Neurological SciencesPub Date : 2025-08-01Epub Date: 2025-04-22DOI: 10.1007/s10072-025-08171-1
Xiaoyang Lei, Mingzhu Meng, Dian He
{"title":"Anti-LGI1 encephalitis in a COVID-19 patient with positive SARS-CoV-2 in CSF.","authors":"Xiaoyang Lei, Mingzhu Meng, Dian He","doi":"10.1007/s10072-025-08171-1","DOIUrl":"10.1007/s10072-025-08171-1","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"4029-4032"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The association between information processing speed and clinical features in people with multiple sclerosis and neuromyelitis optica: a comparative study.","authors":"Saeed Vaheb, Ziba Rajaei, Vahid Shaygannejad, Hojjatallah Alaei, Alireza Afshari-Safavi, Omid Mirmosayyeb","doi":"10.1007/s10072-025-08193-9","DOIUrl":"10.1007/s10072-025-08193-9","url":null,"abstract":"<p><p>Multiple Sclerosis (MS) and Neuromyelitis Optica Spectrum Disorder (NMOSD) are both autoimmune inflammatory disorders affecting the central nervous system. Cognitive decline is a common symptom in both disorders, particularly affecting information processing speed (IPS). The current study investigated the association between IPS and clinical parameters in people with MS (PwMS) and NMOSD (PwNMOSD). A total of 945 participants were enrolled in the study, including 617 PwMS, 128 PwNMOSD, and 200 healthy controls. IPS was evaluated using the Symbol Digit Modalities Test (SDMT). Clinical, serological, and radiological factors were retrospectively collected. General Linear Model (GLM) was used for data analysis. Based on GLM multivariate analysis adjusted for age, sex, and educational level, a significant association was observed between IPS and Expanded Disability Status Scale (EDSS), disease progression, disease duration, brain atrophy, and brain lesion load in PwMS. Similarly, significant association was found between IPS and EDSS, Aquaporin-4 (AQP-4) antibody positivity, brain atrophy, and number of cervical lesions in PwNMOSD. This study confirms the association between IPS and key risk factors such as EDSS, brain atrophy, and lesion load in PwMS. Additionally, it reveals a link between IPS and new factors, including AQP-4 antibody positivity and cervical lesions in PwNMOSD. Furthermore, disease progression emerged as a significant factor affecting IPS in PwMS.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3783-3795"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurological SciencesPub Date : 2025-08-01Epub Date: 2025-04-21DOI: 10.1007/s10072-025-08176-w
Chengzhe Wang, Ziyi Chen, Guanzhong Ni
{"title":"Cortical laminar necrosis related to convulsive status epilepticus.","authors":"Chengzhe Wang, Ziyi Chen, Guanzhong Ni","doi":"10.1007/s10072-025-08176-w","DOIUrl":"10.1007/s10072-025-08176-w","url":null,"abstract":"<p><p>Cortical laminar necrosis (CLN) is a lasting brain injury distinguished by high-intensity cortical lesions on T1-weighted Magnetic Resonance Imaging (MRI) that adhere to the gyral anatomy of the cerebral cortex. We report a case of convulsive status epilepticus following COVID-19 infection. When the brain MRI scan was performed 58 days after convulsive status epilepticus, cortical T1 hyperintensities and SWI linear gyral hypointensities involving both the cerebral hemispheres, indicative of CLN. This case highlights the typical MRI findings of CLN, SWIsequences may be particularly useful in understanding the pathophysiology of hypoxic CLN.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"4095-4096"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurological SciencesPub Date : 2025-08-01Epub Date: 2025-05-05DOI: 10.1007/s10072-025-08223-6
Alfeo Julius R Sy, Veeda Michelle M Anlacan, Adrian B Yu, Roland Dominic G Jamora
{"title":"New onset steroid-responsive Hashimoto's encephalopathy in the older population: a scoping review.","authors":"Alfeo Julius R Sy, Veeda Michelle M Anlacan, Adrian B Yu, Roland Dominic G Jamora","doi":"10.1007/s10072-025-08223-6","DOIUrl":"10.1007/s10072-025-08223-6","url":null,"abstract":"<p><strong>Background: </strong>Hashimoto's encephalopathy (HE) is a rare autoimmune disorder which can mimic late-life neuropsychiatric symptoms as part of a dementia syndrome. Our objective was to review the clinical profile and management outcomes of new onset HE in older adults based on available literature.</p><p><strong>Methods: </strong>We conducted a comprehensive search for studies on patients aged 65 years and older with newly diagnosed HE across multiple databases, including Medline, Web of Science, Wiley Online Library, and The Cochrane Library, covering publications up to January 2024. Clinical information was extracted and analyzed using Descriptive statistics.</p><p><strong>Results: </strong>Out of 608 articles screened, 45 articles detailing 51 patients were included. Majority of older patients (n = 48, 94.1%) were initially treated with steroids. Methylprednisolone 1 g/day was given in 37.2% (n = 19) for a minimum of 3 days before tapering. Some initiated a reduced dose of 500 mg/ day (n = 5, 9.8%) with similar outcomes. Response is favorable, with 56.8% (n = 29) returning to near baseline functional status, while 29.4% (n = 15) showed partial improvement.