Neurological Sciences最新文献_第6页

Impact of upper extremity robotic rehabilitation on respiratory parameters, functional capacity and dyspnea in patients with stroke: a randomized controlled study. 上肢机器人康复对中风患者呼吸参数、功能能力和呼吸困难的影响：随机对照研究。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-03-01 Epub Date: 2024-11-11 DOI: 10.1007/s10072-024-07868-z

Büşra Okumuş, Buket Akıncı, Güzin Kaya Aytutuldu, Mehmet Salih Baran

{"title":"Impact of upper extremity robotic rehabilitation on respiratory parameters, functional capacity and dyspnea in patients with stroke: a randomized controlled study.","authors":"Büşra Okumuş, Buket Akıncı, Güzin Kaya Aytutuldu, Mehmet Salih Baran","doi":"10.1007/s10072-024-07868-z","DOIUrl":"10.1007/s10072-024-07868-z","url":null,"abstract":"Background: Stroke leads to reduced mobility and functional capacity, also negatively affects respiratory functions and muscle strength.Aim: To examine the effects of adding upper extremity robotic rehabilitation to conventional treatment on respiratory parameters, functional capacity, mobility, and dyspnea.Method: Thirty-four stroke patients aged 18-65/years were randomized into Conventional Rehabilitation (CR) or Upper Extremity Robotic Rehabilitation (RR) groups. Both groups received conventional treatment for 5 days/week, for 6 weeks. Additionally, the RR group participated in upper extremity robotic rehabilitation (ExoRehab X, Houston Bionics) twice/week. Respiratory muscle strength (Maximum Inspiratory Pressure-MIP and Maximum Expiratory Pressure-MEP) and respiratory functions (forced expiratory flow first second (FEV1)), forced vital capacity (FVC), FEV1/FVC, peak expiratory flow (PEF), and forced expiratory flow-25-75% (FEF 25-75%) were assessed. Functional capacity was evaluated with 6-minute walk test (6-MWT), mobility was assessed with Timed Up and Go (TUG) test, and dyspnea was measured using Dyspnea-12 test.Results: Both groups showed improvements in MIP, MEP, 6MWT and TUG scores. Additionally, significant increases were observed in PEF in the CR group and in FVC, FEV1, %FEF 25-75, and reduced dyspnea in the RR group (all p < 0.05). The groups were similar in terms of mean changes, except for FVC (p = 0.004) and FEV1 (p = 0.002), which were significantly higher in RR group.Conclusion: Combining upper extremity robotic rehabilitation with conventional rehabilitation in stroke patients led to similar improvements in respiratory muscle strength, functional capacity, and mobility while also improving some respiratory parameters and reducing the perception of dyspnea.Trial registration number: NCT05550311.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"1257-1266"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KLHL11-associated rhomboencephalitis presenting as clippers-like syndrome. 表现为剪子样综合征的KLHL11相关性重型脑炎

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-03-01 Epub Date: 2024-11-10 DOI: 10.1007/s10072-024-07858-1

Jin Li, Ling Bai, Yushan Yuan, Jianzhao Zhai, Minjin Wang

引用次数: 0

RAB32 Ser71Arg in Chinese patients with Parkinson's disease. 中国帕金森病患者的RAB32 Ser71Arg

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-03-01 Epub Date: 2024-12-09 DOI: 10.1007/s10072-024-07910-0

Yinge Xue, Minglei Liu, Kaixin Chen, Yuming Xu, Jing Yang

引用次数: 0

Three hertz orthostatic tremor as "red flag sign" candidate for multiple system atrophy. 三赫兹正位震颤是多系统萎缩的 "红旗信号 "候选者。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-03-01 Epub Date: 2024-09-20 DOI: 10.1007/s10072-024-07762-8

