misfolding, aggregation of the other and increasing neurotoxicity. These proteins also share common post-translational modifications, cellular clearance mechanisms, and are influenced by similar microenvironmental factors that favor protein aggregation. This review explores the potential mechanisms by which α-Syn in PD may influence tau pathology, potentially exacerbating AD like disease progression that may potentially contribute to cognitive decline in PD. This review also delves into the underlying molecular pathways, such as prion-like propagation, cross-seeding, and inflammatory responses that could mediate this interaction, leading to enhanced neurodegeneration in comorbid cases. Further, various clinical implications of proteins' interplay, relevance to mixed neurodegenerative phenotypes, and potential therapeutic strategies targeting both α-Syn and tau pathologies have also been discussed in this manuscript.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"4779-4789"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor, regarding \"Stroke, idiopathic thrombocytopenic purpura and avatrombopag: two cases of coincident events\" recently published by Boy and colleagues.","authors":"Senta Frol, Matjaž Sever","doi":"10.1007/s10072-025-08288-3","DOIUrl":"10.1007/s10072-025-08288-3","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5497-5498"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}