</p><p><strong>Conclusion: </strong>Evidence from 51 cases highlight the disorder's variable course in the older population; often mimicking other age-related conditions leading to diagnostic challenges and delays in management. A tailored approach is required, balancing the benefits of immunomodulatory therapies with potential risks. Further research is essential to understand the mechanism of HE in the older population and enhance patient outcomes by developing standardized treatment protocols tailored to this vulnerable population.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3505-3523"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurological SciencesPub Date : 2025-08-01Epub Date: 2025-04-17DOI: 10.1007/s10072-025-08164-0
Mirko Duradoni, Andrea Frosini, Giorgio Gronchi, Andrea Peru
{"title":"A new instrument for the assessment of laterality: evidence from confirmatory analysis.","authors":"Mirko Duradoni, Andrea Frosini, Giorgio Gronchi, Andrea Peru","doi":"10.1007/s10072-025-08164-0","DOIUrl":"10.1007/s10072-025-08164-0","url":null,"abstract":"<p><p>Despite its importance, the assessment of laterality in scientific and clinical contexts remains inconsistent. Many studies rely on self-reports or outdated questionnaires (in terms of daily-related actions), often neglecting lateralization of the lower limbs, eyes, and ears without considering the four effectors at the same time. To address these limitations, we developed the Florence Laterality Inventory (FLI), a 16-item scale designed to provide a comprehensive assessment of hand, foot/leg, eye, and ear preference through more contemporary and relevant questions. Our study, conducted with 225 participants, confirmed a four-factor structure through confirmatory factor analysis (CFA), demonstrating good reliability for the hand, eye, and ear subscales and, to a lesser extent, also for foot/leg. Correlations with established measures of laterality and handedness supported the concurrent validity of the scale. The FLI scale offers an updated multidimensional instrument to measure lateralization, addressing the shortcomings of previous questionnaires and adapting to modern contexts.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3593-3600"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurological SciencesPub Date : 2025-08-01Epub Date: 2025-04-21DOI: 10.1007/s10072-025-08183-x
Yuru Wang, Kangzhi Li, Lihong Si, Shui Liu, Xu Yang
{"title":"Abnormal neural circuits and altered brain network topological properties in patients with chronic unilateral vestibulopathy.","authors":"Yuru Wang, Kangzhi Li, Lihong Si, Shui Liu, Xu Yang","doi":"10.1007/s10072-025-08183-x","DOIUrl":"10.1007/s10072-025-08183-x","url":null,"abstract":"<p><strong>Background: </strong>Chronic unilateral vestibulopathy (CUVP) is one of the most common causes of chronic dizziness/vertigo. The brain functional mechanisms of CUVP are currently unclear. The study aimed to clarify changes in brain topological properties and subnetwork functional connectivity in CUVP patients, elucidating the neural mechanisms behind their poor dynamic compensation.</p><p><strong>Methods: </strong>A total of 44 participants were included (22 CUVP patients and 22 age- and sex-matched healthy controls). Resting-state functional MRI was performed on all subjects. Network-Based Statistics (NBS) analysis was conducted to identify abnormal neural circuits in CUVP. Graph-theoretical analysis (GTA) was performed to elucidate changes in brain network topological properties. Correlation analysis was conducted to examine the relationship between brain network changes and clinical symptom severity.</p><p><strong>Results: </strong>NBS analysis revealed an abnormal neural network in CUVP patients, with key nodes including the parieto-insular vestibular cortex, sensory-motor cortex, occipital visual cortex, brainstem, and cerebellum. The most significant functional connectivity abnormalities were observed between the brainstem and visual/sensorimotor networks. Graph-theoretical analysis indicated increased characteristic path length, decreased global and local efficiency in CUVP patients. Node properties showed reduced node efficiency and clustering coefficients in multiple nodes within the visual and sensorimotor networks. Correlation analysis indicated that brain network topology and changes in brainstem-sensorimotor network connectivity were negatively correlated with DHI scores.</p><p><strong>Conclusion: </strong>CUVP patients exhibit multisensory integration abnormalities and changes in brain network topology at both the brainstem/cerebellar and cortical levels, which may underlie the potential neural basis for poor vestibular compensation in CUVP patients.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3851-3863"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Maternal and fetal outcomes in pregnant women with PRES and HELLP syndrome.","authors":"Shree Rath","doi":"10.1007/s10072-025-08390-6","DOIUrl":"https://doi.org/10.1007/s10072-025-08390-6","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}