Yuzhou Wang, Churong Liu, Wenhua Zheng, Mengyun Li, Xiaodi Li

{"title":"Three hertz orthostatic tremor as \"red flag sign\" candidate for multiple system atrophy.","authors":"Yuzhou Wang, Churong Liu, Wenhua Zheng, Mengyun Li, Xiaodi Li","doi":"10.1007/s10072-024-07762-8","DOIUrl":"10.1007/s10072-024-07762-8","url":null,"abstract":"Aim: This study investigates the potential of 3-Hz orthostatic tremor (OT) as a diagnostic red-flag sign for differentiating multiple system atrophy (MSA) from Parkinson's disease (PD).Patients and methods: A total of 615 PD patients and 234 MSA patients (120 MSA-P and 114 MSA-C) participated. OT at ~ 3 Hz and other frequencies was identified through rhythmic postural sway on the stabilogram map and confirmed by fast Fourier transform (FFT) analysis. Extensive assessment of OT occurrence, preferential stance conditions, sway direction, frequency spectrum, and intensity was performed and compared between the two diseases.Results: Significant differences in OT features were observed. In PD, 104 patients (16.9%) exhibited tremors, mainly on a firm platform (79.8%), and preferentially in the medial-lateral direction (59.6%). About 40% of PD-related OT showed double peaks in the FFT map, with a frequency spectrum from 3.3 to 12.4 Hz. MSA tremors were observed in 133 patients (56.8%, including 46 MSA-P and 87 MSA-C patients), occurring after proprioceptive sensory input deprivation (94.7%). OT in MSA occurred exclusively in the anterior-posterior direction (100%), with no sub- or ultra-harmonics in the FFT map. Binominal logistic regression analyses demonstrated that frequency and stance conditions independently contributed to differentiating PD- and MSA-related OT. The 3-Hz tremor exhibited a sensitivity of 0.568, perfect specificity (1), an approximate negative predictive value of 0.8592, and a positive predictive value of 1 for MSA identification.Conclusions: This study establishes the 3-Hz orthostatic tremor as a promising red flag sign for MSA identification.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"1217-1224"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positive H3K27M cytology in cerebrospinal fluid in diffuse midline glioma. 弥漫中线胶质瘤脑脊液中 H3K27M 细胞学阳性。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-03-01 Epub Date: 2024-11-15 DOI: 10.1007/s10072-024-07839-4

Honami Kawai, Takaaki Hattori, Yutaka Nakajima, Takanori Yokota, Iichiroh Onishi

引用次数: 0

Innovative multidisciplinary tool for screening bowel and bladder symptoms in multiple sclerosis. 用于筛查多发性硬化症患者肠道和膀胱症状的创新型多学科工具。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-03-01 Epub Date: 2024-11-20 DOI: 10.1007/s10072-024-07888-9

Giampaolo Brichetto, Stefania Musco, Margherita Monti Bragadin, Erica Grange, Gianfranco Lamberti, Vincenzo Pedace, Sara Rinaldi

{"title":"Innovative multidisciplinary tool for screening bowel and bladder symptoms in multiple sclerosis.","authors":"Giampaolo Brichetto, Stefania Musco, Margherita Monti Bragadin, Erica Grange, Gianfranco Lamberti, Vincenzo Pedace, Sara Rinaldi","doi":"10.1007/s10072-024-07888-9","DOIUrl":"10.1007/s10072-024-07888-9","url":null,"abstract":"Introduction: Bowel and bladder symptoms are frequent in people with Multiple Sclerosis (PwMS) and early diagnosis and treatment become crucial to improve their quality of life (QoL). The study aims to design a multidisciplinary questionnaire for screening bladder and bowel symptoms in PwMS.Materials and methods: The Bowel and Bladder Symptoms Screening in Multiple Sclerosis (BBSS-MS) questionnaire for screening bowel and bladder symptoms was designed in Italian following a three-steps process. In the first step, a dedicated board of experts identified a pool of items, which will be analysed for content, clarity, and consistency during the second step. During the third step, the relevance of each item was evaluated through a two-round process following the Delphi method. For each round of the Delphi method, medians, the 25th and 75th percentiles, and the IQR of the score for each statement were calculated. Stata 16.1 software was used to conduct all analyses.Results: The Board identified 22 items to include in the BBSS-MS, based on existing questionnaire and clinical expertise. After discussing about the comprehensibility and clarity of items, the first version of the BBSS-MS composed of 22 items was proposed. Following, a Panel of 44 experts scored the relevance of each question and all the questions reached the score to be included in the questionnaire. The final 21-item version of the BBSS-MS was proposed.Discussion and conclusion: To our knowledge, the BBSS-MS represents the first self-reported hybrid questionnaire for screening bladder and bowel symptoms in an Italian MS population.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"1285-1290"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Henryk Higier (1866-1942) and Stanisław Higier (1894-1942) - father and son in the history of neurology. 亨利克·希格尔（1866-1942）和Stanisław希格尔(1894-1942)-神经病学史上的父子。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-03-01 Epub Date: 2024-12-23 DOI: 10.1007/s10072-024-07954-2

Slawomir Gonkowski

引用次数: 0

Effect and optimal exercise prescription of robot-assisted gait training on lower extremity motor function in stroke patients: a network meta-analysis. 机器人辅助步态训练对中风患者下肢运动功能的影响和最佳运动处方：一项网络荟萃分析。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-03-01 Epub Date: 2024-09-23 DOI: 10.1007/s10072-024-07780-6

Haiping Huang, Xinyi Su, Beisi Zheng, Manting Cao, Yuqian Zhang, Jianer Chen

{"title":"Effect and optimal exercise prescription of robot-assisted gait training on lower extremity motor function in stroke patients: a network meta-analysis.","authors":"Haiping Huang, Xinyi Su, Beisi Zheng, Manting Cao, Yuqian Zhang, Jianer Chen","doi":"10.1007/s10072-024-07780-6","DOIUrl":"10.1007/s10072-024-07780-6","url":null,"abstract":"Objective: This study aimed to evaluate the effectiveness of robot-assisted gait training (RAGT) and explore the optimal exercise prescription using a network meta-analysis approach.Data sources: A comprehensive search was conducted on randomized controlled trials comparing robotic and conventional rehabilitation published up to January 2024 in PubMed, Web of Science, Cochrane Library, Embase, CNKI, VIP, Wanfang, and SinoMed databases.Review methods: The evaluation parameters included Fugl-Meyer Assessment of Lower Extremity (FMA-LE), Functional Ambulation Category (FAC), Berg Balance Scale (BBS), and 6-Minute Walk Test (6MWT). Two investigators independently performed study screening, data extraction, and bias evaluation. Data were merged, analyzed, and plotted using Review Manager 5.4.1 and Stata 18.0 software.Results: A total of 21 articles involving 822 subjects were included in the analysis. RAGT positively influenced FMA-LE score (MD = 3.74, 95%CI 3.02-4.46, P < 0.05), FAC score (MD = 0.31, 95%CI 0.1-0.53, P < 0.05), BBS score (MD = 3.63, 95%CI 2.46-4.80, P < 0.05), and 6MWT score (MD = 23.73, 95%CI 15.31-32.14, P < 0.05). Surface under the cumulative ranking curve (SUCRA) values indicated that an exercise time of 40-60 min/training (97.4%), exercise frequency of 2-5 times/week (87.6%), and exercise duration of 8-12 weeks (78.1%) were most effective in improving the FMA-LE score.Conclusions: RAGT can effectively improve lower limb motor function, walking function, balance function, and walking endurance in stroke patients. For optimal improvement in FMA-LE score, an exercise time of 40-60 min/training, exercise frequency of 2-5 times/week, and exercise duration of 8-12 weeks are recommended.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"1151-1167"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-induced liver injury during valproic acid and cenobamate coadministration: a direct consequence or an unforeseen event? 丙戊酸和仙诺巴马特联合用药期间药物诱发的肝损伤：直接后果还是意外事件？

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-03-01 Epub Date: 2024-11-07 DOI: 10.1007/s10072-024-07864-3

Thomas Giannelli, Giovanni Falcicchio

引用次数: 0

Human herpesvirus 6 (HHV-6) encephalitis secondary to chimeric antigen receptor (CAR)-T cell therapy. 继发于嵌合抗原受体（CAR）-T 细胞疗法的人类疱疹病毒 6（HHV-6）脑炎。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-03-01 Epub Date: 2024-11-05 DOI: 10.1007/s10072-024-07860-7

Fahang Yi, Ningxiang Qin, Liang Wang

{"title":"Human herpesvirus 6 (HHV-6) encephalitis secondary to chimeric antigen receptor (CAR)-T cell therapy.","authors":"Fahang Yi, Ningxiang Qin, Liang Wang","doi":"10.1007/s10072-024-07860-7","DOIUrl":"10.1007/s10072-024-07860-7","url":null,"abstract":"Background: Human herpesvirus (HHV)-6 encephalitis secondary to chimeric antigen receptor (CAR)-T cell therapyis relatively rare in clinical practice and needs to be differentiated from immune effector cell-associatedneurotoxicity syndrome (ICANS).Methods: We retrospectively reported a case of HHV-6 encephalitis secondary to CAR-T cell therapy.Results: A male patient from China with diffuse large B-cell lymphoma underwent chimeric CAR-T cell therapy anddeveloped a generalized rash on the 8th day, followed by cognitive changes, memory loss, and disorientation onthe 14th day after CAR-T cell therapy. Initially, ICANS was suspected. A lumbar puncture was performed on the 18th day. The cerebrospinal fluid (CSF) analysis revealed slightly elevated protein levels and a high presence of HHV-6B sequences by mNGS. Brain MRI showed bilateral hippocampal abnormalities. The patient was ultimatelydiagnosed with HHV-6 encephalitis and treated with ganciclovir and dexamethasone. After one week of treatment,follow-up CSF analysis showed a reduction in HHV-6B sequences. The patient was discharged with improvedmemory and orientation.Conclusion: HHV-6 encephalitis secondary to CAR-T cell therapy may be easily confused with ICANS. Timely andaggressive diagnostic procedures, such as mNGS of CSF and cranial imaging, along with prompt antiviral therapy,are crucial for improving patient outcomes.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"1323-1327"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0